Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Sarcoma

Open-data reference.

128 US clinical trials · 58 currently recruiting

Active & Recent Trials

RECRUITING 12,000 participants

Molecular Testing for the MD Anderson Cancer Center Personalized Cancer Therapy Program

M.D. Anderson Cancer Center

NCT01772771

RECRUITING 6,035 participants

Comprehensive Omics Analysis of Pediatric and Adult Solid Tumors and Establishment of a Repository for Related Biological Studies

National Cancer Institute (NCI)

NCT01109394

RECRUITING 6,000 participants

Specimen and Data Study for Ovarian Cancer Early Detection and Prevention

Northwestern University

NCT00005095

RECRUITING 5,000 participants

Pediatric Radiation Therapy Registry

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT07129317

RECRUITING 3,000 participants

Novel Biochemical and Molecular Determinants for Soft Tissue Sarcoma

Memorial Sloan Kettering Cancer Center

NCT00579566

RECRUITING 2,100 participants

Cohort to Augment the Understanding of Sarcoma Survivorship Across the Lifespan

Vanderbilt-Ingram Cancer Center

NCT06482957

RECRUITING NA 1,020 participants

Video Education With Result Dependent dIsclosure

Dana-Farber Cancer Institute

NCT05225428

RECRUITING 800 participants

PROMIS and Mobility Evaluation in Sarcoma Patients

University of Calgary

NCT07227961

RECRUITING 400 participants

BostonGene and Exigent Genomic INsight Study

BostonGene

NCT06272864

RECRUITING Phase 2 320 participants

18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection

National Cancer Institute (NCI)

NCT06503146

RECRUITING 300 participants

LCI-SAR-BSTS-CTDNA-001: Circulating Tumor DNA Liquid Biopsy in Sarcoma Patients

Wake Forest University Health Sciences

NCT06958107

RECRUITING Phase 2 260 participants

GALLANT: Metronomic Gemcitabine, Doxorubicin, Docetaxel and Nivolumab for Advanced Sarcoma

Sarcoma Oncology Research Center

NCT04535713

RECRUITING NA 260 participants

Symptom Management and Transitioning to Engagement With Post-treatment Care for Adolescent and Young Adult Cancer Survivors

Duke University

NCT06371768

RECRUITING NA 250 participants

WATCH (Wearable Artificial inTelligence for Cardiac Function and Health Monitoring)

Mayo Clinic

NCT07058064

RECRUITING Phase 1 250 participants

A Study of MGC026 in Participants With Advanced Solid Tumors

MacroGenics

NCT06242470

RECRUITING NA 250 participants

Locally AblatiVe TherApy in OLigO-pRogressive SOlid TUmorS (VALOROUS)

University of California, Davis

NCT06103669

RECRUITING Phase 2 240 participants

Adoptive Transfer of Tumor Infiltrating Lymphocytes for Advanced Solid Cancers

Udai Kammula

NCT03935893

RECRUITING Phase 2 200 participants

Talimogene Laherparepvec, Nivolumab and Trabectedin for Sarcoma

Sarcoma Oncology Research Center

NCT03886311

RECRUITING 180 participants

Disease Outcomes and Toxicities in Patients With Gastrointestinal and Sarcomatous Malignancies

UNC Lineberger Comprehensive Cancer Center

NCT05743426

RECRUITING Phase 1 166 participants

A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors

Epkin

NCT06789172

RECRUITING Phase 1 150 participants

First-in-Human Trial of DS-2243a in Participants With Advanced Solid Tumors

Daiichi Sankyo

NCT06644755

RECRUITING Phase 2 140 participants

A Study of AdAPT-001 in Subjects With Sarcoma and Refractory Solid Tumors

EpicentRx

NCT04673942

RECRUITING NA 120 participants

Enhanced Recovery After Surgery in Extremity Sarcoma

Joshua Lawrenz

NCT04461171

RECRUITING Phase 1 112 participants

Lead-212 PSV359 Therapy for Patients With Solid Tumors

Perspective Therapeutics

NCT06710756

RECRUITING Phase 2 110 participants

Fluorescent Intra-operative Tumor Margin Examination

Kurt Weiss

NCT04719156

RECRUITING 100 participants

Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors

Washington University School of Medicine

NCT04354064

RECRUITING Phase 1 98 participants

Retifanlimab (Anti-PD-1 Antibody) With Gemcitabine and Docetaxel in Patients With Advanced Soft Tissue Sarcoma

