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ClinicalTrials.gov 27 recruiting now official registry

Smoking clinical trials

27 of 124 indexed Smoking trials are currently recruiting.

124 US clinical trials · 27 currently recruiting

Smoking is the subject of 124 registered US clinical trials on ClinicalTrials.gov, 27 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is RAI Services Company, running 9 of these trials.

The research picture

Smoking has 124 registered US clinical trials, 27 of them open to new participants right now, about 22% of the total.

27
recruiting participants now
22%
of trials open to enrollment
13
in Phase 3–4 (later-stage)
9
top sponsor: RAI Services Company
Phase 19Phase 213Phase 34Phase 49

Active & Recent Trials

124 total, page 1 of 3

RECRUITING 5,122 participants

The Efficacy of Conventional Screening Versus mHealth Screening in Early Detection of Oral Potentially Malignant Disorders and Oral Cancer Amongst the Rural Population of Varanasi: A Prospective and Blinded Study

Memorial Sloan Kettering Cancer Center

NCT06535867

RECRUITING Phase 2 3,600 participants

App for Reducing Cravings to Smoke

H. Lee Moffitt Cancer Center and Research Institute

NCT06088498

RECRUITING NA 3,200 participants

Refer2Quit: Evaluating a Proactive, Tailored, Population Health Approach for Tobacco Treatment for Household Smokers Through a Pediatric Care Network

Children's Hospital of Philadelphia

NCT06582693

RECRUITING 2,000 participants

Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies

Weill Medical College of Cornell University

NCT01776398

RECRUITING NA 850 participants

Personalized Tobacco Treatment in Primary Care (MOTIVATE)

Washington University School of Medicine

NCT05846841

RECRUITING NA 800 participants

Take A Break - Rural

Wake Forest University Health Sciences

NCT05790486

RECRUITING NA 768 participants

Leveraging Community Pharmacists to Optimize Smoking Cessation Services for Rural Smokers in Appalachia

University of Virginia

NCT05660525

RECRUITING Phase 3 488 participants

Integrating Financial Coaching and Smoking Cessation Coaching

NYU Langone Health

NCT05154669

RECRUITING NA 440 participants

Technology Assisted Motivational Interviewing

University of California, San Francisco

NCT06713603

RECRUITING NA 408 participants

Actívatexto: Advancing Smoking Cessation and Physical Activity Among Latinos

University of Rochester

NCT06926608

RECRUITING NA 340 participants

Black Impact: The Mechanisms Underlying Psychosocial Stress Reduction in a Cardiovascular Health Intervention

Ohio State University

NCT06055036

RECRUITING NA 290 participants

Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS

Philip Morris Products S.A.

NCT07108166

RECRUITING Phase 4 279 participants

Modifying Progesterone and Estradiol Levels to Prevent Postpartum Cigarette Smoking Relapse and Reduce Secondhand Smoke Exposure in Infants and Children

University of Minnesota

NCT04783857

RECRUITING NA 256 participants

Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction

Yale University

NCT06077240

RECRUITING Phase 2 222 participants

A Study of Brenipatide in Adults Who Quit Smoking Cigarettes and Want to Avoid Relapse

Eli Lilly and Company

NCT07223840

RECRUITING NA 210 participants

The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers

Abramson Cancer Center at Penn Medicine

NCT06264154

RECRUITING NA 208 participants

Clinical Alternatives for Reducing Harm Using E-cigarettes

Medical University of South Carolina

NCT07039292

RECRUITING NA 150 participants

Linking Brain Network Dynamics to Imminent Smoking Lapse Risk and Behavior

Penn State University

NCT05572671

RECRUITING NA 112 participants

Precision Treatment to Promote Smoking Cessation and Survival in Oncology Patients

Washington University School of Medicine

NCT07166120

RECRUITING NA 100 participants

Enhancing Motivation to Quit Smoking Via Self-Help Intervention Targeted to Cancer Type

University of Utah

NCT06484179

RECRUITING NA 100 participants

Bayesian Neurobehavioral Phenotyping: From Mechanism Identification to Personalized Neuromodulation Treatments. R61 PHASE

M.D. Anderson Cancer Center

NCT06991062

RECRUITING NA 90 participants

Inspire HER: Inspiring the Heart and Emotions for Radical Health

University of Alabama at Birmingham

NCT06966258

RECRUITING NA 90 participants

Ethnic Microaggressions and Smoking Behaviors Among Latinx Adults

University of Houston

NCT05490927

RECRUITING Phase 2 76 participants

The Potential of Kava in Enabling Tobacco Cessation - Its Holistic Effects in Managing Stress and Insomnia Associated With Abstinence

University of Florida

NCT05814055

RECRUITING NA 60 participants

Effects of a Specific Substance in Smokers

Oregon Health and Science University

NCT04281979

RECRUITING NA 40 participants

Abuse Liability for Five Modern Oral Nicotine Products

RAI Services Company

NCT07132814

RECRUITING NA 10 participants

A Study Evaluating the Use of an Indoor Air Quality Monitor to Promote a Smoke-free Home

