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ClinicalTrials.gov 45 recruiting now official registry

Advanced Cancer clinical trials

45 of 123 indexed Advanced Cancer trials are currently recruiting.

123 US clinical trials · 45 currently recruiting

Advanced Cancer is the subject of 123 registered US clinical trials on ClinicalTrials.gov, 45 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 85 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 19 of these trials.

The research picture

Advanced Cancer has 123 registered US clinical trials, 45 of them open to new participants right now, about 37% of the total.

45
recruiting participants now
37%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
19
top sponsor: M.D. Anderson Cancer Center
Phase 171Phase 214Phase 32

Active & Recent Trials

123 total, page 2 of 3

ACTIVE NOT RECRUITING Phase 1 249 participants

Sirolimus or Everolimus or Temsirolimus and Vorinostat in Advanced Cancer

M.D. Anderson Cancer Center

NCT01087554

ACTIVE NOT RECRUITING Phase 2 160 participants

Study of Osimertinib With and Without Ramucirumab in Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

Xiuning Le

NCT03909334

ACTIVE NOT RECRUITING Phase 1 153 participants

Study of EOS-448 With Standard of Care and/or Investigational Therapies in Participants With Advanced Solid Tumors

iTeos Belgium

NCT05060432

ACTIVE NOT RECRUITING Phase 1 150 participants

A Trial to Evaluate Safety and Tolerability of TST001 in Advanced or Metastatic Solid Tumors

Suzhou Transcenta Therapeutics Co.

NCT04396821

ACTIVE NOT RECRUITING Phase 1 110 participants

COM902 (A TIGIT Inhibitor) in Subjects With Advanced Malignancies

Compugen

NCT04354246

ACTIVE NOT RECRUITING Phase 2 98 participants

Effects of Mirtazapine on Appetite in Advanced Cancer Patients

M.D. Anderson Cancer Center

NCT00488072

ACTIVE NOT RECRUITING Phase 1 91 participants

A Study of AB801 Monotherapy and Combination Therapy in Participants With Advanced Malignancies

Arcus Biosciences

NCT06120075

ACTIVE NOT RECRUITING Phase 1 85 participants

Study of Avutometinib (VS-6766) + Adagrasib in KRAS G12C NSCLC Patients

Verastem

NCT05375994

ACTIVE NOT RECRUITING 84 participants

Meaning-Centered Counseling for Chinese Patients Who Are Being Treated for Advanced Cancer

Memorial Sloan Kettering Cancer Center

NCT02112188

ACTIVE NOT RECRUITING Phase 1 82 participants

FS120 Phase 1/1b Study in Patients With Advanced Malignancies

invoX Pharma Limited

NCT04648202

ACTIVE NOT RECRUITING NA 70 participants

Care Planning Framework in Advanced Cancer (ABC123)

University of Colorado, Denver

NCT05408507

ACTIVE NOT RECRUITING NA 60 participants

Better Real-time Information on Documentation of Goals of Care for Engagement in Serious Illness Communication

Dana-Farber Cancer Institute

NCT07147023

ACTIVE NOT RECRUITING 52 participants

Identifying Family Members in Need of Support While Caregiving and After Loss

Memorial Sloan Kettering Cancer Center

NCT02455505

ACTIVE NOT RECRUITING Phase 1 40 participants

Study of AB598 Monotherapy and Combination Therapy in Participants With Advanced Cancers

Arcus Biosciences

NCT05891171

ACTIVE NOT RECRUITING Phase 1 40 participants

A Study Evaluating DS-1055a in Participants With Relapsed or Refractory Locally Advanced or Metastatic Solid Tumors

Daiichi Sankyo

NCT04419532

ACTIVE NOT RECRUITING Phase 1 30 participants

A Study to Assess the Safety, Pharmacokinetics, and Antitumor Activity of Oral TACH101 in Participants With Advanced or Metastatic Cancer

Tachyon Therapeutics

NCT05076552

ACTIVE NOT RECRUITING Phase 2 30 participants

Lenvatinib in Locally Advanced Invasive Thyroid Cancer

Massachusetts Eye and Ear Infirmary

NCT04321954

ACTIVE NOT RECRUITING Phase 1 30 participants

Personalized Immunotherapy in Adults With Advanced Cancers Immunotherapy in Adults With Advanced Cancers

Ezra Cohen

NCT03568058

ACTIVE NOT RECRUITING NA 19 participants

Meaning-Centered Intervention for Muslim Patients Who Are Being Treated for Advanced Cancer

Memorial Sloan Kettering Cancer Center

NCT04435444

ACTIVE NOT RECRUITING Phase 1 10 participants

Assessing the Immunogenicity of pING-hHER3FL

Herbert Lyerly

NCT03832855

COMPLETED 459 participants

Measuring Sleep Disturbance Among Cancer Patients

M.D. Anderson Cancer Center

NCT00505544

COMPLETED Phase 1 451 participants

Study of the Safety, Pharmacokinetics and Antitumor Activities of BGB-A317 in Participants With Advanced Tumors

