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ClinicalTrials.gov 133 recruiting now official registry

Advanced Solid Tumor clinical trials

133 of 190 indexed Advanced Solid Tumor trials are currently recruiting.

190 US clinical trials · 133 currently recruiting

Advanced Solid Tumor is the subject of 190 registered US clinical trials on ClinicalTrials.gov, 133 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 186 in Phase 1-2 (earlier-stage). The most active sponsor is Daiichi Sankyo, running 7 of these trials.

The research picture

Advanced Solid Tumor has 190 registered US clinical trials, 133 of them open to new participants right now, about 70% of the total.

133
recruiting participants now
70%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
7
top sponsor: Daiichi Sankyo
Phase 1180Phase 26

Active & Recent Trials

190 total, page 3 of 4

RECRUITING Phase 1 80 participants

AMT-116 in Patients With Advanced Solid Tumors

Multitude Therapeutics

NCT05725291

RECRUITING Phase 1 80 participants

A Safety and Efficacy Study of HCB101, Fc-fusion Protein Targeting SIRPα-CD47 Pathway, in Solid or Hematological Tumors

FBD Biologics Limited

NCT05892718

RECRUITING Phase 1 80 participants

A Study Evaluating the Safety and Efficacy of HB0036 in Subjects With Advanced Solid Tumors

Shanghai Huaota Biopharmaceutical Co.

NCT05417321

RECRUITING Phase 1 77 participants

M0324 as Monotherapy and in Combination With Pembrolizumab or Chemotherapy in Participants With Selected Advanced Solid Tumors

EMD Serono Research & Development Institute

NCT07166601

RECRUITING Phase 1 75 participants

A Study of XB628 in Participants With Recurrent Advanced or Metastatic Solid Tumors

Exelixis

NCT06952010

RECRUITING Phase 1 70 participants

Study of SGN1 in Patients With Advanced Solid Tumor

Guangzhou Sinogen Pharmaceutical Co.

NCT05038150

RECRUITING Phase 1 70 participants

A Phase 1, Dose-escalation Study of [225Ac]-FPI-2068 in Adult Patients With Advanced Solid Tumours

AstraZeneca

NCT06147037

RECRUITING Phase 1 70 participants

ARC101 in Advanced Solid Tumors

Third Arc Bio

NCT06672185

RECRUITING Phase 1 70 participants

Pemigatinib + Afatinib in Advanced Refractory Solid Tumors

Massachusetts General Hospital

NCT06302621

RECRUITING Phase 1 70 participants

A Phase 1, First in Human Study of TORL-4-500 in Patients With Advanced Cancer

TORL Biotherapeutics

NCT06005740

RECRUITING Phase 1 68 participants

First in Human Study of UCT-03-008 in Participants With Advanced Solid Tumors

1200 Pharma

NCT05103046

RECRUITING Phase 1 65 participants

A Study to Evaluate PEEL-224 in Patients With Advanced Solid Tumors

Peel Therapeutics

NCT05329103

RECRUITING Phase 1 65 participants

Hyperpolarized 13C MRI as a Biomarker in Advanced Solid Tumors

Robert Bok, MD, PhD

NCT05599048

RECRUITING Phase 1 63 participants

A First-in-Human Study of BG-C0902 Alone and in Combination With Other Therapeutic Agents in Patients With Advanced Solid Tumors

BeOne Medicines

NCT07181681

RECRUITING Phase 1 61 participants

Study to Evaluate IMP9064 as a Monotherapy or in Combination in Patients With Advanced Solid Tumors

Impact Therapeutics

NCT05269316

RECRUITING Phase 1 60 participants

Metformin Combined With Chemotherapy and/or Immunotherapy in Solid Malignancies

Barbara Ann Karmanos Cancer Institute

NCT07098299

RECRUITING Phase 1 52 participants

Phase Ib Trial of the KRAS G12C Inhibitor Adagrasib (MRTX849) in Combination With the PARP Inhibitor Olaparib in Patients With KRAS G12C Mutated Advanced Solid Tumors, With a Focus on Gynecological, Breast, Pancreatic and KEAP1 Mutated Non-small Cell Lung Cancers

M.D. Anderson Cancer Center

NCT06130254

RECRUITING Phase 1 52 participants

Anti-GD2 ADC M3554 in Advanced Solid Tumors

EMD Serono Research & Development Institute

NCT06641908

RECRUITING Phase 1 52 participants

Study of CX-5461 in Patients With Solid Tumours and BRCA1/2, PALB2 or Homologous Recombination Deficiency (HRD) Mutation

Senhwa Biosciences

NCT04890613

RECRUITING Phase 1 52 participants

Study of SGR-3515 In Participants With Advanced Solid Tumors.

Schrödinger

NCT06463340

RECRUITING 50 participants

A Study to Assess the Long-term Safety Outcomes in Patients Previously Treated With RP1, RP2, or RP3

Replimune

NCT06887348

RECRUITING Phase 1 50 participants

An Engineered Sirpα Fused to Anti-Pd-L1 And Tgf-β Fusion Protein (HCB301) in Subjects With Selected Advanced Tumors

FBD Biologics Limited

NCT06487624

RECRUITING Phase 1 50 participants

A Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of TT125-802 in Subjects With Advanced Solid Tumors

TOLREMO therapeutics

NCT06403436

RECRUITING Phase 1 49 participants

A Study of LM-24C5 For Advanced Solid Tumors

LaNova Medicines Limited

NCT06187402

RECRUITING Phase 1 43 participants

Phase 1 Study of Intratumoral Administration of VAX014 With Expansion in Combination With a Checkpoint Inhibitor in Subjects With Advanced Solid Tumors

Vaxiion Therapeutics

NCT05901285

RECRUITING Phase 1 42 participants

A Phase I Safety and Pharmacokinetic Study of Gamitrinib Administered Intravenously to Patients With Advanced Cancer

Fox Chase Cancer Center

NCT04827810

RECRUITING Phase 1 40 participants

A Study to Assess Safety and Efficacy of SOT201 in Patients With Advanced/Metastatic Cancer

SOTIO Biotech

NCT06163391

RECRUITING Phase 1 39 participants

Safety and Preliminary Effectiveness of BNT317, an Investigational Therapy for Advanced Solid Tumors

BioNTech SE

NCT06750185

RECRUITING Phase 1 32 participants

A Study of RNK05047 in Subjects With Advanced Solid Tumors/Diffuse Large B-cell Lymphoma (CHAMP-1)

Ranok Therapeutics (Hangzhou) Co.

