Agenus

24 total trials 13 completed

Agenus sponsors 24 registered US clinical trials on ClinicalTrials.gov, none currently recruiting, and 13 completed. 3 of these trials are in Phase 3-4 (later-stage) and 21 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Advanced Cancer, with 2 trials.

Trial Pipeline

24 total, page 1 of 1

ACTIVE NOT RECRUITING Phase 2

A Study of Botensilimab in Participants With Metastatic Pancreatic Cancer

NCT05630183

ACTIVE NOT RECRUITING Phase 2

A Study of Botensilimab (AGEN1181) for the Treatment of Advanced Melanoma

NCT05529316

ACTIVE NOT RECRUITING Phase 2

A Study of Botensilimab and Balstilimab for the Treatment of Colorectal Cancer

NCT05608044

ACTIVE NOT RECRUITING Phase 2

RaPiDS- A Phase 2 Study of Anti-PD-1 Independently or in Combination With Anti-CTLA-4 in Second-Line Cervical Cancer

NCT03894215

ACTIVE NOT RECRUITING Phase 1

Fc-Engineered Anti-CTLA-4 Monoclonal Antibody in Advanced Cancer

NCT03860272

COMPLETED Phase 1

Study of AGEN1571 in Participants With Advanced Solid Tumors

NCT05377528

COMPLETED Phase 1

A Study Investigating AGEN1777 in Participants With Advanced Solid Tumors

NCT05025085

TERMINATED Phase 1

A Study in Subjects With Advanced Solid Tumors

NCT04156100

COMPLETED Phase 1

Anti-CD137 and Anti-CTLA-4 Monoclonal Antibody in Patients With Advanced Cancer

NCT04121676

COMPLETED Phase 1

Phase 1a Study to Evaluate Immunogenicity of ASV®

NCT03673020

COMPLETED Phase 1

Subjects With Metastatic or Locally Advanced Solid Tumors, and Expansion Into Select Solid Tumors (Cervical)

NCT03495882

COMPLETED Phase 1

A Study of AGEN2034 in Advanced Tumors and Cervical Cancer

NCT03104699

TERMINATED Phase 1

Safety and Tolerability Study of AutoSynVax™ Vaccine in Subjects With Advanced Cancer

NCT02992977

COMPLETED Phase 1

AGEN1884, an Anti-CTLA-4 Human Monoclonal Antibody in Participants With Advanced or Refractory Cancer and Who Have Progressed With PD-1/PD-L1 Inhibitor as Their Most Recent Therapy

NCT02694822

COMPLETED Phase 2

Biological Efficacy Study of HerpV Vaccine With QS-21 to Treat Participants With Recurrent Genital Herpes

NCT01687595

TERMINATED Phase 2

Study of Vitespen (HSPPC-96, Oncophage ®) for Immune Response Assessment in Participants With Resectable Renal Cell Carcinoma at Intermediate Risk of Recurrence

NCT01147536

COMPLETED Phase 1

Study of L-NDDP (Aroplatin) in Patients With Advanced Solid Malignancies or B-Cell Lymphoma

NCT00316511

COMPLETED Phase 1

Trial Evaluating Safety, Tolerability and Immune Response of AG-707

NCT00231049

TERMINATED Phase 3

Clinical Trial Studying a Personalized Cancer Vaccine in Patients With Non-metastatic Kidney Cancer

NCT00126178

TERMINATED Phase 2

AG-858 in Patients Who Are Cytogenetically Positive After Treatment With Gleevec™

NCT00058747

TERMINATED Phase 2

Trial to Compare the Routes of Administration of an Investigational, Personalized, Therapeutic Cancer Vaccine Oncophage (HSPPC-96) in Patients With Metastatic Renal Cell Carcinoma

NCT00082459

COMPLETED Phase 3

Study of Heat Shock Protein-Peptide Complex (HSPPC-96) Versus IL-2/DTIC for Stage IV Melanoma

NCT00039000

COMPLETED Phase 3

Survival Study Of Oncophage® vs. Observation In Patients With Kidney Cancer

NCT00033904

COMPLETED Phase 2

A Safety and Effectiveness Study of Vaccine Therapy in Patients With Indolent Lymphoma

NCT00081809

What the Pipeline for Agenus Shows

According to the ClinicalTrials.gov registry, Agenus is linked to 24 US clinical trials across every stage of research activity. Of those, 0 studies are currently recruiting, about 0% of the sponsor's indexed portfolio, and 13 are already marked complete, representing roughly 54% of the total.

The phase mix for Agenus reports 3 late-stage studies (Phase 3 and Phase 4 combined) and 21 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for Agenus is Advanced Cancer with 2 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.