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ClinicalTrials.gov 37 recruiting now official registry

Rheumatoid Arthritis clinical trials

37 of 199 indexed Rheumatoid Arthritis trials are currently recruiting.

199 US clinical trials · 37 currently recruiting

Rheumatoid Arthritis is the subject of 199 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 32 are in Phase 3-4 (later-stage) and 77 in Phase 1-2 (earlier-stage). The most active sponsor is Zimmer Biomet, running 13 of these trials.

The research picture

Rheumatoid Arthritis has 199 registered US clinical trials, 37 of them open to new participants right now, about 19% of the total.

37
recruiting participants now
19%
of trials open to enrollment
32
in Phase 3–4 (later-stage)
13
top sponsor: Zimmer Biomet
Phase 133Phase 244Phase 325Phase 47

Active & Recent Trials

199 total, page 4 of 4

COMPLETED Phase 2 51 participants

Multicenter Study to Evaluate CRx-102 vs. Each of Its Components to Treat Active Rheumatoid Arthritis

Zalicus

NCT00551707

COMPLETED NA 51 participants

Gold Factor on Knee Joint Health and Function

4Life Research

NCT05347602

COMPLETED NA 50 participants

Rheumatoid Arthritis Coping Enhancement

Duke University

NCT04246827

COMPLETED Phase 2 50 participants

A Study Exploring the Safety, Tolerability and Efficacy of a 4 Week Course of INCB018424 in Subjects With Active Rheumatoid Arthritis

Incyte Corporation

NCT00550043

COMPLETED Phase 2 50 participants

A Safety Analysis of Oral Prednisone as a Pre-Treatment for Rituximab in Rheumatoid Arthritis.

University of South Florida

NCT00580229

COMPLETED Phase 1 48 participants

Safety, Tolerability, and Pharmacokinetics of a Single Oral Dose of SKI-O-703 in Healthy Volunteers

Oscotec

NCT02717988

COMPLETED 46 participants

Analysis of B Cells From Autoimmune Individuals

University of Colorado, Denver

NCT02747277

COMPLETED Phase 1 44 participants

A Study of JNJ-67484703 in Participants With Active Rheumatoid Arthritis

Janssen Research & Development

NCT04985812

COMPLETED Phase 2 43 participants

A Magnetic Resonance Imaging Study and Arthroscopic Biopsy Substudy in Subjects With Active Rheumatoid Arthritis Receiving VX-509, an Oral JAK3 Inhibitor

Vertex Pharmaceuticals Incorporated

NCT01754935

COMPLETED NA 40 participants

Ultrasound Assessment of Rheumatoid Arthritis Patients Who Changed Diet

Veena Ranganath, MD, MS

NCT02881307

COMPLETED 40 participants

CLUE Study: Connective Tissue Disease Leg Ulcer Etiology Study

George Washington University

NCT00522002

COMPLETED Phase 2 36 participants

The Role of Cytokines on Growth Hormone Suppression in Premenopausal Women With Rheumatoid Arthritis and the Effect of Treatment With Etanercept

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

NCT00034060

COMPLETED Phase 1 36 participants

Acetabular Shell Positioning Using Patient Specific Instruments

The Cleveland Clinic

NCT01791738

COMPLETED Phase 3 34 participants

Benefits of Injectable Abatacept Using Magnetic Resonance Imaging (MRI) in Rheumatoid Arthritis (RA) Patients

Arthritis & Rheumatic Disease Specialties Research

NCT01351480

COMPLETED Phase 3 33 participants

Usability of an AI for M923 in Subjects With Moderate to Severe RA

Momenta Pharmaceuticals

NCT02722044

COMPLETED Phase 4 32 participants

IL-7 and IL-7R Expression in RA Patients With Active vs. Inactive Disease Treated With DMARD or CIMZIA

University of Illinois at Chicago

NCT02451748

COMPLETED Phase 1 32 participants

A Study to Investigate Safety, Tolerability, and PK of Oral Doses of TCK-276 in Patients With Rheumatoid Arthritis

Teijin America

NCT05437419

COMPLETED Phase 1 32 participants

Comparison of the Safety and Pharmacokinetics of Two SAR153191 (REGN88) Drug Products in Rheumatoid Arthritis Patients

Sanofi

NCT01328522

COMPLETED Phase 2 31 participants

ACP-196 Versus Placebo in Subjects With Rheumatoid Arthritis on Background Methotrexate

Acerta Pharma

NCT02387762

COMPLETED Phase 1 31 participants

Evaluate the Safety, Tolerability, Pharmacokinetics,and Clinical Activity of FB704A

Fountain Biopharma

NCT03890302

COMPLETED Phase 4 31 participants

Centocor Microarray Study of Patients

University of Rochester

NCT00462072

COMPLETED Phase 3 30 participants

Hydroxychloroquine to Improve Insulin Sensitivity in Rheumatoid Arthritis

Brigham and Women's Hospital

NCT01132118

COMPLETED Phase 2 29 participants

A Study To Evaluate The Mechanism Of Action Of CP-690,550 In Patients With Rheumatoid Arthritis

Pfizer

NCT00976599

COMPLETED Phase 1 26 participants

Phase 1b Study of PLX5622 in Rheumatoid Arthritis Patients Who Are Receiving Methotrexate

