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Smoking clinical trials
27 of 124 indexed Smoking trials are currently recruiting.
124 US clinical trials · 27 currently recruiting
Smoking is the subject of 124 registered US clinical trials on ClinicalTrials.gov, 27 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is RAI Services Company, running 9 of these trials.
The research picture
Smoking has 124 registered US clinical trials, 27 of them open to new participants right now, about 22% of the total.
- 27
- recruiting participants now
- 22%
- of trials open to enrollment
- 13
- in Phase 3–4 (later-stage)
- 9
- top sponsor: RAI Services Company
Active & Recent Trials
124 total, page 2 of 3
Cessation Service Use and Effectiveness for Hospitalized Smokers
Kaiser Permanente
NCT01236079
A Medical Assistant-Based Program to Promote Healthy Behaviors in Primary Care
The University of Texas Health Science Center at San Antonio
NCT00273806
Survey of Smokers Treated in the Emergency Department (ED) on Ownership and Usage of Cell Phones
Yale University
NCT01820533
Improving Tobacco Treatment Rates for Cancer Patients Who Smoke
Abramson Cancer Center at Penn Medicine
NCT04738643
A 26-week Extension of the ZRHR-ERS-09-US Study Evaluating Biological and Functional Changes in Healthy Smokers After Switching to THS 2.2
Philip Morris Products S.A.
NCT02649556
Clinical Outcomes of a Nationwide, Naturalistic E-Cig Trial (CONNECT)
Medical University of South Carolina
NCT03453385
Connect to Quit for Smoking
University of Pittsburgh
NCT01299896
Asian Youth and Tobacco Control Survey
M.D. Anderson Cancer Center
NCT00642317
Telephone Care Coordination for Smokers in VA Mental Health Clinics
VA Office of Research and Development
NCT00724308
Proactive Health Intervention for Tobacco Users (Get PHIT)
Kaiser Permanente
NCT00169260
Study of TA-NIC to Assess the Efficacy and Safety of the Vaccine as an Aid to Smoking Cessation
Celtic Pharma Development Services
NCT00633321
Identifying Treatments to Motivate Smokers to Quit
University of Wisconsin, Madison
NCT01122238
Tobacco Status Project: Social Media Intervention for Young Adult Smokers
University of California, San Francisco
NCT02207036
Bupropion SR Plus Counseling for Smoking Cessation
University of Wisconsin, Madison
NCT01621009
Improving Health Behaviors Through Telephone Linked Care
American Academy of Family Physicians
NCT00314197
Efficacy of Naltrexone in Women's Smoking Cessation
University of Chicago
NCT00271024
HIV-related Accelerated Aging of the Airway Epithelium
Weill Medical College of Cornell University
NCT01974219
Strategies to Avoid Returning to Smoking
University of Pittsburgh
NCT00757068
Evaluating the Effects of Supplemental Vitamin C on Infant Lung Function in Pregnant Smoking Women
Oregon Health and Science University
NCT00632476
Protecting the 'Hood Against Tobacco
University of California, San Francisco
NCT00187603
Smoking Cessation for Adults With Attention Deficit Hyperactivity Disorder (ADHD)
University of Cincinnati
NCT00253747
Bupropion for Hospitalized Smokers With Acute Cardiovascular Disease
Massachusetts General Hospital
NCT00181818
Group Counseling for Smoking Cessation
American University
NCT00104481
Tobacco Tactics Website for Operating Engineers
University of Michigan
NCT01124110
CSD170304: Study to Assess Nicotine Uptake in Smokers From Electronic and Combustible Cigarettes
RAI Services Company
NCT03294356
Innovative Smartphone Application of a New Behavioral Method to Quit Smoking: Pilot Trial (Smart Quit)
Fred Hutchinson Cancer Center
NCT01812070
CSD210903: A Study to Determine Subject Puffing Patterns of a Heated Tobacco Product With Four Non-Combusted Cigarette Variants in an Ambulatory Setting
RAI Services Company
NCT05307822
Smoking Tobacco and Drinking Study
University of California, San Francisco
NCT03163303
Physiological Responses in Tobacco Chippers
Oregon Health and Science University
NCT01237834
A Facebook Intervention for Young Sexual and Gender Minority Smokers
University of California, San Francisco
NCT03259360
CPT-SMART for Treatment of PTSD and Cigarette Smoking
VA Office of Research and Development
NCT03978442
Alpha-1 Carrier Genomics Study
Medical University of South Carolina
NCT02810327
The Moment Study: Mixed Method E-cigarette Study
Truth Initiative
NCT02261363
N-acetylcysteine for Tobacco Use Disorder
Medical University of South Carolina
NCT02737358
CSD170501: Study to Assess Biomarkers of Tobacco Exposure in Smokers During In-Clinic Confinement Switch to an Electronic Cigarette
RAI Services Company
NCT03170674
Computer-Assisted Intervention for Smoking During Pregnancy
Wayne State University
NCT01028131
Long-term Varenicline Treatment for Smoking Cessation
University of Wisconsin, Madison
NCT00828113
Electronic Cigarettes (E-cigarettes) as a Harm Reduction Strategy
NYU Langone Health
NCT02628964
Modeling Stress-precipitated Smoking Behavior for Medication Development
Yale University
NCT00773357
Hollings Cancer Center Varenicline Sampling Study
Medical University of South Carolina
NCT03742154
Oxidative Stress and Vitamin E Requirements
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00067899
Parent Willingness to Participate in Tobacco Trials in the Pediatric Clinical Setting
St. Jude Children's Research Hospital
NCT01673243
A Pilot Randomized Controlled Trial of Financial Incentives, Text Messaging, and Usual Care for Homeless Smokers
Massachusetts General Hospital
NCT02565381
Increasing Cessation Motivation and Treatment Engagement Among Smokers in Pain
Syracuse University
NCT03996902
CSD200907: A Study to Assess Elements of Abuse Liability for a Heated Tobacco Product With Four Non-Combusted Cigarette Variants
RAI Services Company
NCT05114863
Impact of Low Nicotine Cigarette Messaging on Perceptions and Cigarette Choices
Masonic Cancer Center, University of Minnesota
NCT04740008
Connecting Alaska Native People to Quit Smoking
Mayo Clinic
NCT03645941
Smoking Cessation Smartphone App for Cancer Patients (Quit2Heal Study)
Fred Hutchinson Cancer Center
NCT03600038
Young Adults' Reactions to Low Nicotine Cigarette Advertising
Abramson Cancer Center at Penn Medicine
NCT04906148
Effects of Sulforaphane (SFN) on Immune Response to Live Attenuated Influenza Virus in Smokers and Nonsmokers
University of North Carolina, Chapel Hill
NCT01269723
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 9 |
| Phase 2 | 13 |
| Phase 3 | 4 |
| Phase 4 | 9 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Smoking Trial Landscape
124 indexed Smoking studies · 27 recruiting (22%).
Phase mix: 13 late (III/IV) vs 22 early (I/II).
Top sponsor: RAI Services Company (9 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Smoking?
PlainTrial tracks 124 US clinical trials for Smoking, of which 27 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Smoking?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.