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ClinicalTrials.gov 44 recruiting now official registry

Surgery clinical trials

44 of 121 indexed Surgery trials are currently recruiting.

121 US clinical trials · 44 currently recruiting

Surgery is the subject of 121 registered US clinical trials on ClinicalTrials.gov, 44 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 8 in Phase 1-2 (earlier-stage). The most active sponsor is University of Wisconsin, Madison, running 6 of these trials.

The research picture

Surgery has 121 registered US clinical trials, 44 of them open to new participants right now, about 36% of the total.

44
recruiting participants now
36%
of trials open to enrollment
21
in Phase 3–4 (later-stage)
6
top sponsor: University of Wisconsin, Madison
Phase 13Phase 25Phase 39Phase 412

Active & Recent Trials

121 total, page 1 of 3

RECRUITING 5,000,000 participants

The Pediatric Anesthesia Quality Improvement Project

The Society for Pediatric Anesthesia

NCT00674388

RECRUITING 1,200,000 participants

The Million Anesthesia Cases Study (MACS) - a Cohort Study of Preoperative Fasting and Perioperative Outcomes

Massachusetts General Hospital

NCT07022951

RECRUITING NA 13,000 participants

Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial

Washington University School of Medicine

NCT05991453

RECRUITING NA 10,000 participants

Collecting Outcomes and Managing Pain After Surgery

Duke University

NCT03834818

RECRUITING NA 1,900 participants

The ImPreSS Trial: Pharmacogenomic Decision Making at Time of Surgery

University of Chicago

NCT03729180

RECRUITING NA 1,200 participants

RCT: Early Feeding After PEG Placement

Carilion Clinic

NCT04110613

RECRUITING NA 1,100 participants

Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury

University of Colorado, Denver

NCT06349577

RECRUITING 1,000 participants

Terumo Aortic Global Endovascular Registry

Vascutek

NCT04246463

RECRUITING Phase 4 900 participants

Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial

University of Michigan

NCT05722002

RECRUITING Phase 4 900 participants

Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial

University of Michigan

NCT06671002

RECRUITING Phase 3 880 participants

Post-Discharge Risk-Based Management in Patients Undergoing High-Risk Elective Major Cancer Operations (PRS II)

Fox Chase Cancer Center

NCT05454280

RECRUITING Phase 3 760 participants

Sentinel Node Biopsy in Endometrial Cancer

Queensland Centre for Gynaecological Cancer

NCT04073706

RECRUITING Phase 4 606 participants

Lovenox 30 mg Twice Daily (BID) Versus 40 mg Once Daily (QD)

Oregon Health and Science University

NCT02342444

RECRUITING 600 participants

Maestro 1.1 Post-Market Registry

Moon Surgical

NCT06103136

RECRUITING 431 participants

Evaluation of Resection Techniques for Pancreatic Tumors

Methodist Health System

NCT05128890

RECRUITING NA 300 participants

Improving Total Knee Arthroplasty Dissatisfaction Through a Personalized Approach Focusing on PROMs Phenotypes

The Cleveland Clinic

NCT06298721

RECRUITING NA 266 participants

A Study of Opportunistic Salpingectomy to Prevent Ovarian Cancer

Memorial Sloan Kettering Cancer Center

NCT06312124

RECRUITING Phase 2 242 participants

Prevent Cardiac Surgery Associated AKI Trial

George Washington University

NCT06620523

RECRUITING NA 170 participants

Music Interventions During Wide-Awake Hand Surgery

University of Wisconsin, Madison

NCT05472909

RECRUITING NA 150 participants

Optimizing Pain Self-Management in Total Knee Arthroplasty

University of Virginia

NCT06038240

RECRUITING Phase 2 140 participants

Factor VIII Inhibitor Bypass Activity (FEIBA) Versus Fresh Frozen Plasma As First Line Therapy For Bleeding After Cardiac Surgery

Northwell Health

NCT07032792

RECRUITING NA 134 participants

Effect of Fasting on Patient Outcomes After Wide-Awake, Local Anesthesia-only, No Tourniquet (WALANT) Procedures

University of California, Irvine

NCT05819801

RECRUITING NA 100 participants

Brain Function Monitoring During Surgery

University of Chicago

NCT06619730

RECRUITING NA 100 participants

Methods for Effective Disposal of Surplus Analgesics to Facilitate Elimination

University of Michigan

NCT05991687

RECRUITING NA 90 participants

Building Resilience for Surgical Recovery

The University of Texas Health Science Center, Houston

NCT06174701

RECRUITING Early Phase 1 80 participants

Ethyl Chloride Spray to Reduce Pain From Local Anesthesia During Mohs Micrographic Surgery

