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Type 2 Diabetes: full-pipeline trial registry
103 of 289 indexed Type 2 Diabetes trials are currently recruiting.
Corpus placement: #30 of 28,963 conditions by registered trial count.
289 US clinical trials · 103 currently recruiting · #30 of 28,963 conditions by registered trial count
Type 2 Diabetes: 289 US clinical trials tracked, 103 recruiting.
Type 2 Diabetes is the subject of 289 registered US clinical trials on ClinicalTrials.gov, 103 of them currently open to new participants. 56 are in Phase 3-4 (later-stage) and 42 in Phase 1-2 (earlier-stage). The most active sponsor is Eli Lilly and Company, running 20 of these trials.
Open enrollment snapshot
Type 2 Diabetes has 289 registered US clinical trials, 103 of them open to new participants right now, about 36% of the total.
- 103
- recruiting participants now
- 36%
- of trials open to enrollment
- 56
- in Phase 3-4 (later-stage)
- 20
- top sponsor: Eli Lilly and Company
Corpus placement: #30 of 28,963 conditions by registered trial count on ClinicalTrials.gov-derived indexes. Registry reference only, not medical advice.
Key findings
What ClinicalTrials.gov does not surface for Type 2 Diabetes on its own pages , computed from the registry mirror as of 2026-07-11. Each line carries its own denominator so it can be quoted as it stands.
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Type 2 Diabetes recruits in line with its size-band peers.
103 of 289 indexed trials (35.6%) are open to enrollment, against a 37.2% average across 135 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Type 2 Diabetes trials is spread across many organizations.
Eli Lilly and Company accounts for 20 of 289 trials (6.9%). 140 distinct sponsors appear on at least one study for this condition label.
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Typical Type 2 Diabetes enrolment sits around 96 participants.
Median target enrolment is 96 among the 289 trials that report a genuine target (sentinel values excluded). 145 of those (50.2%) plan for fewer than 100 participants.
-
Type 2 Diabetes research is mostly interventional.
257 interventional and 32 observational studies make up this index (88.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
289 total, page 3 of 6
Acute Exercise and Endogenous Glucose Production in Type 2 Diabetes: Implications for Glycemic Control and Treatment of Hepatic Steatosis
AdventHealth Translational Research Institute
NCT06993454
Acute and Chronic Effects of Oral Ketones in Subjects With HFrEF and Diabetes
The University of Texas Health Science Center at San Antonio
NCT06108076
Brown Adipose Tissue Activation by Spinal Cord Stimulation
Oregon Health and Science University
NCT04326192
Comparative Study of Tirzepatide Versus Dulaglutide (SURPASS CVOT) or Semaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes
Brigham and Women's Hospital
NCT06779929
INcreTin-based thERapies for Cardiovascular Event PrevenTion in Patients With and Without ASCVD (INTERCEPT-ASCVD)
Brigham and Women's Hospital
NCT07417618
Emulation of the REWIND Cardiovascular Outcomes Trial in Healthcare Claims Data.
Brigham and Women's Hospital
NCT07417631
Comparative Effectiveness of Tirzepatide vs Semaglutide in Participants With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction
Brigham and Women's Hospital
NCT06980623
Comparative Effectiveness of Oral Semaglutide vs Sitagliptin Among Individuals With Heart Failure With Preserved Ejection Fraction (STEP-HFpEF DM ORAL)
Brigham and Women's Hospital
NCT07390110
A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk
Eli Lilly and Company
NCT05803421
SWIFT: Study of Women, Infant Feeding and Type 2 Diabetes After GDM Pregnancy
Kaiser Permanente
NCT01967030
Study of Clinical Response to Acute Metformin By Leveraging Evaluations During a Mixed Meal Tolerance Test for Exploring Glycemia and GeneticS
Massachusetts General Hospital
NCT02087826
A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor
Novo Nordisk A/S
NCT06221969
A Study of Retatrutide (LY3437943) in Participants With Type 2 Diabetes Mellitus Who Have Obesity or Overweight
Eli Lilly and Company
NCT05929079
A Study of Tirzepatide Compared With Intensified Conventional Care in Adult Participants With Type 2 Diabetes
Eli Lilly and Company
NCT05433584
Generic Drugs (Dapagliflozin and Saxagliptin) Treat Type 2 Diabetes Patients With Controlled Cancers
Han Xu, M.D., Ph.D., FAPCR, Sponsor-Investigator, IRB Chair
NCT07033585
Financial Incentives And Nurse Coaching to Enhance Diabetes Outcomes (FINANCE-DM)-1
State University of New York at Buffalo
NCT04203173
A Study of Investigational Tirzepatide (LY3298176) Doses in Participants With Type 2 Diabetes and Obesity
Eli Lilly and Company
NCT06037252
