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ClinicalTrials.gov 21 recruiting now official registry

Pulmonary Arterial Hypertension clinical trials

21 of 64 indexed Pulmonary Arterial Hypertension trials are currently recruiting.

64 US clinical trials · 21 currently recruiting

Pulmonary Arterial Hypertension is the subject of 64 registered US clinical trials on ClinicalTrials.gov, 21 of them currently open to new participants. 18 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is Actelion, running 7 of these trials.

The research picture

Pulmonary Arterial Hypertension has 64 registered US clinical trials, 21 of them open to new participants right now, about 33% of the total.

21
recruiting participants now
33%
of trials open to enrollment
18
in Phase 3–4 (later-stage)
7
top sponsor: Actelion
Phase 16Phase 216Phase 37Phase 411

Active & Recent Trials

64 total, page 2 of 2

COMPLETED 34 participants

Right Ventricular Metabolism in Pulmonary Arterial Hypertension

Vanderbilt University Medical Center

NCT02763735

COMPLETED Phase 4 32 participants

Safely Change From Bosentan to Ambrisentan in Pulmonary Hypertension

University of Alabama at Birmingham

NCT01330108

COMPLETED Phase 1 30 participants

Subcutaneous Elafin in Healthy Subjects

Roham T. Zamanian

NCT03522935

COMPLETED Phase 2 26 participants

Effects of DHEA in Pulmonary Hypertension

Rhode Island Hospital

NCT03648385

COMPLETED Phase 4 25 participants

A Clinical Trial of Ambrisentan and Tadalafil in Pulmonary Arterial Hypertension Associated With Systemic Sclerosis

Johns Hopkins University

NCT01042158

COMPLETED Phase 4 20 participants

Inhaled Iloprost for Sarcoidosis-associated Pulmonary Hypertension

University of Cincinnati

NCT00403650

COMPLETED Phase 3 20 participants

Safety Study of the Switch From Oral Selexipag to Intravenous Selexipag in Subjects With Stable Pulmonary Arterial Hypertension

Actelion

NCT03187678

COMPLETED Phase 2 18 participants

Anastrozole in Patients With Pulmonary Arterial Hypertension

University of Pennsylvania

NCT01545336

COMPLETED Phase 1 12 participants

Sorafenib Study: Dosing in Patients With Pulmonary Arterial Hypertension (PAH)

University of Chicago

NCT00452218

COMPLETED Phase 1 12 participants

A Study of Ranolazine Acute Administration and Short Term Administration in Pulmonary Arterial Hypertension

University of Chicago

NCT01757808

COMPLETED Phase 2 10 participants

Nitric Oxide, GeNO Nitrosyl Delivery System

Wake Forest University Health Sciences

NCT01165047

COMPLETED NA 6 participants

Oral Iron Supplementation in Pulmonary Hypertension

The Cleveland Clinic

NCT01446848

COMPLETED Phase 4 6 participants

Transition From Injectable Prostacyclin Medication to Inhaled Prostacyclin Medication

Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

NCT01268553

COMPLETED Phase 4 2 participants

Epoprostenol for Injection in Pulmonary Arterial Hypertension - Extension of AC-066A401

Actelion

NCT01105117

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Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 16
Phase 3 7
Phase 4 11

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Pulmonary Arterial Hypertension Trial Landscape

64 indexed Pulmonary Arterial Hypertension studies · 21 recruiting (33%).

Phase mix: 18 late (III/IV) vs 22 early (I/II).

Top sponsor: Actelion (7 trials), 9 others listed. 14 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Pulmonary Arterial Hypertension?

PlainTrial tracks 64 US clinical trials for Pulmonary Arterial Hypertension, of which 21 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Pulmonary Arterial Hypertension?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.