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Pulmonary Arterial Hypertension clinical trials
21 of 64 indexed Pulmonary Arterial Hypertension trials are currently recruiting.
64 US clinical trials · 21 currently recruiting
Pulmonary Arterial Hypertension is the subject of 64 registered US clinical trials on ClinicalTrials.gov, 21 of them currently open to new participants. 18 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is Actelion, running 7 of these trials.
The research picture
Pulmonary Arterial Hypertension has 64 registered US clinical trials, 21 of them open to new participants right now, about 33% of the total.
- 21
- recruiting participants now
- 33%
- of trials open to enrollment
- 18
- in Phase 3–4 (later-stage)
- 7
- top sponsor: Actelion
Active & Recent Trials
64 total, page 2 of 2
Right Ventricular Metabolism in Pulmonary Arterial Hypertension
Vanderbilt University Medical Center
NCT02763735
Safely Change From Bosentan to Ambrisentan in Pulmonary Hypertension
University of Alabama at Birmingham
NCT01330108
Subcutaneous Elafin in Healthy Subjects
Roham T. Zamanian
NCT03522935
Effects of DHEA in Pulmonary Hypertension
Rhode Island Hospital
NCT03648385
A Clinical Trial of Ambrisentan and Tadalafil in Pulmonary Arterial Hypertension Associated With Systemic Sclerosis
Johns Hopkins University
NCT01042158
Inhaled Iloprost for Sarcoidosis-associated Pulmonary Hypertension
University of Cincinnati
NCT00403650
Safety Study of the Switch From Oral Selexipag to Intravenous Selexipag in Subjects With Stable Pulmonary Arterial Hypertension
Actelion
NCT03187678
Anastrozole in Patients With Pulmonary Arterial Hypertension
University of Pennsylvania
NCT01545336
Sorafenib Study: Dosing in Patients With Pulmonary Arterial Hypertension (PAH)
University of Chicago
NCT00452218
A Study of Ranolazine Acute Administration and Short Term Administration in Pulmonary Arterial Hypertension
University of Chicago
NCT01757808
Nitric Oxide, GeNO Nitrosyl Delivery System
Wake Forest University Health Sciences
NCT01165047
Oral Iron Supplementation in Pulmonary Hypertension
The Cleveland Clinic
NCT01446848
Transition From Injectable Prostacyclin Medication to Inhaled Prostacyclin Medication
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
NCT01268553
Epoprostenol for Injection in Pulmonary Arterial Hypertension - Extension of AC-066A401
Actelion
NCT01105117
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 6 |
| Phase 2 | 16 |
| Phase 3 | 7 |
| Phase 4 | 11 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Pulmonary Arterial Hypertension Trial Landscape
64 indexed Pulmonary Arterial Hypertension studies · 21 recruiting (33%).
Phase mix: 18 late (III/IV) vs 22 early (I/II).
Top sponsor: Actelion (7 trials), 9 others listed. 14 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Pulmonary Arterial Hypertension?
PlainTrial tracks 64 US clinical trials for Pulmonary Arterial Hypertension, of which 21 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Pulmonary Arterial Hypertension?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.