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ClinicalTrials.gov 37 recruiting now official registry

Diabetes Mellitus, Type 1 clinical trials

Every US clinical trial registered for Diabetes Mellitus, Type 1 — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

112 US clinical trials · 37 currently recruiting

The research picture

Diabetes Mellitus, Type 1 has 112 registered US clinical trials, 37 of them open to new participants right now — about 33% of the total.

37
recruiting participants now
33%
of trials open to enrollment
30
in Phase 3–4 (later-stage)
11
top sponsor: Novo Nordisk A/S

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 75,000 participants

TrialNet Pathway to Prevention of T1D

University of South Florida

NCT00097292

RECRUITING 50,000 participants

The T1D Exchange Registry

T1D Exchange, United States

NCT04629586

RECRUITING 4,000 participants

Genetics Of Autoimmunity In Type I Diabetes

Medical College of Wisconsin

NCT03648918

RECRUITING NA 1,178 participants

Best Practice Advisories to Reduce Inequities in Technology Use for People With Type 1 Diabetes

T1D Exchange, United States

NCT06931275

RECRUITING Phase 3 877 participants

A Research Study to See How a Weekly Insulin, Insulin Icodec, Helps in Reducing the Blood Sugar Compared to Daily Insulin Glargine, Both in Combination With Insulin Aspart, in Adults With Type 1 Diabetes

Novo Nordisk A/S

NCT07076199

RECRUITING 500 participants

T1D Pregnancy & Me

Jaeb Center for Health Research

NCT06959316

RECRUITING 400 participants

Type 1 Diabetes Recurrence in Pancreas Transplants

University of Miami

NCT01047865

RECRUITING NA 324 participants

Closed Loop and Education for Hypoglycemia Awareness Restoration

Milton S. Hershey Medical Center

NCT06325202

RECRUITING Phase 3 300 participants

A Study of Baricitinib (LY3009104) to Preserve Beta Cell Function in Children and Adults Newly Diagnosed With Type 1 Diabetes (BARICADE-PRESERVE)

Eli Lilly and Company

NCT07222332

RECRUITING NA 200 participants

Behavioral Approaches to Reduce Diabetes Distress in Adults With Type 1 Diabetes: A Pragmatic SMART

University of North Carolina, Chapel Hill

NCT06405373

RECRUITING NA 160 participants

National Institute of Diabetes and Digestive Kidney Diseases* Share Plus: Continuous Glucose Monitoring with Data Sharing in Older Adults with Type 1 Diabetes* and Their Care Partners to Improve Time in Range and Reduce Diabetes Distress.

University of Utah

NCT05937321

RECRUITING NA 160 participants

Food Insecurity Reduction & Strategy Team

Stanford University

NCT06329375

RECRUITING Phase 2 150 participants

Repeat BCG Vaccinations For The Treatment Of Pediatric Type 1 Diabetes

Massachusetts General Hospital

NCT05180591

RECRUITING Phase 3 150 participants

A Study of Baricitinib (LY3009104) for the Delay of Stage 3 Type 1 Diabetes in At-Risk Children and Adults

Eli Lilly and Company

NCT07222137

RECRUITING Phase 3 150 participants

Cadisegliatin as Adjunctive Therapy to Insulin in Participants With Type 1 Diabetes

vTv Therapeutics

NCT06334133

RECRUITING NA 140 participants

Hybrid Closed Loop Effectiveness Trial in Adults With Type 1 Diabetes

Boston Medical Center

NCT06236607

RECRUITING NA 128 participants

Diabetes Learning in Virtual Environments Just in Time for Community Reentry

Louise Reagan

NCT05286892

RECRUITING NA 120 participants

Device Use Reimagined Through Education And Mentorship

University of California, San Francis

NCT06546930

RECRUITING NA 82 participants

Randomized Trial of Supplemental Synchronous and Asynchronous Telehealth to Improve Glycemic Control for Pediatric Patients With Type 1 Diabetes

