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NCT05547321 · ClinicalTrials.gov registry record · Phase 1
Efficacy and Safety Study of OMTX705, Monotherapy and Anti-PD-1-combined, in Subjects With Advanced Solid Tumors.
A Phase 1 study of Advanced Solid Tumor, sponsored by Oncomatryx Biopharma S.L..
- Recruiting
- Registry status
- Phase 1
- Development phase
- 150
- Enrollment target
- 9
- Study locations
NCT05547321: Recruiting Phase 1 study of Advanced Solid Tumor, sponsored by Oncomatryx Biopharma S.L..
NCT05547321 is a Phase 1 study of Advanced Solid Tumor that is actively recruiting participants, run by Oncomatryx Biopharma S.L.. The registered enrollment target is 150 participants, below the 192-participant average among 189 other Advanced Solid Tumor trials with a reported enrollment target (22% lower). The trial reports 9 study locations across 7 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05547321, a Phase 1 study of Advanced Solid Tumor, is actively recruiting participants, sponsored by Oncomatryx Biopharma S.L..
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 150 participants
- Enrollment target
- 9
- Study locations
Study Summary
Open-label, two parallel arm, multicenter, Phase 1 dose-escalation study to evaluate the safety and tolerability of OMTX705, both as monotherapy or in combination with pembrolizumab (Part 1) or tislelizumab (Part 2) in the treatment of patients with advanced or metastatic cancer in whom there is no available standard therapeutic option.
Primary Outcome
Frequency by grade of treatment-emergent adverse events (TEAEs).
Conditions Studied
Interventions
- DRUG Pembrolizumab
- DRUG OMTX705
Study Locations (9)
Barcelona
- Hospital Universitari Vall d'Hebron - Barcelona
- ICO L'Hospitalet - L'Hospitalet de Llobregat
Madrid
- Hospital 12 Octubre - Madrid
- Hospital MD Anderson - Madrid
Massachusetts
- Beth Israel Deaconess Medical Center - Boston
Galicia
- Hospital Clínico Universitario de Santiago - Santiago de Compostela
Guipúzcoa
- Hospital Universitario de Donostia - San Sebastián
Navarre
- Clínica Universitaria de Navarra - Pamplona
Other
- Onkologikoa - San Sebastián
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 150 participants |
| Start Date | 2022-10-20 |
| Est. Completion | 2027-12 |
| Phase | Phase 1 |
What NCT05547321 shows while recruiting
NCT05547321 is an interventional study that assigns participants to a tested intervention. The registered 150 participants enrollment target is mid-sized for trials with a published cap, below the 192-participant average among 189 other Advanced Solid Tumor trials with a reported enrollment target (22% lower).
The record links to 1 condition, with Advanced Solid Tumor appearing as the primary indexed condition, and to 2 interventions - of which Pembrolizumab is the first listed.
NCT05547321 lists 9 locations in 7 states (Barcelona, Madrid, Massachusetts).
Frequently Asked Questions
What is clinical trial NCT05547321 about?
NCT05547321 is a clinical study titled "Efficacy and Safety Study of OMTX705, Monotherapy and Anti-PD-1-combined, in Subjects With Advanced Solid Tumors.". Open-label, two parallel arm, multicenter, Phase 1 dose-escalation study to evaluate the safety and tolerability of OMTX705, both as monotherapy or in combination with pembrolizumab (Part 1) or tislelizumab (Part 2) in the treatment of patients with advanced or metastatic cancer in whom there is no ...
What is the current status of trial NCT05547321?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 150 participants. The study started on 2022-10-20. Estimated completion is 2027-12.
What conditions does trial NCT05547321 study?
This clinical trial studies the following conditions: Advanced Solid Tumor.
What interventions are being tested in trial NCT05547321?
The interventions under investigation include: Pembrolizumab (DRUG), OMTX705 (DRUG).
Who is sponsoring clinical trial NCT05547321?
This trial is sponsored by Oncomatryx Biopharma S.L., which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05547321 being conducted?
This trial has 9 study locations across Massachusetts, Barcelona, Galicia, Guipúzcoa, Madrid. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Advanced Solid Tumor
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05547321's enrollment target sits among peer trials
150 86th of 189 higher than 100 of 189 other Advanced Solid Tumor trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Advanced Solid Tumor trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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