Children's Oncology Group

Open enrollment across a mixed-phase pipeline

According to ClinicalTrials.gov-derived indexes, Children's Oncology Group sits in the top decile of US sponsors by registered trial count (#104 of 15,742 sponsors by registered trial count).

342 total trials 33 currently recruiting 260 completed top decile by trial count

Children's Oncology Group: 342 sponsored US clinical trials, 33 recruiting.

Children's Oncology Group sponsors 342 registered US clinical trials on ClinicalTrials.gov, 33 of them currently recruiting, and 260 completed. 103 of these trials are in Phase 3-4 (later-stage) and 128 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Leukemia, with 12 trials.

Top-decile sponsor footprint

Children's Oncology Group ranks in the top decile of sponsors by registered trial count (#104 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

B 88/100

260 of 262 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (99.2%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

342 total, page 7 of 7

COMPLETED

Collecting and Storing Tissue, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma or Other Soft Tissue Sarcoma

NCT00919269

COMPLETED Phase 2

Combination Chemotherapy in Treating Children With Very High Risk Acute Lymphocytic Leukemia

NCT00003783

COMPLETED Phase 3

Combination Chemotherapy With or Without Amifostine in Treating Young Patients With Liver Cancer

NCT00003994

COMPLETED Phase 3

Antibiotic Therapy With or Without G-CSF in Treating Children With Neutropenia and Fever Caused by Chemotherapy

NCT00003739

COMPLETED Phase 2

Chemotherapy in Treating Children With Relapsed Acute Leukemia, Acute Myeloid Leukemia, or Blastic Phase Chronic Myelogenous Leukemia

NCT00003735

COMPLETED Phase 2

Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphocytic Leukemia

NCT00003671

COMPLETED

Genetic Study of Children With Soft Tissue Sarcoma or Rhabdomyosarcoma

NCT00003793

COMPLETED Phase 1

Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Newly Diagnosed Brain Stem Glioma

NCT00003625

COMPLETED Phase 2

Etoposide Plus Radiation Therapy Followed by Combination Chemotherapy in Treating Children With Newly Diagnosed Advanced Medulloblastoma

NCT00003573

COMPLETED Phase 1

Colony-Stimulating Factors in Treating Children With Recurrent or Refractory Solid Tumors

NCT00003597

COMPLETED Phase 2

Vinorelbine in Treating Children With Recurrent or Refractory Cancers

NCT00003234

COMPLETED Phase 2

Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Recurrent or Refractory Hodgkin's or Non-Hodgkin's Lymphoma

NCT00002941

COMPLETED Phase 3

Surgery in Treating Children With Neuroblastoma

NCT00003119

COMPLETED Phase 2

Carboplatin and Vincristine Plus Radiation Therapy Followed By Adjuvant Chemotherapy in Treating Young Patients With Newly Diagnosed CNS Embryonal Tumors

NCT00003203

COMPLETED Phase 1

Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Infants With Malignant Brain or Spinal Cord Tumors

NCT00003141

COMPLETED Phase 1

Combination Chemotherapy in Treating Children With Stage III or Stage IV Non-Hodgkin's Lymphoma or Acute Lymphoblastic Leukemia

NCT00003217

COMPLETED Phase 1

Interleukin-2 in Treating Children Who Have Undergone Bone Marrow Transplantation for Acute Myeloid Leukemia

NCT00009698

COMPLETED Phase 2

Chemotherapy in Treating Children With Recurrent Acute Myeloid Leukemia

NCT00003178

COMPLETED Phase 2

Vinblastine and Methotrexate in Treating Children With Desmoid Tumors

NCT00003019

COMPLETED Phase 2

Combination Chemotherapy in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome

NCT00002805

COMPLETED Phase 3

Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma

NCT00002995

COMPLETED Phase 3

Combination Chemotherapy in Treating Children With Progressive Brain Tumors

NCT00002944

COMPLETED Phase 3

Combination Chemotherapy With or Without Dexrazoxane in Treating Children With Hodgkin's Disease

