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ClinicalTrials.gov 38 recruiting now official registry

Neuroblastoma clinical trials

Every US clinical trial registered for Neuroblastoma — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

97 US clinical trials · 38 currently recruiting

The research picture

Neuroblastoma has 97 registered US clinical trials, 38 of them open to new participants right now — about 39% of the total.

38
recruiting participants now
39%
of trials open to enrollment
6
in Phase 3–4 (later-stage)
19
top sponsor: Memorial Sloan Kettering Cancer Center

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 6,035 participants

Comprehensive Omics Analysis of Pediatric and Adult Solid Tumors and Establishment of a Repository for Related Biological Studies

National Cancer Institute (NCI)

NCT01109394

RECRUITING 2,415 participants

Prospective Comprehensive Molecular Analysis of Endocrine Neoplasms

National Cancer Institute (NCI)

NCT01005654

RECRUITING 2,070 participants

Molecular Characterization of Neuroblastic Tumor: Correlation With Clinical Outcome

Memorial Sloan Kettering Cancer Center

NCT00588068

RECRUITING 1,000 participants

Neuroblastoma Biology Study

New Approaches to Neuroblastoma Therapy Consortium

NCT01587300

RECRUITING Phase 3 750 participants

Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

Children's Oncology Group

NCT03126916

RECRUITING Phase 2 500 participants

Pediatric Precision Laboratory Advanced Neuroblastoma Therapy

Giselle Sholler

NCT02559778

RECRUITING Phase 3 478 participants

Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

National Cancer Institute (NCI)

NCT06172296

RECRUITING Phase 2 441 participants

Neuroblastoma Maintenance Therapy Trial

Giselle Sholler

NCT02679144

RECRUITING Phase 1 289 participants

Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas

Milton S. Hershey Medical Center

NCT06465199

RECRUITING Phase 2 286 participants

A Study of a Vaccine in Combination With β-glucan and GM-CSF in People With Neuroblastoma

Memorial Sloan Kettering Cancer Center

NCT04936529

RECRUITING Phase 2 200 participants

Iodine I 131 Metaiodobenzylguanidine in Treating Patients With Recurrent, Progressive, or Refractory Neuroblastoma or Malignant Pheochromocytoma or Paraganglioma

Memorial Sloan Kettering Cancer Center

NCT00107289

RECRUITING Phase 1 147 participants

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

Children's Oncology Group

NCT04851119

RECRUITING Phase 2 131 participants

Eflornithine (DFMO) and Etoposide for Relapsed/Refractory Neuroblastoma

Giselle Sholler

NCT04301843

RECRUITING Phase 2 122 participants

Naxitamab for High-Risk Neuroblastoma Patients With Primary Refractory Disease or Incomplete Response to Salvage Treatment in Bone and/or Bone Marrow

Y-mAbs Therapeutics

NCT03363373

RECRUITING Phase 1 104 participants

Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors

Milton S. Hershey Medical Center

NCT06541262

RECRUITING Phase 2 98 participants

Tipifarnib and Naxitamab for Relapsed/Refractory Neuroblastoma

Giselle Sholler

NCT06540963

RECRUITING Phase 2 94 participants

A Study of a Vaccine in Combination With Beta-glucan in People With Neuroblastoma

Memorial Sloan Kettering Cancer Center

NCT06057948

RECRUITING Phase 2 93 participants

Naxitamab Added to Induction for Newly Diagnosed High-Risk Neuroblastoma

Giselle Sholler

NCT05489887

RECRUITING Phase 1 90 participants

Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)

Merck Sharp & Dohme

NCT06395103

RECRUITING Phase 2 86 participants

A Study of Cabozantinib as a Maintenance Agent to Prevent Progression or Recurrence in High-Risk Pediatric Solid Tumors

Nationwide Children's Hospital

NCT05135975

RECRUITING NA 84 participants

Resource Intervention to Support Equity (RISE) in High-Risk Neuroblastoma

Dana-Farber Cancer Institute

NCT06831552

RECRUITING Phase 1 70 participants

GD2 Specific CAR and Interleukin-15 Expressing Autologous NKT Cells to Treat Children With Neuroblastoma

