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NCT04754581 · ClinicalTrials.gov registry record · NA
Dynamic in Vivo PET Imaging and ex Vivo Biopsies From Skeletal Muscle and Adipose Tissue to Investigate the Effects of Exercise on Insulin Resistance and Mitochondrial Energetics in Type 2 Diabetes
A NA study of Type 2 Diabetes, sponsored by AdventHealth Translational Research Institute.
- Recruiting
- Registry status
- NA
- Development phase
- 12
- Enrollment target
- 1
- Study location
NCT04754581: Recruiting NA study of Type 2 Diabetes, sponsored by AdventHealth Translational Research Institute.
NCT04754581 is a NA study of Type 2 Diabetes that is actively recruiting participants, run by AdventHealth Translational Research Institute. The registered enrollment target is 12 participants, below the 3,924-participant average among 327 other Type 2 Diabetes trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04754581, a NA study of Type 2 Diabetes, is actively recruiting participants, sponsored by AdventHealth Translational Research Institute.
- RECRUITING
- Registry status
- NA
- Development phase
- 12 participants
- Enrollment target
- 1
- Study location
Study Summary
The overall aim of this pilot study is to investigate the effects of exercise training on skeletal muscle and adipose tissue insulin resistance in subjects with Type 2 Diabetes (T2D).
Primary Outcome
Muscle glucose uptake will be assessed two times (pre and post exercise intervention) on the biceps femoris and vastus lateralis through PET imaging and hyperinsulinemic euglycemic clamp.
Conditions Studied
Interventions
- PROCEDURE Muscle Biopsy
- OTHER Maximal ATP Production (ATPmax)
- OTHER Exercise Testing (VO2max)
- PROCEDURE Adipose Tissue Biopsy
- OTHER Hyperinsulinemic euglycemic clamp
Study Locations (1)
Florida
- AdventHealth Translational Research Institute - Orlando
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12 participants |
| Start Date | 2021-03-30 |
| Est. Completion | 2025-06 |
| Phase | NA |
What NCT04754581 shows while recruiting
NCT04754581 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 12 participants, a relatively small participant target, below the 3,924-participant average among 327 other Type 2 Diabetes trials with a reported enrollment target (100% lower).
The record links to 1 condition, with Type 2 Diabetes appearing as the primary indexed condition, and to 5 interventions - of which Muscle Biopsy is the first listed.
NCT04754581 reports a single indexed study location in Florida.
Frequently Asked Questions
What is clinical trial NCT04754581 about?
NCT04754581 is a clinical study titled "Dynamic in Vivo PET Imaging and ex Vivo Biopsies From Skeletal Muscle and Adipose Tissue to Investigate the Effects of Exercise on Insulin Resistance and Mitochondrial Energetics in Type 2 Diabetes". The overall aim of this pilot study is to investigate the effects of exercise training on skeletal muscle and adipose tissue insulin resistance in subjects with Type 2 Diabetes (T2D).
What is the current status of trial NCT04754581?
This trial is currently recruiting. It is a NA study. The enrollment target is 12 participants. The study started on 2021-03-30. Estimated completion is 2025-06.
What conditions does trial NCT04754581 study?
This clinical trial studies the following conditions: Type 2 Diabetes.
What interventions are being tested in trial NCT04754581?
The interventions under investigation include: Muscle Biopsy (PROCEDURE), Maximal ATP Production (ATPmax) (OTHER), Exercise Testing (VO2max) (OTHER), Adipose Tissue Biopsy (PROCEDURE), Hyperinsulinemic euglycemic clamp (OTHER).
Who is sponsoring clinical trial NCT04754581?
This trial is sponsored by AdventHealth Translational Research Institute, which has 54 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04754581 being conducted?
This trial has 1 study location across Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Type 2 Diabetes
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04754581's enrollment target sits among peer trials
12 314th of 327 higher than 9 of 327 other Type 2 Diabetes trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Type 2 Diabetes trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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