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ACTIVE NOT RECRUITING Phase 2

A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-031/LIGHTRAY EXTENSION)

NCT06925750 · View on ClinicalTrials.gov ↗

Study Summary

Researchers are looking for other ways to treat pulmonary arterial hypertension (PAH). Sotatercept is a study medicine that is designed to treat PAH. A past study, MK-7962-024 (LIGHTRAY) (NCT06664801), learned about the safety and effects of sotatercept in people with PAH. One of the goals of that study was to learn about sotatercept when given at a dose (amount) based on the weight range a person is in (weight-banded doses) compared to when given based on a person's exact weight. This is an extension study, which means people who took part in MK-7962-024 (LIGHTRAY) may be able to join this study. In this extension study, people will get weight-banded doses of sotatercept. The main goal of this study is to learn about the safety of weight-banded doses of sotatercept and if people tolerate it over a longer period of time.

Interventions

  • BIOLOGICAL Sotatercept
  • DRUG Background PAH Therapy

Study Locations (20)

Buenos Aires

  • Centro Medico Capital ( Site 0002) — La Plata
  • Instituto de Investigaciones Clinicas Mar del Plata ( Site 0006) — Mar del Plata

Other

  • Instituto de Cardiologia Juana F. Cabral ( Site 0008) — Corrientes
  • Hospital Provincial Jose Maria Cullen ( Site 0005) — Santa Fe

New South Wales

  • Royal Prince Alfred Hospital ( Site 0103) — Camperdown
  • Westmead Hospital ( Site 0100) — Westmead

Bogota D.C.

  • Clinica Colsanitas - Sede Reina Sofia ( Site 0303) — Bogotá
  • Fundacion Santa Fe de Bogota ( Site 0302) — Bogotá

Colorado

  • University of Colorado Anschutz Medical Campus-University of Colorado Hospital Cardiac and Vascular ( Site 1930) — Aurora

Kansas

  • University of Kansas Medical Center ( Site 1928) — Kansas City

New Mexico

  • University of New Mexico Health Sciences Center - Department of Internal Medicine ( Site 1916) — Albuquerque

Córdoba Province

  • Instituto Medico Rio Cuarto ( Site 0010) — Río Cuarto

Trial Details

FieldValue
Enrollment Target 130 participants
Start Date 2025-05-12
Est. Completion 2028-06-16
Phase Phase 2

Sponsor

Merck Sharp & Dohme

741 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06925750

The ClinicalTrials.gov registry entry for NCT06925750 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 130 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Pulmonary Arterial Hypertension appearing as the primary indexed condition, and to 2 interventions — of which Sotatercept is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06925750 reports 20 study locations spanning 16 distinct geographic areas — top geographies include Buenos Aires, Other, New South Wales. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06925750 about?

NCT06925750 is a clinical study titled "A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-031/LIGHTRAY EXTENSION)". Researchers are looking for other ways to treat pulmonary arterial hypertension (PAH). Sotatercept is a study medicine that is designed to treat PAH. A past study, MK-7962-024 (LIGHTRAY) (NCT06664801), learned about the safety and effects of sotatercept in people with PAH. One of the goals of that ...

What is the current status of trial NCT06925750?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 130 participants. The study started on 2025-05-12. Estimated completion is 2028-06-16.

What conditions does trial NCT06925750 study?

This clinical trial studies the following conditions: Pulmonary Arterial Hypertension. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06925750?

The interventions under investigation include: Sotatercept (BIOLOGICAL), Background PAH Therapy (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06925750?

This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06925750 being conducted?

This trial has 20 study locations across Colorado, Kansas, New Mexico, Buenos Aires, Córdoba Province. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial