National Institute on Drug Abuse (NIDA)

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, National Institute on Drug Abuse (NIDA) sits in the top decile of US sponsors by registered trial count (#108 of 15,742 sponsors by registered trial count).

335 total trials 14 currently recruiting 292 completed early-phase tilt top decile by trial count

National Institute on Drug Abuse (NIDA): 335 sponsored US clinical trials, 14 recruiting.

National Institute on Drug Abuse (NIDA) sponsors 335 registered US clinical trials on ClinicalTrials.gov, 14 of them currently recruiting, and 292 completed. 30 of these trials are in Phase 3-4 (later-stage) and 202 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Cocaine-Related Disorders, with 17 trials.

Top-decile sponsor footprint

National Institute on Drug Abuse (NIDA) ranks in the top decile of sponsors by registered trial count (#108 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

C 71/100

292 of 316 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (92.4%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

335 total, page 2 of 7

COMPLETED

Understanding Drug Abuse Treatment Outcomes

NCT01678833

COMPLETED

Health Outcomes by Neighborhood - Baltimore

NCT01571752

COMPLETED

Individual Differences in Reward and Impulse Control

NCT01621607

TERMINATED Early Phase 1

Pexacerfont for Stress-induced Food Craving

NCT01656577

COMPLETED

Stem Cell Study of Genetics and Drug Addiction

NCT01534624

TERMINATED Phase 1

Pioglitazone to Treat Opioid Withdrawal Symptoms

NCT01517165

COMPLETED Phase 1

Phase 1 Naltrexone-Bupropion-Methamphetamine Interaction Study

NCT01359930

COMPLETED

Brain Functions Underlying Visuospatial Attention Deficits in Schizophrenia

NCT01399437

COMPLETED

Brain Circuits in Schizophrenia and Smoking

NCT01369966

COMPLETED

Neutral Correlates of Risk-taking in Adolescents Exposed to Drugs Prenatally

NCT01365988

COMPLETED

Characterization of Phenotypic and Genotypic Regressors for Imaging

NCT01148381

COMPLETED

Nicotinic Modulation of the Default Network of Resting Brain Function

NCT01240616

COMPLETED Early Phase 1

Automated Prize-based Contingency Management to Increase Counseling Attendance in Opiate-Replacement-Therapy Patients

NCT01229163

COMPLETED

Effects of Antipsychotics on Eating and Food Craving in People With Schizophrenia

NCT01222793

COMPLETED

Assessment of Cannabis Craving in Schizophrenia Using Virtual Reality

NCT01212081

TERMINATED Phase 1

Interactions Between Intravenous (IV) Cocaine and Lofexidine

NCT01148992

COMPLETED

The Effects of Expectation on Natural and Drug -Induced Rewards

NCT01036230

COMPLETED

Nicotine Reinforcement and Smoking-Cue Reactivity: Association With Genetic Polymorphisms

NCT01505725

COMPLETED Phase 1

Oral Fluid, Plasma and Whole Pharmacokinetics and Stability Following Smoked Cannabis

NCT01071616

COMPLETED Phase 1

Assessing Top Down and Bottom Up Attention Mechanisms in Smokers Using Nicotine Nasal Spray

NCT01136642

COMPLETED Phase 1

Phase 1 Study to Evaluate RDC-0313 Coadministered With Buprenorphine to Opioid-Experienced Healthy Adults

NCT01046539

COMPLETED

Measuring Distress Tolerance With Functional MRI

NCT01038232

COMPLETED

Prenatal Drug Exposure: Effects on the Adolescent Brain and Behavior Development

NCT01020669

COMPLETED

Risk Perception in Drug-Dependent Adults With and Without Schizophrenia

NCT01031563

COMPLETED

Assessment of Craving in Nicotine-Dependent Patients With Schizophrenia Using Virtual Reality

NCT01031433

COMPLETED

Developing Field Tools for Real-Time Assessment of Exposure to Psychosocial Stress and Drug Use in an Outpatient Treatment Population

NCT00787423

TERMINATED

Brain Glutamate Receptors and Cocaine Dependence

NCT00951314

COMPLETED Phase 1

Pilot Study of Transcranial Magnetic Stimulation (TMS) in Nicotine Addiction

NCT01031693

COMPLETED Phase 2

Reinforcement-Based Treatment for Pregnant Drug Abusers

NCT01177982

COMPLETED

Breath Carbon Monoxide and Cotinine as Biomarkers to Distinguish Smokers From Nonsmokers