University of California, Davis

NCT04428658

RECRUITING NA 80 participants

Game-based Pediatric Diabetes Education

Carnegie Mellon University

NCT06264258

RECRUITING Phase 3 60 participants

Type 1 Diabetes Impacts of Semaglutide on Cardiovascular Outcomes

University of Colorado, Denver

NCT05819138

RECRUITING Phase 1 60 participants

Cellular Therapy for Type 1 Diabetes Using Mesenchymal Stem Cells

Medical University of South Carolina

NCT04061746

RECRUITING NA 58 participants

Efficacy and Safety of a Ketogenic Diet in Type 1 Diabetes

Washington University School of Medicine

NCT06503809

RECRUITING Phase 3 52 participants

A Safety, Tolerability, and Efficacy Study of VX-880 in Participants With Type 1 Diabetes

Vertex Pharmaceuticals Incorporated

NCT04786262

RECRUITING NA 52 participants

Carbohydrate Beta Cell Function and Glucose Control in Children With Diabetes

Boston Children's Hospital

NCT05899166

RECRUITING NA 50 participants

Continuous Glucose Metrics in Patients With Gastroparesis in Type 1 or Type 2 Diabetes

Samita Garg

NCT06046833

RECRUITING 50 participants

Breaking Disparities in Access to Advanced Diabetes Technologies in Children With Type 1 Diabetes

Nemours Children's Clinic

NCT05849753

RECRUITING NA 40 participants

Starting Technology in At Risk Type 1 Diabetes Study

University of California, Los Angeles

NCT06453928

RECRUITING NA 30 participants

Effect of Inhaled Technosphere Insulin vs RAA Insulin on Exercise-Induced Hypoglycemia in Adults With T1D Using Automated Insulin Delivery

Jaeb Center for Health Research

NCT06880835

RECRUITING Phase 1 20 participants

Subcutaneous Pharmacokinetic Evaluation of Monomeric Insulin and Lyumjev in Adults With Type 1 Diabetes

Stanford University

NCT07090824

RECRUITING Phase 1 20 participants

Improving Islet Transplantation Outcomes With Gastrin for Type I Diabetes

City of Hope Medical Center

NCT03746769

RECRUITING NA 20 participants

Feasibility Study of Extended Wear Insulin Infusion Set Options During Home Use in People With Type 1 Diabetes

Tandem Diabetes Care

NCT07325461

RECRUITING NA 20 participants

Islet Transplantation in Patients With "Brittle" Type I Diabetes

University of Chicago

NCT01630850

RECRUITING Phase 1 18 participants

Safety and Efficacy of CELZ-201 in Patients With Recent Onset Type 1 Diabetes

Creative Medical Technology Holdings

NCT05626712

RECRUITING Early Phase 1 16 participants

Regulation of Brain Glucose Metabolism in Type 1 Diabetes

Yale University

NCT05317455

RECRUITING Phase 1 13 participants

A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus

Otsuka Pharmaceutical Factory

NCT06575426

RECRUITING Phase 2 10 participants

Islet Transplantation in Type 1 Diabetic Kidney Allograft

University of Chicago

NCT01241864

ACTIVE NOT RECRUITING Phase 2 227 participants

Phase 2b Trial Comparing HDV-Insulin Lispro to Insulin Lispro in Adults With Type 1 Diabetes Receiving Insulin Degludec

Diasome Pharmaceuticlas

NCT06238778

ACTIVE NOT RECRUITING 188 participants

Recent-Onset Type 1 Diabetes Extension Study Evaluating the Long-Term Safety of Teplizumab (PROTECT Extension)

Provention Bio, a Sanofi Company

NCT04598893

ACTIVE NOT RECRUITING NA 150 participants

Using Technology to Address Disparities and Promote Healthcare Equity in Type 1 Diabetes Registry

