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NCT07128303 · ClinicalTrials.gov registry record · Phase 1
Study of GS-5319 in Adults With Solid Tumors
A Phase 1 study of Advanced Solid Tumor, sponsored by Gilead Sciences.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 178
- Enrollment target
- 8
- Study locations
NCT07128303: Recruiting Phase 1 study of Advanced Solid Tumor, sponsored by Gilead Sciences.
NCT07128303 is a Phase 1 study of Advanced Solid Tumor that is actively recruiting participants, run by Gilead Sciences. The registered enrollment target is 178 participants, roughly in line with the 192-participant average among 189 other Advanced Solid Tumor trials with a reported enrollment target. The trial reports 8 study locations across 4 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07128303, a Phase 1 study of Advanced Solid Tumor, is actively recruiting participants, sponsored by Gilead Sciences.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 178 participants
- Enrollment target
- 8
- Study locations
Study Summary
The goal of this clinical study is to learn more about the study drug, GS-5319, its dosing, safety and tolerability in adults with solid tumors, where the participants show a specific gene alteration in the tumor. The gene helps produce methylthioadenosine phosphorylase (MTAP) enzyme. MTAP enzyme helps in normal growth of cells. The primary objectives of the study are to assess the safety and tolerability of GS-5319 in participants with methylthioadenosine phosphorylase (MTAP)-deleted advanced solid tumors and to identify the maximum tolerated dose (MTD)/maximum administered dose (MAD) and/or the recommended dose for expansion (RDE).
Conditions Studied
Interventions
- DRUG GS-5319
Study Locations (8)
Other
- Asan Medical Center - Seoul
- Samsung Medical Center - Seoul
- Vall d'Hebron Institute of Oncology (VHIO) - Barcelona
- START Madrid - FJD - Hospital Fundación Jiménez Díaz - Phase I Clinical Trials Unit - Madrid
- START - Centro Oncológico Clara Campal - Madrid
Massachusetts
- Beth Israel Deaconess Medical Center - Boston
Texas
- START San Antonio - San Antonio
Virginia
- NEXT Virginia - Fairfax
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 178 participants |
| Start Date | 2025-08-28 |
| Est. Completion | 2028-05 |
| Phase | Phase 1 |
What NCT07128303 shows while recruiting
NCT07128303 is an interventional study that assigns participants to a tested intervention. The registered 178 participants enrollment target is mid-sized for trials with a published cap, roughly in line with the 192-participant average among 189 other Advanced Solid Tumor trials with a reported enrollment target.
The record links to 1 condition, with Advanced Solid Tumor appearing as the primary indexed condition, and to 1 intervention - of which GS-5319 is the first listed.
NCT07128303 lists 8 locations in 4 states (Other, Massachusetts, Texas).
Frequently Asked Questions
What is clinical trial NCT07128303 about?
NCT07128303 is a clinical study titled "Study of GS-5319 in Adults With Solid Tumors". The goal of this clinical study is to learn more about the study drug, GS-5319, its dosing, safety and tolerability in adults with solid tumors, where the participants show a specific gene alteration in the tumor. The gene helps produce methylthioadenosine phosphorylase (MTAP) enzyme. MTAP enzyme he...
What is the current status of trial NCT07128303?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 178 participants. The study started on 2025-08-28. Estimated completion is 2028-05.
What conditions does trial NCT07128303 study?
This clinical trial studies the following conditions: Advanced Solid Tumor.
What interventions are being tested in trial NCT07128303?
The interventions under investigation include: GS-5319 (DRUG).
Who is sponsoring clinical trial NCT07128303?
This trial is sponsored by Gilead Sciences, which has 504 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07128303 being conducted?
This trial has 8 study locations across Massachusetts, Texas, Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Advanced Solid Tumor
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07128303's enrollment target sits among peer trials
178 72nd of 189 higher than 118 of 189 other Advanced Solid Tumor trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Advanced Solid Tumor trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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