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COMPLETED Phase 2

A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (PAH) (MK-7962-024)

NCT06664801 · View on ClinicalTrials.gov ↗

Study Summary

Researchers are looking for other ways to treat people with PAH. In PAH, the blood vessels in the lungs become thick and narrow, which makes it harder for blood to flow to the lungs. The goal of the study is to learn: * What happens to different doses of sotatercept in a person's body over time when it is given using weight-banded doses compared to weight-based doses. There may be differences in how the medicine works with the new dosing method (weight-banded dosing) being studied in this trial. * About the safety of sotatercept and if people tolerate it

Interventions

  • BIOLOGICAL Sotatercept
  • BIOLOGICAL Background PAH Therapy

Study Locations (20)

Other

  • Hospital Britanico de Buenos Aires ( Site 0004) — CABA
  • Instituto de Cardiologia Juana F. Cabral ( Site 0008) — Corrientes
  • Hospital Provincial Jose Maria Cullen ( Site 0005) — Santa Fe

Buenos Aires

  • Centro Medico Capital ( Site 0002) — La Plata
  • Instituto de Investigaciones Clinicas Mar del Plata ( Site 0006) — Mar del Plata

New South Wales

  • Royal Prince Alfred Hospital ( Site 0103) — Camperdown
  • Westmead Hospital ( Site 0100) — Westmead

Arizona

  • Pulmonary Associates, PA ( Site 1903) — Phoenix

Colorado

  • University of Colorado Anschutz Medical Campus-University of Colorado Hospital Cardiac and Vascular ( Site 1930) — Aurora

Indiana

  • Indiana University Health Methodist Hospital ( Site 1905) — Indianapolis

Kansas

  • University of Kansas Medical Center ( Site 1928) — Kansas City

Kentucky

  • Norton Pulmonary Specialists ( Site 1935) — Louisville

Trial Details

FieldValue
Enrollment Target 164 participants
Start Date 2024-11-14
Est. Completion 2025-11-20
Phase Phase 2

Sponsor

Merck Sharp & Dohme

741 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06664801

The ClinicalTrials.gov registry entry for NCT06664801 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 164 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Pulmonary Arterial Hypertension appearing as the primary indexed condition, and to 2 interventions — of which Sotatercept is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06664801 reports 20 study locations spanning 16 distinct geographic areas — top geographies include Other, Buenos Aires, New South Wales. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06664801 about?

NCT06664801 is a clinical study titled "A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (PAH) (MK-7962-024)". Researchers are looking for other ways to treat people with PAH. In PAH, the blood vessels in the lungs become thick and narrow, which makes it harder for blood to flow to the lungs. The goal of the study is to learn: * What happens to different doses of sotatercept in a person's body over time wh...

What is the current status of trial NCT06664801?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 164 participants. The study started on 2024-11-14. Estimated completion is 2025-11-20.

What conditions does trial NCT06664801 study?

This clinical trial studies the following conditions: Pulmonary Arterial Hypertension. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06664801?

The interventions under investigation include: Sotatercept (BIOLOGICAL), Background PAH Therapy (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06664801?

This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06664801 being conducted?

This trial has 20 study locations across Arizona, Colorado, Indiana, Kansas, Kentucky. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial