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ClinicalTrials.gov 37 recruiting now official registry

Bipolar Disorder clinical trials

37 of 163 indexed Bipolar Disorder trials are currently recruiting.

163 US clinical trials · 37 currently recruiting

Bipolar Disorder is the subject of 163 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 45 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 11 of these trials.

The research picture

Bipolar Disorder has 163 registered US clinical trials, 37 of them open to new participants right now, about 23% of the total.

37
recruiting participants now
23%
of trials open to enrollment
45
in Phase 3–4 (later-stage)
11
top sponsor: Massachusetts General Hospital
Phase 13Phase 212Phase 323Phase 422

Active & Recent Trials

163 total, page 1 of 4

RECRUITING 16,000 participants

Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers

National Institute of Mental Health (NIMH)

NCT00024635

RECRUITING 1,260 participants

NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder

National Institute of Mental Health (NIMH)

NCT05669703

RECRUITING 1,000 participants

University of Iowa Interventional Psychiatry Service Patient Registry

Mark Niciu

NCT04480918

RECRUITING NA 600 participants

Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations

Massachusetts General Hospital

NCT04296604

RECRUITING Phase 3 500 participants

Safety and Tolerability Trial of Lumateperone in Pediatric Patients With Schizophrenia, Bipolar Disorder or Autism Spectrum Disorder

Intra-Cellular Therapies

NCT06229210

RECRUITING Phase 3 424 participants

A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or Lamotrigine

Bristol-Myers Squibb

NCT07140913

RECRUITING Phase 2 400 participants

A Study of Brenipatide in Adult Participants With Bipolar Disorder (RENEW-Bipolar-1)

Eli Lilly and Company

NCT07286175

RECRUITING Phase 3 400 participants

A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression)

Xenon Pharmaceuticals

NCT07172516

RECRUITING NA 350 participants

Enhanced Coordinated Specialty Care for Early Psychosis

Mclean Hospital

NCT06071858

RECRUITING NA 300 participants

Taking Action for College Students

Temple University

NCT06700902

RECRUITING 200 participants

mHealth Estimate-based Algorithms Signaling Upcoming Recurrence of Episodes in Bipolar Disorders

VA Office of Research and Development

NCT06204705

RECRUITING NA 200 participants

Cerebellar Stimulation and Cognitive Control

Krystal Parker, PhD

NCT03217110

RECRUITING 200 participants

Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study

Mayo Clinic

NCT06897670

RECRUITING NA 190 participants

CBT-CP for Veterans With SMI

VA Office of Research and Development

NCT06758414

RECRUITING NA 150 participants

Healthy Lifestyles in Bipolar Disorder: Bay Area Study

University of California, Berkeley

NCT06555406

RECRUITING NA 136 participants

Intermittent Theta Burst Stimulation (iTBS) for Emotion Regulation in Bipolar Disorder

Massachusetts General Hospital

NCT06274567

RECRUITING NA 120 participants

Early Intervention for Youth at High Risk for Bipolar Disorder

University of Pittsburgh

NCT04815239

RECRUITING NA 111 participants

Reduction of Anticholinergic Medications Among Persons With Schizophrenia or Other Psychiatric Disorders

University of Pittsburgh

NCT07043803

RECRUITING NA 107 participants

Examining Neurobiological Mechanisms Underlying the Therapeutic Effect of the Ketogenic Diet in Bipolar Disorder (BD)

University of Pittsburgh

NCT06081426

RECRUITING 100 participants

Attentional Biases, Reward Sensitivity, and Cognitive Control in Adults With Bipolar Disorder

University Hospitals Cleveland Medical Center

NCT03829787

RECRUITING NA 100 participants

Use of Ketosis in Modulating Metabolic Pathways in Bipolar Disorder

Stony Brook University

NCT06373016

RECRUITING NA 100 participants

Acute Alcohol Response In Bipolar Disorder: a Longitudinal Alcohol Administration/fMRI Study

University of Texas at Austin

NCT05838274

RECRUITING NA 100 participants

Personalized Mobile Cognitive Behavioral Therapy Application

Weill Medical College of Cornell University

NCT05699525

RECRUITING NA 84 participants

Visual Perception in Schizophrenia

University of Rochester

NCT06911931

RECRUITING NA 80 participants

Enhancing Rehabilitation for Veterans With Serious Mental Illness

VA Office of Research and Development

NCT06586164

RECRUITING 80 participants

Children's Bipolar Network Treatment Trial I

University of California, Los Angeles

NCT05427123

RECRUITING NA 70 participants

A Future Thinking Intervention for Comorbid Tobacco Use Disorder and Bipolar Disorder

