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NCT05375994 · ClinicalTrials.gov registry record · Phase 1
Study of Avutometinib (VS-6766) + Adagrasib in KRAS G12C NSCLC Patients
A Phase 1 study of Non-Small Cell Lung Cancer and Advanced Cancer, sponsored by Verastem.
- Active
- Registry status
- Phase 1
- Development phase
- 85
- Enrollment target
- 8
- Study locations
NCT05375994: Active Phase 1 study of Non-Small Cell Lung Cancer and Advanced Cancer, sponsored by Verastem.
NCT05375994 is a Phase 1 study of Non-Small Cell Lung Cancer and Advanced Cancer that is active but no longer recruiting, run by Verastem. The registered enrollment target is 85 participants, below the 652-participant average among 454 other Non-Small Cell Lung Cancer trials with a reported enrollment target (87% lower). The trial reports 8 study locations across 8 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05375994, a Phase 1 study of Non-Small Cell Lung Cancer and Advanced Cancer, is active but no longer recruiting, sponsored by Verastem.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 85 participants
- Enrollment target
- 8
- Study locations
Study Summary
This study will assess the safety and efficacy of avutometinib (VS-6766) in combination with adagrasib in patients with G12C Non-Small Cell Lung Cancer (NSCLC) who have been exposed to prior G12C inhibitor and experienced progressive disease.
Primary Outcome
Assessment of Dose-limiting toxicities (DLTs)
Conditions Studied
Interventions
- DRUG avutometinib (VS-6766) and adagrasib
Study Locations (8)
California
- UCSF Thoracic Oncology - San Francisco
Colorado
- University of Colorado Hospital Anschutz Cancer Pavllion - Aurora
Florida
- Mayo Clinic Cancer Center - Jacksonville
Minnesota
- Mayo Clinic Cancer Center - Rochester
New York
- Memorial Sloan Kettering Cancer Center - New York
North Carolina
- University of North Carolina at Chapel Hill - Chapel Hill
Virginia
- Virginia Cancer Specialists, NEXT Oncology - Fairfax
Wisconsin
- Medical College Wisconsin - Milwaukee
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 85 participants |
| Start Date | 2022-08-01 |
| Est. Completion | 2026-01-01 |
| Phase | Phase 1 |
What the registry record for NCT05375994 still lists
NCT05375994 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 85 participants, a relatively small participant target, below the 652-participant average among 454 other Non-Small Cell Lung Cancer trials with a reported enrollment target (87% lower).
The record links to 6 conditions, with Non-Small Cell Lung Cancer appearing as the primary indexed condition, and to 1 intervention - of which avutometinib (VS-6766) and adagrasib is the first listed.
NCT05375994 lists 8 locations in 8 states (California, Colorado, Florida).
Frequently Asked Questions
What is clinical trial NCT05375994 about?
NCT05375994 is a clinical study titled "Study of Avutometinib (VS-6766) + Adagrasib in KRAS G12C NSCLC Patients". This study will assess the safety and efficacy of avutometinib (VS-6766) in combination with adagrasib in patients with G12C Non-Small Cell Lung Cancer (NSCLC) who have been exposed to prior G12C inhibitor and experienced progressive disease.
What is the current status of trial NCT05375994?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 85 participants. The study started on 2022-08-01. Estimated completion is 2026-01-01.
What conditions does trial NCT05375994 study?
This clinical trial studies the following conditions: Non-Small Cell Lung Cancer, Advanced Cancer, Metastatic Cancer, KRAS Activating Mutation, Malignant Neoplasm of Lung.
What interventions are being tested in trial NCT05375994?
The interventions under investigation include: avutometinib (VS-6766) and adagrasib (DRUG).
Who is sponsoring clinical trial NCT05375994?
This trial is sponsored by Verastem, which has 21 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05375994 being conducted?
This trial has 8 study locations across California, Colorado, Florida, Minnesota, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT05375994's enrollment target sits among peer trials
85 259th of 454 higher than 192 of 454 other Non-Small Cell Lung Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Non-Small Cell Lung Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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