Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Smoking: early-phase trial registry
27 of 124 indexed Smoking trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #96 of 28,707 conditions by registered trial count.
124 US clinical trials · 27 currently recruiting · #96 of 28,707 conditions by registered trial count
Smoking: 124 US clinical trials tracked, 27 recruiting.
Smoking is the subject of 124 registered US clinical trials on ClinicalTrials.gov, 27 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is RAI Services Company, running 9 of these trials.
Enrollment posture brief
Registry condition smoking
OPEN 27 | RECR 22% | LATE 13 | EARLY 22 | RANK #96 | SPON 9
Volume-matched condition peers
Nearest open-share peer: Plaque Psoriasis (22% recruiting · 46 trials)
Smoking lists 27 open slots (22% of 124 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Smoking on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Smoking is recruiting below its size-band peers.
27 of 124 indexed trials (21.8%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Smoking trials is spread across many organizations.
RAI Services Company accounts for 9 of 124 trials (7.3%). 62 distinct sponsors appear on at least one study for this condition label.
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Typical Smoking enrolment sits around 165 participants.
Median target enrolment is 165 among the 124 trials that report a genuine target (sentinel values excluded). 48 of those (38.7%) plan for fewer than 100 participants.
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Smoking research is mostly interventional.
113 interventional and 11 observational studies make up this index (91.1% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
124 total, page 2 of 3
Cessation Service Use and Effectiveness for Hospitalized Smokers
Kaiser Permanente
NCT01236079
A Medical Assistant-Based Program to Promote Healthy Behaviors in Primary Care
The University of Texas Health Science Center at San Antonio
NCT00273806
Survey of Smokers Treated in the Emergency Department (ED) on Ownership and Usage of Cell Phones
Yale University
NCT01820533
Improving Tobacco Treatment Rates for Cancer Patients Who Smoke
Abramson Cancer Center at Penn Medicine
NCT04738643
A 26-week Extension of the ZRHR-ERS-09-US Study Evaluating Biological and Functional Changes in Healthy Smokers After Switching to THS 2.2
Philip Morris Products S.A.
NCT02649556
Clinical Outcomes of a Nationwide, Naturalistic E-Cig Trial (CONNECT)
Medical University of South Carolina
NCT03453385
Connect to Quit for Smoking
University of Pittsburgh
NCT01299896
Asian Youth and Tobacco Control Survey
M.D. Anderson Cancer Center
NCT00642317
Telephone Care Coordination for Smokers in VA Mental Health Clinics
VA Office of Research and Development
NCT00724308
Proactive Health Intervention for Tobacco Users (Get PHIT)
Kaiser Permanente
NCT00169260
Study of TA-NIC to Assess the Efficacy and Safety of the Vaccine as an Aid to Smoking Cessation
Celtic Pharma Development Services
NCT00633321
Identifying Treatments to Motivate Smokers to Quit
University of Wisconsin, Madison
NCT01122238
Tobacco Status Project: Social Media Intervention for Young Adult Smokers
University of California, San Francisco
NCT02207036
Bupropion SR Plus Counseling for Smoking Cessation
University of Wisconsin, Madison
NCT01621009
Improving Health Behaviors Through Telephone Linked Care
American Academy of Family Physicians
NCT00314197
Efficacy of Naltrexone in Women's Smoking Cessation
University of Chicago
NCT00271024
HIV-related Accelerated Aging of the Airway Epithelium
Weill Medical College of Cornell University
NCT01974219
Strategies to Avoid Returning to Smoking
University of Pittsburgh
NCT00757068
Evaluating the Effects of Supplemental Vitamin C on Infant Lung Function in Pregnant Smoking Women
Oregon Health and Science University
NCT00632476
Protecting the 'Hood Against Tobacco
University of California, San Francisco
NCT00187603
Smoking Cessation for Adults With Attention Deficit Hyperactivity Disorder (ADHD)
University of Cincinnati
NCT00253747
