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NCT07196462 · ClinicalTrials.gov registry record · NA
Precision Brain Stimulation to Reduce Cannabis Craving in Schizophrenia
A NA study of Schizophrenia and Cannabis Use, sponsored by Vanderbilt University Medical Center.
- Recruiting
- Registry status
- NA
- Development phase
- 100
- Enrollment target
- 1
- Study location
NCT07196462: Recruiting NA study of Schizophrenia and Cannabis Use, sponsored by Vanderbilt University Medical Center.
NCT07196462 is a NA study of Schizophrenia and Cannabis Use that is actively recruiting participants, run by Vanderbilt University Medical Center. The registered enrollment target is 100 participants, below the 219-participant average among 315 other Schizophrenia trials with a reported enrollment target (54% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07196462, a NA study of Schizophrenia and Cannabis Use, is actively recruiting participants, sponsored by Vanderbilt University Medical Center.
- RECRUITING
- Registry status
- NA
- Development phase
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
The central hypothesis is this: Brain circuits most relevant to cannabis use in schizophrenia are distinct from pathways identified in healthy controls who use cannabis. This study seeks to provide evidence that targeted stimulation of the DMN leads to both altered network activity and a concomitant behavioral change in cue-induced craving and cognitive performance in individuals with schizophrenia and schizoaffective disorder, while targeted stimulation of the L DLPFC leads to these changes in healthy controls who use cannabis. This study will test a model that integrates brain network pathophysiology and cognition to 1) explain the prevalence of cannabis use in schizophrenia and 2) identify a target for engagement in schizophrenia. This study seeks to establish a neuroscientific framework to guide future treatment-oriented studies aimed at reducing craving and improving cognitive performance in individuals with schizophrenia and schizoaffective disorder. This is a study of the effect of 2 rTMS interventions on functional connectivity and craving in individuals with schizophrenia or schizoaffective disorder and healthy controls who use cannabis. Aim 1: Target Engagement: Determine if rTMS manipulates functional connectivity of each target (DMN, L DLPFC) (n=100). Aim 2: Clinical Efficacy: Determine if rTMS affects cue-induced craving and if craving change correlates with change in functional connectivity (n=100). As an exploratory analysis, the factors that explain individual variance in rTMS-induced connectivity change will also be explored.
Primary Outcome
Cue-induced craving will be measured using a 0-10 Visual Analog Scale (VAS) before, during, and after in-scanner presentation of visual cannabis cues. Whole DMN and L DLPFC-left insula connectivity will be calculated.
Conditions Studied
Interventions
- DEVICE 3 Minute iTBS to the L DLPFC
- DEVICE One-Minute, Personalized, DMN Targeted CTBS
Study Locations (1)
Tennessee
- Vanderbilt Psychiatric Hospital - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2026-01-15 |
| Est. Completion | 2027-12-31 |
| Phase | NA |
What NCT07196462 shows while recruiting
NCT07196462 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 219-participant average among 315 other Schizophrenia trials with a reported enrollment target (54% lower).
The record links to 4 conditions, with Schizophrenia appearing as the primary indexed condition, and to 2 interventions - of which 3 Minute iTBS to the L DLPFC is the first listed.
NCT07196462 reports a single indexed study location in Tennessee.
Frequently Asked Questions
What is clinical trial NCT07196462 about?
NCT07196462 is a clinical study titled "Precision Brain Stimulation to Reduce Cannabis Craving in Schizophrenia". The central hypothesis is this: Brain circuits most relevant to cannabis use in schizophrenia are distinct from pathways identified in healthy controls who use cannabis. This study seeks to provide evidence that targeted stimulation of the DMN leads to both altered network activity and a concomitant...
What is the current status of trial NCT07196462?
This trial is currently recruiting. It is a NA study. The enrollment target is 100 participants. The study started on 2026-01-15. Estimated completion is 2027-12-31.
What conditions does trial NCT07196462 study?
This clinical trial studies the following conditions: Schizophrenia, Cannabis Use, Psychosis, rTMS.
What interventions are being tested in trial NCT07196462?
The interventions under investigation include: 3 Minute iTBS to the L DLPFC (DEVICE), One-Minute, Personalized, DMN Targeted CTBS (DEVICE).
Who is sponsoring clinical trial NCT07196462?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07196462 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Schizophrenia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07196462's enrollment target sits among peer trials
100 140th of 315 higher than 169 of 315 other Schizophrenia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Schizophrenia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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