Baylor College of Medicine

NCT03294954

RECRUITING Phase 2 62 participants

NANT 2021-01 Phase II STING (Sequential Temozolomide, Irinotecan, NK Cells and GD2 mAb) Trial

New Approaches to Neuroblastoma Therapy Consortium

NCT06450041

RECRUITING NA 47 participants

MCT for the Harvard/UCSF ROBIN Center

Brigham and Women's Hospital

NCT06000787

RECRUITING Phase 2 45 participants

N10: A Study of Reduced Chemotherapy and Monoclonal Antibody (mAb)-Based Therapy in Children With Neuroblastoma

Memorial Sloan Kettering Cancer Center

NCT06528496

RECRUITING Phase 1 41 participants

Autologous B7-H3 Chimeric Antigen Receptor T Cells in Relapsed/Refractory Solid Tumors

Crystal Mackall, MD

NCT06500819

RECRUITING 40 participants

Biomarkers of Resiliency In Childhood Cancer Surgery

Mayo Clinic

NCT06674811

RECRUITING Phase 1 34 participants

Phase I Trial of rhIL-15 Plus Dinutuximab Plus Irinotecan/Temozolomide for Children and Young Adults With Relapsed/Refractory Neuroblastoma

National Cancer Institute (NCI)

NCT06995872

RECRUITING Phase 1 32 participants

B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)

St. Jude Children's Research Hospital

NCT04897321

RECRUITING NA 30 participants

Phase II Study of Proton Radiation Therapy for Neuroblastoma

Massachusetts General Hospital

NCT02112617

RECRUITING Phase 1 27 participants

Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors

University of Florida

NCT06625190

RECRUITING Phase 1 24 participants

Allogeneic Expanded Gamma Delta T Cells With GD2 Chemoimmunotherapy in Relapsed /Refractory Neuroblastoma or Refractory/ Relapsed Osteosarcoma

Emory University

NCT05400603

RECRUITING Phase 1 23 participants

A Study of Avutometinib for People With Solid Tumor Cancers

Memorial Sloan Kettering Cancer Center

NCT06104488

RECRUITING Phase 1 20 participants

Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors

Valent Technologies

NCT04337177

RECRUITING Phase 1 18 participants

Selective Antigen Specific T Cells and CAR T Cells in Subjects With Relapsed/Refractory Embryonal Tumors (SABRE)

Children's National Research Institute

NCT07172958

RECRUITING Phase 1 18 participants

Study of CAR T-Cells Targeting the GD2 With IL-15+iCaspase9 for Relapsed/Refractory Neuroblastoma or Relapsed/Refractory Osteosarcoma

UNC Lineberger Comprehensive Cancer Center

NCT03721068

RECRUITING Phase 1 18 participants

Feasibility Study of Prolonged Administration of Naxitamab, Irinotecan, and Temozolomide for Patients With Relapsed or Refractory Neuroblastoma

Steven DuBois, MD

NCT07027748

RECRUITING Phase 2 12 participants

Myeloablative Consolidation Therapy and Tandem Autologous Stem Cell Rescue in Patients With High-Risk Neuroblastoma

Masonic Cancer Center, University of Minnesota

NCT02605421

ACTIVE NOT RECRUITING 1,275 participants

Genomic Structural Variation in Cancer Susceptibility

Memorial Sloan Kettering Cancer Center

NCT00996710

ACTIVE NOT RECRUITING Phase 3 621 participants

Response and Biology-Based Risk Factor-Guided Therapy in Treating Younger Patients With Non-high Risk Neuroblastoma

Children's Oncology Group

NCT02176967

ACTIVE NOT RECRUITING Phase 1 374 participants

Bivalent Vaccine With Escalating Doses of the Immunological Adjuvant OPT-821, in Combination With Oral β-glucan for High-Risk Neuroblastoma

Memorial Sloan Kettering Cancer Center

NCT00911560

ACTIVE NOT RECRUITING Phase 1 186 participants

Combination Therapy of Antibody Hu3F8 With Granulocyte- Macrophage Colony Stimulating Factor (GM-CSF) in Patients With Relapsed/Refractory High-Risk Neuroblastoma

