Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

COMPLETED Phase 2

Study to Assess Safety and Effectiveness of Branebrutinib Treatment in Participants With Active Systemic Lupus Erythematosus or Primary Sjögren's Syndrome, or Branebrutinib Treatment Followed by Open-label Abatacept Treatment in Study Participants With Active Rheumatoid Arthritis

NCT04186871 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to evaluate the safety and effectiveness of treatment with branebrutinib treatment in participants with active systemic Lupus Erythematosus (SLE) or Primary Sjögren's Syndrome (pSS), or branebrutinib treatment followed by open-label abatacept treatment in study participants with active Rheumatoid Arthritis (RA).

Interventions

  • DRUG abatacept
  • DRUG branebrutinib
  • DRUG branebrutinib placebo

Study Locations (20)

Florida

  • Local Institution — Brandon
  • Local Institution - 0062 — DeBary
  • Local Institution - 0035 — Hialeah
  • Local Institution — Jacksonville
  • Local Institution - 0029 — Plantation

California

  • Local Institution - 0002 — Covina
  • Local Institution - 0024 — Encino
  • Local Institution - 0034 — San Diego
  • Local Institution - 0032 — Upland

Michigan

  • Local Institution - 0041 — Ann Arbor
  • Local Institution - 0082 — Grand Blanc

Missouri

  • Local Institution - 0096 — St Louis
  • Local Institution - 0040 — St Louis

Arizona

  • Local Institution - 0019 — Phoenix

Georgia

  • Local Institution - 0009 — Lawrenceville

Illinois

  • Local Institution - 0014 — Skokie

Indiana

  • Local Institution — Evansville

Trial Details

FieldValue
Enrollment Target 119 participants
Start Date 2020-01-07
Est. Completion 2022-12-05
Phase Phase 2

Sponsor

Bristol-Myers Squibb

504 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04186871

The ClinicalTrials.gov registry entry for NCT04186871 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 119 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Bristol-Myers Squibb, which has 504 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 4 conditions, with Rheumatoid Arthritis appearing as the primary indexed condition, and to 3 interventions — of which abatacept is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04186871 reports 20 study locations spanning 11 distinct geographic areas — top geographies include Florida, California, Michigan. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04186871 about?

NCT04186871 is a clinical study titled "Study to Assess Safety and Effectiveness of Branebrutinib Treatment in Participants With Active Systemic Lupus Erythematosus or Primary Sjögren's Syndrome, or Branebrutinib Treatment Followed by Open-label Abatacept Treatment in Study Participants With Active Rheumatoid Arthritis". The purpose of this study is to evaluate the safety and effectiveness of treatment with branebrutinib treatment in participants with active systemic Lupus Erythematosus (SLE) or Primary Sjögren's Syndrome (pSS), or branebrutinib treatment followed by open-label abatacept treatment in study participa...

What is the current status of trial NCT04186871?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 119 participants. The study started on 2020-01-07. Estimated completion is 2022-12-05.

What conditions does trial NCT04186871 study?

This clinical trial studies the following conditions: Rheumatoid Arthritis, Systemic Lupus Erythematosus, Primary Sjögren's Syndrome, Autoimmune Disorder. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04186871?

The interventions under investigation include: abatacept (DRUG), branebrutinib (DRUG), branebrutinib placebo (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04186871?

This trial is sponsored by Bristol-Myers Squibb, which has 504 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04186871 being conducted?

This trial has 20 study locations across Arizona, California, Florida, Georgia, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial