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NCT07217652 · ClinicalTrials.gov registry record · NA
Investigating Mediodorsal Thalamus Representations Underlying Human Cognitive Flexibility
A NA study of Schizophrenia and Attention Deficit Disorder With Hyperactivity (ADHD), sponsored by Kai Hwang.
- Recruiting
- Registry status
- NA
- Development phase
- 100
- Enrollment target
- 1
- Study location
NCT07217652 is a NA study of Schizophrenia and Attention Deficit Disorder With Hyperactivity (ADHD) that is actively recruiting participants, run by Kai Hwang. The registered enrollment target is 100 participants, below the 219-participant average among 315 other Schizophrenia trials with a reported enrollment target (54% lower). The trial reports 1 study location across 1 state.
The verdict
NCT07217652, a NA study of Schizophrenia and Attention Deficit Disorder With Hyperactivity (ADHD), is actively recruiting participants, sponsored by Kai Hwang.
- RECRUITING
- Registry status
- NA
- Development phase
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this basic experimental research study is to examine how the human thalamus supports flexible thinking and behavior. Specifically, the research aims to elucidate how the mediodorsal (MD) thalamus encodes and updates "context"-the mental framework that determines which rules or actions are relevant in a given situation. This work may contribute to understanding why certain psychiatric conditions, such as schizophrenia and ADHD, involve difficulties with cognitive flexibility and control. The primary research questions are: Does the MD thalamus represent the context that organizes how working memory guides task selection? Does the MD thalamus signal when context needs to be updated after a change in task demands? Do these thalamic representations support generalization to new situations or rules? Participants will complete cognitive tasks while undergoing high-resolution brain imaging using 7-Tesla MRI. The investigators will combine behavioral data, computational modeling, and advanced neuroimaging analyses to examine how the thalamus interacts with the cortex during flexible decision-making.
Conditions Studied
Interventions
- OTHER High-resolution fMRI during working memory, cognitive control, and decision-making tasks
Study Locations (1)
Iowa
- The University of Iowa - Iowa City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2025-12-01 |
| Est. Completion | 2030-07-30 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07217652
The ClinicalTrials.gov registry entry for NCT07217652 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 100 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 219-participant average among 315 other Schizophrenia trials with a reported enrollment target (54% lower). The listed sponsor is Kai Hwang, which has 2 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Schizophrenia appearing as the primary indexed condition, and to 1 intervention - of which High-resolution fMRI during working memory, cognitive control, and decision-making tasks is the first listed.
NCT07217652 reports 1 study location spanning 1 distinct geographic area - top geographies include Iowa.
Frequently Asked Questions
What is clinical trial NCT07217652 about?
NCT07217652 is a clinical study titled "Investigating Mediodorsal Thalamus Representations Underlying Human Cognitive Flexibility". The goal of this basic experimental research study is to examine how the human thalamus supports flexible thinking and behavior. Specifically, the research aims to elucidate how the mediodorsal (MD) thalamus encodes and updates "context"-the mental framework that determines which rules or actions ar...
What is the current status of trial NCT07217652?
This trial is currently recruiting. It is a NA study. The enrollment target is 100 participants. The study started on 2025-12-01. Estimated completion is 2030-07-30.
What conditions does trial NCT07217652 study?
This clinical trial studies the following conditions: Schizophrenia, Attention Deficit Disorder With Hyperactivity (ADHD).
What interventions are being tested in trial NCT07217652?
The interventions under investigation include: High-resolution fMRI during working memory, cognitive control, and decision-making tasks (OTHER).
Who is sponsoring clinical trial NCT07217652?
This trial is sponsored by Kai Hwang, which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07217652 being conducted?
This trial has 1 study location across Iowa. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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