University of Chicago

NCT06899984

ACTIVE NOT RECRUITING NA 80 participants

Testing an Integrated Care Model Trial

Emory University

NCT06448429

ACTIVE NOT RECRUITING Phase 2 78 participants

Diabetes Autoimmunity Withdrawn In New Onset and In Established Patients

Tolerion

NCT03895437

ACTIVE NOT RECRUITING Phase 2 78 participants

Janus Kinase (JAK) Inhibitors to Preserve C-Peptide Production in New Onset Type 1 Diabetes (T1D)

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT05743244

ACTIVE NOT RECRUITING Phase 4 60 participants

Metformin for Preeclampsia Prevention in Pregnant Women With Type 1 Diabetes Mellitus

Maisa N. Feghali, MD

NCT03570632

ACTIVE NOT RECRUITING NA 50 participants

Recurrent Hypoglycemia in Type 1 Diabetes (Aim 2)

University of Minnesota

NCT04387422

ACTIVE NOT RECRUITING 50 participants

MEtabolic and Renal Effects of AutoMAted Insulin Delivery Systems in Youth With Type 1 Diabetes Mellitus

University of Colorado, Denver

NCT03945747

ACTIVE NOT RECRUITING Phase 1 50 participants

Allogenic Islet Cell Transplantation

University of Chicago

NCT00160732

ACTIVE NOT RECRUITING NA 37 participants

Type 1 Together: A Peer Mentorship Program to Bolster Use of CGM

Nemours Children's Clinic

NCT06203067

ACTIVE NOT RECRUITING NA 20 participants

Family-Based Treatment for Type 1 Diabetes

State University of New York at Buffalo

NCT05756361

ACTIVE NOT RECRUITING Phase 4 20 participants

Teplizumab in Pediatric Stage 2 Type 1 Diabetes

Sanofi

NCT05757713

COMPLETED Phase 3 1,398 participants

The Efficacy and Safety of Liraglutide as Adjunct Therapy to Insulin in the Treatment of Type 1 Diabetes

Novo Nordisk A/S

NCT01836523

COMPLETED 1,212 participants

The Loop Observational Study

Jaeb Center for Health Research

NCT03838900

COMPLETED Phase 3 1,108 participants

Efficacy and Safety of Faster-acting Insulin Aspart Compared to NovoRapid® Both in Combination With Insulin Degludec in Adults With Type 1 Diabetes

Novo Nordisk A/S

NCT02500706

COMPLETED Phase 3 730 participants

Empagliflozin as Adjunctive to InSulin thErapy Over 52 Weeks in Patients With Type 1 Diabetes Mellitus (EASE-2)

Boehringer Ingelheim

NCT02414958

COMPLETED Phase 3 629 participants

Comparison of NN1250 Plus Insulin Aspart With Insulin Glargine Plus Insulin Aspart in Type 1 Diabetes

Novo Nordisk A/S

NCT00982228

COMPLETED Phase 3 582 participants

A Research Study to Compare a New Weekly Insulin, Insulin Icodec, and an Available Daily Insulin, Insulin Degludec, Both in Combination With Mealtime Insulin in People With Type 1 Diabetes (ONWARDS 6)

Novo Nordisk A/S

NCT04848480

COMPLETED Phase 3 548 participants

Comparison of NN5401 Plus Insulin Aspart With Insulin Detemir Plus Insulin Aspart in Type 1 Diabetes

Novo Nordisk A/S

NCT00978627

COMPLETED Phase 3 536 participants

A Study in Adults With Type 1 Diabetes

Eli Lilly and Company

NCT01421147

COMPLETED Phase 4 513 participants

NovoLog Observation Trial in Subjects With Type 1 and Type 2 Diabetes

Novo Nordisk A/S

NCT00095446

COMPLETED Phase 3 494 participants

Evaluate the Efficacy of Insulin Patients With Type 1 Diabetes

Eli Lilly and Company

NCT00356109

COMPLETED Phase 3 478 participants

Mylan Insulin Aspart Study

Mylan

NCT03760068

COMPLETED Phase 3 385 participants

Study of Human Insulin Inhalation Powder in Patients With Type 1 Diabetes

Eli Lilly and Company

NCT00127634

COMPLETED Phase 3 362 participants

A Trial Investigating the Efficacy and Safety of Insulin Degludec/Insulin Aspart Once Daily Plus Insulin Aspart for the Remaining Meals Versus Insulin Detemir Once or Twice Daily Plus Meal Time Insulin Aspart in Children and Adolescents With Type 1 Diabetes Mellitus

