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Diabetes Mellitus, Type 1 clinical trials
Every US clinical trial registered for Diabetes Mellitus, Type 1 — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
112 US clinical trials · 37 currently recruiting
The research picture
Diabetes Mellitus, Type 1 has 112 registered US clinical trials, 37 of them open to new participants right now — about 33% of the total.
- 37
- recruiting participants now
- 33%
- of trials open to enrollment
- 30
- in Phase 3–4 (later-stage)
- 11
- top sponsor: Novo Nordisk A/S
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
TrialNet Pathway to Prevention of T1D
University of South Florida
NCT00097292
The T1D Exchange Registry
T1D Exchange, United States
NCT04629586
Genetics Of Autoimmunity In Type I Diabetes
Medical College of Wisconsin
NCT03648918
Best Practice Advisories to Reduce Inequities in Technology Use for People With Type 1 Diabetes
T1D Exchange, United States
NCT06931275
A Research Study to See How a Weekly Insulin, Insulin Icodec, Helps in Reducing the Blood Sugar Compared to Daily Insulin Glargine, Both in Combination With Insulin Aspart, in Adults With Type 1 Diabetes
Novo Nordisk A/S
NCT07076199
T1D Pregnancy & Me
Jaeb Center for Health Research
NCT06959316
Type 1 Diabetes Recurrence in Pancreas Transplants
University of Miami
NCT01047865
Closed Loop and Education for Hypoglycemia Awareness Restoration
Milton S. Hershey Medical Center
NCT06325202
A Study of Baricitinib (LY3009104) to Preserve Beta Cell Function in Children and Adults Newly Diagnosed With Type 1 Diabetes (BARICADE-PRESERVE)
Eli Lilly and Company
NCT07222332
Behavioral Approaches to Reduce Diabetes Distress in Adults With Type 1 Diabetes: A Pragmatic SMART
University of North Carolina, Chapel Hill
NCT06405373
National Institute of Diabetes and Digestive Kidney Diseases* Share Plus: Continuous Glucose Monitoring with Data Sharing in Older Adults with Type 1 Diabetes* and Their Care Partners to Improve Time in Range and Reduce Diabetes Distress.
University of Utah
NCT05937321
Food Insecurity Reduction & Strategy Team
Stanford University
NCT06329375
Repeat BCG Vaccinations For The Treatment Of Pediatric Type 1 Diabetes
Massachusetts General Hospital
NCT05180591
A Study of Baricitinib (LY3009104) for the Delay of Stage 3 Type 1 Diabetes in At-Risk Children and Adults
Eli Lilly and Company
NCT07222137
Cadisegliatin as Adjunctive Therapy to Insulin in Participants With Type 1 Diabetes
vTv Therapeutics
NCT06334133
Hybrid Closed Loop Effectiveness Trial in Adults With Type 1 Diabetes
Boston Medical Center
NCT06236607
Diabetes Learning in Virtual Environments Just in Time for Community Reentry
Louise Reagan
NCT05286892
Device Use Reimagined Through Education And Mentorship
University of California, San Francis
NCT06546930
Randomized Trial of Supplemental Synchronous and Asynchronous Telehealth to Improve Glycemic Control for Pediatric Patients With Type 1 Diabetes
University of California, Davis
NCT04428658
Game-based Pediatric Diabetes Education
Carnegie Mellon University
NCT06264258
Type 1 Diabetes Impacts of Semaglutide on Cardiovascular Outcomes
University of Colorado, Denver
NCT05819138
Cellular Therapy for Type 1 Diabetes Using Mesenchymal Stem Cells
Medical University of South Carolina
NCT04061746
Efficacy and Safety of a Ketogenic Diet in Type 1 Diabetes
Washington University School of Medicine
NCT06503809
A Safety, Tolerability, and Efficacy Study of VX-880 in Participants With Type 1 Diabetes
Vertex Pharmaceuticals Incorporated
NCT04786262
Carbohydrate Beta Cell Function and Glucose Control in Children With Diabetes
Boston Children's Hospital
NCT05899166
Continuous Glucose Metrics in Patients With Gastroparesis in Type 1 or Type 2 Diabetes
Samita Garg
NCT06046833
Breaking Disparities in Access to Advanced Diabetes Technologies in Children With Type 1 Diabetes
Nemours Children's Clinic
NCT05849753
Starting Technology in At Risk Type 1 Diabetes Study
University of California, Los Angeles
NCT06453928
Effect of Inhaled Technosphere Insulin vs RAA Insulin on Exercise-Induced Hypoglycemia in Adults With T1D Using Automated Insulin Delivery
Jaeb Center for Health Research
NCT06880835
Subcutaneous Pharmacokinetic Evaluation of Monomeric Insulin and Lyumjev in Adults With Type 1 Diabetes
Stanford University
NCT07090824
Improving Islet Transplantation Outcomes With Gastrin for Type I Diabetes
City of Hope Medical Center
NCT03746769