Plexxikon

NCT01329991

COMPLETED Phase 1 26 participants

Study to Assess the Safety, Tolerability, and Pharmacokinetics of AMP-110 in Subjects With Rheumatoid Arthritis

MedImmune

NCT01878123

COMPLETED Phase 2 25 participants

A Fish Oil Supplement to Maintain Body Weight in Patients With Disease-Related Weight Loss

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT00094562

COMPLETED Phase 1 24 participants

A Study To Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of ASP2408 After Multiple Dose Subcutaneous Injections in Patients With Rheumatoid Arthritis on Methotrexate

Astellas Pharma Global Development

NCT02052375

COMPLETED NA 22 participants

Treatment of Hypovitaminosis D in Rheumatoid Arthritis

University of Wisconsin, Madison

NCT00423358

COMPLETED Phase 1 21 participants

A Study to Investigate How JNJ-39758979 May Affect the Plasma Levels of Methotrexate in Rheumatoid Arthritis Participants

Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

NCT01442545

COMPLETED NA 20 participants

Sleep and Immunity in Rheumatoid Arthritis : Remicade Substudy

University of California, Los Angeles

NCT00948610

COMPLETED Phase 1 20 participants

Safety and Tolerability of MORAb-022 in Healthy and Rheumatoid Arthritis Subjects

Morphotek

NCT01357759

COMPLETED Phase 3 20 participants

An Evaluation of the Optimal Dose of Tofacitinib Needed to Achieve Low Disease Activity (LDA) or Clinical Remission in Patients With Active Rheumatoid Arthritis (RA) as Measured From a Clinical and Structural Perspective

Norman B. Gaylis, MD

NCT02566967

COMPLETED NA 20 participants

Effects of Administration of SCFA in Rheumatoid Arthritis Inadequate Responders

NYU Langone Health

NCT05718583

COMPLETED Phase 1 19 participants

A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Multiple Subcutaneous Injections of ABT-122 in Subjects With Rheumatoid Arthritis

AbbVie

NCT01853033

COMPLETED Phase 4 18 participants

Milnacipran for Treatment of Pain in Older Adults With Rheumatoid Arthritis

University of California, Los Angeles

NCT01225991

COMPLETED NA 18 participants

ACTH Gel Therapy in Rheumatoid Arthritis

Dana Ascherman

NCT02030028

COMPLETED NA 18 participants

Yoga as Self-Care for Arthritis in Minority Communities

National Institutes of Health Clinical Center (CC)

NCT01617421

COMPLETED Phase 1 17 participants

A Multicenter, Postmarketing Study Evaluating the Concentration of Cimzia® in Mature Breast Milk of Lactating Mothers

UCB Biosciences

NCT02154425

COMPLETED NA 16 participants

Virtual Reality Meditation for Fatigue

University of Washington

NCT04804462

COMPLETED 15 participants

Exploratory Trial to Evaluate Premature Endothelial Dysfunction in Early Rheumatoid Arthritis(RA)Compared to Patients With Established RA, and Normal Subjects

Orrin M Troum, M.D. and Medical Associates

NCT01499732

COMPLETED Phase 1 15 participants

Study of LX3305 and Methotrexate in Subjects With Stable Rheumatoid Arthritis

Lexicon Pharmaceuticals

NCT00847886

COMPLETED NA 14 participants

Safety and Efficacy of Vagus Nerve Stimulator in Patients With Rheumatoid Arthritis (RA)

SetPoint Medical Corporation

NCT03437473

COMPLETED Phase 1 14 participants

Safety, Tolerance, Pharmacokinetics and Activity of HE3286 in Patients With Rheumatoid Arthritis

Harbor Therapeutics

NCT00712114

COMPLETED NA 14 participants

Acupressure in Rheumatoid Arthritis

University of Michigan

NCT05412121

COMPLETED NA 13 participants

KickStart30: A 30-Day Intervention for Patients With Rheumatoid Arthritis (RA)

University of Texas at Austin

NCT03993548

COMPLETED Phase 2 12 participants

Impact of Subcutaneous Abatacept in Rheumatoid Arthritis Assessing Inhibition of Structural Damage

Orrin M Troum, M.D. and Medical Associates

NCT01333878

COMPLETED Phase 3 10 participants

Rituximab in Rheumatoid Arthritis Lung Disease

Eric Matteson

NCT00578565

COMPLETED Phase 1 1 participants

Use of Cross-linked Donor Corneas as Carriers for the Boston Keratoprosthesis

Joseph B. Ciolino, MD

NCT01582880

COMPLETED Phase 2

Safety and Efficacy of a Monoclonal Antibody for Treatment of Rheumatoid Arthritis.

Xoma (US)

NCT00034203

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Phase Distribution

PhaseTrial count
Phase 1 33
Phase 2 44
Phase 3 25
Phase 4 7

Top Sponsors

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Rheumatoid Arthritis Trial Landscape

199 indexed Rheumatoid Arthritis studies · 37 recruiting (19%).

Phase mix: 32 late (III/IV) vs 77 early (I/II).

Top sponsor: Zimmer Biomet (13 trials), 9 others listed. 49 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Rheumatoid Arthritis?

PlainTrial tracks 199 US clinical trials for Rheumatoid Arthritis, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Rheumatoid Arthritis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.