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Advanced Cancer clinical trials
45 of 123 indexed Advanced Cancer trials are currently recruiting.
123 US clinical trials · 45 currently recruiting
Advanced Cancer is the subject of 123 registered US clinical trials on ClinicalTrials.gov, 45 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 85 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 19 of these trials.
The research picture
Advanced Cancer has 123 registered US clinical trials, 45 of them open to new participants right now, about 37% of the total.
- 45
- recruiting participants now
- 37%
- of trials open to enrollment
- 2
- in Phase 3–4 (later-stage)
- 19
- top sponsor: M.D. Anderson Cancer Center
Active & Recent Trials
123 total, page 2 of 3
Sirolimus or Everolimus or Temsirolimus and Vorinostat in Advanced Cancer
M.D. Anderson Cancer Center
NCT01087554
Study of Osimertinib With and Without Ramucirumab in Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
Xiuning Le
NCT03909334
Study of EOS-448 With Standard of Care and/or Investigational Therapies in Participants With Advanced Solid Tumors
iTeos Belgium
NCT05060432
A Trial to Evaluate Safety and Tolerability of TST001 in Advanced or Metastatic Solid Tumors
Suzhou Transcenta Therapeutics Co.
NCT04396821
COM902 (A TIGIT Inhibitor) in Subjects With Advanced Malignancies
Compugen
NCT04354246
Effects of Mirtazapine on Appetite in Advanced Cancer Patients
M.D. Anderson Cancer Center
NCT00488072
A Study of AB801 Monotherapy and Combination Therapy in Participants With Advanced Malignancies
Arcus Biosciences
NCT06120075
Study of Avutometinib (VS-6766) + Adagrasib in KRAS G12C NSCLC Patients
Verastem
NCT05375994
Meaning-Centered Counseling for Chinese Patients Who Are Being Treated for Advanced Cancer
Memorial Sloan Kettering Cancer Center
NCT02112188
FS120 Phase 1/1b Study in Patients With Advanced Malignancies
invoX Pharma Limited
NCT04648202
Care Planning Framework in Advanced Cancer (ABC123)
University of Colorado, Denver
NCT05408507
Better Real-time Information on Documentation of Goals of Care for Engagement in Serious Illness Communication
Dana-Farber Cancer Institute
NCT07147023
Identifying Family Members in Need of Support While Caregiving and After Loss
Memorial Sloan Kettering Cancer Center
NCT02455505
Study of AB598 Monotherapy and Combination Therapy in Participants With Advanced Cancers
Arcus Biosciences
NCT05891171
A Study Evaluating DS-1055a in Participants With Relapsed or Refractory Locally Advanced or Metastatic Solid Tumors
Daiichi Sankyo
NCT04419532
A Study to Assess the Safety, Pharmacokinetics, and Antitumor Activity of Oral TACH101 in Participants With Advanced or Metastatic Cancer
Tachyon Therapeutics
NCT05076552
Lenvatinib in Locally Advanced Invasive Thyroid Cancer
Massachusetts Eye and Ear Infirmary
NCT04321954
Personalized Immunotherapy in Adults With Advanced Cancers Immunotherapy in Adults With Advanced Cancers
Ezra Cohen
NCT03568058
Meaning-Centered Intervention for Muslim Patients Who Are Being Treated for Advanced Cancer
Memorial Sloan Kettering Cancer Center
NCT04435444
Assessing the Immunogenicity of pING-hHER3FL
Herbert Lyerly
NCT03832855
Measuring Sleep Disturbance Among Cancer Patients
M.D. Anderson Cancer Center
NCT00505544
Study of the Safety, Pharmacokinetics and Antitumor Activities of BGB-A317 in Participants With Advanced Tumors
BeiGene
NCT02407990
Sativex® for Relieving Persistent Pain in Patients With Advanced Cancer
Jazz Pharmaceuticals
NCT01361607
Study of REGN2810 (Anti-PD-1) in Patients With Advanced Malignancies
