National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sits in the top decile of US sponsors by registered trial count (#74 of 15,742 sponsors by registered trial count).

490 total trials 50 currently recruiting 398 completed early-phase tilt top decile by trial count

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): 490 sponsored US clinical trials, 50 recruiting.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sponsors 490 registered US clinical trials on ClinicalTrials.gov, 50 of them currently recruiting, and 398 completed. 69 of these trials are in Phase 3-4 (later-stage) and 178 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Obesity, with 25 trials.

Top-decile sponsor footprint

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) ranks in the top decile of sponsors by registered trial count (#74 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

C 74/100

398 of 424 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (93.9%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

490 total, page 3 of 10

COMPLETED Phase 2

ATG-GCSF in New Onset Type 1 Diabetes

NCT02215200

COMPLETED

Comparing Pain in Patients Undergoing Percutaneous Versus Transjugular Techniques of Liver Biopsy

NCT02311348

COMPLETED Phase 1

Vitamin E Pharmacokinetics and Biomarkers in Normal and Obese Women

NCT00862433

COMPLETED Phase 1

Acute Effects of Canagliflozin, a Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitor on Bone Metabolism in Healthy Volunteers

NCT02404870

COMPLETED

Seroprevalence of Hepatitis E in People With an Organ Transplant

NCT02190253

COMPLETED Phase 1

Evaluation of Safety, Tolerability, and Antiviral Activity of Chlorcyclizine HCl in Patients With Chronic Hepatitis C

NCT02118012

COMPLETED

TODAY2 Phase 2 Follow-up

NCT02310724

COMPLETED Phase 2

Study of Human Non-Shivering Thermogenesis and Basal Metabolic Rate

NCT01950520

COMPLETED Phase 2

Investigation of the Gut Microbiota in Regulating Nutrient Absorption in Humans

NCT02037295

TERMINATED

Study of the Effect of a Very-Low-Carbohydrate Diet on Energy Expenditure

NCT01967563

COMPLETED

Evaluation of Sickle Cell Liver Disease

NCT01950429

COMPLETED Phase 1

Safety Study of Intravenous Immunoglobulin (IVIG) Post-Portoenterostomy in Infants With Biliary Atresia

NCT01854827

COMPLETED

Identifying Risk for Diabetes and Heart Disease in Women

NCT01809288

COMPLETED NA

Predicting Adherence to a Heart-Healthy Diet in Lean and Obese Individuals

NCT01862796

COMPLETED

The Physiology of Fatigue in Patients With Chronic Liver Disease

NCT01867385

COMPLETED Phase 2

Treatment for Non-Alcoholic Fatty Liver With Different Doses of Vitamin E

NCT01792115

COMPLETED Phase 2

New Treatment Response in People With and Without Cirrhosis From Chronic Hepatitis C

NCT01888900

COMPLETED Phase 2

Aprepitant for the Relief of Nausea in Patients With Chronic Nausea and Vomiting of Presumed Gastric Origin Trial

NCT01149369

COMPLETED Phase 3

Lifestyle Interventions for Expectant Mothers (LIFE-Moms Phoenix) - Phoenix

NCT01812694

COMPLETED Phase 2

CTLA4-Ig (Abatacept)for Prevention of Abnormal Glucose Tolerance and Diabetes in Relatives At -Risk for Type 1

NCT01773707

COMPLETED Phase 2

Short-term Effects of Leptin in People With Lipodystrophy

NCT01778556

COMPLETED

Chronic Cold Exposure and Energy Metabolism in Humans

NCT01730105

COMPLETED Phase 3

Combination Therapy of Pegylated Interferon Alfa-2a and Tenofovir Versus Tenofovir Monotherapy in Chronic Hepatitis B

NCT01369212

COMPLETED Phase 3

Entecavir/Pegylated Interferon in Immune Tolerant Children With Chronic Hepatitis B Virus (HBV) Infection

NCT01368497

COMPLETED

Evaluation of People With Gastrointestinal Disease

NCT01639924

COMPLETED Phase 2

Cysteamine Bitartrate Delayed-Release for the Treatment of NAFLD in Children

NCT01529268

TERMINATED Phase 3

Combination Entecavir and Peginterferon Therapy in HBeAg-Positive Immune-Tolerant Adults With Chronic Hepatitis B

