Cytokinetics

31 total trials 3 currently recruiting 22 completed

Cytokinetics sponsors 31 registered US clinical trials on ClinicalTrials.gov, 3 of them currently recruiting, and 22 completed. 10 of these trials are in Phase 3-4 (later-stage) and 21 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Heart Failure, with 2 trials.

Trial Pipeline

31 total, page 1 of 1

RECRUITING Phase 2

AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF

NCT06793371

RECRUITING Phase 3

Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

NCT06736574

RECRUITING Phase 2

A Study to Evaluate the Effect of Aficamten in Pediatric Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM).

NCT06412666

ACTIVE NOT RECRUITING Phase 3

Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic nHCM

NCT06081894

COMPLETED Phase 3

Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Metoprolol Succinate in Adults With Symptomatic oHCM

NCT05767346

COMPLETED Phase 1

Study to Evaluate the Effect of Aficamten Administration on QT/QTc Interval

NCT05924815

COMPLETED Phase 1

A Single and Multiple Ascending Dose Study of CK-4021586 in Healthy Adult Participants

NCT05877053

TERMINATED Phase 1

A Single and Multiple Ascending Dose Study of CK-3828136 in Healthy Adult Participants

NCT05662215

TERMINATED Phase 3

A Phase 3, Open-Label Extension of COURAGE-ALS (CY 5031)

NCT05442775

COMPLETED Phase 3

Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic oHCM

NCT05186818

TERMINATED Phase 3

A Study to Evaluate the Efficacy and Safety of Reldesemtiv in Patients With Amyotrophic Lateral Sclerosis (ALS)

NCT04944784

COMPLETED Phase 2

Dose-finding Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CK-3773274 in Adults With Hypertrophic Cardiomyopathy

NCT04219826

COMPLETED Phase 3

Study to Assess the Effect of Omecamtiv Mecarbil on Exercise Capacity in Subjects With Heart Failure

NCT03759392

COMPLETED Phase 1

A Single and Multiple Ascending Dose Study of CK-3773274 in Healthy Adult Subjects

NCT03767855

COMPLETED Phase 2

A Study to Evaluate Efficacy, Safety and Tolerability of CK-2127107 in Patients With Amyotrophic Lateral Sclerosis (ALS)

NCT03160898

COMPLETED Phase 3

Registrational Study With Omecamtiv Mecarbil (AMG 423) to Treat Chronic Heart Failure With Reduced Ejection Fraction

NCT02929329

COMPLETED Phase 3

A Study for Patients Who Completed VITALITY-ALS (CY 4031)

NCT02936635

COMPLETED Phase 2

A Study of CK-2127107 in Patients With Spinal Muscular Atrophy

NCT02644668

COMPLETED Phase 3

Ventilatory Investigation of Tirasemtiv and Assessment of Longitudinal Indices After Treatment for a Year

NCT02496767

COMPLETED Phase 2

COSMIC-HF - Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure

NCT01786512

COMPLETED Phase 1

Pharmacokinetics Study of AMG 423 in Healthy Subjects and Subjects With Various Degrees of Renal Insufficiency

NCT01737866

COMPLETED Phase 2

Study of Safety, Tolerability & Efficacy of CK-2017357 in Amyotrophic Lateral Sclerosis (ALS)

NCT01709149

COMPLETED Phase 2

Dose Titration Study to Test Safety and Effects of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS)

NCT01486849

COMPLETED Phase 2

A Study to Evaluate the Effects of Multiple Doses of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS)

NCT01378676

COMPLETED Phase 2

Study to Evaluate the Safety and Efficacy of IV Infusion Treatment With Omecamtiv Mecarbil in Subjects With Left Ventricular Systolic Dysfunction Hospitalized for Acute Heart Failure (ATOMIC-AHF)

NCT01300013

TERMINATED Phase 2

Pharmacodynamic Study of CK-2017357 in Patients With Generalized Myasthenia Gravis

NCT01268280

COMPLETED Phase 2

A Study of CK-2017357 in Patients With Peripheral Artery Disease and Symptomatic Claudication

NCT01131013

COMPLETED Phase 2

A Study of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS)

NCT01089010

TERMINATED Phase 2

Phase II Study of the Effect of CK-1827452 Injection on Myocardial Efficiency

NCT00748579

COMPLETED Phase 2

A Study of CK-1827452 Infusion in Stable Heart Failure

NCT00624442

COMPLETED Phase 1

A Study of SB-743921 in Non-Hodgkin Lymphoma and Hodgkin Lymphoma

NCT00343564

What the Pipeline for Cytokinetics Shows

According to the ClinicalTrials.gov registry, Cytokinetics is linked to 31 US clinical trials across every stage of research activity. Of those, 3 studies are currently recruiting, about 10% of the sponsor's indexed portfolio, and 22 are already marked complete, representing roughly 71% of the total.

The phase mix for Cytokinetics reports 10 late-stage studies (Phase 3 and Phase 4 combined) and 21 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for Cytokinetics is Heart Failure with 2 linked trials, and 7 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.