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NCT00002827 · ClinicalTrials.gov registry record · Phase 3
Chemotherapy Followed by Radiation Therapy in Treating Young Patients With Newly Diagnosed Hodgkin's Disease
A Phase 3 study of Lymphoma and Cardiac Toxicity, sponsored by Children's Oncology Group.
- Completed
- Registry status
- Phase 3
- Development phase
- 294
- Enrollment target
- 20
- Study locations
NCT00002827: Completed Phase 3 study of Lymphoma and Cardiac Toxicity, sponsored by Children's Oncology Group.
NCT00002827 is a Phase 3 study of Lymphoma and Cardiac Toxicity that has completed, run by Children's Oncology Group. The registered enrollment target is 294 participants, below the 483-participant average among 299 other Lymphoma trials with a reported enrollment target (39% lower). The trial reports 20 study locations across 12 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00002827, a Phase 3 study of Lymphoma and Cardiac Toxicity, has completed, sponsored by Children's Oncology Group.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 294 participants
- Enrollment target
- 20
- Study locations
Study Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage cancer cells. Combining chemotherapy with radiation therapy may kill more cancer cells. It is not yet known if chemotherapy is more effective with or without dexrazoxane for Hodgkin's disease. PURPOSE: Randomized phase III trial to compare the effectiveness of combination chemotherapy, with or without dexrazoxane, followed by radiation therapy in treating young patients with newly diagnosed stage I, stage II, or stage III Hodgkin's disease.
Primary Outcome
The Wilcoxon test will be used to evaluate whether DLCO values differ between the two arms.
Conditions Studied
Interventions
- DRUG etoposide
- BIOLOGICAL filgrastim
- DRUG dexrazoxane hydrochloride
- DRUG doxorubicin hydrochloride
- BIOLOGICAL bleomycin sulfate
Study Locations (20)
California
- Long Beach Memorial Medical Center - Long Beach
- Children's Hospital Los Angeles - Los Angeles
- Jonsson Comprehensive Cancer Center, UCLA - Los Angeles
- Children's Hospital of Orange County - Orange
- UCSF Cancer Center and Cancer Research Institute - San Francisco
- David Grant Medical Center - Travis Air Force Base
Michigan
- University of Michigan Comprehensive Cancer Center - Ann Arbor
- CCOP - Kalamazoo - Kalamazoo
Minnesota
- University of Minnesota Cancer Center - Minneapolis
- Mayo Clinic Cancer Center - Rochester
New York
- Kaplan Cancer Center - New York
- Memorial Sloan-Kettering Cancer Center - New York
Colorado
- Children's Hospital of Denver - Denver
District of Columbia
- Children's National Medical Center - Washington D.C.
Illinois
- University of Chicago Cancer Research Center - Chicago
Indiana
- Indiana University Cancer Center - Indianapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 294 participants |
| Start Date | 1996-10 |
| Est. Completion | 2008-06 |
| Phase | Phase 3 |
What the finished NCT00002827 record still lists
NCT00002827 is an interventional study that assigns participants to a tested intervention. The registered 294 participants enrollment target is mid-sized for trials with a published cap, below the 483-participant average among 299 other Lymphoma trials with a reported enrollment target (39% lower).
The record links to 2 conditions, with Lymphoma appearing as the primary indexed condition, and to 5 interventions - of which etoposide is the first listed.
NCT00002827 names 20 study sites across 12 states, led by California, Michigan, Minnesota.
Frequently Asked Questions
What is clinical trial NCT00002827 about?
NCT00002827 is a clinical study titled "Chemotherapy Followed by Radiation Therapy in Treating Young Patients With Newly Diagnosed Hodgkin's Disease". RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage cancer cells. Combining chemotherapy with radiation therapy may kill more cancer cells. It is not yet known if chemotherapy is ...
What is the current status of trial NCT00002827?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 294 participants. The study started on 1996-10. Estimated completion is 2008-06.
What conditions does trial NCT00002827 study?
This clinical trial studies the following conditions: Lymphoma, Cardiac Toxicity.
What interventions are being tested in trial NCT00002827?
The interventions under investigation include: etoposide (DRUG), filgrastim (BIOLOGICAL), dexrazoxane hydrochloride (DRUG), doxorubicin hydrochloride (DRUG), bleomycin sulfate (BIOLOGICAL).
Who is sponsoring clinical trial NCT00002827?
This trial is sponsored by Children's Oncology Group, which has 342 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00002827 being conducted?
This trial has 20 study locations across California, Colorado, District of Columbia, Illinois, Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT00002827's enrollment target sits among peer trials
294 35th of 299 higher than 265 of 299 other Lymphoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Lymphoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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