NCT01369199

COMPLETED NA

Energy Expenditure Responses to Different Temperatures

NCT01568671

COMPLETED Phase 2

Lonafarnib for Chronic Hepatitis D

NCT01495585

COMPLETED

Metabolic Effects of Synthetic Thyroid Hormone for Thyroid Cancer Treatment

NCT01441154

COMPLETED

Withdrawal of Therapy After Long-Term Antiviral Treatment for Chronic Hepatitis B

NCT01581554

TERMINATED Phase 2

Effects of Caloric Restriction Alone Versus Postoperative Caloric Restriction Following Bariatric Surgery on Glucose Metabolism in Patients With Diabetes Mellitus

NCT01083108

COMPLETED Phase 2

The Farnesoid X Receptor (FXR) Ligand Obeticholic Acid in NASH Treatment Trial(FLINT)

NCT01265498

COMPLETED

TODAY2 Phase 1 Immediate Post-Intervention Observational Follow-up Study

NCT01364350

COMPLETED Phase 2

Evaluation of Cortisol Resistance in Young Sedentary and Endurance-Trained Men

NCT01294319

COMPLETED Phase 1

Metabolic Effects of Non-Nutritive Sweeteners

NCT01200940

COMPLETED Phase 1

Developing Biomarkers of Dietary Intake

NCT01237093

COMPLETED NA

Water Deprivation Protocol

NCT01224704

COMPLETED Phase 2

Canakinumab Study in Individuals With Newly Diagnosed Type 1 Diabetes

NCT00947427

COMPLETED

Duration of Long-term Immunity After Hepatitis B Virus Immunization

NCT01182311

COMPLETED

Role of Donor Genetics and Recipient Genetics in Kidney Transplant Outcomes

NCT01143532

COMPLETED Phase 2

Teplizumab for Prevention of Type 1 Diabetes In Relatives "At-Risk"

NCT01030861

COMPLETED Phase 2

Investigating the Use of Quercetin on Glucose Absorption in Obesity, and Obesity With Type 2 Diabetes

NCT00065676

COMPLETED

Prediction by Ultrasound of the Risk of Hepatic Cirrhosis in Cystic Fibrosis

NCT01144507

COMPLETED Phase 1

Quitting Caffeine for Better Glucose Metabolism

NCT01030796

COMPLETED Phase 2

Partners for Better Health in Adolescent Type 2 Diabetes: The Buddy Study

NCT01007266

TERMINATED

Diet-Induced-Obesity Resistant Phenotypes in Humans

NCT00999154

COMPLETED NA

Family Weight Management Study

NCT00851201

TERMINATED

Natural History of Autoimmune Diabetes and Its Complications

NCT00896610

COMPLETED Phase 3

The Effects of Exenatide (Byetta ) on Energy Expenditure and Weight Loss in Nondiabetic Obese Subjects

NCT00856609

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Phase Distribution

PhaseTrial count
Phase 1 42
Phase 2 136
Phase 3 55
Phase 4 14

What is open in the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) pipeline

50 recruiting of 490 indexed (10% open); 398 completed (81%).

Phase mix: 69 late (III/IV) vs 178 early (I/II) (early-phase heavy).

Top condition: Obesity (25 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): open-pipeline peers nationwide

Peers matched on 490 registered trials and 10% open enrollment, not the therapeutic-area sidebar.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 0200400600 8%10%12%14%16%18% Total trials Recruiting share National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Beth Israel Deaconess Medical CenterFred Hutchinson Cancer CenterNational Heart, Lung, and Blood Institute (NHLBI)H. Lee Moffitt Cancer Center and Research InstituteMirati TherapeuticsJames J. Peters Veterans Affairs Medical CenterCalifornia Pacific Medical Center Research InstituteNational Institute of Environmental Health Sciences (NIEHS)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 490 trials (± recruiting share)

Sponsors near 10% open enrollment (± trial volume)

What to do with this National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) page

490 registered trials is a research-attention snapshot, not an endorsement of National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) or any single study.

  • 50 of National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)'s trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Obesity is the condition National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Obesity trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) pipeline card: 490 registered trials from official public datasets.Report a data error.