Feasibility Study of Extended Wear Insulin Infusion Set Options During Home Use in People With Type 1 Diabetes
Tandem Diabetes Care
NCT07325461
Islet Transplantation in Patients With "Brittle" Type I Diabetes
University of Chicago
NCT01630850
Safety and Efficacy of CELZ-201 in Patients With Recent Onset Type 1 Diabetes
Creative Medical Technology Holdings
NCT05626712
Regulation of Brain Glucose Metabolism in Type 1 Diabetes
Yale University
NCT05317455
A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus
Otsuka Pharmaceutical Factory
NCT06575426
Islet Transplantation in Type 1 Diabetic Kidney Allograft
University of Chicago
NCT01241864
Phase 2b Trial Comparing HDV-Insulin Lispro to Insulin Lispro in Adults With Type 1 Diabetes Receiving Insulin Degludec
Diasome Pharmaceuticlas
NCT06238778
Recent-Onset Type 1 Diabetes Extension Study Evaluating the Long-Term Safety of Teplizumab (PROTECT Extension)
Provention Bio, a Sanofi Company
NCT04598893
Using Technology to Address Disparities and Promote Healthcare Equity in Type 1 Diabetes Registry
University of Chicago
NCT06899984
Testing an Integrated Care Model Trial
Emory University
NCT06448429
Diabetes Autoimmunity Withdrawn In New Onset and In Established Patients
Tolerion
NCT03895437
Janus Kinase (JAK) Inhibitors to Preserve C-Peptide Production in New Onset Type 1 Diabetes (T1D)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT05743244
Metformin for Preeclampsia Prevention in Pregnant Women With Type 1 Diabetes Mellitus
Maisa N. Feghali, MD
NCT03570632
Recurrent Hypoglycemia in Type 1 Diabetes (Aim 2)
University of Minnesota
NCT04387422
MEtabolic and Renal Effects of AutoMAted Insulin Delivery Systems in Youth With Type 1 Diabetes Mellitus
University of Colorado, Denver
NCT03945747
Allogenic Islet Cell Transplantation
University of Chicago
NCT00160732
Type 1 Together: A Peer Mentorship Program to Bolster Use of CGM
Nemours Children's Clinic
NCT06203067
Family-Based Treatment for Type 1 Diabetes
State University of New York at Buffalo
NCT05756361
Teplizumab in Pediatric Stage 2 Type 1 Diabetes
Sanofi
NCT05757713
The Efficacy and Safety of Liraglutide as Adjunct Therapy to Insulin in the Treatment of Type 1 Diabetes
Novo Nordisk A/S
NCT01836523
The Loop Observational Study
Jaeb Center for Health Research
NCT03838900
Efficacy and Safety of Faster-acting Insulin Aspart Compared to NovoRapid® Both in Combination With Insulin Degludec in Adults With Type 1 Diabetes
Novo Nordisk A/S
NCT02500706
Empagliflozin as Adjunctive to InSulin thErapy Over 52 Weeks in Patients With Type 1 Diabetes Mellitus (EASE-2)
Boehringer Ingelheim
NCT02414958
Comparison of NN1250 Plus Insulin Aspart With Insulin Glargine Plus Insulin Aspart in Type 1 Diabetes
Novo Nordisk A/S
NCT00982228
A Research Study to Compare a New Weekly Insulin, Insulin Icodec, and an Available Daily Insulin, Insulin Degludec, Both in Combination With Mealtime Insulin in People With Type 1 Diabetes (ONWARDS 6)
Novo Nordisk A/S
NCT04848480
Comparison of NN5401 Plus Insulin Aspart With Insulin Detemir Plus Insulin Aspart in Type 1 Diabetes
Novo Nordisk A/S
NCT00978627
A Study in Adults With Type 1 Diabetes
Eli Lilly and Company
NCT01421147
NovoLog Observation Trial in Subjects With Type 1 and Type 2 Diabetes
Novo Nordisk A/S
NCT00095446
Evaluate the Efficacy of Insulin Patients With Type 1 Diabetes
Eli Lilly and Company
NCT00356109
Mylan Insulin Aspart Study
Mylan
NCT03760068
Study of Human Insulin Inhalation Powder in Patients With Type 1 Diabetes
Eli Lilly and Company
NCT00127634
A Trial Investigating the Efficacy and Safety of Insulin Degludec/Insulin Aspart Once Daily Plus Insulin Aspart for the Remaining Meals Versus Insulin Detemir Once or Twice Daily Plus Meal Time Insulin Aspart in Children and Adolescents With Type 1 Diabetes Mellitus
Novo Nordisk A/S
NCT01835431
Patient and Parent Preferences for an On-Body Automated Insulin Delivery System
Joslin Diabetes Center
NCT03534544
Afrezza® INHALE-1 Study in Pediatrics
Mannkind Corporation
NCT04974528
Evaluation of Dose-titration of Pramlintide During Initiation of Therapy in Patients Trying to Improve Glucose Control
AstraZeneca
NCT00042458
Effect of Insulin Glulisine Compared to Insulin Aspart and Insulin Lispro When Administered by Continuous Subcutaneous Insulin Infusion (CSII) on Specific Pump Parameters in Patient With Type 1 Diabetes Mellitus
Sanofi
NCT00607087
Post Approval Study of the Eversense® Continuous Glucose Monitoring
Senseonics
NCT03908125
Evaluation of Blood Volume and Perceived Pain During Fingerstick Monitoring of Blood Glucose
