National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sits in the top decile of US sponsors by registered trial count (#74 of 15,742 sponsors by registered trial count).

490 total trials 50 currently recruiting 398 completed early-phase tilt top decile by trial count

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): 490 sponsored US clinical trials, 50 recruiting.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sponsors 490 registered US clinical trials on ClinicalTrials.gov, 50 of them currently recruiting, and 398 completed. 69 of these trials are in Phase 3-4 (later-stage) and 178 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Obesity, with 25 trials.

Top-decile sponsor footprint

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) ranks in the top decile of sponsors by registered trial count (#74 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

C 74/100

398 of 424 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (93.9%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

490 total, page 6 of 10

COMPLETED Phase 1

Long-Term Exercise Maintenance Via Internet Support

NCT00260117

COMPLETED NA

Metabolic Effects of Chemical Interactions in Toxicity

NCT00253773

COMPLETED Phase 3

Pioglitazone vs Vitamin E vs Placebo for Treatment of Non-Diabetic Patients With Nonalcoholic Steatohepatitis (PIVENS)

NCT00063622

COMPLETED Phase 2

Weight Management in Nonalcoholic Steatohepatitis

NCT00266019

COMPLETED NA

The Effect of Ethanol on Overnight Glucose Regulation in Type 2

NCT00566592

COMPLETED

Donor Recipient Kidney Function Following Open Surgical vs. Laparoscopic Kidney Donation

NCT00100516

COMPLETED Phase 2

Effects of Hydrocortisone, Melatonin, and Placebo on Jet Lag

NCT00097474

COMPLETED Phase 3

PEDS-C: Pegylated Interferon +/- Ribavirin for Children With Hepatitis C

NCT00100659

COMPLETED Phase 2

Podocyte Retinoids

NCT00098020

COMPLETED

Adrenal Function in Critical Illness

NCT00156767

COMPLETED NA

Improving Metabolic Assessments in Type 1 Diabetes Mellitus Clinical Trials

NCT00105352

COMPLETED Phase 3

Focal Segmental Glomerulosclerosis Clinical Trial (FSGS-CT)

NCT00135811

COMPLETED

TEDDY - The Environmental Determinants of Diabetes in the Young

NCT00279318

COMPLETED Phase 2

Uric Acid in Essential Hypertension in Children

NCT00288184

COMPLETED

Insulin Resistance in Severely Obese Patients

NCT00275223

COMPLETED Phase 3

Randomized Trial of EUS Neurolysis in Pancreas Cancer

NCT00279292

COMPLETED

Infectious Agents in Pediatric Crohn's

NCT00237055

COMPLETED NA

Program to Reduce Incontinence by Diet and Exercise

NCT00091988

COMPLETED

Genetics of Interstitial Cystitis

NCT00237081

COMPLETED NA

Reimbursement Effects on Enrollment in Obesity Treatment

NCT00250510

COMPLETED Phase 2

New Onset of Type 1 Diabetes Mycophenolate Mofetil-Daclizumab Clinical Trial

NCT00100178

COMPLETED NA

Screening for Barrett's Esophagus in Otolaryngology Patients

NCT00695227

COMPLETED Phase 3

Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY)

NCT00081328

COMPLETED Phase 4

Exercise Training in Type 2 Diabetes and Hypertension

NCT00212303

COMPLETED Phase 2

Effects of Tumor Necrosis Factor (TNF)-Alpha Antagonism in Patients With Metabolic Syndrome

NCT00111956

COMPLETED NA

Gender, Obesity, C-Reactive Protein, and Oxidative Stress

NCT00079963

COMPLETED Phase 2

The Effect of Thyroid Hormone on Drug Elimination in Cancer Patients

NCT00080574

TERMINATED Phase 3

Minimally Invasive Surgical Therapy for BPH

NCT00064649

COMPLETED

Events Preceding Interstitial Cystitis (EPIC)

NCT00248664

COMPLETED NA

Metabolic Analysis in Human Sulfur Amino Acid Deficiency

NCT00253760

COMPLETED Phase 2

Combination Drug Therapy Followed by Single Drug Steroid Free Therapy to Prevent Organ Rejection in Kidney Transplantation

NCT00076570

COMPLETED

Obesity and Fatty Acid Flux Comparison Trials

NCT00074945

COMPLETED

Kidney Transplantation in Patients With Cystinosis

NCT00074516

COMPLETED

Improving Diabetes in Primary Care (IMPACT)

NCT00108927

COMPLETED

The Effects of Overfeeding on Obesity-Prone (OP) and Obesity-Resistant (OR) Women

NCT00072917

COMPLETED

Fat Cell Size in Insulin Resistance

NCT00341406

COMPLETED NA

Enhanced Internet Behavior Therapy for Treating Obesity

NCT00212238

COMPLETED NA

Videoendoscopic Drainage of Infected Pancreatic Collections

NCT00061269

COMPLETED NA

Interaction of Cobalamin Status With Nitrous Oxide in Relation to Postoperative Cognitive Changes in the Elderly

NCT00212147

COMPLETED Phase 1

Islet Transplantation for Patients With Type 1 Diabetes

NCT00073281

COMPLETED NA

Conservative Treatment of Postprostatectomy Incontinence

NCT00212264

COMPLETED NA

Peer-enhanced Intervention to Support Teen Weight Loss

NCT00285558

COMPLETED Phase 2

The Effect of Vitamin D and Calcium on Bone in Pediatric HIV

NCT00724178

COMPLETED Phase 2

Improving Outcomes in Patients With Kidney Disease Due to Diabetes

NCT00381134

COMPLETED NA

Evaluation of California's SB 19 Pupil Nutrition Act

NCT00067847

COMPLETED Phase 3

Steroid Treatment for Kidney Disease

NCT00065611

COMPLETED

ORWH:SCOR on Sex and Gender Factors Affecting Women's Incontinence

NCT00069368

COMPLETED Phase 2

Evaluating the Use of Thymoglobulin, Sirolimus, and Donor Bone Marrow With Kidney Transplantation Patients

NCT00062712

COMPLETED Phase 2

Treating Nonalcoholic Steatohepatitis With Pioglitazone

NCT00062764

COMPLETED Phase 2

Treating Nonalcoholic Steatohepatitis (NASH) With Metformin

NCT00063232

← Previous Page 6 of 10 Next →

Phase Distribution

PhaseTrial count
Phase 1 42
Phase 2 136
Phase 3 55
Phase 4 14

What is open in the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) pipeline

50 recruiting of 490 indexed (10% open); 398 completed (81%).

Phase mix: 69 late (III/IV) vs 178 early (I/II) (early-phase heavy).

Top condition: Obesity (25 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): open-pipeline peers nationwide

Peers matched on 490 registered trials and 10% open enrollment, not the therapeutic-area sidebar.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 0200400600 8%10%12%14%16%18% Total trials Recruiting share National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Beth Israel Deaconess Medical CenterFred Hutchinson Cancer CenterNational Heart, Lung, and Blood Institute (NHLBI)H. Lee Moffitt Cancer Center and Research InstituteMirati TherapeuticsJames J. Peters Veterans Affairs Medical CenterCalifornia Pacific Medical Center Research InstituteNational Institute of Environmental Health Sciences (NIEHS)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 490 trials (± recruiting share)

Sponsors near 10% open enrollment (± trial volume)

What to do with this National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) page

490 registered trials is a research-attention snapshot, not an endorsement of National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) or any single study.

  • 50 of National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)'s trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Obesity is the condition National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Obesity trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) pipeline card: 490 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.