NCT00005578

COMPLETED

Gene Testing to Help in the Diagnosis and Treatment of Childhood Brain Tumors

NCT00003096

COMPLETED Phase 3

Radiation Therapy Plus Combination Chemotherapy in Treating Children With Medulloblastoma

NCT00002875

COMPLETED Phase 3

Combination Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia

NCT00002816

COMPLETED Phase 3

Chemotherapy Followed by Radiation Therapy in Treating Young Patients With Newly Diagnosed Hodgkin's Disease

NCT00002827

COMPLETED Phase 3

Combination Chemotherapy in Treating Children With Acute Lymphocytic Leukemia

NCT00002812

COMPLETED Phase 2

Combination Chemotherapy, Surgery, and Radiation Therapy in Treating Children With Advanced Soft Tissue Sarcoma

NCT00002804

COMPLETED Phase 2

Combination Chemotherapy, Bone Marrow Transplantation, and Radiation Therapy in Treating Infants With Acute Lymphoblastic Leukemia

NCT00002785

COMPLETED Phase 2

Induction Intensification in Treating Infants With Newly Diagnosed Acute Lymphoblastic Leukemia

NCT00002756

COMPLETED Phase 1

Combination Chemotherapy Plus Peripheral Stem Cell Transplantation Followed by Surgery and/or Radiation Therapy in Treating Young Patients With Advanced Neuroblastoma

NCT00002740

COMPLETED Phase 3

Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia

NCT00002744

COMPLETED Phase 3

Chemotherapy With or Without Surgery, Radiation Therapy, or Stem Cell Transplantation in Treating Young Patients With Kidney Tumors

NCT00002610

COMPLETED Phase 3

Combination Chemotherapy Alone or With Radiation Therapy in Treating Children With Kidney Cancer

NCT00002611

COMPLETED

Detection of Residual Disease in Children Receiving Therapy for Acute Myeloid Leukemia or Myelodysplastic Syndrome

NCT00003790

COMPLETED Phase 2

Interferon Alfa in Treating Children With HIV-Related Cancer

NCT00002621

COMPLETED Phase 3

Combination Chemotherapy in Treating Pediatric Patients With Advanced-Stage Large Cell Lymphoma

NCT00002618

COMPLETED Phase 2

Combination Chemotherapy Followed by Bone Marrow and/or Peripheral Stem Cell Transplantation in Treating Patients With Recurrent Medulloblastoma or CNS Germ Cell Tumors

NCT00002594

COMPLETED Phase 2

Combination Chemotherapy in Treating Children With Lymphoma

NCT00002590

COMPLETED

Development of Strategies to Increase Enrollment in Clinical Trials for Children With Cancer

NCT00002485

COMPLETED Phase 3

Combination Chemotherapy in Treating Children With Neuroblastoma

NCT00003093

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What is open in the Children's Oncology Group pipeline

33 recruiting of 342 indexed (10% open); 260 completed (76%).

Phase mix: 103 late (III/IV) vs 128 early (I/II) (balanced across stages).

Top condition: Leukemia (12 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Children's Oncology Group: open-pipeline peers nationwide

Peers matched on 342 registered trials and 10% open enrollment, not the therapeutic-area sidebar.

Children's Oncology Group sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 0200400600800 5%10%15%20%25% Total trials Recruiting share Children's Oncology GroupNational Institute of Mental Health (NIMH)Ohio State University Comprehensive Cancer CenterMontefiore Medical CenterCedars-Sinai Medical CenterChildren's Hospitals and Clinics of MinnesotaCytokineticsSanofiJoslin Diabetes Center
Children's Oncology Group sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

Children's Oncology Group sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 342 trials (± recruiting share)

Sponsors near 10% open enrollment (± trial volume)

What to do with this Children's Oncology Group page

342 registered trials is a research-attention snapshot, not an endorsement of Children's Oncology Group or any single study.

  • 33 of Children's Oncology Group's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Leukemia is the condition Children's Oncology Group studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Leukemia trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. Children's Oncology Group pipeline card: 342 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.