National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sits in the top decile of US sponsors by registered trial count (#74 of 15,742 sponsors by registered trial count).

490 total trials 50 currently recruiting 398 completed early-phase tilt top decile by trial count

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): 490 sponsored US clinical trials, 50 recruiting.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sponsors 490 registered US clinical trials on ClinicalTrials.gov, 50 of them currently recruiting, and 398 completed. 69 of these trials are in Phase 3-4 (later-stage) and 178 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Obesity, with 25 trials.

Top-decile sponsor footprint

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) ranks in the top decile of sponsors by registered trial count (#74 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

C 74/100

398 of 424 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (93.9%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

490 total, page 7 of 10

COMPLETED Phase 1

Safety and Pharmacokinetics (PK) of hOKT3g1 (Ala-Ala) in Type 1 Diabetes Mellitus (T1DM)

NCT00073255

COMPLETED NA

Vermont Diabetes Information System

NCT00109369

COMPLETED Phase 2

The Medical College of Georgia PLAY Project: Exercise Dose and Insulin Sensitivity in Obese Children

NCT00108901

COMPLETED Phase 2

Testosterone and Physical Function in HIV+ Men

NCT00260143

COMPLETED Phase 2

Substrate Cycling in Energy Metabolism

NCT00361751

COMPLETED NA

Epidemiology of Gallbladder Sludge and Stones in Pregnancy

NCT00131131

COMPLETED

Hepatitis C: Grading and Staging by MR

NCT00059397

COMPLETED Phase 2

Treatment of Cholestatic Pruritus With Sertraline

NCT00058903

COMPLETED Phase 2

Type 2 Diabetes Primary Prevention for At Risk Girls

NCT00063674

COMPLETED Phase 1

Wise Mind: Environmental Approach for Obesity Prevention

NCT00065039

COMPLETED Phase 1

Improving Body Image in Middle Schoolers

NCT00067652

COMPLETED NA

Increasing Physical Activity Levels in Low-Income Women

NCT00065026

TERMINATED NA

Treatment of Diabetic Nephropathy

NCT00065559

COMPLETED

The Role of Connective Tissue Growth Factor in the Development of Kidney Disease After Organ Transplantation

NCT00056784

COMPLETED Phase 4

The Effects of Anti-Inflammatory Treatment on Insulin Resistance in Healthy Volunteers

NCT00339833

COMPLETED NA

Increased Gluconeogenesis is One Cause of Cystic Fibrosis Related Diabetes (CFRD)

NCT00082238

COMPLETED Phase 4

Low-Dose Peginterferon and Ribavirin to Treat Chronic Hepatitis C in Patients Infected With HCV Genotype 2 or 3

NCT00056862

COMPLETED Phase 1

Adjuvant Nutrition for Critically Ill Trauma Patients

NCT00067132

COMPLETED NA

Factors Affecting Caloric Regulation in Human Feeding

NCT00108784

COMPLETED Phase 2

Study of Thyrotropin-Releasing Hormone in Normal Volunteers and in Patients With Thyroid or Pituitary Abnormalities

NCT00054756

COMPLETED NA

Obesity Prevention in African American School Children

NCT00061165

COMPLETED Phase 3

Clopidogrel Prevention of Early Arteriovenous (AV) Fistula Thrombosis

NCT03289520

COMPLETED Phase 3

Aggrenox Prevention of Access Stenosis

NCT00067119

COMPLETED

Quality of Life in Pediatric Inflammatory Bowel Disease

NCT00061737

COMPLETED Phase 2

Sirolimus Therapy for Idiopathic and Lupus Membranous Nephropathy

NCT00050713

COMPLETED Phase 1

Prevention of Type 2 Diabetes Mellitus in Children

NCT00073268

COMPLETED Phase 4

Insulin Resistance and Central Nervous System (CNS) Function in Type 2 Diabetes

NCT00212290

COMPLETED NA

Effect of Varying Testosterone Levels on Insulin Sensitivity in Normal and IHH Men

NCT00470990

COMPLETED NA

Breaking Down Barriers to Diabetes Self-Care

NCT00142922

COMPLETED NA

Impact of Non-Commercialism Policy in Seattle Schools

NCT00063700

COMPLETED NA

A Cafeteria Based Study of Weight Gain Prevention

NCT00573482

COMPLETED NA

Modifying the Home Television Watching Environment

NCT00065052

COMPLETED Phase 3

Hepatitis C Antiviral Resistance in African-Americans

NCT00038974

COMPLETED NA

Evaluation of Diabetes Self-Management Consultant Care

NCT00109720

COMPLETED NA

Treatment of Binge Eating Disorder

NCT00041743

TERMINATED Phase 2

Trial of High-dose Urso in Primary Sclerosing Cholangitis

NCT00059202

TERMINATED NA

Pre-ESRD Syndrome in High Risk African Americans

NCT00224939

COMPLETED Phase 2

Sirolimus for Focal Segmental Glomerulosclerosis

NCT00040508

COMPLETED Phase 2

Folic Acid for Vascular Outcome Reduction In Transplantation (FAVORIT)

NCT00064753

COMPLETED Phase 1

Detection and Cytotoxic T Lymphocyte Therapy of Post-Transplant Lymphoproliferative Disorder After Liver Transplant

NCT00063648

COMPLETED Phase 3

Prevention of Osteoporosis in Men With Prostate Cancer

NCT00048841

COMPLETED

Esophageal Motility and Airway Defenses Among Infants

NCT00062452

COMPLETED Phase 2

Strength Training for Obesity Prevention

NCT00030160

COMPLETED NA

Treatment of Binge Eating Disorder

NCT00039936

COMPLETED Phase 4

Effectiveness of Brief Counseling for Weight Management

NCT00212199

COMPLETED NA

Family-Centered Diabetes Project - Sharing Wisdom

NCT00438126

COMPLETED Phase 2

Gamma Interferon Therapy for Chronic Hepatitis C

NCT00028275

COMPLETED Phase 4

Pegylated Interferon and Ribavirin to Treat Chronic Hepatitis C With and Without Kidney Disease

NCT00028093

COMPLETED

Glucocorticoid-induced Osteopenia in Children

NCT00289328

COMPLETED Phase 2

Leptin to Treat Severe Insulin Resistance - Pilot Study

NCT00027456

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Phase Distribution

PhaseTrial count
Phase 1 42
Phase 2 136
Phase 3 55
Phase 4 14

What is open in the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) pipeline

50 recruiting of 490 indexed (10% open); 398 completed (81%).

Phase mix: 69 late (III/IV) vs 178 early (I/II) (early-phase heavy).

Top condition: Obesity (25 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): open-pipeline peers nationwide

Peers matched on 490 registered trials and 10% open enrollment, not the therapeutic-area sidebar.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 0200400600 8%10%12%14%16%18% Total trials Recruiting share National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Beth Israel Deaconess Medical CenterFred Hutchinson Cancer CenterNational Heart, Lung, and Blood Institute (NHLBI)H. Lee Moffitt Cancer Center and Research InstituteMirati TherapeuticsJames J. Peters Veterans Affairs Medical CenterCalifornia Pacific Medical Center Research InstituteNational Institute of Environmental Health Sciences (NIEHS)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 490 trials (± recruiting share)

Sponsors near 10% open enrollment (± trial volume)

What to do with this National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) page

490 registered trials is a research-attention snapshot, not an endorsement of National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) or any single study.

  • 50 of National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)'s trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Obesity is the condition National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Obesity trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) pipeline card: 490 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.