Memorial Sloan Kettering Cancer Center

NCT01757626

ACTIVE NOT RECRUITING Phase 2 153 participants

Therapy for Children With Advanced Stage Neuroblastoma

St. Jude Children's Research Hospital

NCT01857934

ACTIVE NOT RECRUITING Phase 2 128 participants

Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors

Pfizer

NCT03709680

ACTIVE NOT RECRUITING 93 participants

Neuroblastoma Precision Trial

New Approaches to Neuroblastoma Therapy Consortium

NCT02868268

ACTIVE NOT RECRUITING Phase 1 71 participants

A Study of LY3295668 Erbumine in Participants With Relapsed/Refractory Neuroblastoma

Eli Lilly and Company

NCT04106219

ACTIVE NOT RECRUITING Phase 1 65 participants

Engineered Neuroblastoma Cellular Immunotherapy (ENCIT)-01

Seattle Children's Hospital

NCT02311621

ACTIVE NOT RECRUITING Phase 1 44 participants

Phase I Study of 131-I mIBG Followed by Nivolumab & Dinutuximab Beta Antibodies in Children With Relapsed/Refractory Neuroblastoma

University Hospital Southampton NHS Foundation Trust

NCT02914405

ACTIVE NOT RECRUITING Phase 2 41 participants

Treatment With Dinutuximab, Sargramostim (GM-CSF), and Isotretinoin in Combination With Irinotecan and Temozolomide After Intensive Therapy for People With High-Risk Neuroblastoma (NBL)

Children's Oncology Group

NCT04385277

ACTIVE NOT RECRUITING Phase 1 30 participants

Dose Escalation Study of CLR 131 in Pediatric Relapsed/Refractory Malignant Tumors Including Neuroblastoma and Sarcomas

Cellectar Biosciences

NCT03478462

ACTIVE NOT RECRUITING Early Phase 1 26 participants

A Study of N9 Chemotherapy in Children With Neuroblastoma

Memorial Sloan Kettering Cancer Center

NCT04947501

ACTIVE NOT RECRUITING Phase 1 26 participants

iC9-GD2-CAR-VZV-CTLs/Refractory or Metastatic GD2-positive Sarcoma and Neuroblastoma

Baylor College of Medicine

NCT01953900

ACTIVE NOT RECRUITING Phase 1 24 participants

PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy

University of Florida

NCT04837547

ACTIVE NOT RECRUITING Early Phase 1 20 participants

An Investigational Scan (68Ga-DOTATATE PET/CT) in Diagnosing Pediatric Metastatic Neuroendocrine Tumors

Mayo Clinic

NCT04040088

ACTIVE NOT RECRUITING Phase 1 18 participants

Sorafenib and Cyclophosphamide/Topotecan in Patients With Relapsed and Refractory Neuroblastoma

New Approaches to Neuroblastoma Therapy Consortium

NCT02298348

ACTIVE NOT RECRUITING Phase 1 13 participants

Immunotherapy of Relapsed Refractory Neuroblastoma With Expanded NK Cells

New Approaches to Neuroblastoma Therapy Consortium

NCT02573896

ACTIVE NOT RECRUITING Early Phase 1 13 participants

18F-Fluorodopamine PET Studies of Neuroblastoma and Pheochromocytoma

St. Jude Children's Research Hospital

NCT03541720

ACTIVE NOT RECRUITING Phase 1 11 participants

Allogeneic Tumor Cell Vaccination With Oral Metronomic Cytoxan in Patients With High-Risk Neuroblastoma

Baylor College of Medicine

NCT01192555

ACTIVE NOT RECRUITING Phase 1 11 participants

3rd Generation GD-2 Chimeric Antigen Receptor and ICaspase Suicide Safety Switch, Neuroblastoma, GRAIN