Novo Nordisk A/S

NCT01835431

COMPLETED 362 participants

Patient and Parent Preferences for an On-Body Automated Insulin Delivery System

Joslin Diabetes Center

NCT03534544

COMPLETED Phase 3 319 participants

Afrezza® INHALE-1 Study in Pediatrics

Mannkind Corporation

NCT04974528

COMPLETED Phase 3 296 participants

Evaluation of Dose-titration of Pramlintide During Initiation of Therapy in Patients Trying to Improve Glucose Control

AstraZeneca

NCT00042458

COMPLETED Phase 4 289 participants

Effect of Insulin Glulisine Compared to Insulin Aspart and Insulin Lispro When Administered by Continuous Subcutaneous Insulin Infusion (CSII) on Specific Pump Parameters in Patient With Type 1 Diabetes Mellitus

Sanofi

NCT00607087

COMPLETED NA 273 participants

Post Approval Study of the Eversense® Continuous Glucose Monitoring

Senseonics

NCT03908125

COMPLETED NA 250 participants

Evaluation of Blood Volume and Perceived Pain During Fingerstick Monitoring of Blood Glucose

Becton, Dickinson and Company

NCT00741390

COMPLETED Phase 3 242 participants

Efficacy, Safety and Preference Study of a Insulin Pen PDS290 vs. a Novo Nordisk Marketed Insulin Pen in Diabetics

Novo Nordisk A/S

NCT00773279

COMPLETED NA 222 participants

Peer i-Coaching for Activated Self-Management Optimization in Adolescents and Young Adults With Chronic Conditions

Duke University

NCT03938324

COMPLETED NA 157 participants

Managing Type 1 and High Risk Type 2 Diabetes in the Hospital Setting: Glucose as a Vital Sign

Scripps Whittier Diabetes Institute

NCT03068273

COMPLETED NA 131 participants

Day and Night Closed-loop in Young People With Type 1 Diabetes

Jaeb Center for Health Research

NCT02925299

COMPLETED NA 120 participants

Pilot Study of Brief Intervention to Support Diabetes Health-Related Quality of Life

Baylor College of Medicine

NCT05234944

COMPLETED Phase 1 115 participants

Evaluation of TTP399 in Patients With Type 1 Diabetes

vTv Therapeutics

NCT03335371

COMPLETED Phase 2 110 participants

Clinical Trial of SB-509 in Subjects With Diabetic Neuropathy

Sangamo Therapeutics

NCT00406458

COMPLETED NA 103 participants

Diabetes Pump With Predictive Low Glucose Suspend Pivotal Trial

Tandem Diabetes Care

NCT03195140

COMPLETED Phase 2 91 participants

Clinical Trial of SB-509 in Subjects With Diabetic Neuropathy

Sangamo Therapeutics

NCT00476931

COMPLETED 85 participants

Clinical Startup of the 670G Closed Loop Insulin Delivery System

Stanford University

NCT03017482

COMPLETED 79 participants

Assessment of Mealtime Bolus Insulin Behavior

Eli Lilly and Company

NCT03368807

COMPLETED Phase 3 77 participants

Efficacy and Safety of Nasal Glucagon for Treatment of Hypoglycemia in Adults

Eli Lilly and Company

NCT01994746

COMPLETED NA 73 participants

Insulin-Glucose-Glucagon Network: Defining a Type 1 Diabetes Progression Index

University of Virginia

NCT02663661

COMPLETED NA 68 participants

ACT1ON Phase 2 (SMART Pilot) and Phase 3 (Efficacy Trial Development)

