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NCT06108076 · ClinicalTrials.gov registry record · Early Phase 1
Acute and Chronic Effects of Oral Ketones in Subjects With HFrEF and Diabetes
A Early Phase 1 study of Type 2 Diabetes and Heart Failure, Reduced Ejection Fraction, sponsored by The University of Texas Health Science Center at San Antonio.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 10
- Enrollment target
- 1
- Study location
NCT06108076: Recruiting Early Phase 1 study of Type 2 Diabetes and Heart Failure, Reduced Ejection Fraction, sponsored by The University of Texas Health Science Center at San Antonio.
NCT06108076 is a Early Phase 1 study of Type 2 Diabetes and Heart Failure, Reduced Ejection Fraction that is actively recruiting participants, run by The University of Texas Health Science Center at San Antonio. The registered enrollment target is 10 participants, below the 3,924-participant average among 327 other Type 2 Diabetes trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06108076, a Early Phase 1 study of Type 2 Diabetes and Heart Failure, Reduced Ejection Fraction, is actively recruiting participants, sponsored by The University of Texas Health Science Center at San Antonio.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 10 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will provide insight into whether cardiac function changes with oral Ketone Esters (KE) administered to patients with Type 2 Diabetes Mellitus (T2DM) and Heart failure with reduced ejection fraction (HFrEF). Plasma ketones are avidly extracted by cardiac muscle and their uptake is not dependent upon insulin or influenced by insulin resistance.
Primary Outcome
Change in cardiac efficiency after acute dosing of KE, measured by change in Left-ventricular function measured using Cardiac MRI and expressed as a percentage.
Conditions Studied
Interventions
- DRUG Ketone Monoester (KE)
Study Locations (1)
Texas
- University of Texas Health Science Center at San Antonio - San Antonio
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2024-01-16 |
| Est. Completion | 2026-12-31 |
| Phase | Early Phase 1 |
What NCT06108076 shows while recruiting
NCT06108076 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 3,924-participant average among 327 other Type 2 Diabetes trials with a reported enrollment target (100% lower).
The record links to 2 conditions, with Type 2 Diabetes appearing as the primary indexed condition, and to 1 intervention - of which Ketone Monoester (KE) is the first listed.
NCT06108076 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT06108076 about?
NCT06108076 is a clinical study titled "Acute and Chronic Effects of Oral Ketones in Subjects With HFrEF and Diabetes". This study will provide insight into whether cardiac function changes with oral Ketone Esters (KE) administered to patients with Type 2 Diabetes Mellitus (T2DM) and Heart failure with reduced ejection fraction (HFrEF). Plasma ketones are avidly extracted by cardiac muscle and their uptake is not dep...
What is the current status of trial NCT06108076?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 10 participants. The study started on 2024-01-16. Estimated completion is 2026-12-31.
What conditions does trial NCT06108076 study?
This clinical trial studies the following conditions: Type 2 Diabetes, Heart Failure, Reduced Ejection Fraction.
What interventions are being tested in trial NCT06108076?
The interventions under investigation include: Ketone Monoester (KE) (DRUG).
Who is sponsoring clinical trial NCT06108076?
This trial is sponsored by The University of Texas Health Science Center at San Antonio, which has 378 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06108076 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Type 2 Diabetes
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06108076's enrollment target sits among peer trials
10 321st of 327 higher than 4 of 327 other Type 2 Diabetes trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Type 2 Diabetes trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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