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NCT04940663 · ClinicalTrials.gov registry record · NA
Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness
A NA study of Schizophrenia and Psychosis, sponsored by Massachusetts General Hospital.
- Recruiting
- Registry status
- NA
- Development phase
- 120
- Enrollment target
- 1
- Study location
NCT04940663: Recruiting NA study of Schizophrenia and Psychosis, sponsored by Massachusetts General Hospital.
NCT04940663 is a NA study of Schizophrenia and Psychosis that is actively recruiting participants, run by Massachusetts General Hospital. The registered enrollment target is 120 participants, below the 219-participant average among 315 other Schizophrenia trials with a reported enrollment target (45% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04940663, a NA study of Schizophrenia and Psychosis, is actively recruiting participants, sponsored by Massachusetts General Hospital.
- RECRUITING
- Registry status
- NA
- Development phase
- 120 participants
- Enrollment target
- 1
- Study location
Study Summary
The proposed research will test the hypothesis that objective social isolation and loneliness are linked to neurobehavioral mechanisms involved in social perception and motivation in individuals with and without serious mental illness. Moreover, it will investigate the specific dynamic interactions among these experiences in daily life and how they, and their neurobehavioral predictors, are linked to day-to-day functioning. The findings of this project could provide novel targets for therapeutics aimed at improving functioning and overall quality of life in individuals with serious mental illnesses, as well as quantitative phenotypes for use in early detection efforts.
Primary Outcome
UCLA Loneliness Scale(20 and 4 item), Social Network Index, Social Anhedonia Scale, Penn facial affect recognition Task, Social Disconnectedness Scale, Social Provisions Scale
Conditions Studied
Interventions
- BEHAVIORAL EMA
Study Locations (1)
Massachusetts
- Massachusetts General Hospital - Charlestown
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 120 participants |
| Start Date | 2022-07-13 |
| Est. Completion | 2026-06 |
| Phase | NA |
What NCT04940663 shows while recruiting
NCT04940663 is an interventional study that assigns participants to a tested intervention. The registered 120 participants enrollment target is mid-sized for trials with a published cap, below the 219-participant average among 315 other Schizophrenia trials with a reported enrollment target (45% lower).
The record links to 2 conditions, with Schizophrenia appearing as the primary indexed condition, and to 1 intervention - of which EMA is the first listed.
NCT04940663 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT04940663 about?
NCT04940663 is a clinical study titled "Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness". The proposed research will test the hypothesis that objective social isolation and loneliness are linked to neurobehavioral mechanisms involved in social perception and motivation in individuals with and without serious mental illness. Moreover, it will investigate the specific dynamic interactions ...
What is the current status of trial NCT04940663?
This trial is currently recruiting. It is a NA study. The enrollment target is 120 participants. The study started on 2022-07-13. Estimated completion is 2026-06.
What conditions does trial NCT04940663 study?
This clinical trial studies the following conditions: Schizophrenia, Psychosis.
What interventions are being tested in trial NCT04940663?
The interventions under investigation include: EMA (BEHAVIORAL).
Who is sponsoring clinical trial NCT04940663?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04940663 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Schizophrenia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04940663's enrollment target sits among peer trials
120 120th of 315 higher than 190 of 315 other Schizophrenia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Schizophrenia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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