National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sits in the top decile of US sponsors by registered trial count (#74 of 15,742 sponsors by registered trial count).

490 total trials 50 currently recruiting 398 completed early-phase tilt top decile by trial count

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): 490 sponsored US clinical trials, 50 recruiting.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sponsors 490 registered US clinical trials on ClinicalTrials.gov, 50 of them currently recruiting, and 398 completed. 69 of these trials are in Phase 3-4 (later-stage) and 178 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Obesity, with 25 trials.

Top-decile sponsor footprint

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) ranks in the top decile of sponsors by registered trial count (#74 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

C 74/100

398 of 424 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (93.9%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

490 total, page 4 of 10

COMPLETED

Human Atherosclerotic Plaque Inflammation Imaged Using PDG-PET/CT

NCT00958815

COMPLETED Phase 2

Reduced Carbohydrate Versus Fat in Obese Subjects

NCT00846040

COMPLETED Phase 2

Effects of Recombinant Human Glutamic Acid Decarboxylase on the Progression of Type 1 Diabetes in New Onset Subjects

NCT00529399

TERMINATED Phase 2

Novel Therapy to Preserve Beta Cell Function in New Onset Type 1 Diabetes

NCT00837759

COMPLETED

Long-term Follow-up of HALT-C Sustained Virological Responders

NCT00825877

COMPLETED Phase 1

Assessment of the Effects of a DPP-4 Inhibitor (Sitagliptin) Januvia on Immune Function in Healthy Individuals

NCT00813228

COMPLETED Phase 3

Nortriptyline for Idiopathic Gastroparesis

NCT00765895

COMPLETED

Pharmacogenomic Response to Thyrotropin-Releasing Hormone Stimulation in Healthy Volunteers: The Influence of a Common Type 2 Deiodinase Genetic Polymorphism on Serum T3

NCT00812149

COMPLETED Phase 3

Improving Health Habits in Impoverished Populations

NCT00569595

COMPLETED Phase 2

Predicting Weight Gain and Weight Loss Associated With Overeating or Fasting

NCT00687115

COMPLETED Phase 2

Primary Prevention of Hypertension in Obese Adolescents

NCT00288158

COMPLETED

Experimental Device to Improve Colonoscopy

NCT00719641

COMPLETED Phase 2

High-Dose Ribavirin and Peginterferon to Treat Chronic Hepatitis C Genotype 1

NCT00735969

COMPLETED NA

Cognitive Behavioral Treatment of Depression in ESRD Patients on Dialysis

NCT00618475

COMPLETED

TODAY Genetics Study

NCT00722397

COMPLETED Phase 1

Viral Kinetics and Liver Gene Expression in Response to Ribavirin and Peginterferon Therapy of Chronic Hepatitis C

NCT00718172

COMPLETED Early Phase 1

Antioxidant Treatment of Type 2 Diabetes

NCT00609102

COMPLETED Phase 3

Thyroid Hormones Homeostasis and Energy Metabolism Changes During Stimulation of Endogenously Secreted Bile Acids (BAs)

NCT00706381

COMPLETED Phase 1

Oral Nifedipine to Treat Iron Overload

NCT00712738

COMPLETED

A New Method for Determining Gastric Acid Output Using a Wireless Capsule

NCT00702533

COMPLETED NA

Physical Therapy in Women With Interstitial Cystitis

NCT00733603

COMPLETED

Effects of Diet Changes on Metabolism

NCT00523627

COMPLETED

Hepatitis C Treatment and Atherosclerosis

NCT00659256

COMPLETED NA

Parental Management of Young Children's Diabetes

NCT00847327

COMPLETED Phase 2

Intravenous CTLA4-lg Treatment in Recent Onset Type 1 Diabetes Mellitus

NCT00505375

COMPLETED NA

Computer Based Intervention for Type 2 Diabetes in Youth

NCT00570466

COMPLETED

Intraperative Assessment of Renal Perfusion Using Infrared Imaging

NCT00595179

COMPLETED Phase 2

African American Study of Kidney Disease and Hypertension ABPM Pilot Study

NCT00582777

COMPLETED NA

Addressing Emotional and Cognitive Factors in Behavioral Weight Loss Treatment

NCT00533052

COMPLETED Early Phase 1

Adolescent Self-Management of Type 1 Diabetes: an Intervention (Completed)

