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Smoking clinical trials
27 of 124 indexed Smoking trials are currently recruiting.
124 US clinical trials · 27 currently recruiting
Smoking is the subject of 124 registered US clinical trials on ClinicalTrials.gov, 27 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is RAI Services Company, running 9 of these trials.
The research picture
Smoking has 124 registered US clinical trials, 27 of them open to new participants right now, about 22% of the total.
- 27
- recruiting participants now
- 22%
- of trials open to enrollment
- 13
- in Phase 3–4 (later-stage)
- 9
- top sponsor: RAI Services Company
Active & Recent Trials
124 total, page 1 of 3
The Efficacy of Conventional Screening Versus mHealth Screening in Early Detection of Oral Potentially Malignant Disorders and Oral Cancer Amongst the Rural Population of Varanasi: A Prospective and Blinded Study
Memorial Sloan Kettering Cancer Center
NCT06535867
App for Reducing Cravings to Smoke
H. Lee Moffitt Cancer Center and Research Institute
NCT06088498
Refer2Quit: Evaluating a Proactive, Tailored, Population Health Approach for Tobacco Treatment for Household Smokers Through a Pediatric Care Network
Children's Hospital of Philadelphia
NCT06582693
Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies
Weill Medical College of Cornell University
NCT01776398
Personalized Tobacco Treatment in Primary Care (MOTIVATE)
Washington University School of Medicine
NCT05846841
Take A Break - Rural
Wake Forest University Health Sciences
NCT05790486
Leveraging Community Pharmacists to Optimize Smoking Cessation Services for Rural Smokers in Appalachia
University of Virginia
NCT05660525
Integrating Financial Coaching and Smoking Cessation Coaching
NYU Langone Health
NCT05154669
Technology Assisted Motivational Interviewing
University of California, San Francisco
NCT06713603
Actívatexto: Advancing Smoking Cessation and Physical Activity Among Latinos
University of Rochester
NCT06926608
Black Impact: The Mechanisms Underlying Psychosocial Stress Reduction in a Cardiovascular Health Intervention
Ohio State University
NCT06055036
Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS
Philip Morris Products S.A.
NCT07108166
Modifying Progesterone and Estradiol Levels to Prevent Postpartum Cigarette Smoking Relapse and Reduce Secondhand Smoke Exposure in Infants and Children
University of Minnesota
NCT04783857
Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction
Yale University
NCT06077240
A Study of Brenipatide in Adults Who Quit Smoking Cigarettes and Want to Avoid Relapse
Eli Lilly and Company
NCT07223840
The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers
Abramson Cancer Center at Penn Medicine
NCT06264154
Clinical Alternatives for Reducing Harm Using E-cigarettes
Medical University of South Carolina
NCT07039292
Linking Brain Network Dynamics to Imminent Smoking Lapse Risk and Behavior
Penn State University
NCT05572671
Precision Treatment to Promote Smoking Cessation and Survival in Oncology Patients
Washington University School of Medicine
NCT07166120
Enhancing Motivation to Quit Smoking Via Self-Help Intervention Targeted to Cancer Type
University of Utah
NCT06484179
Bayesian Neurobehavioral Phenotyping: From Mechanism Identification to Personalized Neuromodulation Treatments. R61 PHASE
M.D. Anderson Cancer Center
NCT06991062
Inspire HER: Inspiring the Heart and Emotions for Radical Health
University of Alabama at Birmingham
NCT06966258
Ethnic Microaggressions and Smoking Behaviors Among Latinx Adults
University of Houston
NCT05490927
The Potential of Kava in Enabling Tobacco Cessation - Its Holistic Effects in Managing Stress and Insomnia Associated With Abstinence
University of Florida
NCT05814055
Effects of a Specific Substance in Smokers
Oregon Health and Science University
NCT04281979
Abuse Liability for Five Modern Oral Nicotine Products
RAI Services Company
NCT07132814
A Study Evaluating the Use of an Indoor Air Quality Monitor to Promote a Smoke-free Home
Memorial Sloan Kettering Cancer Center
NCT06693700
Effect of Helpers Program On-line Training on Smoking Relapse and Social Networks
University of Colorado, Denver
NCT05641974
Impact of Patient-Centered Approach for Communicating Coronary Calcium on Cardiovascular Health
American College of Radiology
NCT06055972
A Pragmatic Trial of Chronic Disease Approaches to Ameliorate Tobacco Related Cardiovascular Disease Health Disparities
University of Minnesota
NCT05671380
Literacy and Smoking Risk Communications
M.D. Anderson Cancer Center
NCT00684437
Centralized Lung Cancer EARly Detection Among Smokers (CLEAR Study)
M.D. Anderson Cancer Center
NCT04200534
Improving the Reach & Effectiveness of Smoking Cessation Services Targeted to Veterans Living With HIV
Seattle Institute for Biomedical and Clinical Research
NCT04505371
Digitally Enhanced Smoking Cessation for High Risk Smokers
Dana-Farber Cancer Institute
NCT04691297
Smoking Cessation for Depressed Smokers
M.D. Anderson Cancer Center
NCT00494728
The Effect of Tobacco Products on Wound Healing
University of Minnesota
NCT04870970
Smartphone-delivered Scheduled Smoking With Compliance Facilitation as an Adjunct Cessation Therapy: a Feasibility Study
M.D. Anderson Cancer Center
NCT05763771
Racial Differences in Circadian and Sleep Mechanisms for Nicotine Dependence, Craving, and Withdrawal
University of Alabama at Birmingham
NCT03968900
A Study to Develop a Strategy to Increase Lung Cancer Screening in Women Who May Be at Risk for Lung Cancer
Memorial Sloan Kettering Cancer Center
NCT04848961
Enhancing Mental and Physical Health of Women Veterans
VA Office of Research and Development
NCT05050266
Reducing Tobacco-associated Lung Cancer Risk: A Randomized Clinical Trial of AB-free Kava
University of Florida
NCT05081882
Quitlink : A Leveraging Solution to Tobacco Counseling
Virginia Ambulatory Care Outcomes Research Network
NCT00112268
Tobacco Cessation Via Public Health Dental Clinics
Oregon Research Institute
NCT00683839
Helping Poor Smokers Quit
Washington University School of Medicine
NCT03194958
Proactive Outreach for Smokers in VA Mental Health
VA Office of Research and Development
NCT01737281
'Questions About Quitting' Smoking Cessation Trial
Kaiser Permanente
NCT00992264
Evaluating a Telephone-Based Smoking Cessation Program Among People in the Military (The AFIII Study)
University of Tennessee
NCT00632411
A Test of Short and Long Term Naturalistic Outcomes of Smokers Who Sample Smokeless Tobacco
Medical University of South Carolina
NCT01509586
A Comparative Effectiveness & Long Term Health Study in Wisconsin Smokers
University of Wisconsin, Madison
NCT01553084
Improving the Population-Wide Effectiveness of U.S. Tobacco Cessation Quitlines
University of Wisconsin, Madison
NCT01087905
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 9 |
| Phase 2 | 13 |
| Phase 3 | 4 |
| Phase 4 | 9 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Smoking Trial Landscape
124 indexed Smoking studies · 27 recruiting (22%).
Phase mix: 13 late (III/IV) vs 22 early (I/II).
Top sponsor: RAI Services Company (9 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Smoking?
PlainTrial tracks 124 US clinical trials for Smoking, of which 27 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Smoking?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.