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Bipolar Disorder clinical trials
37 of 163 indexed Bipolar Disorder trials are currently recruiting.
163 US clinical trials · 37 currently recruiting
Bipolar Disorder is the subject of 163 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 45 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 11 of these trials.
The research picture
Bipolar Disorder has 163 registered US clinical trials, 37 of them open to new participants right now, about 23% of the total.
- 37
- recruiting participants now
- 23%
- of trials open to enrollment
- 45
- in Phase 3–4 (later-stage)
- 11
- top sponsor: Massachusetts General Hospital
Active & Recent Trials
163 total, page 2 of 4
Seroquel in Bipolar Depression Versus SSRI
AstraZeneca
NCT00119652
Study on the Efficacy, Safety, and Tolerability of Cariprazine Relative to Placebo in Participants With Bipolar I Depression
Forest Laboratories
NCT02670551
Study Evaluating Bifeprunox in Bipolar Depression
Wyeth is now a wholly owned subsidiary of Pfizer
NCT00134459
Adapting the Bipolar Care Model for Chronic Care Management in Community-based Health Care Sites
University of Michigan
NCT00747201
Dexmedetomidine in the Treatment of Agitation Associated With Bipolar Disorder
BioXcel Therapeutics
NCT04276883
Study of Outcome and Safety of Lithium, Divalproex and Risperidone for Mania in Children and Adolescents
Washington University School of Medicine
NCT00057681
Study of Licarbazepine in the Treatment of Manic Episodes of Bipolar Disorder
Novartis Pharmaceuticals
NCT00107926
Optimizing Electroconvulsive Therapy for Depression
New York State Psychiatric Institute
NCT00045916
Lamictal as Add-on Treatment for Bipolar I Disorder in Pediatric Patients
GlaxoSmithKline
NCT00723450
A Study of Pregnant and Postpartum Women With and Without Mood Disorders
Johns Hopkins University
NCT03615794
Early Detection and Intervention for the Prevention of Psychosis
MaineHealth
NCT00531518
Implementation Trial of Evidence Based Practices for Mood Disorders
University of Arkansas
NCT02150577
The Appeal and Impact of E-cigarettes in Smokers With SMI
Dartmouth-Hitchcock Medical Center
NCT03050853
Treatment of Bipolar Mania in Older Adults
Weill Medical College of Cornell University
NCT00254488
A Study of the Relationship of Psychosocial Function With Mood Symptoms in Offspring of Parents With Bipolar Disorder
Janssen Research & Development
NCT03017781
Triiodothyronine (T3) Supplementation in the Treatment of Bipolar and Unipolar Depression.
Hadassah Medical Organization
NCT00158990
LiveWell: A Mobile Intervention for Bipolar Disorder
Northwestern University
NCT03088462
Open Label Extension Study of Licarbazepine in the Treatment of Manic Episodes of Bipolar I Disorder
Novartis
NCT00139594
Examination of Glutamate and mGluR5 in Psychiatric Disorders
Yale University
NCT02727972
Comparing Mobile Health (mHealth) and Clinic-Based Self-Management Interventions for Serious Mental Illness
Dartmouth-Hitchcock Medical Center
NCT02421965
Supported Employment: Motivational Enhancement for Entry and Outcome
VA Office of Research and Development
NCT01041976
Virtual Reality Job Interview Training in Severe Mental Illness
University of Michigan
NCT03049813
Valproate Efficacy in Cocaine-Bipolar Comorbidity
University of Miami
NCT00240110
The Evaluation and Follow-up of Patients With Bipolar Disorder
National Institute of Mental Health (NIMH)
NCT00001652
An Outpatient Study of the Effectiveness and Safety of Depakote ER in the Treatment of Mania/Bipolar Disorder in Children and Adolescents
Abbott
NCT00067262
The Role of Dysmyelination in Cognitive Impairment of Psychotic Spectrum Disorders
NYU Langone Health
NCT03166098
Contingency Management of Alcohol Abuse in the Severely Mentally ILL
University of Washington
NCT01567943
Quetiapine Extended Release (XR) in Bipolar Patients With Comorbid Generalized Anxiety Disorder (GAD)
University Hospitals Cleveland Medical Center
NCT00671853
Evaluation of A Statewide Program to Prevent Early Mortality and to Promote Fitness in Persons With SMI
Dartmouth-Hitchcock Medical Center
NCT02334280
Bipolar Disorder in Pregnancy and the Postpartum Period: Predictors of Morbidity
Massachusetts General Hospital
NCT00580268
Self-Management Addressing Heart Disease Risk Trial
US Department of Veterans Affairs
NCT00499096
Quetiapine in Patients With Bipolar and Alcohol Abuse/Dependence
University of Texas Southwestern Medical Center
NCT00223249
Family Intervention for Mental Illness and Substance Abuse
Dartmouth-Hitchcock Medical Center
NCT00043693
Brain Imaging in Depression
National Institute of Mental Health (NIMH)
NCT00050700
Targeting Cognition in Bipolar Disorder With Pramipexole
Brigham and Women's Hospital
NCT02397837
Acute Treatment of Bipolar II Depression
Stanford University
NCT00074776
Bipolar Disorder in Epilepsy
Northwell Health
NCT00365482
Development of a Personalized Real-time Intervention for Bipolar Disorder
University of California, San Diego
NCT01670123
Pilot Trial of Peer Support for Bipolar Disorder
Kaiser Permanente
NCT02404246
Mobile Self-Tracking of Mental Health
VA Office of Research and Development
NCT05023252
Neuroimaging Epigenetics of Prospective Postpartum Depression Biomarkers
Johns Hopkins University
NCT03638687
Development of a Mobile Heath Augmented Brief Suicide Prevention Intervention for People With SMI
University of California, San Diego
NCT03198364
Aripiprazole for Bipolar Disorder and Alcohol Use Disorder
University of Texas Southwestern Medical Center
NCT02918370
Treatment of Mania Symptoms With Drug Therapy
Palo Alto Veterans Institute for Research
NCT00183443
Efficacy Study of Quetiapine Plus Topiramate for Reducing Cannabis Consumption and Bipolar Mania
University of Cincinnati
NCT00393978
Reducing Suicide Risk in Adolescents and Young Adults Via a Psychobehavioral Intervention to Regularize Daily Rhythms
Yale University
NCT05317481
Omega-3 Fatty Acids in Children and Adolescents With Bipolar Disorder
University of Rochester
NCT00252486
Uridine Adolescent Bipolar Depression Randomized Controlled Trial
University of Utah
NCT01805440
Study of Aripiprazole (Abilify) in Children With Symptoms of Mania
University Hospitals Cleveland Medical Center
NCT00194077
Treatment of Geriatric Bipolar Mood Disorders: A Pilot Study
University of Pittsburgh
NCT00177567
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 12 |
| Phase 3 | 23 |
| Phase 4 | 22 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Bipolar Disorder Trial Landscape
163 indexed Bipolar Disorder studies · 37 recruiting (23%).
Phase mix: 45 late (III/IV) vs 15 early (I/II).
Top sponsor: Massachusetts General Hospital (11 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Bipolar Disorder?
PlainTrial tracks 163 US clinical trials for Bipolar Disorder, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Bipolar Disorder?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.