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ClinicalTrials.gov 58 recruiting now official registry

Sarcoma clinical trials

58 of 129 indexed Sarcoma trials are currently recruiting.

129 US clinical trials · 58 currently recruiting

Sarcoma is the subject of 129 registered US clinical trials on ClinicalTrials.gov, 58 of them currently open to new participants. 10 are in Phase 3-4 (later-stage) and 80 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 26 of these trials.

The research picture

Sarcoma has 129 registered US clinical trials, 58 of them open to new participants right now, about 45% of the total.

58
recruiting participants now
45%
of trials open to enrollment
10
in Phase 3–4 (later-stage)
26
top sponsor: Memorial Sloan Kettering Cancer Center
Phase 137Phase 243Phase 38Phase 42

Active & Recent Trials

129 total, page 1 of 3

RECRUITING 12,000 participants

Molecular Testing for the MD Anderson Cancer Center Personalized Cancer Therapy Program

M.D. Anderson Cancer Center

NCT01772771

RECRUITING 6,035 participants

Comprehensive Omics Analysis of Pediatric and Adult Solid Tumors and Establishment of a Repository for Related Biological Studies

National Cancer Institute (NCI)

NCT01109394

RECRUITING 6,000 participants

Specimen and Data Study for Ovarian Cancer Early Detection and Prevention

Northwestern University

NCT00005095

RECRUITING 5,000 participants

Pediatric Radiation Therapy Registry

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT07129317

RECRUITING 3,000 participants

Novel Biochemical and Molecular Determinants for Soft Tissue Sarcoma

Memorial Sloan Kettering Cancer Center

NCT00579566

RECRUITING 2,100 participants

Cohort to Augment the Understanding of Sarcoma Survivorship Across the Lifespan

Vanderbilt-Ingram Cancer Center

NCT06482957

RECRUITING NA 1,020 participants

Video Education With Result Dependent dIsclosure

Dana-Farber Cancer Institute

NCT05225428

RECRUITING 800 participants

PROMIS and Mobility Evaluation in Sarcoma Patients

University of Calgary

NCT07227961

RECRUITING 400 participants

BostonGene and Exigent Genomic INsight Study

BostonGene

NCT06272864

RECRUITING Phase 2 320 participants

18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection

National Cancer Institute (NCI)

NCT06503146

RECRUITING 300 participants

LCI-SAR-BSTS-CTDNA-001: Circulating Tumor DNA Liquid Biopsy in Sarcoma Patients

Wake Forest University Health Sciences

NCT06958107

RECRUITING Phase 2 260 participants

GALLANT: Metronomic Gemcitabine, Doxorubicin, Docetaxel and Nivolumab for Advanced Sarcoma

Sarcoma Oncology Research Center

NCT04535713

RECRUITING NA 260 participants

Symptom Management and Transitioning to Engagement With Post-treatment Care for Adolescent and Young Adult Cancer Survivors

Duke University

NCT06371768

RECRUITING NA 250 participants

WATCH (Wearable Artificial inTelligence for Cardiac Function and Health Monitoring)

Mayo Clinic

NCT07058064

RECRUITING Phase 1 250 participants

A Study of MGC026 in Participants With Advanced Solid Tumors

MacroGenics

NCT06242470

RECRUITING NA 250 participants

Locally AblatiVe TherApy in OLigO-pRogressive SOlid TUmorS (VALOROUS)

University of California, Davis

NCT06103669

RECRUITING Phase 2 240 participants

Adoptive Transfer of Tumor Infiltrating Lymphocytes for Advanced Solid Cancers

Udai Kammula

NCT03935893

RECRUITING Phase 2 200 participants

Talimogene Laherparepvec, Nivolumab and Trabectedin for Sarcoma

Sarcoma Oncology Research Center

NCT03886311

RECRUITING 180 participants

Disease Outcomes and Toxicities in Patients With Gastrointestinal and Sarcomatous Malignancies

UNC Lineberger Comprehensive Cancer Center

NCT05743426

RECRUITING Phase 1 166 participants

A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors

Epkin

NCT06789172

RECRUITING Phase 1 150 participants

First-in-Human Trial of DS-2243a in Participants With Advanced Solid Tumors

Daiichi Sankyo

NCT06644755

RECRUITING Phase 2 140 participants

A Study of AdAPT-001 in Subjects With Sarcoma and Refractory Solid Tumors

EpicentRx

NCT04673942

RECRUITING NA 120 participants

Enhanced Recovery After Surgery in Extremity Sarcoma

Joshua Lawrenz

NCT04461171

RECRUITING Phase 1 112 participants

Lead-212 PSV359 Therapy for Patients With Solid Tumors

Perspective Therapeutics

NCT06710756

RECRUITING Phase 2 110 participants

Fluorescent Intra-operative Tumor Margin Examination

Kurt Weiss

NCT04719156

RECRUITING 100 participants

Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors

Washington University School of Medicine

NCT04354064

RECRUITING Phase 1 98 participants

Retifanlimab (Anti-PD-1 Antibody) With Gemcitabine and Docetaxel in Patients With Advanced Soft Tissue Sarcoma