NCT01031121

COMPLETED

Effects of Nicotine on Areas of Impaired and Preserved Functioning in Schizophrenia

NCT01034085

COMPLETED

Screening Protocol for the Evaluation of Research Participants at the Maryland Psychiatric Research Center (MPRC)

NCT01030835

COMPLETED Phase 2

Effectiveness of Motivational Interviewing Supervision in Community Programs

NCT01586676

COMPLETED

A Multi-Modal Investigation of the Smoking Cessation Medication Varenicline: Dopaminergic Modulation of Reward Processing and Cognitive Control

NCT00830739

TERMINATED Phase 4

Oxytocin and Cognitive Behavioral Therapy in Drug Dependence

NCT00975416

COMPLETED Phase 1

Buprenorphine Naltrexone-P1 A-Cocaine

NCT00733720

COMPLETED

Effects of Smoking Cues on Tobacco Craving Responses and the Reinforcing Efficacy of Cigarettes in Adolescent Smokers

NCT01148355

COMPLETED Phase 1

Aripiprazole for Prevention of Relapse to Cocaine Use in Methadone-Maintenance Patients

NCT00780702

COMPLETED Phase 2

Phase 2, Double-Blind, Placebo-Controlled Trial of Bupropion for Methamphetamine Dependence

NCT00687713

COMPLETED Phase 1

Vigabatrin Ph 1 Cocaine Interaction Study

NCT00626834

COMPLETED Phase 1

Effects of Smoking on Opioid Receptor Binding: A PET Study

NCT00618631

TERMINATED Phase 1

Effects of Propranolol on Responses to Drug-Related Imagery Scripts

NCT00688805

COMPLETED Phase 2

Phase 2, Multi-Center Trial of Modafinil for Methamphetamine Dependence

NCT00520286

COMPLETED NA

Preventing Substance Use and Risky Behavior Among Rural African American Youth

NCT00535704

COMPLETED Phase 1

The Discriminative Effects of Tramadol in Humans

NCT00499746

COMPLETED

PET Imaging of Nicotinic Acetylcholine Receptors

NCT01046513

COMPLETED

Optimizing Toxicological Screening in Drug Endangered Children

NCT01037569

COMPLETED Phase 2

Selegiline for Smoking Cessation - 1

NCT00439413

COMPLETED Phase 1

Effects of Sativex(Registered Trademark) and Oral THC on Attention, Affect, Working Memory, Reversal Learning, Physiology and Brain Activation

NCT01037608

COMPLETED

A Timeline Study of Alcohol Use and Its Relationship to Insomnia

NCT00580411

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What is open in the National Institute on Drug Abuse (NIDA) pipeline

14 recruiting of 335 indexed (4% open); 292 completed (87%).

Phase mix: 30 late (III/IV) vs 202 early (I/II) (early-phase heavy).

Top condition: Cocaine-Related Disorders (17 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

National Institute on Drug Abuse (NIDA): open-pipeline peers nationwide

Peers matched on 335 registered trials and 4% open enrollment, not the therapeutic-area sidebar.

National Institute on Drug Abuse (NIDA) sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 0100200300400 0%5%10%15%20%25% Total trials Recruiting share National Institute on Drug Abuse (NIDA)BiogenNational Institutes of Health Clinical Center (CC)GenentechCedars-Sinai Medical CenterAkebia TherapeuticsDentsply Sirona Implants and ConsumablesSmith & NephewMedtronic - MITG
National Institute on Drug Abuse (NIDA) sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

National Institute on Drug Abuse (NIDA) sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 335 trials (± recruiting share)

Sponsors near 4% open enrollment (± trial volume)

What to do with this National Institute on Drug Abuse (NIDA) page

335 registered trials is a research-attention snapshot, not an endorsement of National Institute on Drug Abuse (NIDA) or any single study.

  • 14 of National Institute on Drug Abuse (NIDA)'s trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Cocaine-Related Disorders is the condition National Institute on Drug Abuse (NIDA) studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Cocaine-Related Disorders trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

National Institute on Drug Abuse (NIDA) pipeline card: 335 registered trials from official public datasets.Report a data error.