Memorial Sloan Kettering Cancer Center

NCT04577014

RECRUITING Phase 2 86 participants

A Study of Cabozantinib as a Maintenance Agent to Prevent Progression or Recurrence in High-Risk Pediatric Solid Tumors

Nationwide Children's Hospital

NCT05135975

RECRUITING Phase 1 78 participants

IDOV-Immune for Advanced Solid Tumors

ViroMissile

NCT06910657

RECRUITING Phase 1 72 participants

A Study of CRD3874-SI in People With Solid Tumors

Memorial Sloan Kettering Cancer Center

NCT06021626

RECRUITING Phase 1 70 participants

SLV-154 Treatment of Metastatic Solid Tumors

Solve Therapeutics

NCT06771219

RECRUITING Phase 1 63 participants

Phase 1/2 Trial to Evaluate the Safety and Efficacy of PEEL-224 in Combination With Vincristine and Temozolomide in Adolescents and Young Adults With Relapsed or Refractory Sarcomas

David S Shulman, MD

NCT06709495

RECRUITING NA 60 participants

Study Assessing the Effects of Early Psychiatric Referral on Mental Health and Quality of Life in People With Sarcoma

Memorial Sloan Kettering Cancer Center

NCT06129903

RECRUITING Phase 1 60 participants

GD2-SADA:177Lu-DOTA Complex in Patients With Solid Tumors Known to Express GD2

Y-mAbs Therapeutics

NCT05130255

RECRUITING Phase 1 54 participants

Phase I Trial of TURALIO(R) (Pexidartinib, PLX3397) in Children and Young Adults With Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neurofibromas (PN) and Tenosynovial Giant Cell Tumor ...

National Cancer Institute (NCI)

NCT02390752

RECRUITING Phase 2 51 participants

Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial

University of California, Irvine

NCT06580002

RECRUITING 50 participants

Abductor Reattachment Methods in Proximal Femur Replacements: What is the Best Method?

Duke University

NCT03261544

RECRUITING 50 participants

Recognition of Circulating Tumor DNA in Soft Tissue Sarcoma

Medical College of Wisconsin

NCT03896620

RECRUITING Phase 1 42 participants

Hypofractionated Radiation in Combination With B7-H3-CAR T Cells for Pediatric Patients With Relapsed/Refractory Sarcomas

St. Jude Children's Research Hospital

NCT07222735

RECRUITING Phase 1 41 participants

Autologous B7-H3 Chimeric Antigen Receptor T Cells in Relapsed/Refractory Solid Tumors

Crystal Mackall, MD

NCT06500819

RECRUITING NA 40 participants

Effect of A Multimodal Exercise Intervention on Chemotherapy Uptake in Newly Diagnosed Pediatric and AYA Sarcoma Patients

University of Miami

NCT07359911

RECRUITING 40 participants

Biomarkers of Resiliency In Childhood Cancer Surgery

Mayo Clinic

NCT06674811

RECRUITING 40 participants

Brief Title Mechanisms of Cancer-Related Pain and Opioid Use Among Adolescents and Young Adult Sarcoma Survivors: Pilot Feasibility Study

Roswell Park Cancer Institute

NCT07402577

RECRUITING Phase 1 39 participants

Trial of Nivolumab Following Partially Human Leukocyte Antigen (HLA) Mismatched BMT in Children & Adults With Sarcoma

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT03465592

RECRUITING Phase 2 32 participants

A Study of Pembrolizumab in People With Ultra-Rare Sarcomas

Memorial Sloan Kettering Cancer Center

NCT07089992

RECRUITING Phase 2 30 participants

Phase II Trial of Lung Chemoemobolization

City of Hope Medical Center

NCT05672108

RECRUITING Phase 1 30 participants

A Clinical Study of Intratumoral MVR-T3011 (T3011) Given as a Single Agent and in Combination With Intravenous Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors

ImmVira Pharma Co.

