National Institute on Drug Abuse (NIDA)

335 total trials 14 currently recruiting 292 completed

National Institute on Drug Abuse (NIDA) sponsors 335 registered US clinical trials on ClinicalTrials.gov, 14 of them currently recruiting, and 292 completed. 30 of these trials are in Phase 3-4 (later-stage) and 202 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Cocaine-Related Disorders, with 17 trials.

Trial Pipeline

335 total, page 4 of 7

COMPLETED Phase 2

Effectiveness of Bupropion for Treating Nicotine Dependence in Young People

NCT00129272

COMPLETED NA

Examining the Effectiveness of the Nicotine Patch in Male and Female Smokers - 2

NCT00135746

COMPLETED Phase 2

Buprenorphine as a Treatment for Individuals Dependent on Analgesic Opioids

NCT00218101

COMPLETED Phase 1

A Preliminary Study of Sustained-Release Bupropion for Smoking Cessation in Bipolar Affective Disorder

NCT00593099

COMPLETED Phase 1

Neurobiology and Pharmacokinets of Acute MDMA Administration

NCT01148342

COMPLETED Phase 1

Treatment of Heroin and Cocaine With Methadone Maintenance and Contingency Management

NCT00292110

COMPLETED NA

Behavioral Smoking Cessation Treatment - 1

NCT00110825

COMPLETED NA

Preventing Depression in Methadone Maintenance Patients Receiving Hepatitis C Treatment - 1

NCT00218556

COMPLETED NA

Contingency Management for Attendance - 2

NCT00249639

COMPLETED Phase 2

Effect of Bupropion on Smoking Behavior in Smokers With Schizophrenia

NCT00218231

COMPLETED Phase 3

An Hepatitis B Vaccine Model for HIV Vaccine Trials in Drug Users

NCT00841477

TERMINATED Phase 2

Opioid Agonist and Antagonist Effects on Opioid Dependence

NCT00142727

COMPLETED NA

Positive Choice: Prevention for Positive Health

NCT00447707

COMPLETED Phase 4

Methylphenidate Raclopride Positron Emission Tomography (PET) Test - 11

NCT00015301

COMPLETED Phase 1

A Transtheoretical Model Group Therapy for Cocaine

NCT00178776

COMPLETED

Nicotine and Cotinine Levels in Smokers With Schizophrenia and Schizoaffective Disorder - 2

NCT00135772

COMPLETED

Effects of Pre-Session Supplemental Hydromorphone on Drug Seeking Behavior in Opioid Dependent Individuals

NCT00218309

COMPLETED Phase 3

Chronic Hepatitis Intervention Project for Drug Users

NCT00596843

COMPLETED

Real Time Assessment of Drug Craving, Use, and Abstinence During Outpatient: A Development and Feasibility Study

NCT00292136

COMPLETED

Automatic Versus Evaluative Components of Cue Reactivity

NCT01036126

COMPLETED NA

Vouchers vs. Prizes for Methadone Patients - 1

NCT00249522

COMPLETED

Quantitation of Human Cerebral Nicotinie Receptors With 2[18F]FA-85380 and PET Healthy Non-smokers and Ex-Smokers and in Heavy and Light Situational Smokers

NCT01038245

COMPLETED Phase 2

Bupropion for the Treatment of Methamphetamine Dependence - 1

NCT00069251

COMPLETED NA

Modifying Group Therapy for Bipolar Substance Abusers - 1

NCT00227838

COMPLETED Phase 1

Assessment of Potential Interactions Between Cocaine and RPR 102681 - 1

NCT00067535

COMPLETED NA

Bridging Active Heroin Users to Hepatitis C Treatment Using Buprenorphine - 1

NCT00249574

COMPLETED Phase 4

Treatment of Acute Hepatitis C Virus Infection With Pegylated Interferon in Injection Drug Users

NCT00194480

COMPLETED Phase 2

Naltrexone as Adjunct in Alcoholic Cocaine Dependent Patients - 4

NCT00000307

COMPLETED Phase 1

Effectiveness of N-acetylcysteine in Treating Cocaine Dependent Individuals - 1

NCT00136825

COMPLETED Phase 1

Effectiveness of Naltrexone and Lofexidine in Treating Detoxified Heroin Addicts - 1

NCT00218530

COMPLETED Phase 1

Effectiveness of Self-Help for Dually-Diagnosed Persons - 1

NCT00218582

COMPLETED Phase 2

Comparison of Buprenorphine and Methadone - 3

NCT00000334

COMPLETED Phase 1

Cocaethylene as a Treatment for Cocaine Dependence - 1

NCT00124696

COMPLETED Phase 2

Effectiveness of Using Tobacco Free Snuff in Reducing Negative Effects of Smokeless Tobacco Use

NCT00218270

COMPLETED Phase 2

Maintaining Abstinence in Chronic Cigarette Smokers - 1

NCT00087880

COMPLETED NA

Physician Focused Intervention to Improve Adherence With HIV Antiretrovirals

NCT00870792

COMPLETED Phase 2

Tiagabine for the Treatment of Cocaine Dependence - 1

NCT00086255

COMPLETED

Effects of Nicotine on Cognitive Task Performance and Brain Activity as Measured by fMRI

NCT01036711

TERMINATED NA

Effects of Buprenorphine/Naloxone in Treating Opioid Dependent Individuals Who Are Maintained on Methadone

NCT00000243

COMPLETED

Effects of Nicotine on Brain Activity as Measured by fMRI

NCT01037153

COMPLETED Phase 4

Reinforcement-Based Treatment and Abstinence-Contingent Housing for Drug Abusers

NCT00685620

COMPLETED Phase 2

Clonidine as Adjunct Therapy for the Treatment of Neonatal Abstinence Syndrome

NCT00510016

COMPLETED Phase 2

Combination Pharmacotherapy for Smoking Cessation Among Methadone Patients

NCT00060814

COMPLETED Phase 2

Study to Reduce Intravenous Exposures (STRIVE)

NCT00391482

COMPLETED Phase 2

Ondansetron for the Treatment of Methamphetamine Dependence - 1

NCT00040053

COMPLETED Phase 2

Effects of Transdermal Nicotine on Smoking, Craving and Withdrawal in People With Schizophrenia

NCT00218218

TERMINATED Phase 2

Nicotine Replacement Treatment for Pregnant Smokers - 1

NCT00115687

COMPLETED Phase 2

Effectiveness of Various Smoking Cessation Therapies in Reducing Smoking in Adolescents - 1

NCT00158171

COMPLETED Phase 4

Effects of Buspirone in Opiate Withdrawal

NCT00326235

COMPLETED Phase 2

Incentive Programs for Female Substance Abusers Who Smoke - 3

NCT00064922

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What the Pipeline for National Institute on Drug Abuse (NIDA) Shows

According to the ClinicalTrials.gov registry, National Institute on Drug Abuse (NIDA) is linked to 335 US clinical trials across every stage of research activity. Of those, 14 studies are currently recruiting, about 4% of the sponsor's indexed portfolio, and 292 are already marked complete, representing roughly 87% of the total.

The phase mix for National Institute on Drug Abuse (NIDA) reports 30 late-stage studies (Phase 3 and Phase 4 combined) and 202 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for National Institute on Drug Abuse (NIDA) is Cocaine-Related Disorders with 17 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.