The Cleveland Clinic

Open enrollment across a mixed-phase pipeline

According to ClinicalTrials.gov-derived indexes, The Cleveland Clinic sits in the top decile of US sponsors by registered trial count (#50 of 15,742 sponsors by registered trial count).

688 total trials 99 currently recruiting 437 completed top decile by trial count

The Cleveland Clinic: 688 sponsored US clinical trials, 99 recruiting.

The Cleveland Clinic sponsors 688 registered US clinical trials on ClinicalTrials.gov, 99 of them currently recruiting, and 437 completed. 81 of these trials are in Phase 3-4 (later-stage) and 76 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Atrial Fibrillation, with 9 trials.

Top-decile sponsor footprint

The Cleveland Clinic ranks in the top decile of sponsors by registered trial count (#50 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

F 42/100

437 of 539 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (81.1%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

688 total, page 13 of 14

TERMINATED

The BEACON Registry: Best Expert Agreement for Care of Occult Myocardial Infarction (MI) Nationally

NCT00560248

TERMINATED

Lower Extremity Venous Hemodynamics in Obese Patients Without Clinically Significant Venous Disease

NCT00554541

TERMINATED Early Phase 1

Pilot Study of Inhaled Nitric Oxide to Treat Pulmonary Insufficiency in Congenital Heart Disease

NCT00543933

TERMINATED

Speckle Tracking Imaging in Patients With Low Ejection Fraction Aortic Stenosis (SPArKLE-AS)

NCT00535899

COMPLETED

Variability Analysis as a Predictor of Liberation From Mechanical Ventilation

NCT01140750

COMPLETED

Siemens 3-D C-Arm CT of the Heart Chambers

NCT00619450

COMPLETED Phase 3

Study Comparing TVT With TVT-SECUR for the Treatment of Stress Urinary Incontinence

NCT00534365

COMPLETED

Whole Genome Association Study to Identify and Validate Genes for Restenosis: CardioGene Validation Proposal

NCT00589810

COMPLETED NA

Outcomes Study of Hyperinsulinemic Glucose Control in Cardiac Surgery

NCT00524472

TERMINATED NA

Interscalene Nerve Blocks With Ropivacaine Alone, With Dexamethasone, Plus Systemic Dexamethasone

NCT00519584

COMPLETED NA

Study Comparing Conventional vs. Robotic-assisted Laparoscopic Hysterectomy

NCT00485355

COMPLETED NA

Red Cell Storage Duration and Outcomes in Cardiac Surgery

NCT00458783

COMPLETED NA

Balancing Risk: Red Blood Cell Transfusion Strategies In Cardiac Surgery

NCT00651573

COMPLETED

Urinary Cytokines in Patients With Overactive Bladder (OAB)

NCT00868621

COMPLETED

Pediatric Pain Rehabilitation Program

NCT01340261

COMPLETED

Validation of a Correction Factor for Measurement of an Accurate Ankle-Brachial Index in the Seated Position

NCT00452309

TERMINATED

FIRE-PAD: Functional Improvement Through Revascularization of the Extremities for Peripheral Arterial Disease

NCT00274157

COMPLETED NA

Advanced Medical Therapy Versus Advanced Medical Therapy Plus Bariatric Surgery for the Resolution of Type 2 Diabetes

NCT00432809

COMPLETED NA

Impact of Perioperative Intravenous Fluid Utilization on Postoperative Outcomes

NCT01563991

TERMINATED

Effect of Bedrest With and Without Exercise on the Heart

NCT00598494

COMPLETED Phase 3

Regional Anesthesia and Breast Cancer Recurrence

NCT00418457

COMPLETED NA

A Pilot Study of Efficacy and Tolerability of Levetiracetam Monotherapy in Subjects With Childhood Absence Epilepsy

NCT00361010

COMPLETED Phase 1

Glucose Metabolism in the Immediate and Short Term Follow up After Bariatric Surgery

NCT00488423

TERMINATED

The Use of CT to Identify Damaged Heart Muscle in Patients Undergoing Ventricular Tachycardia Ablation.

NCT00583284

COMPLETED Phase 1

Pilot Study of Rapamycin as Treatment for Autosomal Dominant Polycystic Kidney Disease (ADPKD)

NCT00286156

COMPLETED NA

Does Capnography Prevent Hypoxemia During Endoscopic Retrograde Cholangiopancreatography and Endoscopic Ultrasound?