Regeneron Pharmaceuticals
NCT02383212
Dose Escalation and Expansion Study of FLX475 Monotherapy and in Combination with Pembrolizumab
RAPT Therapeutics
NCT03674567
Care Transition Intervention for Hospitalized Patients With Advanced Cancer
Massachusetts General Hospital
NCT05142345
Hormone Receptor Positive Disease Across Solid Tumor Types: A Phase I Study of Single-Agent Hormone Blockade and Combination Approaches With Targeted Agents to Provide Synergy and Overcome Resistance
M.D. Anderson Cancer Center
NCT01197170
A Study of AGEN2034 in Advanced Tumors and Cervical Cancer
Agenus
NCT03104699
Doxil, Bevacizumab and Temsirolimus Trial
M.D. Anderson Cancer Center
NCT00761644
The PediQUEST Response Intervention Study
Joanne Wolfe, MD, MPH
NCT03408314
Randomized Study of a Hospice Video Educational Tool for Patients With Advanced Cancer and Their Caregivers
Massachusetts General Hospital
NCT03040102
Phase 1/1b Study of MGCD516 in Patients With Advanced Cancer
Mirati Therapeutics
NCT02219711
A Study of Evorpacept (ALX148) in Patients With Advanced Solid Tumors and Lymphoma (ASPEN-01)
ALX Oncology
NCT03013218
Study of Pazopanib and Vorinostat in Patients With Advanced Malignancies
M.D. Anderson Cancer Center
NCT01339871
A Phase 1 Study in Participants With Advanced Cancer
Eli Lilly and Company
NCT01115790
Interactive Voice Response System in Advanced Cancer Patients
M.D. Anderson Cancer Center
NCT00625638
Biomarkers For Immune Checkpoint Inhibitors
Rhode Island Hospital
NCT04204434
Ascending Multiple-Dose Study of Brivanib Alaninate in Combination With Chemotherapeutic Agents in Subjects With Advanced Cancers
Bristol-Myers Squibb
NCT00798252
A Study of ARRY-334543 in Patients With Advanced Cancer
Array Biopharma, now a wholly owned subsidiary of Pfizer
NCT00278902
Hepatic Impairment Study For Crizotinib In Advanced Cancer Patients
Pfizer
NCT01576406
Using Video Images to Improve Advance Care Planning in Patients With Cancer
Massachusetts General Hospital
NCT00970125
A Phase 1a/b Study of IK-175 as a Single Agent and in Combination With Nivolumab in Patients With Locally Advanced or Metastatic Solid Tumors and Urothelial Carcinoma
Ikena Oncology
NCT04200963
A Dose-Escalation Study of ENMD-2076 Administered Orally to Patients With Advanced Cancer
CASI Pharmaceuticals
NCT00658671
Oral STAT3 Inhibitor, TTI-101, in Patients with Advanced Cancers
Tvardi Therapeutics, Incorporated
NCT03195699
A Dose-Escalation Study for Patients With Advanced Cancer
Eli Lilly and Company
NCT01214642
RDEA119 and Sorafenib Combination Dose Escalation Study
Bayer
NCT00785226
Care Transition Intervention for Patients With Cancer
Massachusetts General Hospital
NCT04640714
LY3214996 +/- HCQ in Pancreatic Cancer
Kimberly Perez, MD
NCT04386057
Cisplatin HAI Study in Patients With Advanced Cancer and Dominant Liver Involvement
M.D. Anderson Cancer Center
NCT00507962
Oral Administration of STC-15 in Subjects With Advanced Malignancies
STORM Therapeutics
NCT05584111
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 71 |
| Phase 2 | 14 |
| Phase 3 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Advanced Cancer Trial Landscape
123 indexed Advanced Cancer studies · 45 recruiting (37%).
Phase mix: 2 late (III/IV) vs 85 early (I/II).
Top sponsor: M.D. Anderson Cancer Center (19 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Advanced Cancer?
PlainTrial tracks 123 US clinical trials for Advanced Cancer, of which 45 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Advanced Cancer?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.