NCT00848705

COMPLETED NA

Circuit Training and Motivational Interviewing to Reduce Type 2 Diabetes in Youth

NCT00693511

COMPLETED Phase 3

Effect of Physical Activity on Metabolic Syndrome in Pregnancy & Fetal Outcome

NCT00647595

COMPLETED

The Stress-Hormone System in Alcohol-Dependent Subjects

NCT00536146

COMPLETED

Effects of Bariatric Surgery on Insulin

NCT00535600

COMPLETED NA

The Effect of Dietary Sitosterol on Blood Sugar and Cholesterol

NCT00531128

COMPLETED

Evaluation of Albuminuria HIV-Infected Patients

NCT00524992

TERMINATED Phase 2

Tenofovir Alone Versus Tenofovir With Emtricitabine to Treat Chronic Hepatitis B

NCT00524173

COMPLETED NA

Metabolism and Thyroid Hormone Changes During Exposure to Cold Temperatures

NCT00521729

COMPLETED

Effect of Short-Term Beta-Cell Rest in Adolescents and Young Adults With Type 2 Diabetes Mellitus

NCT00445627

COMPLETED

Effect of Diet on Vascular Disease in Pre-Menopausal Women

NCT00484861

COMPLETED Phase 3

Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR)

NCT00405704

COMPLETED Phase 2

S-Adenosyl Methionine (SAMe) to Treat Patients With Chronic Hepatitis C

NCT00475176

COMPLETED Phase 1

Effects of N-acetylcysteine on Muscle Fatigue in Hemodialysis

NCT00440869

TERMINATED Phase 3

A Randomized Multicenter Double-Blind CT to Evaluate the Efficacy and Safety of Mycophenolate Mofetil . . .

NCT00451867

COMPLETED Phase 3

Oral Insulin for Prevention of Diabetes in Relatives at Risk for Type 1 Diabetes Mellitus

NCT00419562

COMPLETED

Energy Metabolism and Nutrient Absorption in Lean and Obese Individuals

NCT00414063

COMPLETED NA

Physical Therapy Trial for Pelvic Pain

NCT00434343

COMPLETED Phase 2

Botulinum Toxin Injection for the Management of BPH

NCT00451191

COMPLETED

Magnetic Resonance Angiography to Diagnose Atherosclerotic Disease

NCT00382564

COMPLETED NA

Parent Supported Weight Reduction in Down Syndrome

NCT01256112

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Phase Distribution

PhaseTrial count
Phase 1 42
Phase 2 136
Phase 3 55
Phase 4 14

What is open in the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) pipeline

50 recruiting of 490 indexed (10% open); 398 completed (81%).

Phase mix: 69 late (III/IV) vs 178 early (I/II) (early-phase heavy).

Top condition: Obesity (25 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): open-pipeline peers nationwide

Peers matched on 490 registered trials and 10% open enrollment, not the therapeutic-area sidebar.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 0200400600 8%10%12%14%16%18% Total trials Recruiting share National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Beth Israel Deaconess Medical CenterFred Hutchinson Cancer CenterNational Heart, Lung, and Blood Institute (NHLBI)H. Lee Moffitt Cancer Center and Research InstituteMirati TherapeuticsJames J. Peters Veterans Affairs Medical CenterCalifornia Pacific Medical Center Research InstituteNational Institute of Environmental Health Sciences (NIEHS)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 490 trials (± recruiting share)

Sponsors near 10% open enrollment (± trial volume)

What to do with this National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) page

490 registered trials is a research-attention snapshot, not an endorsement of National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) or any single study.

  • 50 of National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)'s trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Obesity is the condition National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Obesity trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) pipeline card: 490 registered trials from official public datasets.Report a data error.