NCT04370587

RECRUITING Phase 2 30 participants

A Study of Pembrolizumab Plus Local Chemotherapy Using Isolated Limb Infusion (ILI) for Patients With Sarcoma in the Arm or Leg

Memorial Sloan Kettering Cancer Center

NCT04332874

RECRUITING Phase 1 26 participants

64Cu-LNTH-1363S in Patients With Sarcoma or Gastrointestinal Tract Cancer

Lantheus Medical Imaging

NCT06298916

RECRUITING Phase 1 25 participants

HER2 Chimeric Antigen Receptor (CAR) T Cells in Combination With Checkpoint Blockade in Patients With Advanced Sarcoma

Baylor College of Medicine

NCT04995003

RECRUITING Phase 2 24 participants

Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial

University of California, Irvine

NCT07447050

RECRUITING NA 20 participants

A Checklist (Advanced Care Planning) for The Assessment of Mobility Needs in Patients With Sarcoma

Fred Hutchinson Cancer Center

NCT05835154

RECRUITING Phase 2 20 participants

Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma

University of Colorado, Denver

NCT07125183

RECRUITING NA 20 participants

GRID Therapy for Extremity Soft Tissue Sarcoma

UNC Lineberger Comprehensive Cancer Center

NCT06073067

RECRUITING Phase 4 20 participants

Hyperbaric Oxygen Therapy for Soft Tissue Sarcoma Pilot Study

Duke University

NCT03144206

RECRUITING Phase 2 16 participants

Study of All-Trans Retinoic Acid (ATRA) and Cemiplimab in Patients With Advanced Leiomyosarcoma

Gabriel Tino

NCT06528769

RECRUITING 10 participants

Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women

Washington University School of Medicine

NCT06904365

RECRUITING Phase 1 8 participants

Palbociclib and Pembrolizumab in Sarcoma

John Rieth

NCT06113809

ACTIVE NOT RECRUITING 57,816 participants

Enrollment on the Childhood Cancer Research Network (CCRN) of the Children's Oncology Group

Children's Oncology Group

NCT01117168

ACTIVE NOT RECRUITING 6,000 participants

Collection of Tissue & Blood From Patients w/ Benign & Malignant Tumors of the Soft Tissue & Gastrointestinal Tract

Memorial Sloan Kettering Cancer Center

NCT00582647

ACTIVE NOT RECRUITING 1,275 participants

Genomic Structural Variation in Cancer Susceptibility

Memorial Sloan Kettering Cancer Center

NCT00996710

ACTIVE NOT RECRUITING 1,150 participants

A Screening Study to Collect Samples for TAA, HLA & HLA Loss of Heterozygosity in Patients With Metastatic Solid Tumors

TScan Therapeutics

NCT05812027

ACTIVE NOT RECRUITING Phase 2 350 participants

9-ING-41 in Patients with Advanced Cancers

Actuate Therapeutics

NCT03678883

ACTIVE NOT RECRUITING Phase 3 220 participants

Randomized Study Comparing Two Dosing Schedules for Hypofractionated Image-Guided Radiation Therapy

Memorial Sloan Kettering Cancer Center

NCT01223248

ACTIVE NOT RECRUITING Phase 4 100 participants

Registry of Sarcoma Patients Treated With Permanently Implantable LDR CivaSheet®

CivaTech Oncology

NCT04033081

ACTIVE NOT RECRUITING NA 92 participants

Oncology Dashboard for the Improvement of Operational Efficiency and Patients Outcomes in Patients With Sarcoma