Baylor College of Medicine

NCT01822652

ACTIVE NOT RECRUITING Phase 1 11 participants

Rapid Administration Pilot for Infusing Dinutuximab

Children's Hospital Los Angeles

NCT05421897

ACTIVE NOT RECRUITING NA 7 participants

PET Imaging of Solid Tumors Using 124I-Humanized 3F8: A Pilot Study

Memorial Sloan Kettering Cancer Center

NCT02307630

COMPLETED Phase 3 968 participants

Surgery in Treating Children With Neuroblastoma

Children's Oncology Group

NCT00003119

COMPLETED Phase 3 464 participants

Combination Chemotherapy and Surgery With or Without Isotretinoin in Treating Young Patients With Neuroblastoma

Children's Oncology Group

NCT00499616

COMPLETED Phase 3 198 participants

A Web-Based Stem Cell Transplant Support System or Standard Care in Young Patients Undergoing Stem Cell Transplant and Their Families

Tufts Medical Center

NCT00782145

COMPLETED Phase 2 164 participants

131 I-MIBG in Treating Patients With Refractory or Relapsed Neuroblastoma

University of California, San Francis

NCT00293319

COMPLETED Phase 2 140 participants

Preventative Trial of Difluoromethylornithine (DFMO) in High Risk Patients With Neuroblastoma That is in Remission

Giselle Sholler

NCT02395666

COMPLETED Phase 2 122 participants

Impact of Ga-68 DOTATOC PET-CT Imaging in Management of Neuroendocrine Tumors

Sue O'Dorisio

NCT02441062

COMPLETED 121 participants

Prevalence+Significance of Paraneoplastic Autoantibodies in Many Cancers

Memorial Sloan Kettering Cancer Center

NCT00608452

COMPLETED 101 participants

iCAT for Recurrent/Refractory/HR Solid Tumors

Dana-Farber Cancer Institute

NCT01853345

COMPLETED Phase 2 90 participants

New Therapeutic Strategies for Patients With Ewing's Sarcoma Family of Tumors, High Risk Rhabdomyosarcoma, and Neuroblastoma

National Cancer Institute (NCI)

NCT00001335

COMPLETED Early Phase 1 78 participants

Local Control With Reduced-dose Radiotherapy for High-Risk Neuroblastoma

Memorial Sloan Kettering Cancer Center

NCT02245997

COMPLETED NA 69 participants

Anti-GD2 3F8 Monoclonal Antibody and GM-CSF for High-Risk Neuroblastoma

Memorial Sloan Kettering Cancer Center

NCT02100930

COMPLETED Phase 2 68 participants

Comparative Study of Sensitivity of Ga-DOTATOC PET vs Octreoscan SPECT + CT

Sue O'Dorisio

NCT01869725

COMPLETED Phase 1 54 participants

Study of MLN8237 in Combination With Irinotecan and Temozolomide

New Approaches to Neuroblastoma Therapy Consortium

NCT01601535

COMPLETED Phase 2 53 participants

Alemtuzumab and Glucocorticoids in Treating Newly Diagnosed Acute Graft-Versus-Host Disease in Patients Who Have Undergone a Donor Stem Cell Transplant

Fred Hutchinson Cancer Center

NCT00410657

COMPLETED Phase 1 40 participants

Recombinant Human Thrombopoietin in Children Receiving Ifosfamide, Carboplatin, and Etoposide Chemotherapy

St. Jude Children's Research Hospital

NCT00187109

COMPLETED Phase 2 39 participants

3F8/GM-CSF Immunotherapy Plus 13-Cis-Retinoic Acid for Consolidation of First Remission After Non-Myeloablative Therapy in Patients With High-Risk Neuroblastoma

Memorial Sloan Kettering Cancer Center

NCT01183429

COMPLETED Phase 2 39 participants

hu14.18-Interleukin-2 Fusion Protein in Treating Young Patients With Recurrent or Refractory Neuroblastoma

Children's Oncology Group

NCT00082758

COMPLETED Phase 2 34 participants

Campath-1H + FK506 and Methylprednisolone for GVHD

Case Comprehensive Cancer Center

NCT00109993

COMPLETED Phase 1 31 participants

N99-02: Melphalan and Buthionine Sulfoximine

New Approaches to Neuroblastoma Therapy Consortium

NCT00005835

COMPLETED Phase 2 30 participants

Rebeccamycin Analog in Treating Children With Relapsed or Refractory Neuroblastoma

