Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05172271 · ClinicalTrials.gov registry record · NA
Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD)
A NA study of Major Depressive Disorder and Bipolar Disorder, sponsored by National Institute of Mental Health (NIMH).
- Active
- Registry status
- NA
- Development phase
- 8
- Enrollment target
- 1
- Study location
NCT05172271 is a NA study of Major Depressive Disorder and Bipolar Disorder that is active but no longer recruiting, run by National Institute of Mental Health (NIMH). The registered enrollment target is 8 participants, below the 377-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state.
The verdict
NCT05172271, a NA study of Major Depressive Disorder and Bipolar Disorder, is active but no longer recruiting, sponsored by National Institute of Mental Health (NIMH).
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 8 participants
- Enrollment target
- 1
- Study location
Study Summary
Background: People with TRD are often helped by electroconvulsive therapy (ECT). But ECT can affect memory and thinking. Researchers want to study a treatment called TEST that uses less electricity. Objective: To study the safety and feasibility of TEST and assess its antidepressant effects. Eligibility: Adults aged 25-64 with major depression that has not been relieved by current treatments. Design: Participants will be admitted to the NIH Clinical Center for 5 18 weeks over 2 3 treatment phases. Their medications may be adjusted. Participants will be interviewed about their depression, side effects, and other treatments they are receiving. They will complete questionnaires. They will give blood and urine samples. Their brain waves and heart rhythm will be recorded. They will take tests of memory, attention, mental functioning, and thinking. Participants will have magnetic resonance imaging (MRI) scans of the head and brain. They will lie on a table that slides in and out of the scanner. Pictures of brain chemicals will also be taken. They may complete tasks during the MRI. Participants will receive TEST and/or sham treatments. They may receive optional ECT. An intravenous catheter will be placed in an arm vein to receive general anesthesia. Two electrodes will be placed on the front of their head. An electric current will be passed from the ECT machine through the electrodes. For sham treatments, they will not receive the electric current. Their breathing, heart rate, brain function, blood pressure, and body movements will be measured. Participants will have 7 follow-up visits over 6 months. Visits can be done via telehealth. Participation will last for up to 42 weeks.
Conditions Studied
Interventions
- DEVICE MagPro TMS Stimulator and coil
- DEVICE Thymatron(R) System IV
- DEVICE Magnetic Resonance Imaging Scanner
- OTHER ECT device without stimulation
Study Locations (1)
Maryland
- National Institutes of Health Clinical Center - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 8 participants |
| Start Date | 2022-11-08 |
| Est. Completion | 2027-10-31 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05172271
The ClinicalTrials.gov registry entry for NCT05172271 describes a study currently listed as active not recruiting, categorized as NA. The registered enrollment target is 8 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 377-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (98% lower). The listed sponsor is National Institute of Mental Health (NIMH), which has 343 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Major Depressive Disorder appearing as the primary indexed condition, and to 4 interventions - of which MagPro TMS Stimulator and coil is the first listed.
NCT05172271 reports 1 study location spanning 1 distinct geographic area - top geographies include Maryland.
Frequently Asked Questions
What is clinical trial NCT05172271 about?
NCT05172271 is a clinical study titled "Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD)". Background: People with TRD are often helped by electroconvulsive therapy (ECT). But ECT can affect memory and thinking. Researchers want to study a treatment called TEST that uses less electricity. Objective: To study the safety and feasibility of TEST and assess its antidepressant effects. Eli...
What is the current status of trial NCT05172271?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 8 participants. The study started on 2022-11-08. Estimated completion is 2027-10-31.
What conditions does trial NCT05172271 study?
This clinical trial studies the following conditions: Major Depressive Disorder, Bipolar Disorder, Unipolar Major Depression.
What interventions are being tested in trial NCT05172271?
The interventions under investigation include: MagPro TMS Stimulator and coil (DEVICE), Thymatron(R) System IV (DEVICE), Magnetic Resonance Imaging Scanner (DEVICE), ECT device without stimulation (OTHER).
Who is sponsoring clinical trial NCT05172271?
This trial is sponsored by National Institute of Mental Health (NIMH), which has 343 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05172271 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Major Depressive Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
Taking Action for College Students
RECRUITING · NA
-
Targeting Large-scale Networks in Depression With Real-time Functional Magnetic Resonance Imaging (fMRI) Neurofeedback
RECRUITING · NA
-
Neural Correlates of Stress and Perceived Control in Adolescent Depression
RECRUITING · NA
-
Positive Processes and Transition to Health (PATH)
RECRUITING · NA
-
Getting Out of the House: Using Behavioral Activation to Increase Community Participation
RECRUITING · NA
-
Amygdala Neurofeedback for Depression - Large Scale Clinical Trial
RECRUITING · NA
Explore more on PlainTrial
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.