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NCT06664801 · ClinicalTrials.gov registry record · Phase 2
A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (PAH) (MK-7962-024)
A Phase 2 study of Pulmonary Arterial Hypertension, sponsored by Merck Sharp & Dohme.
- Completed
- Registry status
- Phase 2
- Development phase
- 164
- Enrollment target
- 20
- Study locations
NCT06664801: Completed Phase 2 study of Pulmonary Arterial Hypertension, sponsored by Merck Sharp & Dohme.
NCT06664801 is a Phase 2 study of Pulmonary Arterial Hypertension that has completed, run by Merck Sharp & Dohme. The registered enrollment target is 164 participants, below the 460-participant average among 63 other Pulmonary Arterial Hypertension trials with a reported enrollment target (64% lower). The trial reports 20 study locations across 16 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06664801, a Phase 2 study of Pulmonary Arterial Hypertension, has completed, sponsored by Merck Sharp & Dohme.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 164 participants
- Enrollment target
- 20
- Study locations
Study Summary
Researchers are looking for other ways to treat people with PAH. In PAH, the blood vessels in the lungs become thick and narrow, which makes it harder for blood to flow to the lungs. The goal of the study is to learn: * What happens to different doses of sotatercept in a person's body over time when it is given using weight-banded doses compared to weight-based doses. There may be differences in how the medicine works with the new dosing method (weight-banded dosing) being studied in this trial. * About the safety of sotatercept and if people tolerate it
Primary Outcome
Steady-state Cavg of sotatercept will be reported.
Conditions Studied
Interventions
- BIOLOGICAL Sotatercept
- BIOLOGICAL Background PAH Therapy
Study Locations (20)
Other
- Hospital Britanico de Buenos Aires ( Site 0004) - CABA
- Instituto de Cardiologia Juana F. Cabral ( Site 0008) - Corrientes
- Hospital Provincial Jose Maria Cullen ( Site 0005) - Santa Fe
Buenos Aires
- Centro Medico Capital ( Site 0002) - La Plata
- Instituto de Investigaciones Clinicas Mar del Plata ( Site 0006) - Mar del Plata
New South Wales
- Royal Prince Alfred Hospital ( Site 0103) - Camperdown
- Westmead Hospital ( Site 0100) - Westmead
Arizona
- Pulmonary Associates, PA ( Site 1903) - Phoenix
Colorado
- University of Colorado Anschutz Medical Campus-University of Colorado Hospital Cardiac and Vascular ( Site 1930) - Aurora
Indiana
- Indiana University Health Methodist Hospital ( Site 1905) - Indianapolis
Kansas
- University of Kansas Medical Center ( Site 1928) - Kansas City
Kentucky
- Norton Pulmonary Specialists ( Site 1935) - Louisville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 164 participants |
| Start Date | 2024-11-14 |
| Est. Completion | 2025-11-20 |
| Phase | Phase 2 |
What the finished NCT06664801 record still lists
NCT06664801 is an interventional study that assigns participants to a tested intervention. The registered 164 participants enrollment target is mid-sized for trials with a published cap, below the 460-participant average among 63 other Pulmonary Arterial Hypertension trials with a reported enrollment target (64% lower).
The record links to 1 condition, with Pulmonary Arterial Hypertension appearing as the primary indexed condition, and to 2 interventions - of which Sotatercept is the first listed.
NCT06664801 names 20 study sites across 16 states, led by Other, Buenos Aires, New South Wales.
Frequently Asked Questions
What is clinical trial NCT06664801 about?
NCT06664801 is a clinical study titled "A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (PAH) (MK-7962-024)". Researchers are looking for other ways to treat people with PAH. In PAH, the blood vessels in the lungs become thick and narrow, which makes it harder for blood to flow to the lungs. The goal of the study is to learn: * What happens to different doses of sotatercept in a person's body over time wh...
What is the current status of trial NCT06664801?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 164 participants. The study started on 2024-11-14. Estimated completion is 2025-11-20.
What conditions does trial NCT06664801 study?
This clinical trial studies the following conditions: Pulmonary Arterial Hypertension.
What interventions are being tested in trial NCT06664801?
The interventions under investigation include: Sotatercept (BIOLOGICAL), Background PAH Therapy (BIOLOGICAL).
Who is sponsoring clinical trial NCT06664801?
This trial is sponsored by Merck Sharp & Dohme, which has 558 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06664801 being conducted?
This trial has 20 study locations across Arizona, Colorado, Indiana, Kansas, Kentucky. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06664801's enrollment target sits among peer trials
164 14th of 63 higher than 50 of 63 other Pulmonary Arterial Hypertension trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Pulmonary Arterial Hypertension trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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