Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
A Clinical Study of to Confirm the Doses of Selexipag in Children With Pulmonary Arterial Hypertension
NCT03492177 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study to confirm the selexipag starting dose(s), selected based on pharmacokinetic (PK) extrapolation from adults, that leads to similar exposure as adults doses in children from greater than or equal to (\>=) 2 to less than (˂) 18 years of age with Pulmonary Arterial Hypertension (PAH), by investigating the PK of selexipag and its active metabolite ACT-333679 in this population.
Conditions Studied
Interventions
- DRUG selexipag (Uptravi)
Study Locations (20)
Other
- State Institution Republican Scientific And Practical Center For Pediatric Surgery — Minsk
- Health Institution 4Th City Children'S Clinical Hospital — Minsk
- UZ Gent — Ghent
- Beijing Anzhen Hospital — Beijing
- Shanghai Childrens Medical Center — Shanghai
- CHU Arnaud de Villeneuve — Montpellier
- Hôpital Necker - Enfants Malades — Paris
- Chu Hopital Des Enfants — Toulouse
- Universitätsklinikum Freiburg Zentrum — Freiburg im Breisgau
- Gottsegen György Országos Kardiológiai Intézet, Felnőtt kardiológiai osztály — Budapest
- Schneider Children's Medical Center — Petach Tikvah
- Sheba Medical Center — Ramat Gan
- Sarawak Heart Center — Kota Samarahan
- Institut Jantung Negara (National Heart Institute) — Kuala Lumpur
- Wojewodzki Szpital Specjalistyczny We Wroclawiu — Wroclaw
- Kazan State Medical University — Kazan'
Colorado
- Children'S Hospital Cardiac Care Center University Of Colorado — Aurora
Iowa
- University of Iowa Hospital — Iowa City
Washington
- Seattle Children's Hospital — Seattle
Quebec
- Centre Hospitalier Sainte Justine — Montreal
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 63 participants |
| Start Date | 2018-07-23 |
| Est. Completion | 2026-12-31 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03492177
The ClinicalTrials.gov registry entry for NCT03492177 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 63 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Actelion, which has 14 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Pulmonary Arterial Hypertension appearing as the primary indexed condition, and to 1 intervention — of which selexipag (Uptravi) is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT03492177 reports 20 study locations spanning 5 distinct geographic areas — top geographies include Other, Colorado, Iowa. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT03492177 about?
NCT03492177 is a clinical study titled "A Clinical Study of to Confirm the Doses of Selexipag in Children With Pulmonary Arterial Hypertension". The purpose of this study to confirm the selexipag starting dose(s), selected based on pharmacokinetic (PK) extrapolation from adults, that leads to similar exposure as adults doses in children from greater than or equal to (\>=) 2 to less than (˂) 18 years of age with Pulmonary Arterial Hypertensio...
What is the current status of trial NCT03492177?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 63 participants. The study started on 2018-07-23. Estimated completion is 2026-12-31.
What conditions does trial NCT03492177 study?
This clinical trial studies the following conditions: Pulmonary Arterial Hypertension. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT03492177?
The interventions under investigation include: selexipag (Uptravi) (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT03492177?
This trial is sponsored by Actelion, which has 14 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT03492177 being conducted?
This trial has 20 study locations across Colorado, Iowa, Washington, Quebec. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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