NCT05487170

RECRUITING Phase 1 31 participants

First in Human, Dose Escalation Study of AN4005

Adlai Nortye Biopharma Co.

NCT04999384

RECRUITING Phase 1 30 participants

Safety, Pharmacokinetics (PK), and Efficacy of ONC 841 in Advanced Solid Tumors

OncoC4

NCT06352359

RECRUITING Phase 1 28 participants

Dose-escalation Study to Assess Safety and Pharmacokinetics of Nab-Sirolimus in Patients With Locally Advanced or Metastatic Solid Tumors and Moderate Liver Impairment

Aadi Bioscience

NCT05661461

RECRUITING Phase 1 28 participants

STM-06: POLARIS-POlymetastic Lesion Ablative Radiotherapy With Immunotherapy Study

University of Illinois at Chicago

NCT07269080

ACTIVE NOT RECRUITING Phase 1 750 participants

A Study of the Pan-KRAS Inhibitor LY4066434 in Participants With KRAS Mutant Solid Tumors

Eli Lilly and Company

NCT06607185

ACTIVE NOT RECRUITING Phase 1 733 participants

Safety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid Tumors and NSCLC

OncoC4

NCT04140526

ACTIVE NOT RECRUITING Phase 1 466 participants

Safety and Efficacy Study of NUV-1511 in Adult Patients With Advanced Solid Tumors

Nuvation Bio

NCT06334432

ACTIVE NOT RECRUITING Phase 1 440 participants

A Study of CLN-619 Alone and in Combination With Pembrolizumab in Advanced Solid Tumors

Cullinan Therapeutics

NCT05117476

ACTIVE NOT RECRUITING Phase 1 329 participants

Study BT8009-100 in Subjects With Nectin-4 Expressing Advanced Malignancies

BicycleTx Limited

NCT04561362

ACTIVE NOT RECRUITING Phase 1 320 participants

A Study to Investigate Safety and Tolerability of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab and/or TransCon TLR7/8 Agonist or Other Anticancer Therapies in Adult Participants With Locally Advanced or Metastatic Solid Tumor Malignancies

Ascendis Pharma Oncology Division A/S

NCT05081609

ACTIVE NOT RECRUITING Phase 1 320 participants

A Study of GRC 54276 in Participants With Advanced Solid Tumors and Lymphomas.

Glenmark Specialty S.A.

NCT05878691

ACTIVE NOT RECRUITING Phase 2 316 participants

A Study of Erdafitinib in Participants With Advanced Solid Tumors and Fibroblast Growth Factor Receptor (FGFR) Gene Alterations

Janssen Research & Development

NCT04083976

ACTIVE NOT RECRUITING Phase 1 310 participants

Safety and Preliminary Anti-Tumor Activity of TYRA-300 in Advanced Urothelial Carcinoma and Other Solid Tumors With FGFR3 Gene Alterations

Tyra Biosciences

NCT05544552

ACTIVE NOT RECRUITING Phase 1 240 participants

QTX3046 in Patients With KRAS G12D Mutations

Quanta Therapeutics

NCT06428500

ACTIVE NOT RECRUITING Phase 1 222 participants

Dose Escalation and Dose Expansion Study of RMC-6291 Monotherapy in Subjects With Advanced KRASG12C Mutant Solid Tumors

Revolution Medicines

NCT05462717

ACTIVE NOT RECRUITING Phase 1 220 participants

Study of ART6043 in Advanced/Metastatic Solid Tumors Patients

Artios Pharma

NCT05898399

ACTIVE NOT RECRUITING NA 211 participants

Meaning-Centered Pain Coping Skills Training for Cancer Pain

Duke University

NCT05385965

ACTIVE NOT RECRUITING Phase 1 209 participants

A Phase 1/2a Study of IMM-1-104 in Participants With Advanced or Metastatic Solid Tumors

Immuneering Corporation

NCT05585320

ACTIVE NOT RECRUITING Phase 1 200 participants

Study BT7480-100 in Patients With Advanced Malignancies Associated With Nectin-4 Expression

BicycleTx Limited

NCT05163041

ACTIVE NOT RECRUITING Phase 1 163 participants

First in Human Study of TORL-2-307-ADC in Participants With Advanced Cancer

TORL Biotherapeutics

NCT05156866

ACTIVE NOT RECRUITING Phase 1 160 participants

A Study of DM919 Alone and in Combination With Pembrolizumab in Advanced Solid Tumors

D2M Biotherapeutics

NCT06328673

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Phase Distribution

PhaseTrial count
Phase 1 180
Phase 2 6

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Advanced Solid Tumor Trial Landscape

190 indexed Advanced Solid Tumor studies · 133 recruiting (70%).

Phase mix: 0 late (III/IV) vs 186 early (I/II).

Top sponsor: Daiichi Sankyo (7 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Advanced Solid Tumor?

PlainTrial tracks 190 US clinical trials for Advanced Solid Tumor, of which 133 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Advanced Solid Tumor?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.