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Bipolar Disorder: later-stage trial registry
37 of 163 indexed Bipolar Disorder trials are currently recruiting, with more weight in Phase 3-4.
Corpus placement: #66 of 28,707 conditions by registered trial count.
163 US clinical trials · 37 currently recruiting · #66 of 28,707 conditions by registered trial count
Bipolar Disorder: 163 US clinical trials tracked, 37 recruiting.
Bipolar Disorder is the subject of 163 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 45 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 11 of these trials.
Enrollment posture brief
Registry condition bipolar-disorder
OPEN 37 | RECR 23% | LATE 45 | EARLY 15 | RANK #66 | SPON 11
Volume-matched condition peers
Nearest open-share peer: Hypogonadism (23% recruiting · 22 trials)
Bipolar Disorder lists 37 open slots (23% of 163 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Bipolar Disorder on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Bipolar Disorder is recruiting below its size-band peers.
37 of 163 indexed trials (22.7%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Bipolar Disorder trials is spread across many organizations.
Massachusetts General Hospital accounts for 11 of 163 trials (6.7%). 73 distinct sponsors appear on at least one study for this condition label.
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Typical Bipolar Disorder enrolment sits around 75 participants.
Median target enrolment is 75 among the 163 trials that report a genuine target (sentinel values excluded). 92 of those (56.4%) plan for fewer than 100 participants.
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Bipolar Disorder research is mostly interventional.
133 interventional and 30 observational studies make up this index (81.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
163 total, page 2 of 4
Seroquel in Bipolar Depression Versus SSRI
AstraZeneca
NCT00119652
Study on the Efficacy, Safety, and Tolerability of Cariprazine Relative to Placebo in Participants With Bipolar I Depression
Forest Laboratories
NCT02670551
Study Evaluating Bifeprunox in Bipolar Depression
Wyeth is now a wholly owned subsidiary of Pfizer
NCT00134459
Adapting the Bipolar Care Model for Chronic Care Management in Community-based Health Care Sites
University of Michigan
NCT00747201
Dexmedetomidine in the Treatment of Agitation Associated With Bipolar Disorder
BioXcel Therapeutics
NCT04276883
Study of Outcome and Safety of Lithium, Divalproex and Risperidone for Mania in Children and Adolescents
Washington University School of Medicine
NCT00057681
Study of Licarbazepine in the Treatment of Manic Episodes of Bipolar Disorder
Novartis Pharmaceuticals
NCT00107926
Optimizing Electroconvulsive Therapy for Depression
New York State Psychiatric Institute
NCT00045916
Lamictal as Add-on Treatment for Bipolar I Disorder in Pediatric Patients
GlaxoSmithKline
NCT00723450
A Study of Pregnant and Postpartum Women With and Without Mood Disorders
Johns Hopkins University
NCT03615794
Early Detection and Intervention for the Prevention of Psychosis
MaineHealth
NCT00531518
Implementation Trial of Evidence Based Practices for Mood Disorders
University of Arkansas
NCT02150577
The Appeal and Impact of E-cigarettes in Smokers With SMI
Dartmouth-Hitchcock Medical Center
NCT03050853
Treatment of Bipolar Mania in Older Adults
Weill Medical College of Cornell University
NCT00254488
A Study of the Relationship of Psychosocial Function With Mood Symptoms in Offspring of Parents With Bipolar Disorder
Janssen Research & Development
NCT03017781
Triiodothyronine (T3) Supplementation in the Treatment of Bipolar and Unipolar Depression.