M.D. Anderson Cancer Center

NCT05216029

ACTIVE NOT RECRUITING Phase 1 72 participants

A Study of HFB200301 as a Single Agent and in Combination With Tislelizumab in Adult Patients With Advanced Solid Tumors

HiFiBiO Therapeutics

NCT05238883

ACTIVE NOT RECRUITING Phase 1 70 participants

Aerosolized Aldesleukin in Treating Patients With Lung Metastases

M.D. Anderson Cancer Center

NCT01590069

ACTIVE NOT RECRUITING Phase 2 65 participants

Irinotecan and Carboplatin as Upfront Window Therapy in Treating Patients With Newly Diagnosed Intermediate-Risk or High-Risk Rhabdomyosarcoma

Memorial Sloan Kettering Cancer Center

NCT00077285

ACTIVE NOT RECRUITING Phase 2 60 participants

Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord

M.D. Anderson Cancer Center

NCT02713269

ACTIVE NOT RECRUITING Phase 2 41 participants

A Study of Talimogene Laherparepvec (T-VEC) in Combination With Pembrolizumab in Patients With Metastatic and/or Locally Advanced Sarcoma

Memorial Sloan Kettering Cancer Center

NCT03069378

ACTIVE NOT RECRUITING Phase 1 36 participants

Her2 Chimeric Antigen Receptor Expressing T Cells in Advanced Sarcoma

Baylor College of Medicine

NCT00902044

ACTIVE NOT RECRUITING Phase 2 33 participants

Study of Abemaciclib in Dedifferentiated Liposarcoma

Memorial Sloan Kettering Cancer Center

NCT02846987

ACTIVE NOT RECRUITING Phase 2 31 participants

SM-88 Maintenance Therapy for Advanced Ewing's Sarcoma and as Salvage Therapy for Sarcoma

Sarcoma Oncology Research Center

NCT03778996

ACTIVE NOT RECRUITING Phase 2 30 participants

A Study of Epacadostat, an IDO1 Inhibitor, in Combination With Pembrolizumab in Patients With Metastatic and/or Locally Advanced Sarcoma

Memorial Sloan Kettering Cancer Center

NCT03414229

ACTIVE NOT RECRUITING Early Phase 1 30 participants

Gemcitabine Plus Ascorbate for Sarcoma in Adults (Pilot)

University of Iowa

NCT04634227

ACTIVE NOT RECRUITING Phase 1 21 participants

Nivolumab or Nivolumab and Azacitidine in Patients With Recurrent, Resectable Osteosarcoma

H. Lee Moffitt Cancer Center and Research Institute

NCT03628209

ACTIVE NOT RECRUITING Early Phase 1 18 participants

68Ga-FAPi-46 PET/CT Scan in Imaging Patients With Sarcoma

Jonsson Comprehensive Cancer Center

NCT04457258

ACTIVE NOT RECRUITING Phase 2 16 participants

A Study of Etrumadenant and Zimberelimab in People With Dedifferentiated Liposarcoma

Memorial Sloan Kettering Cancer Center

NCT05886634

ACTIVE NOT RECRUITING Early Phase 1 15 participants

Irinotecan, Temozolomide and Bevacizumab in Combination With Existing High Dose Alkylator Based Chemotherapy for Treatment of Newly Diagnosed Patients With Desmoplastic Small Round Cell Tumor

Memorial Sloan Kettering Cancer Center

NCT01189643

ACTIVE NOT RECRUITING Phase 1 14 participants

Bevacizumab/Doxorubicin/Radiation for Sarcoma

Massachusetts General Hospital

NCT01746238

ACTIVE NOT RECRUITING Early Phase 1 14 participants

Immunotherapy + Radiation in Resectable Soft Tissue Sarcoma

University of Rochester

NCT03463408

ACTIVE NOT RECRUITING NA 11 participants

Proton Pencil Beam Scanning GRID for Treatment of Bulky Tumors

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT05121545

ACTIVE NOT RECRUITING NA 7 participants

PET Imaging of Solid Tumors Using 124I-Humanized 3F8: A Pilot Study

Memorial Sloan Kettering Cancer Center

NCT02307630

COMPLETED Phase 3 587 participants

Comparison of Combination Chemotherapy Regimens in Treating Patients With Ewing's Sarcoma or Neuroectodermal Tumor

