National Institute on Drug Abuse (NIDA)

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, National Institute on Drug Abuse (NIDA) sits in the top decile of US sponsors by registered trial count (#108 of 15,742 sponsors by registered trial count).

335 total trials 14 currently recruiting 292 completed early-phase tilt top decile by trial count

National Institute on Drug Abuse (NIDA): 335 sponsored US clinical trials, 14 recruiting.

National Institute on Drug Abuse (NIDA) sponsors 335 registered US clinical trials on ClinicalTrials.gov, 14 of them currently recruiting, and 292 completed. 30 of these trials are in Phase 3-4 (later-stage) and 202 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Cocaine-Related Disorders, with 17 trials.

Top-decile sponsor footprint

National Institute on Drug Abuse (NIDA) ranks in the top decile of sponsors by registered trial count (#108 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

C 71/100

292 of 316 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (92.4%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

335 total, page 3 of 7

TERMINATED Phase 1

Ph1 Marinol Interaction Study - Part 1 - 1

NCT00438139

COMPLETED NA

The Neural Basis of Cue-Elicited Cigarette Craving and Its Control

NCT01048957

COMPLETED NA

Dextromethorphan, Gabapentin, and Oxycodone to Treat Opioid-Induced Hyperalgesia

NCT00218374

COMPLETED Phase 1

Ph1 Marinol Interaction Study - Part 2 - 1

NCT00490269

COMPLETED Phase 2

Evaluating Alternative Aftercare Models for Ex-offenders

NCT01586689

COMPLETED

The Neuropsychiatric Evaluation of HIV-Positive and Negative Drug Using Individuals: Study 215

NCT01034800

COMPLETED

Screening Protocol for the Evaluation of Potential Research Subjects

NCT01036971

COMPLETED

Screening Protocol for the Evaluation of Research Participants

NCT01036217

COMPLETED

Influence of Nicotine on Cognitive Function in Schizophrenic Patients With and Without Comorbid Drug Dependence

NCT01037075

COMPLETED Phase 1

Rivastigmine For Methamphetamine Dependent Individuals

NCT00158210

COMPLETED Phase 2

Efficacy of NicVAX in Smokers Who Want to Quit Smoking

NCT00318383

COMPLETED Phase 1

Antagonist-Elicited Cannabis Withdrawal

NCT01041170

COMPLETED

Study of Smoking Abstinence

NCT01035632

COMPLETED Phase 2

Topiramate for the Treatment of Methamphetamine Dependence - 1

NCT00345371

COMPLETED Phase 1

Effects of Nicotine on Elements of Attentions in Smokers and Nonsmokers

NCT01034020

COMPLETED

Neuroimaging Studies of Neurophysiological Phenotypes in Schizophrenia

NCT01036568

COMPLETED NA

Strategies to Help Adult ED Patients Quit Smoking

NCT00297466

COMPLETED Phase 1

Emergency Department Initiated Tobacco Treatment (EDITT)

NCT00252902

COMPLETED

Quiting Marijuana Use: Self-report Study of Quitting Straegies and Withdrawal Symptoms

NCT01603992

COMPLETED Phase 1

Clonidine for Relapse Prevention in Buprenorphine-Maintenance Patients

NCT00295308

COMPLETED Phase 2

Effectiveness of Bupropion Combined With Behavioral Therapy for Treating Methamphetamine Dependence - 2

NCT00135785

COMPLETED

Smoking and Alcohol Initiation

NCT00271843

COMPLETED

Effect of Functional Genetic Polymorphisms on Brain Morphology and Function

NCT01035723

COMPLETED

A Survey on Consumer Use of Over-the-Counter (OTC) Nicotine Patches

NCT00134927

COMPLETED

Assessing the Variability Over Time of Tobacco Carcinogen Biomarkers in Smokers - 2

NCT00158145

COMPLETED Phase 2

Effectiveness of Reducing Smoking in Facilitating Smoking Cessation in Adolescents - 2

NCT00158158

COMPLETED Phase 1

Assessment of Potential Interactions Between Intravenous Cocaine and Atomoxetine - 1