Memorial Sloan Kettering Cancer Center

NCT04577014

RECRUITING Phase 2 86 participants

A Study of Cabozantinib as a Maintenance Agent to Prevent Progression or Recurrence in High-Risk Pediatric Solid Tumors

Nationwide Children's Hospital

NCT05135975

RECRUITING Phase 1 78 participants

IDOV-Immune for Advanced Solid Tumors

ViroMissile

NCT06910657

RECRUITING Phase 1 72 participants

A Study of CRD3874-SI in People With Solid Tumors

Memorial Sloan Kettering Cancer Center

NCT06021626

RECRUITING Phase 1 70 participants

SLV-154 Treatment of Metastatic Solid Tumors

Solve Therapeutics

NCT06771219

RECRUITING Phase 1 63 participants

Phase 1/2 Trial to Evaluate the Safety and Efficacy of PEEL-224 in Combination With Vincristine and Temozolomide in Adolescents and Young Adults With Relapsed or Refractory Sarcomas

David S Shulman, MD

NCT06709495

RECRUITING NA 60 participants

Study Assessing the Effects of Early Psychiatric Referral on Mental Health and Quality of Life in People With Sarcoma

Memorial Sloan Kettering Cancer Center

NCT06129903

RECRUITING Phase 1 60 participants

GD2-SADA:177Lu-DOTA Complex in Patients With Solid Tumors Known to Express GD2

Y-mAbs Therapeutics

NCT05130255

RECRUITING Phase 1 54 participants

Phase I Trial of TURALIO(R) (Pexidartinib, PLX3397) in Children and Young Adults With Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neurofibromas (PN) and Tenosynovial Giant Cell Tumor ...

National Cancer Institute (NCI)

NCT02390752

RECRUITING Phase 2 51 participants

Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial

University of California, Irvine

NCT06580002

RECRUITING 50 participants

Abductor Reattachment Methods in Proximal Femur Replacements: What is the Best Method?

Duke University

NCT03261544

RECRUITING 50 participants

Recognition of Circulating Tumor DNA in Soft Tissue Sarcoma

Medical College of Wisconsin

NCT03896620

RECRUITING Phase 1 42 participants

Hypofractionated Radiation in Combination With B7-H3-CAR T Cells for Pediatric Patients With Relapsed/Refractory Sarcomas

St. Jude Children's Research Hospital

NCT07222735

RECRUITING Phase 1 41 participants

Autologous B7-H3 Chimeric Antigen Receptor T Cells in Relapsed/Refractory Solid Tumors

Crystal Mackall, MD

NCT06500819

RECRUITING NA 40 participants

Effect of A Multimodal Exercise Intervention on Chemotherapy Uptake in Newly Diagnosed Pediatric and AYA Sarcoma Patients

University of Miami

NCT07359911

RECRUITING 40 participants

Biomarkers of Resiliency In Childhood Cancer Surgery

Mayo Clinic

NCT06674811

RECRUITING 40 participants

Brief Title Mechanisms of Cancer-Related Pain and Opioid Use Among Adolescents and Young Adult Sarcoma Survivors: Pilot Feasibility Study

Roswell Park Cancer Institute

NCT07402577

RECRUITING Phase 1 39 participants

Trial of Nivolumab Following Partially Human Leukocyte Antigen (HLA) Mismatched BMT in Children & Adults With Sarcoma

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT03465592

RECRUITING Phase 2 32 participants

A Study of Pembrolizumab in People With Ultra-Rare Sarcomas

Memorial Sloan Kettering Cancer Center

NCT07089992

RECRUITING Phase 2 30 participants

Phase II Trial of Lung Chemoemobolization

City of Hope Medical Center

NCT05672108

RECRUITING Phase 1 30 participants

A Clinical Study of Intratumoral MVR-T3011 (T3011) Given as a Single Agent and in Combination With Intravenous Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors

ImmVira Pharma Co.

NCT04370587

RECRUITING Phase 2 30 participants

A Study of Pembrolizumab Plus Local Chemotherapy Using Isolated Limb Infusion (ILI) for Patients With Sarcoma in the Arm or Leg

Memorial Sloan Kettering Cancer Center

NCT04332874

RECRUITING Phase 1 26 participants

64Cu-LNTH-1363S in Patients With Sarcoma or Gastrointestinal Tract Cancer

Lantheus Medical Imaging

NCT06298916

RECRUITING Phase 1 25 participants

HER2 Chimeric Antigen Receptor (CAR) T Cells in Combination With Checkpoint Blockade in Patients With Advanced Sarcoma

Baylor College of Medicine

NCT04995003

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Phase Distribution

PhaseTrial count
Phase 1 37
Phase 2 43
Phase 3 8
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Sarcoma Trial Landscape

129 indexed Sarcoma studies · 58 recruiting (45%).

Phase mix: 10 late (III/IV) vs 80 early (I/II).

Top sponsor: Memorial Sloan Kettering Cancer Center (26 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Sarcoma?

PlainTrial tracks 129 US clinical trials for Sarcoma, of which 58 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Sarcoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.