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Efficacy and Safety Study of OMTX705, Monotherapy and Anti-PD-1-combined, in Subjects With Advanced Solid Tumors.
NCT05547321 · View on ClinicalTrials.gov ↗
Study Summary
Open-label, two parallel arm, multicenter, Phase 1 dose-escalation study to evaluate the safety and tolerability of OMTX705, both as monotherapy or in combination with pembrolizumab (Part 1) or tislelizumab (Part 2) in the treatment of patients with advanced or metastatic cancer in whom there is no available standard therapeutic option.
Conditions Studied
Interventions
- DRUG Pembrolizumab
- DRUG OMTX705
Study Locations (9)
Barcelona
- Hospital Universitari Vall d'Hebron — Barcelona
- ICO L'Hospitalet — L'Hospitalet de Llobregat
Madrid
- Hospital 12 Octubre — Madrid
- Hospital MD Anderson — Madrid
Massachusetts
- Beth Israel Deaconess Medical Center — Boston
Galicia
- Hospital Clínico Universitario de Santiago — Santiago de Compostela
Guipúzcoa
- Hospital Universitario de Donostia — San Sebastián
Navarre
- Clínica Universitaria de Navarra — Pamplona
Other
- Onkologikoa — San Sebastián
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 150 participants |
| Start Date | 2022-10-20 |
| Est. Completion | 2027-12 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05547321
The ClinicalTrials.gov registry entry for NCT05547321 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 150 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Oncomatryx Biopharma S.L., which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Advanced Solid Tumor appearing as the primary indexed condition, and to 2 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05547321 reports 9 study locations spanning 7 distinct geographic areas — top geographies include Barcelona, Madrid, Massachusetts. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05547321 about?
NCT05547321 is a clinical study titled "Efficacy and Safety Study of OMTX705, Monotherapy and Anti-PD-1-combined, in Subjects With Advanced Solid Tumors.". Open-label, two parallel arm, multicenter, Phase 1 dose-escalation study to evaluate the safety and tolerability of OMTX705, both as monotherapy or in combination with pembrolizumab (Part 1) or tislelizumab (Part 2) in the treatment of patients with advanced or metastatic cancer in whom there is no ...
What is the current status of trial NCT05547321?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 150 participants. The study started on 2022-10-20. Estimated completion is 2027-12.
What conditions does trial NCT05547321 study?
This clinical trial studies the following conditions: Advanced Solid Tumor. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05547321?
The interventions under investigation include: Pembrolizumab (DRUG), OMTX705 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05547321?
This trial is sponsored by Oncomatryx Biopharma S.L., which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05547321 being conducted?
This trial has 9 study locations across Massachusetts, Barcelona, Galicia, Guipúzcoa, Madrid. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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