National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sits in the top decile of US sponsors by registered trial count (#74 of 15,742 sponsors by registered trial count).

490 total trials 50 currently recruiting 398 completed early-phase tilt top decile by trial count

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): 490 sponsored US clinical trials, 50 recruiting.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sponsors 490 registered US clinical trials on ClinicalTrials.gov, 50 of them currently recruiting, and 398 completed. 69 of these trials are in Phase 3-4 (later-stage) and 178 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Obesity, with 25 trials.

Top-decile sponsor footprint

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) ranks in the top decile of sponsors by registered trial count (#74 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

C 74/100

398 of 424 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (93.9%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

490 total, page 5 of 10

COMPLETED Phase 1

A Test of Iron Malabsorption in Patients With Iron Deficiency Anemia

NCT00399191

COMPLETED NA

Middle-School Based Primary Prevention Trial of Type 2 Diabetes

NCT00458029

COMPLETED

Assessment of Beta Cell Mass in Type 1 Diabetes With 11C-Dihydrotetrabenazine and PET Scan

NCT00351650

COMPLETED Phase 1

Efficacy of Increasing Physical Activity to Reduce Children's Visceral Fat

NCT00359957

COMPLETED

Gene Expression and Inflammation in Overweight Subjects

NCT00344266

COMPLETED NA

Nutritional Intervention to Prevent Diabetes

NCT00333554

COMPLETED Phase 2

Statewide (Rhode Island and Neighboring States) Partnerships for Worksite Weight Management

NCT00288145

COMPLETED

Study of Effects From Gastric Bypass Weight Loss on Brain Tissue

NCT00357344

COMPLETED Phase 3

Cinacalcet to Treat Familial Primary Hyperparathyroidism

NCT00325104

COMPLETED NA

Low Magnitude Mechanical Stimuli Effects on Bone Structure in ESRD

NCT00364234

COMPLETED NA

Effects of Caffeinated and Decaffeinated Coffee on Body Weight and Glucose Tolerance

NCT00305097

TERMINATED

Stem Cell Collection

NCT00316069

COMPLETED

Thyroid and Fat Tissue Metabolism

NCT00312715

COMPLETED Phase 2

Polyunsaturated Fatty Acids (PUFA) in Diabetic Fatty Liver

NCT00323414

COMPLETED Phase 3

Efficacy & Safety Study of Pregabalin to Treat Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)

NCT00371033

COMPLETED Phase 2

Treatment of Uterine Fibroids With the Selective Progesterone Receptor Modulator CDB-2914

NCT00290251

COMPLETED

Body Weight Regulation in Patients With Narcolepsy

NCT00283894

COMPLETED Phase 2

Frequent Hemodialysis Network: Daily Trial

NCT00264758

COMPLETED Phase 3

HALT Progression of Polycystic Kidney Disease Study B

NCT01885559

COMPLETED Phase 3

HALT Progression of Polycystic Kidney Disease Study A

NCT00283686

COMPLETED

Kidney Disease Biomarkers

NCT00255398

COMPLETED Phase 2

Effect of Lithium Carbonate on Low-Dose Radioiodine Therapy in Early Thyroid Cancer

NCT00251316

COMPLETED NA

A Randomized, Double-Blinded, Placebo-Controlled Trial of Corticosteroid Therapy Following Portoenterostomy

NCT00294684

TERMINATED Phase 2

Chronic Sleep Deprivation as a Risk Factor for Metabolic Syndrome and Obesity

NCT00261898

COMPLETED

Assessment of Insulin Production From Native Pancreas in Patients With Pancreas Transplants

NCT00246844

COMPLETED Phase 3

Treatment of Nonalcoholic Fatty Liver Disease in Children (TONIC)

NCT00063635

COMPLETED Phase 2

Iron Depletion Therapy for Type 2 DM and NAFLD

NCT00230087

COMPLETED Phase 2

Effect of Omega-3 PUFA Supplementation in NAFLD Patients

NCT00230113

COMPLETED

Mechanisms of Diabetes Control After Weight Loss Surgery

NCT00571220

COMPLETED

T Cell Validation Study Using Blood Samples From Subjects With Recent Onset Type 1 Diabetes Mellitus

NCT00212329

COMPLETED

Cognitive Effects of Bariatric Surgery

NCT00671775

COMPLETED Phase 1

Dietary Variety Versus Dietary Fat Effects in Energy Intake

NCT00285571

COMPLETED NA

Myocardial Function & FFA Metabolism in HIV Metabolic Syndrome

NCT00656851

COMPLETED

Does Metabolic Syndrome Exist in Anorexia Nervosa?

NCT00271921

COMPLETED Phase 2

Pre-Transplant Treatment to Prevent Recurrence of Hepatitis C After Liver Transplantation

NCT00135798

COMPLETED NA

The Diabetes TeleCare Study

NCT00288132

COMPLETED Phase 2

Rituximab in New Onset Type 1 Diabetes

NCT00279305

TERMINATED Phase 2

SAMe to Treat Biliary Cirrhosis Symptoms

NCT00125281

COMPLETED Phase 4

Long-Term Lamivudine Therapy for Chronic Hepatitis B

NCT00120354

COMPLETED Phase 2

Obesity Assessment and Education Through the Internet

NCT00149682

COMPLETED NA

A Trial of Two Diets for Weight and Diabetes Management

NCT00729196

TERMINATED Phase 2

Imuran Dosing in Crohn's Disease Study

NCT00113503

COMPLETED NA

Use of Midlevel Providers in Diabetes Management

NCT00237094

COMPLETED Phase 2

Thyroid and Glucose and Energy Metabolism

NCT00106119

COMPLETED Phase 3

Efficacy of Amitriptyline for Painful Bladder Syndrome (PBS)

NCT00124306

COMPLETED NA

Development of Limited Contact CBT Treatment for IBS

NCT00248586

COMPLETED Phase 3

Trial to Compare Alfuzosin Versus Placebo in the Treatment of Chronic Prostatitis/Chronic Pelvic Pain Syndrome

NCT00103402

COMPLETED Phase 1

Internet Weight Control for Bingeing Adolescents

NCT00125112

TERMINATED

Clinical and Laboratory Investigation of Humans With Informative Iron or Erythroid Phenotypes

NCT00102245

COMPLETED NA

Exercise and Pioglitazone for HIV-Metabolic Syndromes

NCT00639457

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Phase Distribution

PhaseTrial count
Phase 1 42
Phase 2 136
Phase 3 55
Phase 4 14

What is open in the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) pipeline

50 recruiting of 490 indexed (10% open); 398 completed (81%).

Phase mix: 69 late (III/IV) vs 178 early (I/II) (early-phase heavy).

Top condition: Obesity (25 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): open-pipeline peers nationwide

Peers matched on 490 registered trials and 10% open enrollment, not the therapeutic-area sidebar.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 0200400600 8%10%12%14%16%18% Total trials Recruiting share National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Beth Israel Deaconess Medical CenterFred Hutchinson Cancer CenterNational Heart, Lung, and Blood Institute (NHLBI)H. Lee Moffitt Cancer Center and Research InstituteMirati TherapeuticsJames J. Peters Veterans Affairs Medical CenterCalifornia Pacific Medical Center Research InstituteNational Institute of Environmental Health Sciences (NIEHS)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 490 trials (± recruiting share)

Sponsors near 10% open enrollment (± trial volume)

What to do with this National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) page

490 registered trials is a research-attention snapshot, not an endorsement of National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) or any single study.

  • 50 of National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)'s trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Obesity is the condition National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Obesity trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) pipeline card: 490 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.