Memorial Sloan Kettering Cancer Center

NCT06693700

ACTIVE NOT RECRUITING NA 940 participants

Effect of Helpers Program On-line Training on Smoking Relapse and Social Networks

University of Colorado, Denver

NCT05641974

ACTIVE NOT RECRUITING NA 800 participants

Impact of Patient-Centered Approach for Communicating Coronary Calcium on Cardiovascular Health

American College of Radiology

NCT06055972

ACTIVE NOT RECRUITING NA 700 participants

A Pragmatic Trial of Chronic Disease Approaches to Ameliorate Tobacco Related Cardiovascular Disease Health Disparities

University of Minnesota

NCT05671380

ACTIVE NOT RECRUITING NA 494 participants

Literacy and Smoking Risk Communications

M.D. Anderson Cancer Center

NCT00684437

ACTIVE NOT RECRUITING Early Phase 1 358 participants

Centralized Lung Cancer EARly Detection Among Smokers (CLEAR Study)

M.D. Anderson Cancer Center

NCT04200534

ACTIVE NOT RECRUITING NA 226 participants

Improving the Reach & Effectiveness of Smoking Cessation Services Targeted to Veterans Living With HIV

Seattle Institute for Biomedical and Clinical Research

NCT04505371

ACTIVE NOT RECRUITING NA 153 participants

Digitally Enhanced Smoking Cessation for High Risk Smokers

Dana-Farber Cancer Institute

NCT04691297

ACTIVE NOT RECRUITING Phase 1 91 participants

Smoking Cessation for Depressed Smokers

M.D. Anderson Cancer Center

NCT00494728

ACTIVE NOT RECRUITING 60 participants

The Effect of Tobacco Products on Wound Healing

University of Minnesota

NCT04870970

ACTIVE NOT RECRUITING NA 56 participants

Smartphone-delivered Scheduled Smoking With Compliance Facilitation as an Adjunct Cessation Therapy: a Feasibility Study

M.D. Anderson Cancer Center

NCT05763771

ACTIVE NOT RECRUITING NA 50 participants

Racial Differences in Circadian and Sleep Mechanisms for Nicotine Dependence, Craving, and Withdrawal

University of Alabama at Birmingham

NCT03968900

ACTIVE NOT RECRUITING Early Phase 1 30 participants

A Study to Develop a Strategy to Increase Lung Cancer Screening in Women Who May Be at Risk for Lung Cancer

Memorial Sloan Kettering Cancer Center

NCT04848961

ACTIVE NOT RECRUITING NA 20 participants

Enhancing Mental and Physical Health of Women Veterans

VA Office of Research and Development

NCT05050266

ACTIVE NOT RECRUITING Phase 2 20 participants

Reducing Tobacco-associated Lung Cancer Risk: A Randomized Clinical Trial of AB-free Kava

University of Florida

NCT05081882

COMPLETED Phase 3 3,200 participants

Quitlink : A Leveraging Solution to Tobacco Counseling

Virginia Ambulatory Care Outcomes Research Network

NCT00112268

COMPLETED Phase 2 2,637 participants

Tobacco Cessation Via Public Health Dental Clinics

Oregon Research Institute

NCT00683839

COMPLETED NA 1,944 participants

Helping Poor Smokers Quit

Washington University School of Medicine

NCT03194958

COMPLETED NA 1,938 participants

Proactive Outreach for Smokers in VA Mental Health

VA Office of Research and Development

NCT01737281

COMPLETED NA 1,865 participants

'Questions About Quitting' Smoking Cessation Trial

Kaiser Permanente

NCT00992264

COMPLETED NA 1,298 participants

Evaluating a Telephone-Based Smoking Cessation Program Among People in the Military (The AFIII Study)

University of Tennessee

NCT00632411

COMPLETED NA 1,236 participants

A Test of Short and Long Term Naturalistic Outcomes of Smokers Who Sample Smokeless Tobacco

Medical University of South Carolina

NCT01509586

COMPLETED Phase 4 1,086 participants

A Comparative Effectiveness & Long Term Health Study in Wisconsin Smokers

University of Wisconsin, Madison

NCT01553084

COMPLETED Phase 4 987 participants

Improving the Population-Wide Effectiveness of U.S. Tobacco Cessation Quitlines

University of Wisconsin, Madison

NCT01087905

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Phase Distribution

PhaseTrial count
Phase 1 9
Phase 2 13
Phase 3 4
Phase 4 9

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Smoking Trial Landscape

124 indexed Smoking studies · 27 recruiting (22%).

Phase mix: 13 late (III/IV) vs 22 early (I/II).

Top sponsor: RAI Services Company (9 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Smoking?

PlainTrial tracks 124 US clinical trials for Smoking, of which 27 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Smoking?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.