Bupropion for Hospitalized Smokers With Acute Cardiovascular Disease
Massachusetts General Hospital
NCT00181818
Group Counseling for Smoking Cessation
American University
NCT00104481
Tobacco Tactics Website for Operating Engineers
University of Michigan
NCT01124110
CSD170304: Study to Assess Nicotine Uptake in Smokers From Electronic and Combustible Cigarettes
RAI Services Company
NCT03294356
Innovative Smartphone Application of a New Behavioral Method to Quit Smoking: Pilot Trial (Smart Quit)
Fred Hutchinson Cancer Center
NCT01812070
CSD210903: A Study to Determine Subject Puffing Patterns of a Heated Tobacco Product With Four Non-Combusted Cigarette Variants in an Ambulatory Setting
RAI Services Company
NCT05307822
Smoking Tobacco and Drinking Study
University of California, San Francisco
NCT03163303
Physiological Responses in Tobacco Chippers
Oregon Health and Science University
NCT01237834
A Facebook Intervention for Young Sexual and Gender Minority Smokers
University of California, San Francisco
NCT03259360
CPT-SMART for Treatment of PTSD and Cigarette Smoking
VA Office of Research and Development
NCT03978442
Alpha-1 Carrier Genomics Study
Medical University of South Carolina
NCT02810327
The Moment Study: Mixed Method E-cigarette Study
Truth Initiative
NCT02261363
N-acetylcysteine for Tobacco Use Disorder
Medical University of South Carolina
NCT02737358
CSD170501: Study to Assess Biomarkers of Tobacco Exposure in Smokers During In-Clinic Confinement Switch to an Electronic Cigarette
RAI Services Company
NCT03170674
Computer-Assisted Intervention for Smoking During Pregnancy
Wayne State University
NCT01028131
Long-term Varenicline Treatment for Smoking Cessation
University of Wisconsin, Madison
NCT00828113
Electronic Cigarettes (E-cigarettes) as a Harm Reduction Strategy
NYU Langone Health
NCT02628964
Modeling Stress-precipitated Smoking Behavior for Medication Development
Yale University
NCT00773357
Hollings Cancer Center Varenicline Sampling Study
Medical University of South Carolina
NCT03742154
Oxidative Stress and Vitamin E Requirements
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00067899
Parent Willingness to Participate in Tobacco Trials in the Pediatric Clinical Setting
St. Jude Children's Research Hospital
NCT01673243
A Pilot Randomized Controlled Trial of Financial Incentives, Text Messaging, and Usual Care for Homeless Smokers
Massachusetts General Hospital
NCT02565381
Increasing Cessation Motivation and Treatment Engagement Among Smokers in Pain
Syracuse University
NCT03996902
CSD200907: A Study to Assess Elements of Abuse Liability for a Heated Tobacco Product With Four Non-Combusted Cigarette Variants
RAI Services Company
NCT05114863
Impact of Low Nicotine Cigarette Messaging on Perceptions and Cigarette Choices
Masonic Cancer Center, University of Minnesota
NCT04740008
Connecting Alaska Native People to Quit Smoking
Mayo Clinic
NCT03645941
Smoking Cessation Smartphone App for Cancer Patients (Quit2Heal Study)
Fred Hutchinson Cancer Center
NCT03600038
Young Adults' Reactions to Low Nicotine Cigarette Advertising
Abramson Cancer Center at Penn Medicine
NCT04906148
Effects of Sulforaphane (SFN) on Immune Response to Live Attenuated Influenza Virus in Smokers and Nonsmokers
University of North Carolina, Chapel Hill
NCT01269723
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 9 |
| Phase 2 | 13 |
| Phase 3 | 4 |
| Phase 4 | 9 |
Top Sponsors
Named interventions
Most-linked intervention names on Smoking records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Smoking trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Smoking page
124 registered trials, 27 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 27 Smoking trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- RAI Services Company sponsors the most Smoking trials on record, review their full trial history before evaluating a specific study. See RAI Services Company's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Smoking condition card totals 124 registered trials; most-linked intervention Placebo; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.