Children's Oncology Group

NCT00006734

COMPLETED Phase 3 481 participants

Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma

Children's Oncology Group

NCT00354835

COMPLETED Phase 3 370 participants

Surgery With or Without Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Retroperitoneum or Pelvis

Alliance for Clinical Trials in Oncology

NCT00091351

COMPLETED Phase 3 250 participants

Glutamic Acid in Reducing Nerve Damage Caused by Vincristine in Young Patients With Cancer

University of South Florida

NCT00369564

COMPLETED Phase 3 216 participants

Radiation Therapy Compared With Combination Chemotherapy in Treating Patients With Cancer of the Uterus

Gynecologic Oncology Group

NCT00002546

COMPLETED Phase 3 198 participants

A Web-Based Stem Cell Transplant Support System or Standard Care in Young Patients Undergoing Stem Cell Transplant and Their Families

Tufts Medical Center

NCT00782145

COMPLETED NA 163 participants

Incisional Negative Pressure Wound Therapy for Preoperatively Irradiated Lower Extremity Soft Tissue Sarcoma Wounds

Medical University of South Carolina

NCT02638298

COMPLETED Phase 2 136 participants

Trivalent Ganglioside Vaccine With Immunological Adjuvant or Immunological Adjuvant Alone in Metastatic Sarcoma Patients Who Are Rendered Disease Free

MabVax Therapeutics

NCT01141491

COMPLETED Phase 1 120 participants

A Pilot Study for the Treatment of Patients With Metastatic and High Risk Sarcomas and Primitive Neuroectodermal Tumors

National Cancer Institute (NCI)

NCT00001209

COMPLETED 101 participants

iCAT for Recurrent/Refractory/HR Solid Tumors

Dana-Farber Cancer Institute

NCT01853345

COMPLETED Phase 2 85 participants

Troglitazone in Treating Patients With Liposarcoma

Dana-Farber Cancer Institute

NCT00003058

COMPLETED Phase 2 82 participants

Gemcitabine, Docetaxel, and Filgrastim in Treating Patients With Recurrent or Persistent Leiomyosarcoma or Soft Tissue Sarcoma

Memorial Sloan Kettering Cancer Center

NCT00004066

COMPLETED Phase 2 75 participants

S0423 Pemetrexed Disodium in Treating Patients With Recurrent and Unresectable or Metastatic Chondrosarcoma

SWOG Cancer Research Network

NCT00107419

COMPLETED Phase 2 70 participants

Reproducibility of 18F Uptake by Solid Tumors Using PET Imaging Following Intravenous Administration of (18F) Injection

GE Healthcare

NCT00918281

COMPLETED NA 61 participants

Dynamic Contrast Enhanced MRI(DCE-MRI)of Bone Tumors

Memorial Sloan Kettering Cancer Center

NCT00598741

COMPLETED Phase 2 60 participants

S0344 Intralesional Resection in Treating Patients With Chondrosarcoma of the Bone

SWOG Cancer Research Network

NCT00096213

Phase Distribution

PhaseTrial count
Early Phase 1 37
Phase 2 42
Phase 3 8
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Sarcoma Trial Landscape

ClinicalTrials.gov lists 128 US studies indexed under Sarcoma, and 58 of those are currently open to recruitment — roughly 45% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Sarcoma shows 10 late-stage studies (Phase 3 and Phase 4 combined) alongside 79 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Sarcoma is led by Memorial Sloan Kettering Cancer Center with 25 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Sarcoma?

PlainTrial tracks 128 US clinical trials for Sarcoma, of which 58 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Sarcoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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