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NCT05890183 · ClinicalTrials.gov registry record · NA

Improving Cognition Through Telehealth Aerobic Exercise and Cognitive Training After a First Schizophrenia Episode

A NA study of Schizophrenia and Schizoaffective Disorder, sponsored by University of California, Los Angeles.

Recruiting
Registry status
NA
Development phase
100
Enrollment target
1
Study location

NCT05890183: Recruiting NA study of Schizophrenia and Schizoaffective Disorder, sponsored by University of California, Los Angeles.

NCT05890183 is a NA study of Schizophrenia and Schizoaffective Disorder that is actively recruiting participants, run by University of California, Los Angeles. The registered enrollment target is 100 participants, below the 219-participant average among 315 other Schizophrenia trials with a reported enrollment target (54% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT05890183, a NA study of Schizophrenia and Schizoaffective Disorder, is actively recruiting participants, sponsored by University of California, Los Angeles.

RECRUITING
Registry status
NA
Development phase
100 participants
Enrollment target
1
Study location

Study Summary

The participants in the study will receive psychiatric treatment at the UCLA Aftercare Research Program. All participants in this 12-month RCT will receive cognitive training. Half of the patients will also be randomly assigned to the aerobic exercise and strength training condition, and the other half will be randomly assigned to the Healthy Living Group condition. The primary outcome measures are improvement in cognition and level of engagement in the in-group and at-home exercise sessions. Increases in the level of the patient's serum brain-derived neurotropic factor (specifically Mature BDNF) which causes greater brain neuroplasticity and is indicator of engagement in aerobic exercise, will be measured early in the treatment phase in order to confirm engagement of this target. In order to demonstrate the feasibility and portability of this intervention outside of academic research programs, the interventions will be provided via videoconferencing. The proposed study will incorporate additional methods to maximize participation in the exercise condition, including the use of the Moderated Online Social Therapy (MOST) platform to enhance motivation for treatment based on Self-Determination Theory principles, and a "bridging" group to help the participants generalize gains to everyday functioning. In addition, the exercise group participants will receive personally tailored text reminders to exercise.

Primary Outcome

A brain neurotrophic factor that stimulates synaptic plasticity and neurogenesis

Conditions Studied

Schizophrenia Schizoaffective Disorder Schizophreniform Disorder

Interventions

  • BEHAVIORAL Cognitive training
  • BEHAVIORAL Aerobic Exercise Program
  • BEHAVIORAL Moderated Online Social Therapy (MOST)
  • BEHAVIORAL Chorus Participatory Text Messaging Program
  • BEHAVIORAL Healthy Living Group (HLG)

Study Locations (1)

California

  • UCLA Aftercare Research Program - Los Angeles

Trial Details

FieldValue
Enrollment Target 100 participants
Start Date 2023-05-23
Est. Completion 2028-05-31
Phase NA
University of California, Los Angeles

897 total trials

What NCT05890183 shows while recruiting

NCT05890183 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 219-participant average among 315 other Schizophrenia trials with a reported enrollment target (54% lower).

The record links to 3 conditions, with Schizophrenia appearing as the primary indexed condition, and to 5 interventions - of which Cognitive training is the first listed.

NCT05890183 reports a single indexed study location in California.

Frequently Asked Questions

What is clinical trial NCT05890183 about?

NCT05890183 is a clinical study titled "Improving Cognition Through Telehealth Aerobic Exercise and Cognitive Training After a First Schizophrenia Episode". The participants in the study will receive psychiatric treatment at the UCLA Aftercare Research Program. All participants in this 12-month RCT will receive cognitive training. Half of the patients will also be randomly assigned to the aerobic exercise and strength training condition, and the other h...

What is the current status of trial NCT05890183?

This trial is currently recruiting. It is a NA study. The enrollment target is 100 participants. The study started on 2023-05-23. Estimated completion is 2028-05-31.

What conditions does trial NCT05890183 study?

This clinical trial studies the following conditions: Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder.

What interventions are being tested in trial NCT05890183?

The interventions under investigation include: Cognitive training (BEHAVIORAL), Aerobic Exercise Program (BEHAVIORAL), Moderated Online Social Therapy (MOST) (BEHAVIORAL), Chorus Participatory Text Messaging Program (BEHAVIORAL), Healthy Living Group (HLG) (BEHAVIORAL).

Who is sponsoring clinical trial NCT05890183?

This trial is sponsored by University of California, Los Angeles, which has 897 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05890183 being conducted?

This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Schizophrenia

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT05890183's enrollment target sits among peer trials

100 140th of 315 higher than 169 of 315 other Schizophrenia trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Schizophrenia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT05890183

Source: ClinicalTrials.gov NCT05890183, the US trial registry maintained by the National Library of Medicine. NCT05890183 (mid enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.