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Rheumatoid Arthritis: early-phase trial registry
37 of 199 indexed Rheumatoid Arthritis trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #50 of 28,707 conditions by registered trial count.
199 US clinical trials · 37 currently recruiting · #50 of 28,707 conditions by registered trial count
Rheumatoid Arthritis: 199 US clinical trials tracked, 37 recruiting.
Rheumatoid Arthritis is the subject of 199 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 32 are in Phase 3-4 (later-stage) and 77 in Phase 1-2 (earlier-stage). The most active sponsor is Zimmer Biomet, running 13 of these trials.
Enrollment posture brief
Registry condition rheumatoid-arthritis
OPEN 37 | RECR 19% | LATE 32 | EARLY 77 | RANK #50 | SPON 13
Volume-matched condition peers
Nearest open-share peer: Leukemia (19% recruiting · 274 trials)
Rheumatoid Arthritis lists 37 open slots (19% of 199 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Rheumatoid Arthritis on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Rheumatoid Arthritis is recruiting below its size-band peers.
37 of 199 indexed trials (18.6%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Rheumatoid Arthritis trials is spread across many organizations.
Zimmer Biomet accounts for 13 of 199 trials (6.5%). 114 distinct sponsors appear on at least one study for this condition label.
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Typical Rheumatoid Arthritis enrolment sits around 154 participants.
Median target enrolment is 154 among the 198 trials that report a genuine target (sentinel values excluded). 78 of those (39.4%) plan for fewer than 100 participants.
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Rheumatoid Arthritis research is mostly interventional.
154 interventional and 45 observational studies make up this index (77.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
199 total, page 4 of 4
Multicenter Study to Evaluate CRx-102 vs. Each of Its Components to Treat Active Rheumatoid Arthritis
Zalicus
NCT00551707
Gold Factor on Knee Joint Health and Function
4Life Research
NCT05347602
Rheumatoid Arthritis Coping Enhancement
Duke University
NCT04246827
A Study Exploring the Safety, Tolerability and Efficacy of a 4 Week Course of INCB018424 in Subjects With Active Rheumatoid Arthritis
Incyte Corporation
NCT00550043
A Safety Analysis of Oral Prednisone as a Pre-Treatment for Rituximab in Rheumatoid Arthritis.
University of South Florida
NCT00580229
Safety, Tolerability, and Pharmacokinetics of a Single Oral Dose of SKI-O-703 in Healthy Volunteers
Oscotec
NCT02717988
Analysis of B Cells From Autoimmune Individuals
University of Colorado, Denver
NCT02747277
A Study of JNJ-67484703 in Participants With Active Rheumatoid Arthritis
Janssen Research & Development
NCT04985812
A Magnetic Resonance Imaging Study and Arthroscopic Biopsy Substudy in Subjects With Active Rheumatoid Arthritis Receiving VX-509, an Oral JAK3 Inhibitor
Vertex Pharmaceuticals Incorporated
NCT01754935
Ultrasound Assessment of Rheumatoid Arthritis Patients Who Changed Diet
Veena Ranganath, MD, MS
NCT02881307
CLUE Study: Connective Tissue Disease Leg Ulcer Etiology Study
George Washington University
NCT00522002
The Role of Cytokines on Growth Hormone Suppression in Premenopausal Women With Rheumatoid Arthritis and the Effect of Treatment With Etanercept
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NCT00034060
Acetabular Shell Positioning Using Patient Specific Instruments
The Cleveland Clinic
NCT01791738
Benefits of Injectable Abatacept Using Magnetic Resonance Imaging (MRI) in Rheumatoid Arthritis (RA) Patients
Arthritis & Rheumatic Disease Specialties Research
NCT01351480
Usability of an AI for M923 in Subjects With Moderate to Severe RA
Momenta Pharmaceuticals
NCT02722044
IL-7 and IL-7R Expression in RA Patients With Active vs. Inactive Disease Treated With DMARD or CIMZIA
University of Illinois at Chicago
NCT02451748
A Study to Investigate Safety, Tolerability, and PK of Oral Doses of TCK-276 in Patients With Rheumatoid Arthritis
Teijin America
NCT05437419
Comparison of the Safety and Pharmacokinetics of Two SAR153191 (REGN88) Drug Products in Rheumatoid Arthritis Patients
Sanofi
NCT01328522
ACP-196 Versus Placebo in Subjects With Rheumatoid Arthritis on Background Methotrexate
Acerta Pharma
NCT02387762
Evaluate the Safety, Tolerability, Pharmacokinetics,and Clinical Activity of FB704A
Fountain Biopharma
NCT03890302
Centocor Microarray Study of Patients
