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Rheumatoid Arthritis clinical trials
37 of 199 indexed Rheumatoid Arthritis trials are currently recruiting.
199 US clinical trials · 37 currently recruiting
Rheumatoid Arthritis is the subject of 199 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 32 are in Phase 3-4 (later-stage) and 77 in Phase 1-2 (earlier-stage). The most active sponsor is Zimmer Biomet, running 13 of these trials.
The research picture
Rheumatoid Arthritis has 199 registered US clinical trials, 37 of them open to new participants right now, about 19% of the total.
- 37
- recruiting participants now
- 19%
- of trials open to enrollment
- 32
- in Phase 3–4 (later-stage)
- 13
- top sponsor: Zimmer Biomet
Active & Recent Trials
199 total, page 4 of 4
Multicenter Study to Evaluate CRx-102 vs. Each of Its Components to Treat Active Rheumatoid Arthritis
Zalicus
NCT00551707
Gold Factor on Knee Joint Health and Function
4Life Research
NCT05347602
Rheumatoid Arthritis Coping Enhancement
Duke University
NCT04246827
A Study Exploring the Safety, Tolerability and Efficacy of a 4 Week Course of INCB018424 in Subjects With Active Rheumatoid Arthritis
Incyte Corporation
NCT00550043
A Safety Analysis of Oral Prednisone as a Pre-Treatment for Rituximab in Rheumatoid Arthritis.
University of South Florida
NCT00580229
Safety, Tolerability, and Pharmacokinetics of a Single Oral Dose of SKI-O-703 in Healthy Volunteers
Oscotec
NCT02717988
Analysis of B Cells From Autoimmune Individuals
University of Colorado, Denver
NCT02747277
A Study of JNJ-67484703 in Participants With Active Rheumatoid Arthritis
Janssen Research & Development
NCT04985812
A Magnetic Resonance Imaging Study and Arthroscopic Biopsy Substudy in Subjects With Active Rheumatoid Arthritis Receiving VX-509, an Oral JAK3 Inhibitor
Vertex Pharmaceuticals Incorporated
NCT01754935
Ultrasound Assessment of Rheumatoid Arthritis Patients Who Changed Diet
Veena Ranganath, MD, MS
NCT02881307
CLUE Study: Connective Tissue Disease Leg Ulcer Etiology Study
George Washington University
NCT00522002
The Role of Cytokines on Growth Hormone Suppression in Premenopausal Women With Rheumatoid Arthritis and the Effect of Treatment With Etanercept
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NCT00034060
Acetabular Shell Positioning Using Patient Specific Instruments
The Cleveland Clinic
NCT01791738
Benefits of Injectable Abatacept Using Magnetic Resonance Imaging (MRI) in Rheumatoid Arthritis (RA) Patients
Arthritis & Rheumatic Disease Specialties Research
NCT01351480
Usability of an AI for M923 in Subjects With Moderate to Severe RA
Momenta Pharmaceuticals
NCT02722044
IL-7 and IL-7R Expression in RA Patients With Active vs. Inactive Disease Treated With DMARD or CIMZIA
University of Illinois at Chicago
NCT02451748
A Study to Investigate Safety, Tolerability, and PK of Oral Doses of TCK-276 in Patients With Rheumatoid Arthritis
Teijin America
NCT05437419
Comparison of the Safety and Pharmacokinetics of Two SAR153191 (REGN88) Drug Products in Rheumatoid Arthritis Patients
Sanofi
NCT01328522
ACP-196 Versus Placebo in Subjects With Rheumatoid Arthritis on Background Methotrexate
Acerta Pharma
NCT02387762
Evaluate the Safety, Tolerability, Pharmacokinetics,and Clinical Activity of FB704A
Fountain Biopharma
NCT03890302
Centocor Microarray Study of Patients
University of Rochester
NCT00462072
Hydroxychloroquine to Improve Insulin Sensitivity in Rheumatoid Arthritis
Brigham and Women's Hospital
NCT01132118
A Study To Evaluate The Mechanism Of Action Of CP-690,550 In Patients With Rheumatoid Arthritis
Pfizer
NCT00976599
Phase 1b Study of PLX5622 in Rheumatoid Arthritis Patients Who Are Receiving Methotrexate
Plexxikon
NCT01329991
Study to Assess the Safety, Tolerability, and Pharmacokinetics of AMP-110 in Subjects With Rheumatoid Arthritis
