Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT00273377 · ClinicalTrials.gov registry record · Phase 3
The Effects of Hypercapnia, Supplemental Oxygen, and Dexamethasone on Surgical Wound Infection
A Phase 3 study, sponsored by The Cleveland Clinic.
- Completed
- Registry status
- Phase 3
- Development phase
- 2,000
- Enrollment target
NCT00273377: Completed Phase 3 study, sponsored by The Cleveland Clinic.
NCT00273377 is a Phase 3 study that has completed, run by The Cleveland Clinic. The registered enrollment target is 2,000 participants, above the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (159% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00273377, a Phase 3 study, has completed, sponsored by The Cleveland Clinic.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 2,000 participants
- Enrollment target
Study Summary
The investigators will test the hypotheses that mild hypercapnia and supplemental oxygen reduce wound infection risk in patients undergoing colon resection. The investigators will simultaneously test the hypothesis that low-dose dexamethasone (a common treatment for postoperative nausea and vomiting) does not increase infection risk.
Interventions
- DRUG Placebo
- DRUG Dexamethasone
- OTHER Mild intraoperative hypercapnia (50 mmHg vs. 30 mmHg)
- OTHER Supplemental oxygen (80% vs. 30%)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2,000 participants |
| Start Date | 2002-05 |
| Est. Completion | 2007-12 |
| Phase | Phase 3 |
What the finished NCT00273377 record still lists
NCT00273377 is an interventional study that assigns participants to a tested intervention. Its 2,000 participants enrollment target places it among the larger protocols in the corpus, above the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (159% higher).
The record links to 0 conditions, and to 4 interventions - of which Placebo is the first listed.
NCT00273377 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00273377 about?
NCT00273377 is a clinical study titled "The Effects of Hypercapnia, Supplemental Oxygen, and Dexamethasone on Surgical Wound Infection". The investigators will test the hypotheses that mild hypercapnia and supplemental oxygen reduce wound infection risk in patients undergoing colon resection. The investigators will simultaneously test the hypothesis that low-dose dexamethasone (a common treatment for postoperative nausea and vomiting...
What is the current status of trial NCT00273377?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 2,000 participants. The study started on 2002-05. Estimated completion is 2007-12.
What interventions are being tested in trial NCT00273377?
The interventions under investigation include: Placebo (DRUG), Dexamethasone (DRUG), Mild intraoperative hypercapnia (50 mmHg vs. 30 mmHg) (OTHER), Supplemental oxygen (80% vs. 30%) (OTHER).
Who is sponsoring clinical trial NCT00273377?
This trial is sponsored by The Cleveland Clinic, which has 688 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00273377's enrollment target sits among peer trials
2,000 100th of 2000 higher than 1,895 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00001465 · 2,000 participants
Study of the Disease Process of Lymphangioleiomyomatosis
- NCT00001595 · 2,000 participants
An Investigation of Pituitary Tumors and Related Hypothalmic Disorders
- NCT00138931 · 2,000 participants
Genetics of Cardiovascular and Neuromuscular Disease
- NCT00288119 · 2,000 participants
Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia