Children's Oncology Group

342 total trials 33 currently recruiting 260 completed

Children's Oncology Group sponsors 342 registered US clinical trials on ClinicalTrials.gov, 33 of them currently recruiting, and 260 completed. 103 of these trials are in Phase 3-4 (later-stage) and 128 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Leukemia, with 12 trials.

Trial Pipeline

342 total, page 6 of 7

COMPLETED Phase 2

Immunotherapy Using Cyclosporine, Interferon Gamma, and Interleukin-2 After High-Dose Myeloablative Chemotherapy With Autologous Stem Cell Transplantation in Treating Patients With Refractory or Relapsed Hodgkin's Lymphoma

NCT00070187

COMPLETED

Response or Resistance to Chemotherapy in Young Patients With Acute Lymphoblastic Leukemia Treated With Methotrexate

NCT00898404

COMPLETED Phase 3

Comparison of Two Combination Chemotherapy Regimens With Either Vincristine or Vinblastine in Treating Patients With Advanced Anaplastic Large Cell Lymphoma

NCT00059839

COMPLETED

Collecting and Storing Malignant, Borderline Malignant Neoplasms, and Related Samples From Young Patients With Cancer

NCT00898079

COMPLETED Phase 1

Pemetrexed Disodium in Treating Young Patients With Recurrent Solid Tumors

NCT00070473

COMPLETED Phase 2

Observation or Radiation Therapy and/or Chemotherapy and Second Surgery in Treating Children Who Have Undergone Surgery for Ependymoma

NCT00027846

COMPLETED

Diagnostic Study of Tumor Characteristics in Patients With Ewing's Sarcoma

NCT00048984

COMPLETED Phase 2

Chemotherapy and Radiation Therapy After Surgery in Treating Children With Newly Diagnosed Astrocytoma, Glioblastoma Multiforme, Gliosarcoma, or Diffuse Intrinsic Pontine Glioma

NCT00028795

COMPLETED NA

Study of the Physical and Emotional Needs of Parents Caring for Children Receiving Chemotherapy for Acute Lymphoblastic Leukemia

NCT00056069

COMPLETED Phase 2

Combination Chemotherapy With or Without Donor Bone Marrow Transplantation in Treating Infants With Previously Untreated Acute Lymphoblastic Leukemia

NCT00022126

COMPLETED Phase 3

Chemotherapy With or Without Additional Chemotherapy and/or Radiation Therapy in Treating Children With Newly Diagnosed Hodgkin's Disease

NCT00025259

COMPLETED Phase 3

Combination Chemotherapy in Treating Patients With Previously Untreated Rhabdomyosarcoma

NCT00003958

COMPLETED Phase 2

Docetaxel in Treating Children With Relapsed or Refractory Acute Lymphoblastic or Acute Myeloid Leukemia

NCT00021242

COMPLETED Phase 1

Monoclonal Antibody Plus Chemotherapy in Treating Young Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndromes

NCT00028899

COMPLETED

Brain Function in Children Previously Treated on Clinical Trials POG-9605 and POG-9201

NCT00028509

COMPLETED

Study of Biomarkers in DNA Samples From Patients With Acute Lymphoblastic Leukemia or Acute Myeloid Leukemia

NCT01005277

COMPLETED Phase 3

Hydroxychloroquine in Treating Patients With Newly Diagnosed Chronic Graft-Versus-Host Disease

NCT00031824

COMPLETED Phase 1

STI571 in Treating Patients With Recurrent Leukemia

NCT00004932

COMPLETED Phase 1

Biological Therapy in Treating Children With Refractory or Recurrent Neuroblastoma or Other Tumors

NCT00003750

COMPLETED

Natural History Study of Infants With Adrenal Masses Found on Prenatal and/or Neonatal Imaging

NCT00445718

COMPLETED Phase 3

Comparison of Combination Chemotherapy Regimens in Treating Patients With Ewing's Sarcoma or Neuroectodermal Tumor

NCT00006734

COMPLETED Phase 2

Combination Chemotherapy in Treating Children With Refractory or Relapsed Hodgkin's Lymphoma

NCT00006760

COMPLETED NA

Registration and Informed Consent Study for the Childhood Cancer Research Network

