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NCT05086497 · ClinicalTrials.gov registry record · NA
WBSI Guided Personalized Delivery of TTFields
A NA study of GBM and Glioma Glioblastoma Multiforme, sponsored by Abramson Cancer Center at Penn Medicine.
- Recruiting
- Registry status
- NA
- Development phase
- 155
- Enrollment target
- 2
- Study locations
NCT05086497 is a NA study of GBM and Glioma Glioblastoma Multiforme that is actively recruiting participants, run by Abramson Cancer Center at Penn Medicine. The registered enrollment target is 155 participants, above the 107-participant average among 24 other GBM trials with a reported enrollment target (45% higher). The trial reports 2 study locations across 1 state.
The verdict
NCT05086497, a NA study of GBM and Glioma Glioblastoma Multiforme, is actively recruiting participants, sponsored by Abramson Cancer Center at Penn Medicine.
- RECRUITING
- Registry status
- NA
- Development phase
- 155 participants
- Enrollment target
- 2
- Study locations
Study Summary
This research study is for Glioblastoma (GBM) patients who will be beginning Optune as part of their clinical care, which is a novel treatment that utilizes - tumor treating fields (TTFields), (aka, electrical therapy), which has shown to improve overall survival in large multi-center trials. As a part of this study, participants will either receive Optune with "standard array mapping" (based on regular contrast enhanced MRI) or an "alternative (more precise) array mapping" based on sophisticated state of the art MRI techniques including "whole brain spectroscopy". Whole brain MRI spectroscopy provides additional metabolic information to map out the full extent of tumor spreading within the brain (far beyond from what is seen on regular MRI), by identifying certain metabolites that are present in cancer cells versus healthy tissue. This study is being performed to show whether alternative array mapping improves treatment outcomes, as opposed to the standard array mapping, by maximizing delivery of TTFields dose, thereby achieving more effective tumor cell killing, decreasing the rate of local recurrence, and improving the overall survival as well as quality of life measures.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Whole Brain Spectroscopy Imaging Array Mapping Layout
Study Locations (2)
Pennsylvania
- Abramson Cancer Center - Philadelphia
- Penn Medicine, University of Pennsylvania - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 155 participants |
| Start Date | 2023-01-15 |
| Est. Completion | 2026-06-30 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05086497
The ClinicalTrials.gov registry entry for NCT05086497 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 155 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 107-participant average among 24 other GBM trials with a reported enrollment target (45% higher). The listed sponsor is Abramson Cancer Center at Penn Medicine, which has 402 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with GBM appearing as the primary indexed condition, and to 1 intervention - of which Whole Brain Spectroscopy Imaging Array Mapping Layout is the first listed.
NCT05086497 reports 2 study locations spanning 1 distinct geographic area - top geographies include Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT05086497 about?
NCT05086497 is a clinical study titled "WBSI Guided Personalized Delivery of TTFields". This research study is for Glioblastoma (GBM) patients who will be beginning Optune as part of their clinical care, which is a novel treatment that utilizes - tumor treating fields (TTFields), (aka, electrical therapy), which has shown to improve overall survival in large multi-center trials. As a p...
What is the current status of trial NCT05086497?
This trial is currently recruiting. It is a NA study. The enrollment target is 155 participants. The study started on 2023-01-15. Estimated completion is 2026-06-30.
What conditions does trial NCT05086497 study?
This clinical trial studies the following conditions: GBM, Glioma Glioblastoma Multiforme, Tumor, Brain.
What interventions are being tested in trial NCT05086497?
The interventions under investigation include: Whole Brain Spectroscopy Imaging Array Mapping Layout (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT05086497?
This trial is sponsored by Abramson Cancer Center at Penn Medicine, which has 402 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05086497 being conducted?
This trial has 2 study locations across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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