NCT00675415

COMPLETED NA

Laparoscopic Versus Robotic Assisted Laparoscopic Sacrocolpopexy for Vaginal Prolapse

NCT00551993

COMPLETED NA

Intervenous (IV) Zoledronic Acid After Forteo in Postmenopausal Women

NCT00361595

COMPLETED

Circulating-water Garment With Forced-air Warming and Circulating-water Mattress During Abdominal Surgery

NCT00651898

COMPLETED NA

Effectiveness of Creatine in Preventing Muscle Aching From Cholesterol-Lowering Statin Drugs

NCT00797407

COMPLETED

Tissue Doppler Assessment of Right Ventricular Performance in Acute Heeart Failure

NCT00589758

COMPLETED Early Phase 1

Micro-stream Capnography in Non-intubated Lean and Obese Patients With and Without Obstructive Sleep Apnea

NCT00653471

TERMINATED Phase 4

The Effects of Dexmedetomidine and Remifentanil on Carotid Patients

NCT00335972

TERMINATED NA

Supplemental Postoperative Oxygen and Wound Infection in Morbidly Obese Patients

NCT00315822

COMPLETED

Is Home Positioning Time Associated With Torticollis Rate of Recovery?

NCT00347334

COMPLETED

Caregiver Support in the Coping of Patients Who Are Undergoing a Donor Bone Marrow Transplant

NCT00281814

TERMINATED

NORDIC: Nitric Oxide-Derived Oxidants and Regional Endothelial and Diastolic Dysfunction in Dilated Cardiomyopathy

NCT00293137

COMPLETED Phase 3

Echinacea, Propolis and Vitamin C for URI Prevention in Preschoolers

NCT00231218

COMPLETED Phase 1

Effects of Reiki on Stress

NCT00346671

TERMINATED Phase 2

Gemcitabine and Mitoxantrone in Treating Patients With Relapsed Acute Myeloid Leukemia

NCT00268242

TERMINATED Phase 3

Negative Pressure Wound Therapy: Are All Systems Alike?

NCT00590369

COMPLETED Phase 1

Lyophilized Black Raspberries in Adults With Familial Adenomatous Polyposis (FAP)

NCT00770991

COMPLETED Phase 1

External Beam Radiotherapy and Zevalin for Management of Indolent B-Cell Non-Hodgkin's Lymphoma

NCT00271050

COMPLETED

Bethaherpesviruses in Children Who Are Immune Suppressed

NCT00641121

COMPLETED Phase 1

Prophylactic Urethral Stenting With Memokath After Prostate Implantation for Prostate Adenocarcinoma

NCT00252941

TERMINATED Phase 1

Sodium Stibogluconate and Interferon in Treating Patients With Advanced Solid Tumors, Lymphoma, or Myeloma

NCT00311558

TERMINATED Phase 4

Trial to Study the Effects of Supplementary Omega-3 on Serum C-Reactive Protein Levels

NCT00578578

COMPLETED Phase 2

Temozolomide in Treating Patients With Newly Diagnosed Anaplastic Oligodendroglioma or Mixed Oligoastrocytoma

NCT00400816

COMPLETED

Assessment of Left Ventricular Torsion by Echocardiography Study

NCT00589836

COMPLETED NA

Endoscopic Ultrasound Compared With Pancreatic Function Testing for Diagnosis of Chronic Pancreatitis

NCT00651053

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Phase Distribution

PhaseTrial count
Phase 1 38
Phase 2 38
Phase 3 22
Phase 4 59

What is open in the The Cleveland Clinic pipeline

99 recruiting of 688 indexed (14% open); 437 completed (64%).

Phase mix: 81 late (III/IV) vs 76 early (I/II) (balanced across stages).

Top condition: Atrial Fibrillation (9 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

The Cleveland Clinic: open-pipeline peers nationwide

Peers matched on 688 registered trials and 14% open enrollment, not the therapeutic-area sidebar.

The Cleveland Clinic sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 02004006008001,000 5%10%15%20%25% Total trials Recruiting share The Cleveland ClinicVanderbilt University Medical CenterWeill Medical College of Cornell UniversityIcahn School of Medicine at Mount SinaiSanofiDana-Farber Cancer InstituteModernaTXMasonic Cancer Center, University of MinnesotaAcademic and Community Cancer Research United
The Cleveland Clinic sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

The Cleveland Clinic sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 688 trials (± recruiting share)

Sponsors near 14% open enrollment (± trial volume)

What to do with this The Cleveland Clinic page

688 registered trials is a research-attention snapshot, not an endorsement of The Cleveland Clinic or any single study.

  • 99 of The Cleveland Clinic's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Atrial Fibrillation is the condition The Cleveland Clinic studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Atrial Fibrillation trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. The Cleveland Clinic pipeline card: 688 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.