NCT00433394

COMPLETED Phase 2

Gemcitabine in Treating Children With Relapsed or Refractory Acute Lymphoblastic Leukemia or Acute Myelogenous Leukemia

NCT00006462

COMPLETED Phase 2

Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Neuroblastoma

NCT00017368

COMPLETED Phase 1

Radiation Therapy Plus Carboplatin and Lobradimil in Treating Children With Newly Diagnosed Brain Stem Gliomas

NCT00005602

COMPLETED Phase 3

Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Neuroblastoma

NCT00004188

COMPLETED Phase 1

Temozolomide Plus Lomustine Followed by Radiation Therapy in Treating Patients With High-Grade Malignant Glioma

NCT00006024

COMPLETED Phase 3

Combination Chemotherapy Followed by Second-Look Surgery and Radiation Therapy in Treating Children With Nonmetastatic Medulloblastoma or Primitive Neuroectodermal Tumor

NCT00006461

COMPLETED Phase 1

Irinotecan in Treating Children With Refractory or Advanced Solid Tumors Who Are Receiving Anticonvulsants

NCT00008424

COMPLETED Phase 1

Ecteinascidin 743 in Treating Children With Refractory Solid Tumors

NCT00006463

COMPLETED Phase 3

Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma or Acute Lymphocytic Leukemia

NCT00005977

COMPLETED Phase 3

Enalapril in Treating Heart Damage Patients Who Received Anthracycline Chemotherapy for Childhood Cancer

NCT00003070

COMPLETED Phase 1

Combination Chemotherapy in Treating Children With Solid Tumors That Have Not Responded to Previous Therapy

NCT00006095

COMPLETED Phase 3

Combination Chemotx in Treating Children or Adolescents With Newly Diagnosed Stg III or Stg IV Lymphoblastic Lymphoma

NCT00004228

COMPLETED Phase 3

Comparison of Different Combination Chemotherapy Regimens in Treating Children With Acute Lymphoblastic Leukemia

NCT00005945

COMPLETED Phase 3

Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia

NCT00005596

COMPLETED

Quality of Life in Children Treated for Cancer

NCT00005881

COMPLETED Phase 2

Combination Chemotherapy Plus Amifostine in Treating Children With Malignant Germ Cell Tumors

NCT00003811

COMPLETED Phase 3

Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia

NCT00005585

COMPLETED Phase 3

Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia

NCT00005603

COMPLETED Phase 1

Combination Chemotherapy Followed by Melphalan and Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Acute Myeloid Leukemia

NCT00004056

COMPLETED Phase 2

Combination Chemotherapy and Radiation Therapy in Treating Children With Previously Untreated Stage II, Stage III, or Stage IV Hodgkin's Disease

NCT00004010

COMPLETED Phase 2

Irinotecan in Treating Children With Refractory Solid Tumors

NCT00004078

COMPLETED Phase 3

Combination Chemotherapy Plus Dexrazoxane in Treating Patients With Newly Diagnosed Nonmetastatic Osteosarcoma

NCT00003937

COMPLETED Phase 2

Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Metastatic Rhabdomyosarcoma or Sarcoma

NCT00003955

COMPLETED Phase 1

Combination Chemotherapy Plus Radiation Therapy in Treating Children With Newly Diagnosed Brain Stem Glioma

NCT00003935

COMPLETED Phase 2

Radiation Therapy, Chemotherapy, and Peripheral Stem Cell Transplantation in Treating Patients With Primitive Neuroectodermal Tumors

NCT00003846

COMPLETED Phase 3

Chemotherapy in Treating Children With Down Syndrome and Myeloproliferative Disorder, Acute Myelogenous Leukemia, or Myelodysplastic Syndrome

NCT00003593

COMPLETED NA

Diagnostic Study of Gene Alterations in Children Who Have Been Treated for Relapsed Acute Lymphocytic Leukemia

NCT00003933

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What the Pipeline for Children's Oncology Group Shows

According to the ClinicalTrials.gov registry, Children's Oncology Group is linked to 342 US clinical trials across every stage of research activity. Of those, 33 studies are currently recruiting, about 10% of the sponsor's indexed portfolio, and 260 are already marked complete, representing roughly 76% of the total.

The phase mix for Children's Oncology Group reports 103 late-stage studies (Phase 3 and Phase 4 combined) and 128 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for Children's Oncology Group is Leukemia with 12 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.