Weight Loss in People Living With Overweight or Obesity and Type 2 Diabetes Following Treatment With Cagrilintide
Novo Nordisk A/S
NCT07220759
Effect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3)
Eli Lilly and Company
NCT06297603
Innovative Automated Insulin Delivery System for Type 2 Diabetes
Deka Research and Development
NCT06853990
Lowering the Impact of Food Insecurity in African American Adults With Type 2 Diabetes Mellitus (LIFT-DM)
State University of New York at Buffalo
NCT04181424
Personalized Dietary Management in Type 2 Diabetes
NYU Langone Health
NCT05046886
Diabetes Medical Nutrition Therapy in Southeastern African American Women
Meharry Medical College
NCT04971889
Resilience-Based Diabetes Self-Management Education (RB-DSME) for African Americans
University of Texas at Austin
NCT04282395
Efficacy and Safety of Petrelintide in Participants With Overweight or Obesity and Type 2 Diabetes (ZUPREME 2)
Zealand Pharma
NCT06926842
Together Overcoming Diabetes
Johns Hopkins Bloomberg School of Public Health
NCT04734015
The Hope App Study
See Yourself Health
NCT05729516
Randomized Controlled Trial of Digital Twin Precision Treatment: A Novel Whole Body Digital Twin Enabled Precision Treatment for Type 2 Diabetes
The Cleveland Clinic
NCT05181449
E3 Diabetes - Closing the Gap in Diabetes Control
Rush University Medical Center
NCT06643936
A Study of Tirzepatide (LY3298176) in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes
Eli Lilly and Company
NCT05536804
Preventing Diabetes in Latino Families
Arizona State University
NCT05228522
Changing the Natural History of Type 2 Diabetes ("CHANGE" Study)
Foundation for Atlanta Veterans Education and Research
NCT05040087
Impact of Colorectal Cancer and Nutrition Education Program Among Minority Patients With Type 2 Diabetes
Charles Drew University of Medicine and Science
NCT05765214
Group Versus Traditional Prenatal Care for Diabetes
Washington University School of Medicine
NCT03301792
Continuous Glucose Monitoring Following Hospital Discharge
Kathleen Dungan
NCT05360056
Effects of Modulators of Gluconeogenesis, Glycogenolysis and Glucokinase Activity
University of Alabama at Birmingham
NCT05098470
Conditional Cash Transfer Intervention to Improve T2DM
State University of New York at Buffalo
NCT05559892
Exercise Resistance in Type 2 Diabetes
AdventHealth Translational Research Institute
NCT01911104
Glycemic Control, Type II Diabetes, Parathyroidectomy
The Cleveland Clinic
NCT05761743
Diabetes Nutrition Education and Healthy Food Resource for AIANs With T2D
Colorado State University
NCT06077162
Recreational Basketball to Increase Participation in Diabetes Prevention
Kaiser Permanente
NCT05066542
The Medically Reproducing Bariatric Surgery (MRB) II Study
Durham VA Medical Center
NCT06363747
Understanding and Optimizing Care for Young Adults With Type 1 and Type 2 Diabetes Mellitus Transitioning to Adult Care
Massachusetts General Hospital
NCT05229718
DIALYSIS-TIR Study
University of Texas Southwestern Medical Center
NCT06042153
Application of Time Restriction Feeding in Patients With Type 2 Diabetes Mellitus
OhioHealth
NCT05015504
Glucagon Suppression by Hyperglycemia in the Presence and Absence of Amino Acid Infusion
Mayo Clinic
NCT05264727
Continuous Glucose Monitoring System Feasibility in Youth With T2D
University of California, San Francisco
NCT06089070
Multilevel Lifestyle Intervention to Improve Physical Function in Older Adults With Type 2 Diabetes
The University of Texas Health Science Center at San Antonio
NCT06173804
Care Partner-Assisted Diabetes Self-Management Through Linking Continuous Glucose Monitoring With Mobile Health: Improving Outcomes for Older Adults With Mild Cognitive Impairment
NYU Langone Health
NCT05601583
Daily Protein Pacing Effects on HbA1c in Type 2 Diabetics
Skidmore College
NCT05355090
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 21 |
| Phase 2 | 21 |
| Phase 3 | 34 |
| Phase 4 | 22 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
What is open for Type 2 Diabetes right now
103 recruiting of 289 indexed (36% open).
Phase mix: 56 late (III/IV) vs 42 early (I/II) (balanced across stages).
Top sponsor: Eli Lilly and Company (20 trials), 9 others listed. 50 shown below, recruiting first. #30 of 28,963 conditions by registered trial count.
How open-enrollment share is computed
Open share is recruiting_count divided by trial_count for this condition label in the public registry export. Status can change between pulls; treat the figure as a snapshot of research attention, not treatment availability.
Frequently Asked Questions
How many clinical trials are there for Type 2 Diabetes?
PlainTrial tracks 289 US clinical trials for Type 2 Diabetes, of which 103 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Type 2 Diabetes?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.