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Surgery clinical trials
44 of 121 indexed Surgery trials are currently recruiting.
121 US clinical trials · 44 currently recruiting
Surgery is the subject of 121 registered US clinical trials on ClinicalTrials.gov, 44 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 8 in Phase 1-2 (earlier-stage). The most active sponsor is University of Wisconsin, Madison, running 6 of these trials.
The research picture
Surgery has 121 registered US clinical trials, 44 of them open to new participants right now, about 36% of the total.
- 44
- recruiting participants now
- 36%
- of trials open to enrollment
- 21
- in Phase 3–4 (later-stage)
- 6
- top sponsor: University of Wisconsin, Madison
Active & Recent Trials
121 total, page 2 of 3
Non-pharmacological Treatment for Pain After Spine Surgery
Dan Rhon
NCT04770480
COgnitive and Physical Exercise to Improve Outcomes After Surgery (COPE-iOS) Study
Vanderbilt University Medical Center
NCT04889417
Effects of Weight Loss Surgery on Bone Health in Adolescents
Massachusetts General Hospital
NCT02557438
Evaluating Outcomes in Cardiac Surgery Patients Who Receive Sugammadex vs. Placebo
Endeavor Health
NCT05801679
Multicenter Phase II Study of Transanal TME (taTME)
Icahn School of Medicine at Mount Sinai
NCT03144765
Metabolomic Profiling of Racial Disparity
Nationwide Children's Hospital
NCT06266429
Permissive Hypotension After Cardiac Surgery
Massachusetts General Hospital
NCT06476613
Regional Anesthesia EMG Study
Nationwide Children's Hospital
NCT06287151
Multimodal Analgesia Effect on Post Surgical Patient
University of California, Davis
NCT04240626
TOF Monitoring Using the TetraGraph in Patients Less Than 1 Year of Age
Joseph D. Tobias
NCT06458023
TetraGraph in Rocuronium Infusions
Joseph D. Tobias
NCT06472284
Preparing Older Adults for Major Surgery With Preoperative Comprehensive Geriatric Assessments
University of Wisconsin, Madison
NCT06184919
Buccal Graft + Collagen Matrix Versus Free Gingival Graft for Keratinized Mucosa Augmentation at Implant Sites
Harvard Medical School (HMS and HSDM)
NCT05844475
RESTORE Declined Livers Study
Washington University School of Medicine
NCT04483102
Circadian Rhythm Disruption in the Hospital Intensive Care Environment
University of Pennsylvania
NCT05828680
Increasing Implementation of Post-Operative Opioid Prescribing Guidelines
University of Pennsylvania
NCT05358522
Multicenter Infection Surveillance Study Following Open Heart Surgery
Halyard Health
NCT00673712
Accuracy of Pulse CO-Oximetry Technology in Characterizing Noninvasive SpHb
University of California, Davis
NCT01997502
Outcomes of Intrathecal Analgesia in Colorectal Surgery
Mayo Clinic
NCT03411109
Redesigning Cardiac Surgery to Reduce Neurologic Injury
Dartmouth-Hitchcock Medical Center
NCT00432536
Mapracorat Ophthalmic Suspension, 3% for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery
Bausch & Lomb Incorporated
NCT01591161
ICD-ON Registry: Periop Management of Cardiac Devices
Edward Hospital
NCT02052453
No Opioids PrescrIptions On Discharge After Surgery
Albany Medical College
NCT04469868
Preoperative Chlorhexidine Gluconate (CHG) Cloth on Healthy Subjects
Medline Industries
NCT02222896
Study Exploring the Effect of Music on Pain After Ventral Hernia Surgery
The Cleveland Clinic
NCT05374096
Preoperative Survey to Evaluate Patient Allergy
Nationwide Children's Hospital
NCT05670756
Predictors of Recovery Expectancy
Indiana University
NCT04274491
Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus
University of California, San Francisco
NCT01958320
Study of Recovery of Strength After Surgery Comparing Two Different Medications for Reversal of Muscle Relaxant
Memorial Sloan Kettering Cancer Center
NCT03116997
Opioid Prescribing After Cesarean Delivery
Vanderbilt University Medical Center
NCT03168425
Study Investigating Role of Unalike Patient Positioning on PROMIS Scores
University of Louisville
NCT03446950
Comparison of Ambu Auragain and I-Gel Supraglottic Airways in Adult Patients at an Ambulatory Surgery Center
University of Minnesota
NCT04286581
Management of Antiplatelet Regimen During Surgical Procedures
Baylor Research Institute
NCT03981835
Physical Therapy Following Total Hip Arthroplasty
Orthopedic One
NCT04199390
Foot and Ankle Post-operative Oedema Management Using Geko™
Firstkind
NCT04927234
Ambulatory Gynecologic Surgery: Finding the Optimal Opioid Prescription
Montefiore Medical Center
NCT03588910
Solution Temperature and Fluid Deficit During Hysteroscopy
The University of Texas Health Science Center, Houston
NCT05622097
Prospective Observational Clinical Study to Evaluate Patient Outcomes Following Pharmacogenetic Testing of Patients Undergoing Elective Surgical Procedures
AltheaDx
NCT02605343
Thoracic Epidural Analgesia vs Surgical Site Infiltration With Liposomal Bupivacaine Following Open Gynecologic Surgery
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT04117074
Gastric Ultrasound
Alok Moharir
NCT04127331
Feasibility of Obtaining Pulse Oximetry Readings from the Oropharynx
Joseph D. Tobias
NCT05690633
Virtual Phone Visits Compared to In-Person Physical Visits for Post-Operative Follow-Up at a Sports Medicine Clinic
Jonathan Wu
NCT05998148
Single Shot vs Continuous Interscalene Block for Rotator Cuff Repair
University of Chicago
NCT01122745
What is the Impact of the Presence of a Support Person on Informed Consent
Hartford Hospital
NCT03966469
OPTiMASK: Comparison of Pre-oxygenation With Standard Face Mask Combined With High Flow Nasal Oxygen With Pre-oxygenation With Standard Face Mask Alone
Beth Israel Deaconess Medical Center
NCT05495841
Oxygen Reserve Index: Utility as Early Warning for Desaturation in Morbidly Obese Patients
Masimo Corporation
NCT03021551
TAP Versus Thoracic Epidural in Major Abdominal Resections
Corewell Health West
NCT02197988
Pudendal Nerve Block in Vaginal Surgery
MetroHealth Medical Center
NCT04198714
Comparison of Epidural and TAP Block in Abdominal Surgery
University of Nebraska
NCT01848951
NSS-2 BRIDGE Device in Post-Operative Pain Management
Jacques E. Chelly
NCT03555266
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 5 |
| Phase 3 | 9 |
| Phase 4 | 12 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Surgery Trial Landscape
121 indexed Surgery studies · 44 recruiting (36%).
Phase mix: 21 late (III/IV) vs 8 early (I/II).
Top sponsor: University of Wisconsin, Madison (6 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Surgery?
PlainTrial tracks 121 US clinical trials for Surgery, of which 44 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Surgery?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.