Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT00318760 · ClinicalTrials.gov registry record · Phase 1
Effect of Clonidine on Responses to Imagery Scripts
A Phase 1 study, sponsored by National Institute on Drug Abuse (NIDA).
- Completed
- Registry status
- Phase 1
- Development phase
- 92
- Enrollment target
NCT00318760 is a Phase 1 study that has completed, run by National Institute on Drug Abuse (NIDA). The registered enrollment target is 92 participants.
The verdict
NCT00318760, a Phase 1 study, has completed, sponsored by National Institute on Drug Abuse (NIDA).
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 92 participants
- Enrollment target
Study Summary
Background: \- Research has shown that clonidine, a drug originally prescribed to treat high blood pressure and some symptoms of opioid withdrawal, can help block stress-induced relapse to heroin and cocaine seeking in rats. However, it does not seem to block cue-induced relapse in rats. Researchers are interested in studying whether clonidine shows the same pattern of effects on stress- and cue-induced cravings for heroin or cocaine in humans. Objectives: \- To compare the ability of clonidine to reduce stress- and cue-induced cocaine and heroin craving in drug abusers. Eligibility: \- Individuals between 18 and 55 years of age who are current cocaine or heroin users. Design: * This study will consist of two visits: a screening visit to determine eligibility and an experimental/script session. * Before the script session, participants will provide urine and breath samples for testing. Participants will complete questionnaires to measure their current drug craving and days since last use of cocaine or heroin. * At the start of the script session, participants will receive a dose of clonidine or placebo as directed by the study researchers. Three hours after dosing, participants will be read four scripts (two neutral, one stress-inducing, and one drug-cue-related) with breaks in between each script. After each script, participants will respond to questions about levels of stress and craving. * Participants will provide saliva samples immediately before and during the script readings, and will also be measured for skin response to the scripts.
Interventions
- DRUG Placebo
- DRUG Clonidine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 92 participants |
| Start Date | 2005-06-14 |
| Est. Completion | 2013-08-07 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00318760
The ClinicalTrials.gov registry entry for NCT00318760 describes a study currently listed as completed, categorized as Phase 1. The registered enrollment target is 92 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Institute on Drug Abuse (NIDA), which has 335 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT00318760 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00318760 about?
NCT00318760 is a clinical study titled "Effect of Clonidine on Responses to Imagery Scripts". Background: \- Research has shown that clonidine, a drug originally prescribed to treat high blood pressure and some symptoms of opioid withdrawal, can help block stress-induced relapse to heroin and cocaine seeking in rats. However, it does not seem to block cue-induced relapse in rats. Researcher...
What is the current status of trial NCT00318760?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 92 participants. The study started on 2005-06-14. Estimated completion is 2013-08-07.
What interventions are being tested in trial NCT00318760?
The interventions under investigation include: Placebo (DRUG), Clonidine (DRUG).
Who is sponsoring clinical trial NCT00318760?
This trial is sponsored by National Institute on Drug Abuse (NIDA), which has 335 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
Explore more on PlainTrial
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.