Memorial Sloan Kettering Cancer Center

NCT00003737

COMPLETED Phase 1 30 participants

Combination Chemotherapy Plus Peripheral Stem Cell Transplantation Followed by Surgery and/or Radiation Therapy in Treating Young Patients With Advanced Neuroblastoma

Children's Oncology Group

NCT00002740

COMPLETED Phase 2 22 participants

Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors

Memorial Sloan Kettering Cancer Center

NCT00024258

COMPLETED Phase 1 21 participants

Safety Study for Refractory or Relapsed Neuroblastoma With DFMO Alone and in Combination With Etoposide

Giselle Sholler

NCT01059071

COMPLETED Phase 1 19 participants

Blood T-Cells and EBV Specific CTLs Expressing GD-2 Specific Chimeric T Cell Receptors to Neuroblastoma Patients

Baylor College of Medicine

NCT00085930

COMPLETED Phase 1 19 participants

Decitabine Followed by a Cancer Antigen Vaccine for Patients With Neuroblastoma and Sarcoma

University of Louisville

NCT01241162

COMPLETED Phase 1 18 participants

HSV1716 in Patients With Non-Central Nervous System (Non-CNS) Solid Tumors

Timothy Cripe

NCT00931931

COMPLETED Phase 1 17 participants

N2004-03: Intravenous Fenretinide in Treating Young Patients With Recurrent or Resistant Neuroblastoma

Nant Operations Center

NCT00646230

COMPLETED Phase 1 15 participants

A Phase I Trial of T Cells Expressing an Anti-GD2 Chimeric Antigen Receptor in Children and Young Adults With GD2+ Solid Tumors

National Cancer Institute (NCI)

NCT02107963

COMPLETED Phase 1 13 participants

Neuroblastoma Vaccine for Treatment of High-Risk Neuroblastoma After Chemotherapy

Malcolm Brenner

NCT00048386

COMPLETED Phase 2 9 participants

Cyclophosphamide, Topotecan, and Bevacizumab (CTB) in Patients With Relapsed/Refractory Ewing's Sarcoma and Neuroblastoma

Memorial Sloan Kettering Cancer Center

NCT01492673

COMPLETED Phase 1 9 participants

Using Gene Modified Neuroblastoma Cells for the Treatment of Relapsed/Refractory Neuroblastoma

Baylor College of Medicine

NCT00062855

COMPLETED Phase 2 4 participants

High-Dose 3F8/GM-CSF Immunotherapy Plus 13-Cis-Retinoic Acid for Consolidation of First Remission After Myeloablative Therapy and Autologous Stem-Cell Transplantation

Memorial Sloan Kettering Cancer Center

NCT01183416

COMPLETED Phase 2 3 participants

Chemotherapy, Radiation Therapy, and Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer

Roswell Park Cancer Institute

NCT00003661

COMPLETED Phase 1

Chemotherapy in Treating Children With Neuroblastoma

New Approaches to Neuroblastoma Therapy Consortium

NCT00002730

COMPLETED Phase 1

Ravuconazole in Preventing Fungal Infections in Patients Undergoing Allogeneic Stem Cell Transplantation

National Institutes of Health Clinical Center (CC)

NCT00064311

COMPLETED Phase 1

Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors

Indiana University School of Medicine

NCT00003107

Phase Distribution

PhaseTrial count
Phase 1 47
Phase 2 30
Phase 3 6

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Neuroblastoma Trial Landscape

ClinicalTrials.gov lists 97 US studies indexed under Neuroblastoma, and 38 of those are currently open to recruitment — roughly 39% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Neuroblastoma shows 6 late-stage studies (Phase 3 and Phase 4 combined) alongside 77 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Neuroblastoma is led by Memorial Sloan Kettering Cancer Center with 19 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 97 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Neuroblastoma?

PlainTrial tracks 97 US clinical trials for Neuroblastoma, of which 38 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Neuroblastoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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