University of California, Davis

NCT06920381

RECRUITING Phase 4 80 participants

Transversus Abdominis Plane Block Compared to Local Anesthetic Wound Infiltration in Gynecologic Oncology Surgery

University of Wisconsin, Madison

NCT06213454

RECRUITING NA 75 participants

Ultrasound Evaluation for Improving Patient Selection in vNOTES

The University of Texas Health Science Center, Houston

NCT05623514

RECRUITING Phase 4 70 participants

Evaluating a Dropless Postoperative Regimen After Cataract Surgery in a Vulnerable, County-hospital Population

University of California, San Francisco

NCT05157113

RECRUITING Phase 2 64 participants

A Study of Bevonescein in Patients Undergoing Abdominopelvic Surgery

Alume Biosciences

NCT06662097

RECRUITING NA 60 participants

Green Light for Post-Operative Wellness

Rebecca E Kotcher, MD

NCT07218289

RECRUITING Phase 1 60 participants

Tranexamic Acid in Rhinoplasty: Perioperative Bleeding, Edema and Ecchymosis

Vanderbilt University Medical Center

NCT05774717

RECRUITING NA 50 participants

INCLUDE Program: A Perioperative Wellness Program Tailored for Black Surgical Patients

Washington University School of Medicine

NCT07283783

RECRUITING NA 50 participants

Gastric US in ICU Patient

Dartmouth-Hitchcock Medical Center

NCT05526105

RECRUITING NA 50 participants

AI-driven Clinical Decision Support for Perioperative Blood Orders

Washington University School of Medicine

NCT07223853

RECRUITING NA 50 participants

The Neuralert Stroke Monitor Pilot Trial

Neuralert Technologies

NCT06368193

RECRUITING NA 42 participants

Implementation Pilot of Preoperative CGA Before Major Surgery

University of Wisconsin, Madison

NCT06184724

RECRUITING Phase 3 40 participants

NO During CPB in Neonates to Reduce Risk of AKI

Children's Hospital Medical Center, Cincinnati

NCT04216927

RECRUITING Phase 4 40 participants

Continuous Versus Single Injection Adductor Canal Blocks for Outpatient Total Knee Arthroplasty

University of California, San Diego

NCT06784882

RECRUITING NA 30 participants

Intervention to Improve Utilization of Extended Venous Thromboembolism Prophylaxis After Cancer Surgery

Medical University of South Carolina

NCT06451003

RECRUITING NA 30 participants

Physical Therapy After Endometriosis Excision

Oregon Health and Science University

NCT07127783

RECRUITING NA 30 participants

Geriatric Thoracic Surgery Ambulation Challenge

Dana-Farber Cancer Institute

NCT04630496

RECRUITING NA 27 participants

A Study of the Use of 3D Technology to Guide Head and Neck Surgery

Memorial Sloan Kettering Cancer Center

NCT06676592

RECRUITING 20 participants

LaserEn: SOLTIVE™ Thulium Laser Fiber En Bloc Resection of Bladder Tumors

University of Kansas Medical Center

NCT04979156

ACTIVE NOT RECRUITING NA 66,273 participants

Operating Room Air Filtration/Sterilization

The Cleveland Clinic

NCT04610294

ACTIVE NOT RECRUITING NA 1,456 participants

Perioperative Risk Study

Fox Chase Cancer Center

NCT02456389

ACTIVE NOT RECRUITING Phase 3 1,386 participants

The HeLiX (Hemorrhage During Liver Resection: traneXamic Acid) Trial

Sunnybrook Health Sciences Centre

NCT02261415

ACTIVE NOT RECRUITING NA 484 participants

Nudges for Opioid Reduction After Major Surgery Trial

University of Washington

NCT04927351

ACTIVE NOT RECRUITING NA 313 participants

Insignia™ Hip Stem Outcomes Study

Stryker Orthopaedics

NCT05144191

ACTIVE NOT RECRUITING Phase 4 300 participants

The PASTDUe Nutrition Ecosystem Project (PASTDUe)

Duke University

NCT05127109

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Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 5
Phase 3 9
Phase 4 12

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Surgery Trial Landscape

121 indexed Surgery studies · 44 recruiting (36%).

Phase mix: 21 late (III/IV) vs 8 early (I/II).

Top sponsor: University of Wisconsin, Madison (6 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Surgery?

PlainTrial tracks 121 US clinical trials for Surgery, of which 44 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Surgery?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.