MedImmune
NCT01878123
A Fish Oil Supplement to Maintain Body Weight in Patients With Disease-Related Weight Loss
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT00094562
A Study To Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of ASP2408 After Multiple Dose Subcutaneous Injections in Patients With Rheumatoid Arthritis on Methotrexate
Astellas Pharma Global Development
NCT02052375
Treatment of Hypovitaminosis D in Rheumatoid Arthritis
University of Wisconsin, Madison
NCT00423358
A Study to Investigate How JNJ-39758979 May Affect the Plasma Levels of Methotrexate in Rheumatoid Arthritis Participants
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
NCT01442545
Sleep and Immunity in Rheumatoid Arthritis : Remicade Substudy
University of California, Los Angeles
NCT00948610
Safety and Tolerability of MORAb-022 in Healthy and Rheumatoid Arthritis Subjects
Morphotek
NCT01357759
An Evaluation of the Optimal Dose of Tofacitinib Needed to Achieve Low Disease Activity (LDA) or Clinical Remission in Patients With Active Rheumatoid Arthritis (RA) as Measured From a Clinical and Structural Perspective
Norman B. Gaylis, MD
NCT02566967
Effects of Administration of SCFA in Rheumatoid Arthritis Inadequate Responders
NYU Langone Health
NCT05718583
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Multiple Subcutaneous Injections of ABT-122 in Subjects With Rheumatoid Arthritis
AbbVie
NCT01853033
Milnacipran for Treatment of Pain in Older Adults With Rheumatoid Arthritis
University of California, Los Angeles
NCT01225991
ACTH Gel Therapy in Rheumatoid Arthritis
Dana Ascherman
NCT02030028
Yoga as Self-Care for Arthritis in Minority Communities
National Institutes of Health Clinical Center (CC)
NCT01617421
A Multicenter, Postmarketing Study Evaluating the Concentration of Cimzia® in Mature Breast Milk of Lactating Mothers
UCB Biosciences
NCT02154425
Virtual Reality Meditation for Fatigue
University of Washington
NCT04804462
Exploratory Trial to Evaluate Premature Endothelial Dysfunction in Early Rheumatoid Arthritis(RA)Compared to Patients With Established RA, and Normal Subjects
Orrin M Troum, M.D. and Medical Associates
NCT01499732
Study of LX3305 and Methotrexate in Subjects With Stable Rheumatoid Arthritis
Lexicon Pharmaceuticals
NCT00847886
Safety and Efficacy of Vagus Nerve Stimulator in Patients With Rheumatoid Arthritis (RA)
SetPoint Medical Corporation
NCT03437473
Safety, Tolerance, Pharmacokinetics and Activity of HE3286 in Patients With Rheumatoid Arthritis
Harbor Therapeutics
NCT00712114
Acupressure in Rheumatoid Arthritis
University of Michigan
NCT05412121
KickStart30: A 30-Day Intervention for Patients With Rheumatoid Arthritis (RA)
University of Texas at Austin
NCT03993548
Impact of Subcutaneous Abatacept in Rheumatoid Arthritis Assessing Inhibition of Structural Damage
Orrin M Troum, M.D. and Medical Associates
NCT01333878
Rituximab in Rheumatoid Arthritis Lung Disease
Eric Matteson
NCT00578565
Use of Cross-linked Donor Corneas as Carriers for the Boston Keratoprosthesis
Joseph B. Ciolino, MD
NCT01582880
Safety and Efficacy of a Monoclonal Antibody for Treatment of Rheumatoid Arthritis.
Xoma (US)
NCT00034203
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 33 |
| Phase 2 | 44 |
| Phase 3 | 25 |
| Phase 4 | 7 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Rheumatoid Arthritis Trial Landscape
199 indexed Rheumatoid Arthritis studies · 37 recruiting (19%).
Phase mix: 32 late (III/IV) vs 77 early (I/II).
Top sponsor: Zimmer Biomet (13 trials), 9 others listed. 49 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Rheumatoid Arthritis?
PlainTrial tracks 199 US clinical trials for Rheumatoid Arthritis, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Rheumatoid Arthritis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.