University of Rochester
NCT00462072
Hydroxychloroquine to Improve Insulin Sensitivity in Rheumatoid Arthritis
Brigham and Women's Hospital
NCT01132118
A Study To Evaluate The Mechanism Of Action Of CP-690,550 In Patients With Rheumatoid Arthritis
Pfizer
NCT00976599
Phase 1b Study of PLX5622 in Rheumatoid Arthritis Patients Who Are Receiving Methotrexate
Plexxikon
NCT01329991
Study to Assess the Safety, Tolerability, and Pharmacokinetics of AMP-110 in Subjects With Rheumatoid Arthritis
MedImmune
NCT01878123
A Fish Oil Supplement to Maintain Body Weight in Patients With Disease-Related Weight Loss
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT00094562
A Study To Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of ASP2408 After Multiple Dose Subcutaneous Injections in Patients With Rheumatoid Arthritis on Methotrexate
Astellas Pharma Global Development
NCT02052375
Treatment of Hypovitaminosis D in Rheumatoid Arthritis
University of Wisconsin, Madison
NCT00423358
A Study to Investigate How JNJ-39758979 May Affect the Plasma Levels of Methotrexate in Rheumatoid Arthritis Participants
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
NCT01442545
Sleep and Immunity in Rheumatoid Arthritis : Remicade Substudy
University of California, Los Angeles
NCT00948610
Safety and Tolerability of MORAb-022 in Healthy and Rheumatoid Arthritis Subjects
Morphotek
NCT01357759
An Evaluation of the Optimal Dose of Tofacitinib Needed to Achieve Low Disease Activity (LDA) or Clinical Remission in Patients With Active Rheumatoid Arthritis (RA) as Measured From a Clinical and Structural Perspective
Norman B. Gaylis, MD
NCT02566967
Effects of Administration of SCFA in Rheumatoid Arthritis Inadequate Responders
NYU Langone Health
NCT05718583
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Multiple Subcutaneous Injections of ABT-122 in Subjects With Rheumatoid Arthritis
AbbVie
NCT01853033
Milnacipran for Treatment of Pain in Older Adults With Rheumatoid Arthritis
University of California, Los Angeles
NCT01225991
ACTH Gel Therapy in Rheumatoid Arthritis
Dana Ascherman
NCT02030028
Yoga as Self-Care for Arthritis in Minority Communities
National Institutes of Health Clinical Center (CC)
NCT01617421
A Multicenter, Postmarketing Study Evaluating the Concentration of Cimzia® in Mature Breast Milk of Lactating Mothers
UCB Biosciences
NCT02154425
Virtual Reality Meditation for Fatigue
University of Washington
NCT04804462
Exploratory Trial to Evaluate Premature Endothelial Dysfunction in Early Rheumatoid Arthritis(RA)Compared to Patients With Established RA, and Normal Subjects
Orrin M Troum, M.D. and Medical Associates
NCT01499732
Study of LX3305 and Methotrexate in Subjects With Stable Rheumatoid Arthritis
Lexicon Pharmaceuticals
NCT00847886
Safety and Efficacy of Vagus Nerve Stimulator in Patients With Rheumatoid Arthritis (RA)
SetPoint Medical Corporation
NCT03437473
Safety, Tolerance, Pharmacokinetics and Activity of HE3286 in Patients With Rheumatoid Arthritis
Harbor Therapeutics
NCT00712114
Acupressure in Rheumatoid Arthritis
University of Michigan
NCT05412121
KickStart30: A 30-Day Intervention for Patients With Rheumatoid Arthritis (RA)
University of Texas at Austin
NCT03993548
Impact of Subcutaneous Abatacept in Rheumatoid Arthritis Assessing Inhibition of Structural Damage
Orrin M Troum, M.D. and Medical Associates
NCT01333878
Rituximab in Rheumatoid Arthritis Lung Disease
Eric Matteson
NCT00578565
Use of Cross-linked Donor Corneas as Carriers for the Boston Keratoprosthesis
Joseph B. Ciolino, MD
NCT01582880
Safety and Efficacy of a Monoclonal Antibody for Treatment of Rheumatoid Arthritis.
Xoma (US)
NCT00034203
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 33 |
| Phase 2 | 44 |
| Phase 3 | 25 |
| Phase 4 | 7 |
Top Sponsors
Named interventions
Most-linked intervention names on Rheumatoid Arthritis records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Rheumatoid Arthritis trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Rheumatoid Arthritis page
199 registered trials, 37 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 37 Rheumatoid Arthritis trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Zimmer Biomet sponsors the most Rheumatoid Arthritis trials on record, review their full trial history before evaluating a specific study. See Zimmer Biomet's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Rheumatoid Arthritis condition card totals 199 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.