Hadassah Medical Organization
NCT00158990
LiveWell: A Mobile Intervention for Bipolar Disorder
Northwestern University
NCT03088462
Open Label Extension Study of Licarbazepine in the Treatment of Manic Episodes of Bipolar I Disorder
Novartis
NCT00139594
Examination of Glutamate and mGluR5 in Psychiatric Disorders
Yale University
NCT02727972
Comparing Mobile Health (mHealth) and Clinic-Based Self-Management Interventions for Serious Mental Illness
Dartmouth-Hitchcock Medical Center
NCT02421965
Supported Employment: Motivational Enhancement for Entry and Outcome
VA Office of Research and Development
NCT01041976
Virtual Reality Job Interview Training in Severe Mental Illness
University of Michigan
NCT03049813
Valproate Efficacy in Cocaine-Bipolar Comorbidity
University of Miami
NCT00240110
The Evaluation and Follow-up of Patients With Bipolar Disorder
National Institute of Mental Health (NIMH)
NCT00001652
An Outpatient Study of the Effectiveness and Safety of Depakote ER in the Treatment of Mania/Bipolar Disorder in Children and Adolescents
Abbott
NCT00067262
The Role of Dysmyelination in Cognitive Impairment of Psychotic Spectrum Disorders
NYU Langone Health
NCT03166098
Contingency Management of Alcohol Abuse in the Severely Mentally ILL
University of Washington
NCT01567943
Quetiapine Extended Release (XR) in Bipolar Patients With Comorbid Generalized Anxiety Disorder (GAD)
University Hospitals Cleveland Medical Center
NCT00671853
Evaluation of A Statewide Program to Prevent Early Mortality and to Promote Fitness in Persons With SMI
Dartmouth-Hitchcock Medical Center
NCT02334280
Bipolar Disorder in Pregnancy and the Postpartum Period: Predictors of Morbidity
Massachusetts General Hospital
NCT00580268
Self-Management Addressing Heart Disease Risk Trial
US Department of Veterans Affairs
NCT00499096
Quetiapine in Patients With Bipolar and Alcohol Abuse/Dependence
University of Texas Southwestern Medical Center
NCT00223249
Family Intervention for Mental Illness and Substance Abuse
Dartmouth-Hitchcock Medical Center
NCT00043693
Brain Imaging in Depression
National Institute of Mental Health (NIMH)
NCT00050700
Targeting Cognition in Bipolar Disorder With Pramipexole
Brigham and Women's Hospital
NCT02397837
Acute Treatment of Bipolar II Depression
Stanford University
NCT00074776
Bipolar Disorder in Epilepsy
Northwell Health
NCT00365482
Development of a Personalized Real-time Intervention for Bipolar Disorder
University of California, San Diego
NCT01670123
Pilot Trial of Peer Support for Bipolar Disorder
Kaiser Permanente
NCT02404246
Mobile Self-Tracking of Mental Health
VA Office of Research and Development
NCT05023252
Neuroimaging Epigenetics of Prospective Postpartum Depression Biomarkers
Johns Hopkins University
NCT03638687
Development of a Mobile Heath Augmented Brief Suicide Prevention Intervention for People With SMI
University of California, San Diego
NCT03198364
Aripiprazole for Bipolar Disorder and Alcohol Use Disorder
University of Texas Southwestern Medical Center
NCT02918370
Treatment of Mania Symptoms With Drug Therapy
Palo Alto Veterans Institute for Research
NCT00183443
Efficacy Study of Quetiapine Plus Topiramate for Reducing Cannabis Consumption and Bipolar Mania
University of Cincinnati
NCT00393978
Reducing Suicide Risk in Adolescents and Young Adults Via a Psychobehavioral Intervention to Regularize Daily Rhythms
Yale University
NCT05317481
Omega-3 Fatty Acids in Children and Adolescents With Bipolar Disorder
University of Rochester
NCT00252486
Uridine Adolescent Bipolar Depression Randomized Controlled Trial
University of Utah
NCT01805440
Study of Aripiprazole (Abilify) in Children With Symptoms of Mania
University Hospitals Cleveland Medical Center
NCT00194077
Treatment of Geriatric Bipolar Mood Disorders: A Pilot Study
University of Pittsburgh
NCT00177567
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 12 |
| Phase 3 | 23 |
| Phase 4 | 22 |
Top Sponsors
Named interventions
Most-linked intervention names on Bipolar Disorder records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Bipolar Disorder trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Bipolar Disorder page
163 registered trials, 37 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 37 Bipolar Disorder trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Massachusetts General Hospital sponsors the most Bipolar Disorder trials on record, review their full trial history before evaluating a specific study. See Massachusetts General Hospital's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Bipolar Disorder condition card totals 163 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.