The Cleveland Clinic

Open enrollment across a mixed-phase pipeline

According to ClinicalTrials.gov-derived indexes, The Cleveland Clinic sits in the top decile of US sponsors by registered trial count (#50 of 15,742 sponsors by registered trial count).

688 total trials 99 currently recruiting 437 completed top decile by trial count

The Cleveland Clinic: 688 sponsored US clinical trials, 99 recruiting.

The Cleveland Clinic sponsors 688 registered US clinical trials on ClinicalTrials.gov, 99 of them currently recruiting, and 437 completed. 81 of these trials are in Phase 3-4 (later-stage) and 76 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Atrial Fibrillation, with 9 trials.

Top-decile sponsor footprint

The Cleveland Clinic ranks in the top decile of sponsors by registered trial count (#50 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

F 42/100

437 of 539 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (81.1%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

688 total, page 14 of 14

COMPLETED Phase 1

Reiki/Energy Healing in Prostate Cancer

NCT00065208

COMPLETED Phase 2

Anti-thymocyte Globulin and Cyclosporine as First-Line Therapy in Treating Patients With Severe Aplastic Anemia

NCT01231841

COMPLETED Phase 3

Study Comparing Tension-free Vaginal Tape With the Monarc Procedure for Stress Urinary Incontinence

NCT00475839

COMPLETED Phase 4

Dexmed/Buspirone Synergism on Shivering

NCT00334360

COMPLETED NA

Improving Influenza Vaccination Rates Among Health Care Professionals

NCT00404664

COMPLETED Phase 2

Lenalidomide in Treating Patients With Advanced or Unresectable Kidney Cancer

NCT00403169

COMPLETED Phase 2

Gemcitabine and Irinotecan in Treating Patients With Metastatic Kidney Cancer

NCT00401128

COMPLETED

Safety Monitoring of Patients Having Pulmonary Vein Ablation

NCT00590668

COMPLETED Phase 2

Arsenic Trioxide and Gemtuzumab Ozogamicin in Treating Patients With Advanced Myelodysplastic Syndromes

NCT00274781

COMPLETED NA

Cerebrospinal Fluid Levels of Erlotinib in Patients Receiving Erlotinib For Stage III Non-Small Cell Lung Cancer

NCT00305617

TERMINATED Phase 2

T-Cell Depletion, Donor Hematopoietic Stem Cell Transplant (HSCT), and T-Cell Infusions in Treating Patients With Hematologic Cancer or Other Diseases

NCT00589602

COMPLETED

Clinical Implications of Peripheral Plaque Morphology

NCT00578422

TERMINATED

Echocardiographic Assessment of Cardiovascular Changes in Long Term Space Flight

NCT00598598

COMPLETED NA

Epoetin Alfa in Treating Anemia in Patients Undergoing Chemotherapy for Multiple Myeloma

NCT00400686

TERMINATED Phase 4

Reversing Endothelial and Diastolic Dysfunction and Improving Collagen Turnover in Diastolic Heart Failure

NCT00293150

COMPLETED Phase 1

Imatinib Mesylate, Daunorubicin, and Cytarabine in Treating Patients With Relapsed Acute Myeloid Leukemia

NCT00268229

COMPLETED NA

Prospective Randomized Study of Brain Protection During Aortic Arch Replacement

NCT00606190

TERMINATED

Three Dimensional Imaging and Wireless Technologies to Enhance Medical Care in Space

NCT00598767

COMPLETED Phase 2

GM-CSF and Thalidomide in Treating Patients Undergoing Surgery for High-Risk Prostate Cancer

NCT00400517

COMPLETED Phase 4

Influenza Vaccination in Bone Marrow Transplantation

NCT00419224

TERMINATED NA

The Effect of Fenoldopam in Solitary Partial Nephrectomy Surgery

NCT00743106

COMPLETED Phase 2

Combination Chemotherapy With or Without Surgery & Chemoradiotherapy in Patients With Malignant Pleural Mesothelioma

NCT00354393

COMPLETED Phase 1

Docetaxel and Temozolomide in Treating Patients With Metastatic Cancer

NCT00401180

COMPLETED Phase 3

The Effects of Hypercapnia, Supplemental Oxygen, and Dexamethasone on Surgical Wound Infection

NCT00273377

TERMINATED Phase 2

GM-CSF in Patients With Pulmonary Alveolar Proteinosis

NCT00030056

COMPLETED NA

Endovascular Exclusion of TAAA/AAA Utilizing Fenestrated/Branched Stent Grafts

NCT00583050

COMPLETED Phase 2

Cytomegalovirus Hyperimmune Globulin (CMV-Ig) Replacement in Hypogammaglobulinemic Lung Transplant Recipients

NCT00137748

COMPLETED Phase 1

Interferon Alfa in Treating Patients With Stage IV Solid Tumors, Lymphoma, or Myeloma

NCT00276536

TERMINATED Phase 4

The Effect of Lipitor on Aortic Stenosis

NCT00590135

COMPLETED NA

VP and G-CSF With or Without Rituximab in Autologous Peripheral Stem Cell Transplant For NHL

NCT00274794

COMPLETED Phase 4

Assessment of Cardioversion Using Transesophageal Echocardiography II (ACUTE II)

NCT00289042

COMPLETED Phase 2

Combination Chemotherapy in Treating Patients With Multiple Myeloma

NCT00003493

COMPLETED Phase 2

Rituximab in Treating Patients With Multiple Myeloma

NCT00003554

COMPLETED Phase 2

Combination Chemotherapy Following GM-CSF in Treating Patients With Multiple Myeloma

NCT00003490

COMPLETED NA

Endovascular Exclusion of Abdominal Aortic Aneurysms in High Risk Patients

NCT00583414

COMPLETED Phase 2

Biological Therapy in Treating Patients With Glioblastoma Multiforme

NCT00003185

COMPLETED Phase 4

ABRIDGE: Low Molecular Weight Heparin in Bridging Patients After Mechanical Valve Replacement

NCT00298285

COMPLETED Phase 1

A Phase I - II Safety Study of Filgrastim (Neupogen) to Improve Left Ventricular Function After Severe Acute Myocardial Infarction

NCT00215124

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Phase Distribution

PhaseTrial count
Phase 1 38
Phase 2 38
Phase 3 22
Phase 4 59

What is open in the The Cleveland Clinic pipeline

99 recruiting of 688 indexed (14% open); 437 completed (64%).

Phase mix: 81 late (III/IV) vs 76 early (I/II) (balanced across stages).

Top condition: Atrial Fibrillation (9 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

The Cleveland Clinic: open-pipeline peers nationwide

Peers matched on 688 registered trials and 14% open enrollment, not the therapeutic-area sidebar.

The Cleveland Clinic sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 02004006008001,000 5%10%15%20%25% Total trials Recruiting share The Cleveland ClinicVanderbilt University Medical CenterWeill Medical College of Cornell UniversityIcahn School of Medicine at Mount SinaiSanofiDana-Farber Cancer InstituteModernaTXMasonic Cancer Center, University of MinnesotaAcademic and Community Cancer Research United
The Cleveland Clinic sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

The Cleveland Clinic sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 688 trials (± recruiting share)

Sponsors near 14% open enrollment (± trial volume)

What to do with this The Cleveland Clinic page

688 registered trials is a research-attention snapshot, not an endorsement of The Cleveland Clinic or any single study.

  • 99 of The Cleveland Clinic's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Atrial Fibrillation is the condition The Cleveland Clinic studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Atrial Fibrillation trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. The Cleveland Clinic pipeline card: 688 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.