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RECRUITING Phase 1

A Study of BG-75098 Alone and in Combination With Other Agents in Adults With Advanced Solid Tumors

NCT07226349 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of BG-75098 alone and in combination with BGB-43395 and fulvestrant in participants with advanced solid tumors.

Conditions Studied

Interventions

  • DRUG Fulvestrant
  • DRUG BGB-43395
  • DRUG BG-75098

Study Locations (13)

Texas

  • The University of Texas Md Anderson Cancer Center — Houston
  • Next Houston — Houston

Victoria

  • Cabrini Hospital Malvern — Malvern East
  • Peter Maccallum Cancer Centre — Melbourne

Hubei

  • Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology — Wuhan
  • Union Hospital Tongji Medical College Huazhong University of Science and Technologyjinyinhu Branch — Wuhan

Shandong

  • Qilu Hospital of Shandong University — Jinan
  • Weifang Peoples Hospital — Weifang

Alabama

  • University of Alabama At Birmingham Hospital — Birmingham

New South Wales

  • Blacktown Cancer and Haematology Centre — Blacktown

Queensland

  • Icon Cancer Centre Wesley — Auchenflower

Guangdong

  • Sun Yat Sen Memorial Hospital, Sun Yat Sen University (South) — Guangzhou

Trial Details

FieldValue
Enrollment Target 105 participants
Start Date 2025-12-11
Est. Completion 2029-03-15
Phase Phase 1

Sponsor

BeOne Medicines

138 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07226349

The ClinicalTrials.gov registry entry for NCT07226349 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 105 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is BeOne Medicines, which has 138 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Advanced Solid Tumor appearing as the primary indexed condition, and to 3 interventions — of which Fulvestrant is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07226349 reports 13 study locations spanning 9 distinct geographic areas — top geographies include Texas, Victoria, Hubei. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07226349 about?

NCT07226349 is a clinical study titled "A Study of BG-75098 Alone and in Combination With Other Agents in Adults With Advanced Solid Tumors". The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of BG-75098 alone and in combination with BGB-43395 and fulvestrant in participants with advanced solid tumors.

What is the current status of trial NCT07226349?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 105 participants. The study started on 2025-12-11. Estimated completion is 2029-03-15.

What conditions does trial NCT07226349 study?

This clinical trial studies the following conditions: Advanced Solid Tumor. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07226349?

The interventions under investigation include: Fulvestrant (DRUG), BGB-43395 (DRUG), BG-75098 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07226349?

This trial is sponsored by BeOne Medicines, which has 138 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07226349 being conducted?

This trial has 13 study locations across Alabama, Texas, New South Wales, Queensland, Victoria. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial