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ClinicalTrials.gov official registry

Cocaine-Related Disorders clinical trials

All 28 indexed Cocaine-Related Disorders trials have closed enrollment.

28 US clinical trials ·

Cocaine-Related Disorders is the subject of 28 registered US clinical trials on ClinicalTrials.gov, none currently recruiting. 4 are in Phase 3-4 (later-stage) and 21 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute on Drug Abuse (NIDA), running 17 of these trials.

The research picture

Cocaine-Related Disorders has 28 registered US clinical trials; none are currently listed as recruiting, so most are completed or in follow-up.

0
recruiting participants now
0%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
17
top sponsor: National Institute on Drug Abuse (NIDA)
Phase 16Phase 215Phase 31Phase 43

Active & Recent Trials

28 total, page 1 of 1

COMPLETED Phase 2 208 participants

Combination of Disulfiram Plus Naltrexone to Treat Both Cocaine- and Alcohol-dependent Individuals - 1

University of Pennsylvania

NCT00142844

COMPLETED Phase 2 150 participants

Venlafaxine to Reduce Cocaine Dependence in Depressed Individuals

New York State Psychiatric Institute

NCT00249483

COMPLETED Phase 1 140 participants

Treatment of Heroin and Cocaine With Methadone Maintenance and Contingency Management

National Institute on Drug Abuse (NIDA)

NCT00292110

COMPLETED Phase 2 118 participants

Developing Adaptive Interventions for Cocaine Cessation and Relapse Prevention

The University of Texas Health Science Center, Houston

NCT02896712

COMPLETED NA 96 participants

Progesterone for the Treatment of Cocaine Dependence - 1

University of Minnesota

NCT00218257

COMPLETED Phase 2 60 participants

Ondansetron for the Treatment of Cocaine Dependence - 1

National Institute on Drug Abuse (NIDA)

NCT00033085

COMPLETED Phase 4 42 participants

Quetiapine for Cocaine Use and Cravings

Seattle Institute for Biomedical and Clinical Research

NCT00232336

COMPLETED Phase 2 41 participants

Gepirone vs Placebo in Treatment of Cocaine Dependence - 3

University of Pennsylvania

NCT00000189

COMPLETED NA 32 participants

Cocaine Abuse and Attention Deficit Disorder - 3

National Institute on Drug Abuse (NIDA)

NCT00000268

COMPLETED Phase 2 20 participants

Atomoxetine for Treating Cocaine Abuse in Adults With Attention Deficit Hyperactivity Disorder (ADHD)

New York State Psychiatric Institute

NCT00218543

COMPLETED Phase 1 17 participants

Effectiveness of N-acetylcysteine in Treating Cocaine Dependent Individuals - 1

National Institute on Drug Abuse (NIDA)

NCT00136825

COMPLETED Phase 2 16 participants

Cocaine Abuse and ADHD - 10

National Institute on Drug Abuse (NIDA)

NCT00000275

COMPLETED 10 participants

Therapeutic Potential of Kappa-Opioids Against Cocaine - 1

National Institute on Drug Abuse (NIDA)

NCT00000323

COMPLETED Phase 1 9 participants

Open Label Pharmaco- Magnetic Resonance Spectrography (MRS) Study of Clavulanic Acid

Temple University

NCT03986762

COMPLETED Phase 1 8 participants

Cocaethylene as a Treatment for Cocaine Dependence - 1

National Institute on Drug Abuse (NIDA)

NCT00124696

COMPLETED Phase 1 8 participants

Cocaine-Methylphendidate Interaction Study - 4

National Institute on Drug Abuse (NIDA)

NCT00015067

COMPLETED Phase 4

Modeling Impaired Judgement in Cocaine Abusers - 6

National Institute on Drug Abuse (NIDA)

NCT00015236

COMPLETED Phase 3

Dose Response Trial of Pergolide for Cocaine Dependence - 1

Medical University of South Carolina

NCT00000248

COMPLETED Phase 2

Pharmacological Modulation of Cocaine Effects - 1

National Institute on Drug Abuse (NIDA)

NCT00000201

COMPLETED Phase 2

Risperidone Treatment in Dually-Diagnosed Individuals - 2

National Institute on Drug Abuse (NIDA)

NCT00000267

COMPLETED Phase 2

Evaluation of Benztropine for Cocaine Craving - 2

National Institute on Drug Abuse (NIDA)

NCT00000333

COMPLETED Phase 2

Disulfiram for Cocaine-Alcohol Abuse - 3

Yale University

NCT00000278

COMPLETED Phase 2

Effects of Labetalol on Human Cocaine Use - 8

National Institute on Drug Abuse (NIDA)

NCT00000291

COMPLETED Phase 4

Methylphenidate Raclopride Positron Emission Tomography (PET) Test - 11

National Institute on Drug Abuse (NIDA)

NCT00015301

COMPLETED Phase 2

Flupenthixol Treatment in Schizophrenic Cocaine Abusers - 1

National Institute on Drug Abuse (NIDA)

NCT00000266

COMPLETED Phase 2

IV Cocaine Abuse: A Laboratory Model - 1

New York State Psychiatric Institute

NCT00000212

COMPLETED Phase 2

Risperidone for the Treatment of Cocaine Dependence - 7

National Institute on Drug Abuse (NIDA)

NCT00000342

COMPLETED Phase 1

Prepulse Inhibition of Startle in Cocaine Dependence - 7

National Institute on Drug Abuse (NIDA)

NCT00015249

Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 15
Phase 3 1
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Cocaine-Related Disorders Trial Landscape

28 indexed Cocaine-Related Disorders studies · 0 recruiting (0%).

Phase mix: 4 late (III/IV) vs 21 early (I/II).

Top sponsor: National Institute on Drug Abuse (NIDA) (17 trials), 8 others listed. 28 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Cocaine-Related Disorders?

PlainTrial tracks 28 US clinical trials for Cocaine-Related Disorders, of which 0 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Cocaine-Related Disorders?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.