Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Diabetes Mellitus, Type 1 clinical trials
39 of 119 indexed Diabetes Mellitus, Type 1 trials are currently recruiting.
119 US clinical trials · 39 currently recruiting
Diabetes Mellitus, Type 1 is the subject of 119 registered US clinical trials on ClinicalTrials.gov, 39 of them currently open to new participants. 31 are in Phase 3-4 (later-stage) and 27 in Phase 1-2 (earlier-stage). The most active sponsor is Novo Nordisk A/S, running 11 of these trials.
The research picture
Diabetes Mellitus, Type 1 has 119 registered US clinical trials, 39 of them open to new participants right now, about 33% of the total.
- 39
- recruiting participants now
- 33%
- of trials open to enrollment
- 31
- in Phase 3–4 (later-stage)
- 11
- top sponsor: Novo Nordisk A/S
Active & Recent Trials
119 total, page 1 of 3
TrialNet Pathway to Prevention of T1D
University of South Florida
NCT00097292
The T1D Exchange Registry
T1D Exchange, United States
NCT04629586
Genetics Of Autoimmunity In Type I Diabetes
Medical College of Wisconsin
NCT03648918
Best Practice Advisories to Reduce Inequities in Technology Use for People With Type 1 Diabetes
T1D Exchange, United States
NCT06931275
A Research Study to See How a Weekly Insulin, Insulin Icodec, Helps in Reducing the Blood Sugar Compared to Daily Insulin Glargine, Both in Combination With Insulin Aspart, in Adults With Type 1 Diabetes
Novo Nordisk A/S
NCT07076199
T1D Pregnancy & Me
Jaeb Center for Health Research
NCT06959316
Type 1 Diabetes Recurrence in Pancreas Transplants
University of Miami
NCT01047865
Closed Loop and Education for Hypoglycemia Awareness Restoration
Milton S. Hershey Medical Center
NCT06325202
A Study of Baricitinib (LY3009104) to Preserve Beta Cell Function in Children and Adults Newly Diagnosed With Type 1 Diabetes (BARICADE-PRESERVE)
Eli Lilly and Company
NCT07222332
Behavioral Approaches to Reduce Diabetes Distress in Adults With Type 1 Diabetes: A Pragmatic SMART
University of North Carolina, Chapel Hill
NCT06405373
National Institute of Diabetes and Digestive Kidney Diseases* Share Plus: Continuous Glucose Monitoring with Data Sharing in Older Adults with Type 1 Diabetes* and Their Care Partners to Improve Time in Range and Reduce Diabetes Distress.
University of Utah
NCT05937321
Food Insecurity Reduction & Strategy Team
Stanford University
NCT06329375
Repeat BCG Vaccinations For The Treatment Of Pediatric Type 1 Diabetes
Massachusetts General Hospital
NCT05180591
A Study of Baricitinib (LY3009104) for the Delay of Stage 3 Type 1 Diabetes in At-Risk Children and Adults
Eli Lilly and Company
NCT07222137
Cadisegliatin as Adjunctive Therapy to Insulin in Participants With Type 1 Diabetes
vTv Therapeutics
NCT06334133
Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease
Alessandro Doria
NCT06217302
Hybrid Closed Loop Effectiveness Trial in Adults With Type 1 Diabetes
Boston Medical Center
NCT06236607
Diabetes Learning in Virtual Environments Just in Time for Community Reentry
Louise Reagan
NCT05286892
Device Use Reimagined Through Education And Mentorship
University of California, San Francisco
NCT06546930
Randomized Trial of Supplemental Synchronous and Asynchronous Telehealth to Improve Glycemic Control for Pediatric Patients With Type 1 Diabetes
University of California, Davis
NCT04428658
Game-based Pediatric Diabetes Education
Carnegie Mellon University
NCT06264258
Type 1 Diabetes Impacts of Semaglutide on Cardiovascular Outcomes
University of Colorado, Denver
NCT05819138
Cellular Therapy for Type 1 Diabetes Using Mesenchymal Stem Cells
Medical University of South Carolina
NCT04061746
Efficacy and Safety of a Ketogenic Diet in Type 1 Diabetes
Washington University School of Medicine