NCT00265265

COMPLETED Phase 4

Impact of Smoking Cessation on Sleep - 5

NCT00132821

COMPLETED Phase 1

Effect of Clonidine on Responses to Imagery Scripts

NCT00318760

COMPLETED Phase 3

Smoking Treatment of Prisoners

NCT00110630

COMPLETED NA

Metabolic Effects of Cocaine

NCT00451230

COMPLETED

Cognitive Task Development and Implementation for Functional MRI Studies

NCT01036685

COMPLETED Phase 3

Drug Use Prevention Among Girls Through a Mother-Daughter Intervention

NCT00310258

COMPLETED Phase 3

Effectiveness of Bupropion for Smokers Recovering From Alcohol Dependence

NCT00304707

COMPLETED Phase 2

Addition of Naltrexone to Methadone Taper

NCT00135759

COMPLETED

Reward Processing in Cocaine Addiction

NCT01036074

COMPLETED

Dopamine Function and Reward Processing In Schizophrenia

NCT01035996

COMPLETED Phase 2

Effectiveness of Selegiline in Treating Marijuana Dependent Individuals - 1

NCT00218517

COMPLETED Phase 2

Comparisons of Nicotine-free Cigarettes, Extra Low Nicotine Cigarettes vs. Medicinal Nicotine

NCT00777569

COMPLETED Phase 2

Effectiveness of Bupropion in Treating Marijuana Dependent Individuals

NCT00142870

COMPLETED

fMRI Study of Nicotinic Effect on Neurophysiology of Schizophrenia

NCT01046526

COMPLETED Phase 2

Tramadol to Reduce Opioid Withdrawal Symptoms

NCT00142896

COMPLETED Phase 2

Nicotine Lozenge to Reduce Smokeless Tobacco Use

NCT00218283

TERMINATED Phase 2

Efficacy and Safety of Bupropion for Treatment of Adolescent Smoking

NCT00248118

TERMINATED

Methylphenidate Studies for Drug Abuse Vulnerability Molecular Genentics

NCT00247689

TERMINATED Phase 1

Interaction Between Vanoxerine (GBR 12909) and Cocaine in Cocaine Dependent Individuals

NCT00218049

COMPLETED Phase 2

Atomoxetine for the Treatment of Cannabis Dependence

NCT00167297

COMPLETED Phase 2

Modafinil for the Treatment of Cocaine Dependence - 1

NCT00100100

COMPLETED Phase 2

Baclofen for the Treatment of Cocaine Dependence - 1

NCT00082485

TERMINATED Phase 2

Abuse Potential of Buprenorphine/Naloxone

NCT00149539

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What is open in the National Institute on Drug Abuse (NIDA) pipeline

14 recruiting of 335 indexed (4% open); 292 completed (87%).

Phase mix: 30 late (III/IV) vs 202 early (I/II) (early-phase heavy).

Top condition: Cocaine-Related Disorders (17 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

National Institute on Drug Abuse (NIDA): open-pipeline peers nationwide

Peers matched on 335 registered trials and 4% open enrollment, not the therapeutic-area sidebar.

National Institute on Drug Abuse (NIDA) sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 0100200300400 0%5%10%15%20%25% Total trials Recruiting share National Institute on Drug Abuse (NIDA)BiogenNational Institutes of Health Clinical Center (CC)GenentechCedars-Sinai Medical CenterAkebia TherapeuticsDentsply Sirona Implants and ConsumablesSmith & NephewMedtronic - MITG
National Institute on Drug Abuse (NIDA) sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

National Institute on Drug Abuse (NIDA) sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 335 trials (± recruiting share)

Sponsors near 4% open enrollment (± trial volume)

What to do with this National Institute on Drug Abuse (NIDA) page

335 registered trials is a research-attention snapshot, not an endorsement of National Institute on Drug Abuse (NIDA) or any single study.

  • 14 of National Institute on Drug Abuse (NIDA)'s trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Cocaine-Related Disorders is the condition National Institute on Drug Abuse (NIDA) studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Cocaine-Related Disorders trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

National Institute on Drug Abuse (NIDA) pipeline card: 335 registered trials from official public datasets.Report a data error.