Becton, Dickinson and Company
NCT00741390
Efficacy, Safety and Preference Study of a Insulin Pen PDS290 vs. a Novo Nordisk Marketed Insulin Pen in Diabetics
Novo Nordisk A/S
NCT00773279
Peer i-Coaching for Activated Self-Management Optimization in Adolescents and Young Adults With Chronic Conditions
Duke University
NCT03938324
Managing Type 1 and High Risk Type 2 Diabetes in the Hospital Setting: Glucose as a Vital Sign
Scripps Whittier Diabetes Institute
NCT03068273
Day and Night Closed-loop in Young People With Type 1 Diabetes
Jaeb Center for Health Research
NCT02925299
Pilot Study of Brief Intervention to Support Diabetes Health-Related Quality of Life
Baylor College of Medicine
NCT05234944
Evaluation of TTP399 in Patients With Type 1 Diabetes
vTv Therapeutics
NCT03335371
Clinical Trial of SB-509 in Subjects With Diabetic Neuropathy
Sangamo Therapeutics
NCT00406458
Diabetes Pump With Predictive Low Glucose Suspend Pivotal Trial
Tandem Diabetes Care
NCT03195140
Clinical Trial of SB-509 in Subjects With Diabetic Neuropathy
Sangamo Therapeutics
NCT00476931
Clinical Startup of the 670G Closed Loop Insulin Delivery System
Stanford University
NCT03017482
Assessment of Mealtime Bolus Insulin Behavior
Eli Lilly and Company
NCT03368807
Efficacy and Safety of Nasal Glucagon for Treatment of Hypoglycemia in Adults
Eli Lilly and Company
NCT01994746
Insulin-Glucose-Glucagon Network: Defining a Type 1 Diabetes Progression Index
University of Virginia
NCT02663661
ACT1ON Phase 2 (SMART Pilot) and Phase 3 (Efficacy Trial Development)
University of North Carolina, Chapel Hill
NCT03651622
Comparison of Glycemic Control Achieved With 2 Different Needles
Novo Nordisk A/S
NCT00572052
Copeptin in Adolescent Participants With Type 1 Diabetes and Early Renal Hemodynamic Function
University of Colorado, Denver
NCT03618420
Green Digital Diabetes Waste Project
Florida State University
NCT06071325
Safety Study of Subcutaneously-Injected Prandial INSULIN-PH20 NP Compared to Insulin Lispro Injection in Participants With Type 1 Diabetes Mellitus
Halozyme Therapeutics
NCT00883558
Recurrent Hypoglycemia in Type 1 Diabetes (Aim 1)
University of Minnesota
NCT03410277
Comparison of Hepatic Directed Vesicle (HDV)-Insulin Lispro Versus Insulin Lispro to Further Improve Glycemic Control
Diasome Pharmaceuticals
NCT03096392
Counter-Regulatory Impairment and the Effect of Microvascular Insulin Transfer in Type 1 Diabetes Mellitus
University of Virginia
NCT00943787
Pilot Study of Connected Diabetes Technology
University of California, Davis
NCT04106440
A Trial Evaluating Compatibility and Safety of FIAsp and Insulin Aspart With an External Continuous Subcutaneous Insulin Infusion System in Adult Subjects With Type 1 Diabetes
Novo Nordisk A/S
NCT01999322
A Study To Assess The Safety Of PF-06342674 In Adults With Type 1 Diabetes
Pfizer
NCT02038764
Diabetes Assistant (DiAs) Control-to-Range (CTR) Nocturnal Closed-Loop Camp Study
University of Virginia
NCT01973413
A Pilot Study of Biomarkers of Stress in Youth Who Use Teens.Connect
Yale University
NCT02970656
A Continuous Glucose Monitor Based Insulin Bolus Calculator
Welldoc
NCT05229445
Comparison of Insulin Degludec With Insulin Glargine U100 for Adults With Type 1 Diabetes Crossing Multiple Time Zones.
Sansum Diabetes Research Institute
NCT03668808
Study of Calcium Metabolism in Teenage Girls With Type 1 Diabetes
University of Rochester
NCT03156179
Assessment of an Automatic Closed-loop Insulin Delivery System
Stanford University
NCT02366767
Afrezza® Dosing Optimization Study
Mannkind Corporation
NCT04849845
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 11 |
| Phase 2 | 13 |
| Phase 3 | 22 |
| Phase 4 | 8 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Diabetes Mellitus, Type 1 Trial Landscape
ClinicalTrials.gov lists 112 US studies indexed under Diabetes Mellitus, Type 1, and 37 of those are currently open to recruitment — roughly 33% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Diabetes Mellitus, Type 1 shows 30 late-stage studies (Phase 3 and Phase 4 combined) alongside 24 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Diabetes Mellitus, Type 1 is led by Novo Nordisk A/S with 11 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Diabetes Mellitus, Type 1?
PlainTrial tracks 112 US clinical trials for Diabetes Mellitus, Type 1, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Diabetes Mellitus, Type 1?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.