NCT06503809
A Safety, Tolerability, and Efficacy Study of VX-880 in Participants With Type 1 Diabetes
Vertex Pharmaceuticals Incorporated
NCT04786262
Carbohydrate Beta Cell Function and Glucose Control in Children With Diabetes
Boston Children's Hospital
NCT05899166
Continuous Glucose Metrics in Patients With Gastroparesis in Type 1 or Type 2 Diabetes
Samita Garg
NCT06046833
Breaking Disparities in Access to Advanced Diabetes Technologies in Children With Type 1 Diabetes
Nemours Children's Clinic
NCT05849753
Starting Technology in At Risk Type 1 Diabetes Study
University of California, Los Angeles
NCT06453928
Effect of Inhaled Technosphere Insulin vs RAA Insulin on Exercise-Induced Hypoglycemia in Adults With T1D Using Automated Insulin Delivery
Jaeb Center for Health Research
NCT06880835
Subcutaneous Pharmacokinetic Evaluation of Monomeric Insulin and Lyumjev in Adults With Type 1 Diabetes
Stanford University
NCT07090824
Improving Islet Transplantation Outcomes With Gastrin for Type I Diabetes
City of Hope Medical Center
NCT03746769
Feasibility Study of Extended Wear Insulin Infusion Set Options During Home Use in People With Type 1 Diabetes
Tandem Diabetes Care
NCT07325461
Islet Transplantation in Patients With "Brittle" Type I Diabetes
University of Chicago
NCT01630850
Safety and Efficacy of CELZ-201 in Patients With Recent Onset Type 1 Diabetes
Creative Medical Technology Holdings
NCT05626712
Regulation of Brain Glucose Metabolism in Type 1 Diabetes
Yale University
NCT05317455
CBTi for the Treatment of Insomnia in Type 1 Diabetes
University of Illinois at Chicago
NCT07091318
A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus
Otsuka Pharmaceutical Factory
NCT06575426
Islet Transplantation in Type 1 Diabetic Kidney Allograft
University of Chicago
NCT01241864
Phase 2b Trial Comparing HDV-Insulin Lispro to Insulin Lispro in Adults With Type 1 Diabetes Receiving Insulin Degludec
Diasome Pharmaceuticlas
NCT06238778
Recent-Onset Type 1 Diabetes Extension Study Evaluating the Long-Term Safety of Teplizumab (PROTECT Extension)
Provention Bio, a Sanofi Company
NCT04598893
Using Technology to Address Disparities and Promote Healthcare Equity in Type 1 Diabetes Registry
University of Chicago
NCT06899984
Testing an Integrated Care Model Trial
Emory University
NCT06448429
Diabetes Autoimmunity Withdrawn In New Onset and In Established Patients
Tolerion
NCT03895437
Janus Kinase (JAK) Inhibitors to Preserve C-Peptide Production in New Onset Type 1 Diabetes (T1D)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT05743244
Metformin for Preeclampsia Prevention in Pregnant Women With Type 1 Diabetes Mellitus
Maisa N. Feghali, MD
NCT03570632
Recurrent Hypoglycemia in Type 1 Diabetes (Aim 2)
University of Minnesota
NCT04387422
MEtabolic and Renal Effects of AutoMAted Insulin Delivery Systems in Youth With Type 1 Diabetes Mellitus
University of Colorado, Denver
NCT03945747
Allogenic Islet Cell Transplantation
University of Chicago
NCT00160732
Type 1 Together: A Peer Mentorship Program to Bolster Use of CGM
Nemours Children's Clinic
NCT06203067
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 13 |
| Phase 2 | 14 |
| Phase 3 | 23 |
| Phase 4 | 8 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Diabetes Mellitus, Type 1 Trial Landscape
119 indexed Diabetes Mellitus, Type 1 studies · 39 recruiting (33%).
Phase mix: 31 late (III/IV) vs 27 early (I/II).
Top sponsor: Novo Nordisk A/S (11 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Diabetes Mellitus, Type 1?
PlainTrial tracks 119 US clinical trials for Diabetes Mellitus, Type 1, of which 39 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Diabetes Mellitus, Type 1?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.