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A First-in-Human (FIH) Study of BG-C137, an Anti-Fibroblast Growth Factor Receptor 2b (FGFR2b) Antibody Drug Conjugate, in Participants With Advanced Solid Tumors
NCT06625593 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of BG-C137 alone and in combination with anticancer agents in participants with advanced solid tumors. The study will be conducted in two phases: Phase 1a (Monotherapy Dose Escalation, and Safety Expansion; Combination Dose Confirmation and Safety Expansion) and Phase 1b (Dose Expansion).
Conditions Studied
Interventions
- DRUG BG-C137
- DRUG Anticancer Agents
Study Locations (20)
New South Wales
- Blacktown Cancer and Haematology Centre — Blacktown
- Liverpool Hospital — Liverpool
Victoria
- Monash Health — Clayton
- Cabrini Hospital Malvern — Malvern East
Henan
- The First Affiliated Hospital of Henan University of Science and Technology — Luoyang
- Henan Cancer Hospital — Zhengzhou
California
- Usc Norris Comprehensive Cancer Center (Nccc) — Los Angeles
Connecticut
- Yale Cancer Center — New Haven
Minnesota
- Mayo Clinic Rochester — Rochester
Texas
- Md Anderson Cancer Center — Houston
Washington
- Fred Hutchinson Cancer Research Center — Seattle
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 168 participants |
| Start Date | 2024-12-09 |
| Est. Completion | 2026-12-31 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06625593
The ClinicalTrials.gov registry entry for NCT06625593 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 168 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is BeOne Medicines, which has 138 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Advanced Solid Tumor appearing as the primary indexed condition, and to 2 interventions — of which BG-C137 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06625593 reports 20 study locations spanning 17 distinct geographic areas — top geographies include New South Wales, Victoria, Henan. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06625593 about?
NCT06625593 is a clinical study titled "A First-in-Human (FIH) Study of BG-C137, an Anti-Fibroblast Growth Factor Receptor 2b (FGFR2b) Antibody Drug Conjugate, in Participants With Advanced Solid Tumors". The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of BG-C137 alone and in combination with anticancer agents in participants with advanced solid tumors. The study will be conducted in two phases: Phase 1a (M...
What is the current status of trial NCT06625593?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 168 participants. The study started on 2024-12-09. Estimated completion is 2026-12-31.
What conditions does trial NCT06625593 study?
This clinical trial studies the following conditions: Advanced Solid Tumor. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06625593?
The interventions under investigation include: BG-C137 (DRUG), Anticancer Agents (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06625593?
This trial is sponsored by BeOne Medicines, which has 138 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06625593 being conducted?
This trial has 20 study locations across California, Connecticut, Minnesota, Texas, Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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