Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Hepatic Impairment Study For Crizotinib In Advanced Cancer Patients
NCT01576406 · View on ClinicalTrials.gov ↗
Study Summary
This study is designed to evaluate the potential effect of hepatic impairment on the pharmacokinetics and safety of crizotinib in advanced cancer patients. Advanced cancer patients with mild, moderate or severe liver dysfunction as well as patients with normal liver function will be enrolled in this study.
Conditions Studied
Interventions
- DRUG crizotinib
Study Locations (20)
Georgia
- Emory University Hospital Midtown Laboratory — Atlanta
- Emory University Hospital — Atlanta
- Investigational Drug Service: The Emory Clinic Bldg A — Atlanta
- The Emory Clinic — Atlanta
- Winship Cancer Institute — Atlanta
Ohio
- University Hospital East — Columbus
- Investigational Drug Services — Columbus
- James Cancer Hospital — Columbus
- The Ohio State University, Wexner Medical Center — Columbus
- Martha Morehouse Medical Plaza — Columbus
California
- Keck Hospital of USC — Los Angeles
- LAC&USC Medical Center — Los Angeles
- USC/Norris Comprehensive Cancer Center / Investigational Drug Services — Los Angeles
- USC/Norris Comprehensive Cancer Center — Los Angeles
Colorado
- Anschutz Cancer Pavilion, Room 2224, c/o Melinda Friesleben, Pharm D — Aurora
- University of Colorado Denver - Clinical Translational Research Center — Aurora
- University of Colorado Denver, Anschutz Cancer Pavilion — Aurora
- University of Colorado Denver, Anschutz Inpatient Pavillion — Aurora
Texas
- Cancer Therapy & Research Center at UTHSCSA — San Antonio
- Medical Arts and Research Center-MARC — San Antonio
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 88 participants |
| Start Date | 2012-07 |
| Est. Completion | 2016-06 |
| Phase | Phase 1 |
Interested in This Trial?
Always speak with your doctor before enrolling in a clinical trial.
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01576406
The ClinicalTrials.gov registry entry for NCT01576406 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 88 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Pfizer, which has 769 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Advanced Cancer appearing as the primary indexed condition, and to 1 intervention — of which crizotinib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT01576406 reports 20 study locations spanning 5 distinct geographic areas — top geographies include Georgia, Ohio, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT01576406 about?
NCT01576406 is a clinical study titled "Hepatic Impairment Study For Crizotinib In Advanced Cancer Patients". This study is designed to evaluate the potential effect of hepatic impairment on the pharmacokinetics and safety of crizotinib in advanced cancer patients. Advanced cancer patients with mild, moderate or severe liver dysfunction as well as patients with normal liver function will be enrolled in this...
What is the current status of trial NCT01576406?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 88 participants. The study started on 2012-07. Estimated completion is 2016-06.
What conditions does trial NCT01576406 study?
This clinical trial studies the following conditions: Advanced Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT01576406?
The interventions under investigation include: crizotinib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT01576406?
This trial is sponsored by Pfizer, which has 769 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT01576406 being conducted?
This trial has 20 study locations across California, Colorado, Georgia, Ohio, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How Clinical Trials Work
Understand phases 1-4, trial design, randomization, and the informed consent process.
Patient Rights in Clinical Trials
Your rights as a participant: consent, withdrawal, privacy, and who to contact.
Finding the Right Clinical Trial
A practical guide to searching trials, understanding eligibility, and evaluating options.
All Guides
Browse our complete library of clinical trial educational resources.
Read our methodology — how this data is sourced, computed, and verified.