University of North Carolina, Chapel Hill

NCT03651622

COMPLETED Phase 4 62 participants

Comparison of Glycemic Control Achieved With 2 Different Needles

Novo Nordisk A/S

NCT00572052

COMPLETED Phase 1 50 participants

Copeptin in Adolescent Participants With Type 1 Diabetes and Early Renal Hemodynamic Function

University of Colorado, Denver

NCT03618420

COMPLETED 49 participants

Green Digital Diabetes Waste Project

Florida State University

NCT06071325

COMPLETED Phase 2 48 participants

Safety Study of Subcutaneously-Injected Prandial INSULIN-PH20 NP Compared to Insulin Lispro Injection in Participants With Type 1 Diabetes Mellitus

Halozyme Therapeutics

NCT00883558

COMPLETED NA 47 participants

Recurrent Hypoglycemia in Type 1 Diabetes (Aim 1)

University of Minnesota

NCT03410277

COMPLETED Phase 2 46 participants

Comparison of Hepatic Directed Vesicle (HDV)-Insulin Lispro Versus Insulin Lispro to Further Improve Glycemic Control

Diasome Pharmaceuticals

NCT03096392

COMPLETED NA 41 participants

Counter-Regulatory Impairment and the Effect of Microvascular Insulin Transfer in Type 1 Diabetes Mellitus

University of Virginia

NCT00943787

COMPLETED NA 41 participants

Pilot Study of Connected Diabetes Technology

University of California, Davis

NCT04106440

COMPLETED Phase 3 37 participants

A Trial Evaluating Compatibility and Safety of FIAsp and Insulin Aspart With an External Continuous Subcutaneous Insulin Infusion System in Adult Subjects With Type 1 Diabetes

Novo Nordisk A/S

NCT01999322

COMPLETED Phase 1 37 participants

A Study To Assess The Safety Of PF-06342674 In Adults With Type 1 Diabetes

Pfizer

NCT02038764

COMPLETED NA 32 participants

Diabetes Assistant (DiAs) Control-to-Range (CTR) Nocturnal Closed-Loop Camp Study

University of Virginia

NCT01973413

COMPLETED NA 29 participants

A Pilot Study of Biomarkers of Stress in Youth Who Use Teens.Connect

Yale University

NCT02970656

COMPLETED NA 27 participants

A Continuous Glucose Monitor Based Insulin Bolus Calculator

Welldoc

NCT05229445

COMPLETED Phase 4 25 participants

Comparison of Insulin Degludec With Insulin Glargine U100 for Adults With Type 1 Diabetes Crossing Multiple Time Zones.

Sansum Diabetes Research Institute

NCT03668808

COMPLETED 22 participants

Study of Calcium Metabolism in Teenage Girls With Type 1 Diabetes

University of Rochester

NCT03156179

COMPLETED NA 21 participants

Assessment of an Automatic Closed-loop Insulin Delivery System

Stanford University

NCT02366767

COMPLETED Phase 4 20 participants

Afrezza® Dosing Optimization Study

Mannkind Corporation

NCT04849845

Phase Distribution

PhaseTrial count
Phase 1 11
Phase 2 13
Phase 3 22
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Diabetes Mellitus, Type 1 Trial Landscape

ClinicalTrials.gov lists 112 US studies indexed under Diabetes Mellitus, Type 1, and 37 of those are currently open to recruitment — roughly 33% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Diabetes Mellitus, Type 1 shows 30 late-stage studies (Phase 3 and Phase 4 combined) alongside 24 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Diabetes Mellitus, Type 1 is led by Novo Nordisk A/S with 11 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Diabetes Mellitus, Type 1?

PlainTrial tracks 112 US clinical trials for Diabetes Mellitus, Type 1, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Diabetes Mellitus, Type 1?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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