BeiGene

NCT02407990

COMPLETED Phase 3 399 participants

Sativex® for Relieving Persistent Pain in Patients With Advanced Cancer

Jazz Pharmaceuticals

NCT01361607

COMPLETED Phase 1 398 participants

Study of REGN2810 (Anti-PD-1) in Patients With Advanced Malignancies

Regeneron Pharmaceuticals

NCT02383212

COMPLETED Phase 1 323 participants

Dose Escalation and Expansion Study of FLX475 Monotherapy and in Combination with Pembrolizumab

RAPT Therapeutics

NCT03674567

COMPLETED NA 286 participants

Care Transition Intervention for Hospitalized Patients With Advanced Cancer

Massachusetts General Hospital

NCT05142345

COMPLETED Phase 1 277 participants

Hormone Receptor Positive Disease Across Solid Tumor Types: A Phase I Study of Single-Agent Hormone Blockade and Combination Approaches With Targeted Agents to Provide Synergy and Overcome Resistance

M.D. Anderson Cancer Center

NCT01197170

COMPLETED Phase 1 211 participants

A Study of AGEN2034 in Advanced Tumors and Cervical Cancer

Agenus

NCT03104699

COMPLETED Phase 1 200 participants

Doxil, Bevacizumab and Temsirolimus Trial

M.D. Anderson Cancer Center

NCT00761644

COMPLETED NA 196 participants

The PediQUEST Response Intervention Study

Joanne Wolfe, MD, MPH

NCT03408314

COMPLETED NA 194 participants

Randomized Study of a Hospice Video Educational Tool for Patients With Advanced Cancer and Their Caregivers

Massachusetts General Hospital

NCT03040102

COMPLETED Phase 1 193 participants

Phase 1/1b Study of MGCD516 in Patients With Advanced Cancer

Mirati Therapeutics

NCT02219711

COMPLETED Phase 1 174 participants

A Study of Evorpacept (ALX148) in Patients With Advanced Solid Tumors and Lymphoma (ASPEN-01)

ALX Oncology

NCT03013218

COMPLETED Phase 1 152 participants

Study of Pazopanib and Vorinostat in Patients With Advanced Malignancies

M.D. Anderson Cancer Center

NCT01339871

COMPLETED Phase 1 150 participants

A Phase 1 Study in Participants With Advanced Cancer

Eli Lilly and Company

NCT01115790

COMPLETED NA 136 participants

Interactive Voice Response System in Advanced Cancer Patients

M.D. Anderson Cancer Center

NCT00625638

COMPLETED 119 participants

Biomarkers For Immune Checkpoint Inhibitors

Rhode Island Hospital

NCT04204434

COMPLETED Phase 1 111 participants

Ascending Multiple-Dose Study of Brivanib Alaninate in Combination With Chemotherapeutic Agents in Subjects With Advanced Cancers

Bristol-Myers Squibb

NCT00798252

COMPLETED Phase 1 96 participants

A Study of ARRY-334543 in Patients With Advanced Cancer

Array Biopharma, now a wholly owned subsidiary of Pfizer

NCT00278902

COMPLETED Phase 1 88 participants

Hepatic Impairment Study For Crizotinib In Advanced Cancer Patients

Pfizer

NCT01576406

COMPLETED NA 80 participants

Using Video Images to Improve Advance Care Planning in Patients With Cancer

Massachusetts General Hospital

NCT00970125

COMPLETED Phase 1 78 participants

A Phase 1a/b Study of IK-175 as a Single Agent and in Combination With Nivolumab in Patients With Locally Advanced or Metastatic Solid Tumors and Urothelial Carcinoma

Ikena Oncology

NCT04200963

COMPLETED Phase 1 67 participants

A Dose-Escalation Study of ENMD-2076 Administered Orally to Patients With Advanced Cancer

CASI Pharmaceuticals

NCT00658671

COMPLETED Phase 1 64 participants

Oral STAT3 Inhibitor, TTI-101, in Patients with Advanced Cancers

Tvardi Therapeutics, Incorporated

NCT03195699

COMPLETED Phase 1 63 participants

A Dose-Escalation Study for Patients With Advanced Cancer

Eli Lilly and Company

NCT01214642

COMPLETED Phase 1 62 participants

RDEA119 and Sorafenib Combination Dose Escalation Study

Bayer

NCT00785226

COMPLETED NA 58 participants

Care Transition Intervention for Patients With Cancer

Massachusetts General Hospital

NCT04640714

COMPLETED Phase 2 52 participants

LY3214996 +/- HCQ in Pancreatic Cancer

Kimberly Perez, MD

NCT04386057

COMPLETED Phase 1 51 participants

Cisplatin HAI Study in Patients With Advanced Cancer and Dominant Liver Involvement

M.D. Anderson Cancer Center

NCT00507962

COMPLETED Phase 1 42 participants

Oral Administration of STC-15 in Subjects With Advanced Malignancies

STORM Therapeutics

NCT05584111

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Phase Distribution

PhaseTrial count
Phase 1 71
Phase 2 14
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Advanced Cancer Trial Landscape

123 indexed Advanced Cancer studies · 45 recruiting (37%).

Phase mix: 2 late (III/IV) vs 85 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (19 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Advanced Cancer?

PlainTrial tracks 123 US clinical trials for Advanced Cancer, of which 45 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Advanced Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.