Massachusetts General Hospital

NCT06609902

RECRUITING Phase 2 68 participants

Gabapentin for Restoring GABA/Glutamate Homeostasis in Co-occurring Bipolar and Cannabis Use Disorders

Medical University of South Carolina

NCT05064319

RECRUITING NA 60 participants

Magnetic Seizure Therapy in Bipolar Depression (MST-BpD) and Treatment Resistant Depression (MST-TRD)

Joao L. DeQuevedo

NCT04080778

RECRUITING NA 52 participants

Getting Out of the House: Using Behavioral Activation to Increase Community Participation

Temple University

NCT06336616

RECRUITING Phase 2 50 participants

Correcting Circadian Rhythms to Breakthrough in Bipolar Disorder

Leslie Swanson

NCT06226025

RECRUITING Phase 4 50 participants

A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor

Neurocrine Biosciences

NCT07105111

RECRUITING Phase 2 30 participants

The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects

Yale University

NCT05786066

RECRUITING Phase 2 30 participants

BezafibrateTreatment for Bipolar Depression: A Proof of Concept Study

Massachusetts General Hospital

NCT02481245

RECRUITING Phase 2 30 participants

Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy

Michigan State University

NCT06529029

RECRUITING Phase 2 25 participants

Assessing the Impact of Cannabidiol for Anxiety and Depression in Bipolar Disorder

Mclean Hospital

NCT05457465

RECRUITING NA 20 participants

Acceptability and Feasibility of Work-Oriented Social-Cognitive Skills Training for Veterans With Serious Mental Illness

VA Office of Research and Development

NCT05491538

ACTIVE NOT RECRUITING 6,000 participants

Studying the Health of Asians to Advance Knowledge, Treatments, and Interventions for Depression

University of Texas Southwestern Medical Center

NCT06002204

ACTIVE NOT RECRUITING 4,185 participants

Evaluation of the Genetics of Bipolar Disorder

National Institute of Mental Health (NIMH)

NCT00001174

ACTIVE NOT RECRUITING NA 190 participants

Effectiveness RCT of Customized Adherence Enhancement

Case Western Reserve University

NCT04622150

ACTIVE NOT RECRUITING NA 176 participants

Using mHealth to Improve Adherence and Reduce Blood Pressure in Individuals With Hypertension and Mood Disorders

Case Western Reserve University

NCT04675593

ACTIVE NOT RECRUITING 120 participants

Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder

Brigham and Women's Hospital

NCT03336918

ACTIVE NOT RECRUITING 120 participants

Imaging mGluR5 and Synaptic Density in Psychiatric Disorders

Yale University

NCT03898297

ACTIVE NOT RECRUITING NA 40 participants

Low Field Magnetic Stimulation: Imaging Biomarkers in Geriatric Bipolar Depression

Mclean Hospital

NCT03484494

ACTIVE NOT RECRUITING NA 8 participants

Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD)

National Institute of Mental Health (NIMH)

NCT05172271

COMPLETED NA 2,443 participants

Person-Centered Versus Measurement-Based Care in Mental Health

University of Pittsburgh

NCT02507349

COMPLETED 1,303 participants

Child & Adolescent Bipolar Disorder Brain Imaging and Treatment Study

National Institute of Mental Health (NIMH)

NCT00006177

COMPLETED Phase 4 1,270 participants

A Study of Aripiprazole (Abilify) in Patients With Bipolar Mania

Otsuka Pharmaceutical Development & Commercialization

NCT00261443

COMPLETED Phase 3 1,255 participants

Quetiapine Fumarate Bipolar Maintenance Monotherapy

AstraZeneca

NCT00314184

COMPLETED Phase 4 1,169 participants

A Phase IV Study of the Safety and Efficacy of Aripiprazole in Combination With Lamotrigine in the Long-Term Maintenance Treatment of Patients With Bipolar I Disorder With A Recent Manic or Mixed Episode

Otsuka Pharmaceutical Development & Commercialization

NCT00277212

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Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 12
Phase 3 23
Phase 4 22

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Bipolar Disorder Trial Landscape

163 indexed Bipolar Disorder studies · 37 recruiting (23%).

Phase mix: 45 late (III/IV) vs 15 early (I/II).

Top sponsor: Massachusetts General Hospital (11 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Bipolar Disorder?

PlainTrial tracks 163 US clinical trials for Bipolar Disorder, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Bipolar Disorder?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.